Alantolactone mitigates renal injury induced by diabetes via inhibition of high glucose-mediated inflammatory response and macrophage infiltration

References

• Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98.
   PubMed Web of Science ®Google Scholar
• Ahmad J. Management of diabetic nephropathy: recent progress and future perspective. Diabetes Metab Syndr. 2015;9(4):343–358.
   PubMed Web of Science ®Google Scholar
• Sagoo MK, Gnudi L. Diabetic nephropathy: is there a role for oxidative stress? Free Radical Biol Med. 2018;116:50–63. 20
   PubMed Web of Science ®Google Scholar
• Mora-Gutierrez JM, Garcia-Fernandez N, Slon Roblero MF, et al. Arterial spin labeling MRI is able to detect early hemodynamic changes in diabetic nephropathy. J Magn Reson Imaging. 2017;46(6):1810–1817.
   PubMed Web of Science ®Google Scholar
• Brereton MF, Rohm M, Shimomura K, et al. Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic beta-cells. Nat Commun. 2016;7(1):13496.
   PubMedGoogle Scholar
• Sharma D, Bhattacharya P, Kalia K, et al. Diabetic nephropathy: new insights into established therapeutic paradigms and novel molecular targets. Diabetes Res Clin Prac. 2017;128:91–108.
   PubMed Web of Science ®Google Scholar
• Lv M, Chen Z, Hu G, et al. Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives. Drug Discov Today. 2015;20(3):332–346.
   PubMed Web of Science ®Google Scholar
• Yaribeygi H, Atkin SL, Pirro M, et al. A review of the anti-inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes. J Cell Physiol. 2018;234(6):8152–8161.
   PubMed Web of Science ®Google Scholar
• Yaribeygi H, Atkin SL, Sahebkar A. Interleukin-18 and diabetic nephropathy: a review. J Cell Physiol. 2018;119(7):6080–6093.
   Google Scholar
• Ferenbach D, Kluth DC, Hughes J. Inflammatory cells in renal injury and repair. Semin Nephrol. 2007;27(3):250–259.
   PubMed Web of Science ®Google Scholar
• An X, Zhang M, Zhou S, et al. Xiao-Shen-Formula, a Traditional Chinese Medicine, Improves Glomerular Hyper-Filtration in Diabetic Nephropathy via Inhibiting Arginase Activation and Heparanase Expression. Front Physiol. 2018;9:1195.
   PubMed Web of Science ®Google Scholar
• Cui L, Bu W, Song J, et al. Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. Arch Pharm Res. 2018;41(3):299–313.
   PubMed Web of Science ®Google Scholar
• Wang X, Lan YL, Xing JS, et al. Alantolactone plays neuroprotective roles in traumatic brain injury in rats via anti-inflammatory, anti-oxidative and anti-apoptosis pathways. Am J Transl Res. 2018;10(2):368–380.
   PubMed Web of Science ®Google Scholar
• Kim M, Song K, Kim YS. Alantolactone improves prolonged exposure of interleukin-6-induced skeletal muscle inflammation associated glucose intolerance and insulin resistance. Front Pharmacol. 2017;8:405.
   PubMed Web of Science ®Google Scholar
• Chun J, Choi RJ, Khan S, et al. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-kappaB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. Int Immunopharmacol. 2012;14(4):375–383.
   PubMed Web of Science ®Google Scholar
• Lim HS, Jin SE, Kim OS, et al. Alantolactone from Saussurea lappa exerts antiinflammatory effects by inhibiting chemokine production and STAT1 phosphorylation in TNF-alpha and IFN-gamma-induced in HaCaT cells. Phytother Res. 2015;29(7):1088–1096.
   PubMed Web of Science ®Google Scholar
• Kim M, Song K, Kim YS. Alantolactone improves palmitate-induced glucose intolerance and inflammation in both lean and obese states in vitro: adipocyte and adipocyte-macrophage co-culture system. International Immunopharmacology. 2017;49:187–194.
   PubMed Web of Science ®Google Scholar
• Pan Y, Zhu G, Wang Y, et al. Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart. J Nutr Biochem. 2013;24(1):146–155.
   PubMed Web of Science ®Google Scholar
• Muskiet MH, Tonneijck L, Smits MM, et al. Pleiotropic effects of type 2 diabetes management strategies on renal risk factors. Lancet Diabetes Endocrinol. 2015;3(5):367–381.
   PubMed Web of Science ®Google Scholar
• Anders HJ, Huber TB, Isermann B, et al. CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease. Nat Rev Nephrol. 2018;14(6):361–377.
   PubMed Web of Science ®Google Scholar
• Yeon MJ, Lee MH, Kim DH, et al. Anti-inflammatory effects of Kaempferol on Helicobacter pylori-induced inflammation. Biosci Biotechnol Biochem. 2019;83(1):166–173.
   PubMed Web of Science ®Google Scholar
• Li X, Jin Q, Yao Q, et al. The flavonoid quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice. Front Pharmacol. 2018;9:72.
   PubMed Web of Science ®Google Scholar
• Khajevand-Khazaei MR, Mohseni-Moghaddam P, Hosseini M, et al. Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1. European Journal of Pharmacology. 2018;833:307–313.
   PubMed Web of Science ®Google Scholar
• Barutta F, Bruno G, Grimaldi S, et al. Inflammation in diabetic nephropathy: moving toward clinical biomarkers and targets for treatment. Endocrine. 2015;48(3):730–742.
   PubMed Web of Science ®Google Scholar
• Yadav VR, Prasad S, Sung B, et al. The role of chalcones in suppression of NF-kappaB-mediated inflammation and cancer. Int Immunopharmacol. 2011;11(3):295–309.
   PubMed Web of Science ®Google Scholar
• Navarro-Gonzalez JF, Mora-Fernandez C, Muros de Fuentes M, et al. Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol. 2011;7(6):327–340.
   PubMed Web of Science ®Google Scholar
• Lee YJ, Moon MK, Hwang SM, et al. Anti-Inflammatory effect of Buddleja officinalis on vascular inflammation in human umbilical vein endothelial cells. Am J Chin Med. 2010;38(3):585–598.
   PubMed Web of Science ®Google Scholar