Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis

References

• Symmons D, Turner G, Webb R, et al. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford). 2002; 41(7):793–800.
   PubMed Web of Science ®Google Scholar
• Carmona L, Cross M, Williams B, et al. Rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2010;24(6):733–745.
   PubMed Web of Science ®Google Scholar
• Sparks JA, Chang SC, Deane KD, et al. Associations of smoking and age with inflammatory joint signs among unaffected first-degree relatives of rheumatoid arthritis patients: results from studies of the etiology of rheumatoid arthritis. Arthritis Rheumatol. 2016;68(8):1828–1838.
   PubMed Web of Science ®Google Scholar
• Turner JD, Filer A. The role of the synovial fibroblast in rheumatoid arthritis pathogenesis. Curr Opin Rheumatol. 2015;27(2):175–182.
   PubMed Web of Science ®Google Scholar
• Basu A, Schell J, Scofield RH. Dietary fruits and arthritis. Food Funct. 2018;9(1):70–77.
   PubMed Web of Science ®Google Scholar
• Gardi C, Bauerova K, Stringa B, et al. Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis. Arch Biochem Biophys. 2015;583:150–157.
   PubMed Web of Science ®Google Scholar
• Sung MS, Lee EG, Jeon HS, et al. Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012;35(4):1585–1594.
   PubMed Web of Science ®Google Scholar
• Lai WW, Hsu SC, Chueh FS, et al. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013;33(5):1941–1950.
   PubMed Web of Science ®Google Scholar
• Simpson LJ, Ansel KM. MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Invest. 2015;125(6):2242–2249.
   PubMed Web of Science ®Google Scholar
• Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3–14.
   PubMed Web of Science ®Google Scholar
• Chen G, Umelo IA, Lv S, et al. miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells. PLoS One. 2013;8(3):e60317.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Haupt S, Kreuzer JT, et al. Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis. 2015;74(6):1265–1274.
   PubMed Web of Science ®Google Scholar
• Bogunia-Kubik K, Wysoczanska B, Piatek D, et al. Significance of Polymorphism and expression of miR-146a and NFkB1 genetic variants in patients with rheumatoid arthritis. Arch Immunol Ther Exp. 2016;64(S1):131–136.
   PubMedGoogle Scholar
• Bravo-Cordero JJ, Magalhaes MA, Eddy RJ, et al. Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol. 2013; 14(7):405–415.
   PubMed Web of Science ®Google Scholar
• Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010; 233(1):233–255.
   PubMed Web of Science ®Google Scholar
• Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013;9(1):24–33.
   PubMed Web of Science ®Google Scholar
• Huang M, Wang L, Zeng S, et al. Indirubin inhibits the migration, invasion, and activation of fibroblast-like synoviocytes from rheumatoid arthritis patients. Inflamm Res. 2017;66(5):433–440.
   PubMed Web of Science ®Google Scholar
• Leduc C, Etienne-Manneville S. Intermediate filaments in cell migration and invasion: the unusual suspects. Curr Opin Cell Biol. 2015;32:102–112.
   PubMed Web of Science ®Google Scholar
• Garcia-Roman R, Salazar-Gonzalez D, Rosas S, et al. The differential NF-kB modulation by S-adenosyl-l-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free Radic Res. 2008;42(4):331–343.
   PubMed Web of Science ®Google Scholar
• Tan WF, Lin LP, Li MH, et al. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol. 2003;459(2–3):255–262.
   PubMed Web of Science ®Google Scholar
• Ji JJ, Lin Y, Huang SS, et al. Quercetin: a potential natural drug for adjuvant treatment of rheumatoid arthritis. Afr J Tradit Complem Altern Med. 2013;10(3):418–421.
   PubMedGoogle Scholar
• Pan F, Zhu L, Lv H, et al. Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1. Int J Mol Med. 2016; 38(5):1507–1514.
   PubMed Web of Science ®Google Scholar
• Kim HR, Kim BM, Won JY, et al. Quercetin, a plant polyphenol, has potential for the prevention of bone destruction in rheumatoid arthritis. J Med Food. 2019;22(2):152–161.
   PubMed Web of Science ®Google Scholar
• Javadi F, Ahmadzadeh A, Eghtesadi S, et al. The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial. J Am Coll Nutr. 2017;36(1):9–15.
   PubMed Web of Science ®Google Scholar
• Stanczyk J, Pedrioli DM, Brentano F, et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum. 2008;58(4):1001–1009.
   PubMed Web of Science ®Google Scholar
• Churov AV, Oleinik EK, Knip M. MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential. Autoimmun Rev. 2015;14(11):1029–1037.
   PubMed Web of Science ®Google Scholar
• Kriegsmann M, Randau TM, Gravius S, et al. Expression of miR-146a, miR-155, and miR-223 in formalin-fixed paraffin-embedded synovial tissues of patients with rheumatoid arthritis and osteoarthritis. Virchows Arch. 2016;469(1):93–100.
   PubMed Web of Science ®Google Scholar
• Nakasa T, Miyaki S, Okubo A, et al. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 2008;58(5):1284–1292.
   PubMed Web of Science ®Google Scholar
• Tao SF, He HF, Chen Q. Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells. Mol Cell Biochem. 2015;402(1–2):93–100.
   PubMed Web of Science ®Google Scholar
• Liu H, Du F, Sun L, et al. GATA6 suppresses migration and metastasis by regulating the miR-520b/CREB1 axis in gastric cancer. Cell Death Dis. 2019;10(2):35.
   PubMedGoogle Scholar
• Tian F, Chen J, Zheng S, et al. miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis. BMC Cancer. 2017;17(1):175.
   PubMedGoogle Scholar
• Li H, Feng C, Shi S. miR-196b promotes lung cancer cell migration and invasion through the targeting of GATA6. Oncol Lett. 2018;16(1):247–252.
   PubMed Web of Science ®Google Scholar
• Wang MC, Hung PS, Tu HF, et al. Lipopolysaccharide induces the migration of human dental pulp cells by up-regulating miR-146a. J Endod. 2012;38(12):1598–1603.
   PubMed Web of Science ®Google Scholar