The potential hepatoprotective effects of lovastatin combined with oral hypoglycemic agents in streptozotocin-induced diabetes in rats

References

• Meng JM, Cao SY, Wei XL, et al. Effects and mechanisms of tea for the prevention and management of diabetes mellitus and diabetic complications: an updated review. Antioxidants (Basel). 2019;8(6):pii:E170.
   Google Scholar
• Li Y, Wang C, Huai Q, et al. Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta-analysis of ten randomized controlled trials. Diabetes Metab Res Rev. 2016;32(1):2–10.
   PubMed Web of Science ®Google Scholar
• Ashraf H, Zare S. Preventive effects of aqueous extract of Berberis integerrima Bge. Root on liver injury induced by diabetes mellitus (type 1) in rats. Iran J Pharm Res. 2015;14(1):335–343. PMID: 25561940.
   PubMed Web of Science ®Google Scholar
• Hsiang JC, Gane EJ, Bai WW, et al. Type 2 diabetes: a risk factor for liver mortality and complications in hepatitis B cirrhosis patients. J Gastroenterol Hepatol. 2015;30(3):591–599.
   PubMed Web of Science ®Google Scholar
• Panahi Y, Khalili N, Sahebi E, et al. Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled trial. Drug Res (Stuttg). 2018;68(7):403–409.
   PubMed Web of Science ®Google Scholar
• King RJ, Harrison L, Gilbey SG, et al. Diabetic hepatosclerosis: another diabetes microvascular complication? Diabet Med. 2016;33(2):e5–7.
   PubMed Web of Science ®Google Scholar
• Arata M, Nakajima J, Nishimata S, et al. Nonalcoholic steatohepatitis and insulin resistance in children. WJD. 2014;5(6):917–923.
   Google Scholar
• Wang X, Ao N, Du J, et al. Influence of GLP-1 on oxidative stress injury in non-alcoholic fatty liver disease rats. Zhonghua Gan Zang Bing Za Zhi. 2014;22(10):757–762.
   PubMedGoogle Scholar
• Mohamed J, Nafizah AH, Zariyantey AH, et al. Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation. SQUMJ. 2016;16(2):e132–141.
   Google Scholar
• Afrin R, Arumugam S, Soetikno V, et al. Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats. Free Radic Res. 2015;49(3):279–289.
   PubMed Web of Science ®Google Scholar
• Yokozawa T, Cho EJ, Park CH, et al. Protective effect of proanthocyanidin against diabetic oxidative stress. Evid Based Complement Alternat Med. 2012. DOI:10.1155/2012/623879
   Web of Science ®Google Scholar
• Walther U, Emmrich K, Ramer R, et al. Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARgamma-dependent pathway. Oncotarget. 2016;7(9):10345–10362.
   PubMedGoogle Scholar
• Awad E, Othman EM, Stopper H. Effects of resveratrol, lovastatin and the mTOR-inhibitor RAD-001 on insulin-induced genomic damage in vitro. Molecules. 2017;22(12):2207.
   Web of Science ®Google Scholar
• Kanugula AK, Gollavilli PN, Vasamsetti SB, et al. Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. Febs J. 2014;281(16):3719–3738.
   PubMed Web of Science ®Google Scholar
• Boiati RF, Manchini MT, Jacobsen O, et al. Evaluation of the anti-inflammatory activity of atorvastatin and its effect on alveolar diameter in a model of elastase-induced emphysema in rats. Drug Res (Stuttg). 2015;65(10):540–544.
   PubMed Web of Science ®Google Scholar
• Chaipichit N, Krska J, Pratipanawatr T, et al. Statin adverse effects: patients’ experiences and laboratory monitoring of muscle and liver injuries. Int J Clin Pharm. 2015;37(2):355–364.
   PubMed Web of Science ®Google Scholar
• Perdices EV, Medina-Cáliz I, Hernando S, et al. Hepatotoxicity associated with statin use: analysis of the cases included in the Spanish Hepatotoxicity Registry. Rev Esp Enferm Dig. 2014;106(4):246–254.
   PubMed Web of Science ®Google Scholar
• Chang CH, Chang JC, Lee YC, et al. Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study. J Gastroenterol Hepatol. 2015;30(1):155–162.
   PubMed Web of Science ®Google Scholar
• Adedara IA, Awogbindin IO, Anamelechi JP, et al. Garcinia kola seed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats. Pharm Biol. 2015;53(5):695–704.
   PubMed Web of Science ®Google Scholar
• El-Marasy SA, Abdallah HM, El-Shenawy SM, et al. Anti-depressant effect of hesperidin in diabetic rats. Can J Physiol Pharmacol. 2014;92(11):945–952.
   PubMed Web of Science ®Google Scholar
• Rashmi R, Magesh SB, Ramkumar KM, et al. Antioxidant potential of naringenin helps to protect liver tissue from streptozotocin-induced damage. Rep Biochem Mol Biol. 2018;7(1):76–84. PMC6175592.
   PubMed Web of Science ®Google Scholar
• Povoski SP, McCullough PJ, Zhou W, et al. Induction of diabetes mellitus in Syrian golden hamsters using stored equilibrium solutions of streptozotocin. Lab Anim Sci. 1993;43(4):310–314.
   PubMedGoogle Scholar
• Zeleniuk VH, Zamorskii II, Horoshko OM. Renoprotective efficacy of different doses of statins in experimental acute renal failure. Fiziol Zh. 2014;60(2):75–81. PMID: 25007525.
   PubMedGoogle Scholar
• Gales C, Zamfir C, Radulescu D. Protective effect of magnesium and metformin on endometrium and ovary in experimental diabetes mellitus. Magnes Res. 2014;27(2):69–76.
   PubMed Web of Science ®Google Scholar
• Mikov M, Al-Salami H, Golocorbin-Kon S, et al. The influence of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes. Eur J Drug Metabol Pharmacokinet. 2008;33(3):137–142.
   PubMed Web of Science ®Google Scholar
• Jagdale S, Patil SA, Kuchekar BS, et al. Preparation and characterization of metformin hydrochloride – compritol 888 ATO solid dispersion. J Young Pharm. 2011;3(3):197–204.
   PubMedGoogle Scholar
• Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969;22(2):158–161.
   PubMed Web of Science ®Google Scholar
• Harwood HJ, Schneider M, Stacpoole PW. Measurement of human leukocyte microsomal HMG-CoA reductase activity. J Lipid Res. 1984;25(9):967–978.
   PubMed Web of Science ®Google Scholar
• Clyne B, Olshaker JS. The C-reactive protein. J Emerg Med. 1999;17(6):1019–1025.
   PubMed Web of Science ®Google Scholar
• Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28(1):56–63.
   PubMed Web of Science ®Google Scholar
• Belfield A, Goldberg DM. Normal ranges and diagnostic value of serum 5’nucleotidase and alkaline phosphatase activities in infancy. Arch Dis Child. 1971;46(250):842–846.
   PubMed Web of Science ®Google Scholar
• Commitee S. Recommandations pour la mesure de la concentration catalytique de la lactate deshidrogenase dans le serum humain a 30 C. Ann Biol Clin. 1982;40:87–164.
   PubMedGoogle Scholar
• Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978;86(1):271–278.
   PubMed Web of Science ®Google Scholar
• Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70–77.
   PubMed Web of Science ®Google Scholar
• Keen JH, Habig WH, Jakoby WP. Mechanism for the several activities of the glutathione S-transferases. J Biol Chem. 1976;251(20):6183–6188.
   PubMed Web of Science ®Google Scholar
• Marklund SL. Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice. Mutat Res. 1985;148(1-2):129–134.
   PubMed Web of Science ®Google Scholar
• Aebi H. Catalase in vitro. Meth Enzymol. 1984;105:121–126.
   PubMed Web of Science ®Google Scholar
• Montgomery HAC, Dymock JF. The determination of nitrite in water. Analyst (London). 1961;86:414–416.
   Web of Science ®Google Scholar
• Brouckaert P, Libert B, Everaerdt N, et al. Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6. Immunobiology. 1993;187(3-5):317–329.
   PubMed Web of Science ®Google Scholar
• Bancroft GD, Steven A. Theory and practice of histological technique. London: Churchil Livingstone Publications; 1983.
   Google Scholar
• Divya BT, Mini S. Ethanol extract of Butea monosperma bark modulates dyslipidemia in streptozotocin-induced diabetic rats. Pharm Biol. 2014;52(8):1021–1027.
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860–867.
   PubMed Web of Science ®Google Scholar
• Sirdah MM. Protective and therapeutic effectiveness of taurine in diabetes mellitus: a rationale for antioxidant supplementation. Diabetes Metab Syndr. 2015;9(1):55–64.
   PubMed Web of Science ®Google Scholar
• Murali R, Srinivasan S, Ashokkumar N. Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Biochimie. 2013;95(10):1848–1854.
   PubMed Web of Science ®Google Scholar
• Amacher DE, Schomaker SJ, Aubrecht J. Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics. Mol Diagn Ther. 2013;17(6):343–354.
   PubMed Web of Science ®Google Scholar
• Dahech I, Belghith KS, Hamden K, et al. Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. Int J Biol Macromol. 2011;49(5):942–947.
   PubMed Web of Science ®Google Scholar
• Vozarova B, Stefan N, Lindsay RS, et al. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002;51(6):1889–1895.
   PubMed Web of Science ®Google Scholar
• Garcia Caraballo SC, Comhair TM, Dejong CH, et al. A high-protein diet is anti-steatotic and has no pro-inflammatory side effects in dyslipidaemic APOE2 knock-in mice. Br J Nutr. 2014;112(8):1251–1265.
   PubMed Web of Science ®Google Scholar
• Malaguarnera M, Di Rosa M, Nicoletti F, et al. Molecular mechanisms involved in NAFLD progression. J Mol Med. 2009;87(7):679–695.
   PubMed Web of Science ®Google Scholar
• Ohkuwa T, Sato Y, Naoi M. Hydroxyl radical formation in diabetic rats induced by streptozotocin. Life Sci. 1995;56(21):1789–1798.
   PubMed Web of Science ®Google Scholar
• Bao Z, Yuan X, Duan S, et al. Clinical implication of changes in serum adiponectin in patients with hepatogenic diabetes. Sci Rep. 2015;4(1):5560.
   Google Scholar
• Gundling F, Schumm-Draeger PM, Schepp W. Hepatogenous diabetes - diagnostics and treatment. Z Gastroenterol. 2009;47(05):436–445.
   PubMedGoogle Scholar
• Chogtu B, Magazine R, Bairy KL. Statin use and risk of diabetes mellitus. WJD. 2015;6(2):352–357.
   Google Scholar
• Zhou J, Li W, Xie Q, et al. Effects of simvastatin on glucose metabolism in mouse MIN6 cells. J Diabetes Res. 2014;2014:1–10.
   Web of Science ®Google Scholar
• Krause BR, Newton RS. Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models. Atherosclerosis. 1995;117(2):237–244.
   PubMed Web of Science ®Google Scholar
• Santos FD, Watanabe M, Vasco CF, et al. Antioxidant protection of statins in acute kidney injury induced by sepsis. Rev Esc Enferm Usp. 2014;48(5):820–826.
   PubMed Web of Science ®Google Scholar
• Chung HK, Kim YK, Park JH, et al. The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation. Liver Int. 2015;35(4):1341–1353.
   PubMed Web of Science ®Google Scholar
• El-Mahmoudy A, Shimizu Y, Shiina T, et al. Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism. Int Immunopharmacol. 2005;5(1):195–207.
   PubMed Web of Science ®Google Scholar
• Sindhu S, Singh HK, Salman MT, et al. Effects of atorvastatin and rosuvastatin on high-sensitivity C-reactive protein and lipid profile in obese type 2 diabetes mellitus patients. J Pharmacol Pharmacother. 2011;2(4):261–265.
   PubMedGoogle Scholar
• Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286(3):327–334.
   PubMed Web of Science ®Google Scholar
• Hasnain SZ, Borg DJ, Harcourt BE, et al. Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nat Med. 2014;20(12):1417–1426.
   PubMed Web of Science ®Google Scholar