Nicorandil and atorvastatin attenuate carbon tetrachloride – induced liver fibrosis in rats

References

• Ahmad A, Ahmad R. Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi J Gastroenterol. 2012;18(3):155–167.
   PubMed Web of Science ®Google Scholar
• Lee YA, Wallace MC, Friedman SL. Pathobiology of liver fibrosis: a translational success story. Gut. 2015;64(5):830–841.
   PubMed Web of Science ®Google Scholar
• Bataller R, Brenner D. Liver fibrosis. J Clin Invest. 2005;115(2):209–218.
   PubMed Web of Science ®Google Scholar
• Anavi S, Eisenberg-Bord M, Hahn-Obercyger M, et al. The role of iNOS in cholesterol-induced liver fibrosis. Lab Invest. 2015;95(8):914–924.
   PubMed Web of Science ®Google Scholar
• Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134(6):1655–1669.
   PubMed Web of Science ®Google Scholar
• Bhakuni GS, Bedi O, Bariwal J, et al. Animal models of hepatotoxicity. Inflamm Res. 2016;65(1):13–24.
   PubMed Web of Science ®Google Scholar
• Pütter L. WNT1-inducible signaling pathway protein-1 (WISP1), a novel critical protein in hepatotoxic liver injury. PhD Diss. 2017;72:132–145.
   Google Scholar
• Yacout GA, Elguindy NM, El Azab EF. Hepatoprotective effect of basil (Ocimum basilicum L.) on CCl4-induced liver fibrosis in rats. African J Biotechnol. 2012;11:15702–15711.
   Google Scholar
• Minamiyama Y, Takemura S, Hai S, et al. Nicorandil elevates tissue cGMP levels in a nitric-oxide-independent manner. J Pharmacol Sci. 2007;103(1):33–39.
   PubMed Web of Science ®Google Scholar
• Akindele AJ, Amagon KI, Ekundayo GT, et al. Amelioration of doxorubicin-induced liver and kidney toxicities by nicorandil alone and co-administered with prednisolone and diltiazem. Proc Nigerian Acad Sci. 2019:12(10):12.
   Google Scholar
• Mohamed YS, Ahmed LA, Salem HA, et al. Role of nitric oxide and KATP channel in the protective effect mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats. Biochem Pharmacol. 2018;151:35–142.
   Web of Science ®Google Scholar
• Oliveira MA, Yoshida MI, Belinelo VJ, et al. Degradation kinetics of atorvastatin under stress conditions and chemical analysis by HPLC. Molecules. 2013;18(2):1447–1456.
   PubMed Web of Science ®Google Scholar
• Kamio K, Liu XD, Sugiura H, et al. Statins inhibit matrix metalloproteinase release from human lung fibroblasts. Eur Respir J. 2010;35(3):637–646.
   PubMed Web of Science ®Google Scholar
• Hui AY, Leung WK, Yuen Chan HL, et al. Effect of celecoxib on experimental liver fibrosis in rat. Liver Int. 2006;26(1):125–136.
   PubMed Web of Science ®Google Scholar
• Galicia-Moreno M, Rodríguez-Rivera A, Reyes-Gordillo K, et al. N-acetylcysteine prevents carbon tetrachloride-induced liver cirrhosis: role of liver transforming growth factor-beta and oxidative stress. Eur J Gastroenterol Hepatol. 2009;21:908–914.
   PubMed Web of Science ®Google Scholar
• Mano T, Shinohara R, Nagasaka A, et al. Scavenging effect of nicorandil on free radicals and lipid peroxide in streptozotocin-induced diabetic rats. Metab Clin Exp. 2000;49(4):427–431.
   PubMed Web of Science ®Google Scholar
• Shirin H, Sharvit E, Aeed H, et al. Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats. World J Gastroenterol. 2013;19(2):241–248.
   PubMed Web of Science ®Google Scholar
• Blanchette F, Day R, Dong W, et al. TGFbeta1 regulates gene expression of its own converting enzyme furin. J Clin Invest. 1997;99(8):1974–1983.
   PubMed Web of Science ®Google Scholar
• Patiyal SN, Katoch SS. BETA-adrenoceptor agonist clenbuterol down-regulates matrix metalloproteinase (MMP-9) and results in an impairment of collagen turnover in mice left ventricle. Jpn J Physiol. 2005;55(3):165–172.
   PubMedGoogle Scholar
• Weiss SJ, Klein R, Slivka A, et al. Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J Clin Invest. 1982;70(3):598–607.
   PubMed Web of Science ®Google Scholar
• Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 1978;90(1):37–43.
   PubMed Web of Science ®Google Scholar
• Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963; 61:882–888.
   PubMed Web of Science ®Google Scholar
• Aebi H. Catalase in vitro. Meth Enzymol. 1984; 105:121–126.
   PubMed Web of Science ®Google Scholar
• Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28(1):56–63.
   PubMed Web of Science ®Google Scholar
• Dumas BT, Watson WA, Biggs HG. Albumin standards and the measurement of serum albumin with Bromocresol Green. Clin Chim Acta. 1997;258(1):21–30.
   PubMed Web of Science ®Google Scholar
• Malloy HT, Evelyn KA. The determination of bilirubin with the photoelectric colorimeter. J Biol Chem. 1937;119:481–490.
   Google Scholar
• Watson D. A simple method for the determination of serum cholesterol. Clin Chim Acta. 1960;5:637–643.
   PubMed Web of Science ®Google Scholar
• Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982;28(10):2077–2080.
   PubMed Web of Science ®Google Scholar
• Castelli WP, Doyle JT, Gordon T, et al. HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation. 1977;55(5):767–772.
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.
   PubMed Web of Science ®Google Scholar
• Brouckaert P, Libert C, Everaerdt B, et al. Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6. Immunobiology. 1993;187(3–5):317–329.
   PubMed Web of Science ®Google Scholar
• Bancroft GD, Steven A. Theory and practice of histological technique. 4th ed. New York (NY): Churchill Livingston; 1983.
   Google Scholar
• Merz H, Malisius R, Mannweiler S, et al. A maximized immunohistochemical method for the retrieval and enhancement of hidden antigens. Lab Invest. 1995;73(1):149–156.
   PubMed Web of Science ®Google Scholar
• Shkurupiy VA, Kim LB, Nikonova IK, et al. Hydroxyproline content and fibrogenesis in mouse liver and lungs during the early stages of BCG granulomatosis. Bull Exp Biol Med. 2013;154(3):299–302.
   PubMed Web of Science ®Google Scholar
• Deng G, Wang J, Zhang Q, et al. Hepatoprotective effects of phloridzin on hepatic fibrosis induced by carbon tetrachloride against oxidative stress-triggered damage and fibrosis in rats. Biol Pharm Bull. 2012;35(7):1118–1125.
   PubMed Web of Science ®Google Scholar
• Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets . J Cell Mol Med. 2006;10(1):76–99.
   PubMed Web of Science ®Google Scholar
• Ferrini MG, Vernet D, Magee TR, et al. Antifibrotic role of inducible nitric oxide synthase. Nitric Oxide. 2002;6(3):283–294.
   PubMed Web of Science ®Google Scholar
• Sudo H, Hirata M, Kanada H, et al. Nicorandil improves glomerular injury in rats with mesangioproliferative glomerulonephritis via inhibition of proproliferative and profibrotic growth factors. J Pharmacol Sci. 2009;111(1):53–59.
   PubMed Web of Science ®Google Scholar
• Aprigliano I, Dudas J, Ramadori G, et al. Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. Liver Int. 2008;28(4):546–557.
   PubMed Web of Science ®Google Scholar
• Tsai JH, Liu JY, Wu TT, et al. Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat. 2008;15(7):508–514.
   PubMed Web of Science ®Google Scholar
• Elshazly SM. Ameliorative effect of nicorandil on high fat diet induced non-alcoholic fatty liver disease in rats. Eur J Pharmacol. 2015;748:123–132.
   PubMed Web of Science ®Google Scholar
• Andritoiu CV, Ochiuz L, Andritoiu V, et al. Effect of apitherapy formulations against carbon tetrachloride-induced toxicity in Wistar rats after three weeks of treatment. Molecules. 2014;19(9):13374–13391.
   PubMed Web of Science ®Google Scholar
• Ohta Y, Sahashi D, Sasaki E, et al. Alleviation of carbon tetrachloride-induced chronic liver injury and related dysfunction by L-tryptophan in rats. Ann Clin Biochem. 1999;36(4):504–510.
   PubMedGoogle Scholar
• Essawy AE, Abdel-Moneim AM, Khayyat LI, et al. Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice. J Appl Pharm Sci. 2012;2:21–25.
   Google Scholar
• Argo CK, Loria P, Caldwell SH, et al. Statins in liver disease: a molehill, an iceberg, or neither? Hepatology. 2008;48(2):662–669.
   PubMed Web of Science ®Google Scholar
• Nseir W, Mahamid M. Statins in nonalcoholic fatty liver disease and steatohepatitis: updated review. Curr Atheroscler Rep. 2013;15(3):305–311.
   PubMed Web of Science ®Google Scholar
• Chalasani N, Aljadhey H, Kesterson J, et al. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology. 2004;126(5):1287–1292.,
   PubMed Web of Science ®Google Scholar
• Guimarães DA, Rizzi E, Ceron CS, et al. Atorvastatin and sildenafil decrease vascular TGF- β levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension. Redox Biol. 2015;6:386–395.
   PubMed Web of Science ®Google Scholar
• Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation. 2000;101(2):207–213.
   PubMed Web of Science ®Google Scholar
• O’Sullivan S. Statins: a review of benefits and risks. Pharmacology. 2007;8:52–56.
   Google Scholar
• Chen MH, Chen JC, Tsai CC, et al. The role of TGF-beta 1 and cytokines in the modulation of liver fibrosis by Sho-saiko-to in rat’s bile duct ligated model. J Ethnopharmacol. 2005;97(1):7–13.
   PubMed Web of Science ®Google Scholar
• Wei XM, Heywood GJ, Girolamo ND, et al. Nicorandil inhibits the release of TNF a from a lymphocyte cell line and peripheral blood lymphocytes. Int Immunopharmacol. 2003;3(12):1581–1588.
   PubMed Web of Science ®Google Scholar
• Zhou T, Zhou SH, Qi SS, et al. The effect of atorvastatin on serum myeloperoxidase and CRP levels in patients with acute coronary syndrome. Clin Chim Acta. 2006;368(1–2):168–172.
   PubMed Web of Science ®Google Scholar
• Hyogo H, Yamagishi S-i, Maeda S, et al. Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-α-lowering property. Dig Liver Dis. 2012;44(6):492–496.
   PubMedGoogle Scholar
• Moreno M, Ramalho LN, Sancho-Bru P, et al. Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver. Am J Physiol Gastrointest Liver Physiol. 2009;296:147–156.
   Web of Science ®Google Scholar
• Aviram M, Rosenblat M, Bisgaier CL, et al. Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. Atherosclerosis. 1998;138(2):271–280.
   PubMed Web of Science ®Google Scholar
• Sathyapalan T, Shepherd J, Coady A, et al. Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2012;97(11):3951–3955.
   PubMed Web of Science ®Google Scholar
• Domitrović R, Jakovac H, Tomac J, et al. Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin. Toxicol Appl Pharmacol. 2009;241:11–21.
   Web of Science ®Google Scholar
• Duong HT, Dong Z, Su L, et al. The use of nanoparticles to deliver nitric oxide to hepatic stellate cells for treating liver fibrosis and portal hypertension. Small. 2015;11(19):2291–2304.
   PubMed Web of Science ®Google Scholar