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Original Articles

Fumaric acids as a novel antagonist of TLR-4 pathway mitigates arsenic-exposed inflammation in human monocyte-derived dendritic cells

, ORCID Icon, &
Pages 513-520 | Received 01 Feb 2019, Accepted 14 Jul 2019, Published online: 09 Aug 2019

References

  • Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22:240–273.
  • Martins GR, Gelaleti GB, Moschetta MG, et al. Proinflammatory and anti-inflammatory cytokines mediated by NF-κB factor as prognostic markers in mammary tumors. Mediators Inflamm. 2016;2016:1.
  • Nowarski R, Jackson R, Flavell RA. The stromal intervention: regulation of immunity and inflammation at the epithelial-mesenchymal barrier. Cell. 2017;168:362–375.
  • Hemmi H, Akira S. TLR signalling and the function of dendritic cells. Chem Immunol Allergy. 2005;86:120–135.
  • Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer. Nat Rev Cancer. 2009;9:57–63.
  • Murphy K. Janeway's immunobiology. New York: Garland Science; 2012.
  • Novak N, Koch S, Allam JP, et al. Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis. J Allergy Clin Immunol. 2010;125:50–59.
  • Borg RJ, Samson AL, Au AEL, et al. Dendritic cell-mediated phagocytosis but not immune activation is enhanced by plasmin. PLoS One. 2015;10:e0131216
  • Bourdonnay E, Morzadec C, Fardel O, et al. Redox-sensitive regulation of gene expression in human primary macrophages exposed to inorganic arsenic. J Cell Biochem. 2009;107:537–547.
  • Singh RD, Tiwari R, Khan H, et al. Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. Toxicol Lett. 2015;237:1–10.
  • Rager JE, Bailey KA, Smeester L, et al. Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014;55:196–208.
  • Bjarnason I, Hayllar J, MacPherson AJ, et al. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993;104:1832–1847.
  • Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335:2–13.
  • Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16:821–847.
  • Harirforoosh S, Jamali F. Renal adverse effects of nonsteroidal anti-inflammatory drugs. Expert Opin Drug Saf. 2009;8:669–681.
  • Gillard GO, Collette B, Anderson J, et al. DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner. J Neuroimmunol. 2015;283:74–85.
  • Liu Y, Lv C, Xu Q, et al. Enhanced acid tolerance of Rhizopus oryzae during fumaric acid production. Bioprocess Biosyst Eng. 2015;38:323–328.
  • Bahari A, Salmani V. Environmentally relevant dose of arsenic interferes in functions of human monocytes derived dendritic cells. Toxicol Lett. 2017;275:118–122.
  • Bahari A, Mehrzad J, Mahmoudi M, et al. GST-M1 is transcribed moreso than AKR7A2 in AFB(1)-exposed human monocytes and lymphocytes. J Immunotoxicol. 2015;12:194–198.
  • Macoch M, Morzadec C, Fardel O, et al. Inorganic arsenic impairs differentiation and functions of human dendritic cells. Toxicol Appl Pharmacol. 2013;266:204–213.
  • Macoch M, Morzadec C, Genard R, et al. Nrf2-dependent repression of interleukin-12 expression in human dendritic cells exposed to inorganic arsenic. Free Radic Biol Med. 2015;88:381–390.
  • Steinman RM. Dendritic cells and the control of immunity: enhancing the efficiency of antigen presentation. Mt Sinai J Med. 2001;68:160–166.
  • Bomprezzi R. Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview. Ther Adv Neurol Disord. 2015;8:20–30.
  • Hernandez-Castro B, Doniz-Padilla LM, Salgado-Bustamante M, et al. Effect of arsenic on regulatory T cells. J Clin Immunol. 2009;29:461–469.
  • Morzadec C, Macoch M, Sparfel L, et al. Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone. Free Radic Biol Med. 2014;71:133–145.
  • Nayak AS, Lage CR, Kim CH. Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio). Toxicol Sci. 2007;98:118–124.
  • Rocha RA, Gimeno-Alcaniz JV, Martin-Ibanez R, et al. Arsenic and fluoride induce neural progenitor cell apoptosis. Toxicol Lett. 2011;203:237–244.
  • Calatayud M, Devesa V, Velez D. Differential toxicity and gene expression in Caco-2 cells exposed to arsenic species. Toxicol Lett. 2013;218:70–80.
  • Xu Y, Wang H, Wang Y, et al. Effects of folate on arsenic toxicity in Chang human hepatocytes: involvement of folate antioxidant properties. Toxicol Lett. 2010;195:44–50.
  • Conti L, Cardone M, Varano B, et al. Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes. Eur J Immunol. 2008;38:750–762.

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