217
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4

, &
Pages 271-282 | Received 28 Sep 2020, Accepted 30 Jan 2021, Published online: 09 Mar 2021

References

  • Singer M, Deutschman CS, Seymour CW, et al. The Third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810.
  • Moerer O, Schmid A, Hofmann M, et al. Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use. Intensive Care Med. 2002;28(10):1440–1446.
  • Seymour CW, Cooke CR, Heckbert SR, et al. Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care. 2014;18(5):533.
  • Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–1655.
  • Schulte W, Bernhagen J, Bucala R. Cytokines in sepsis: potent immunoregulators and potential therapeutic targets—an updated view. Mediators Inflamm. 2013;2013:1–16.
  • Wu T-T, Tai Y-T, Cherng Y-G, et al. GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism. PLoS One. 2013;8(8):e72404.
  • Ozer J, Ratner M, Shaw M, et al. The current state of serum biomarkers of hepatotoxicity. Toxicology. 2008;245(3):194–205.
  • Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420(6917):885–891.
  • Nesseler N, Launey Y, Aninat C, et al. Clinical review: the liver in sepsis. Crit Care. 2012;16(5):235–238.
  • Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73(11):3852–3856.
  • Wang PL, Bao Y, Yee M-C, et al. Circular RNA is expressed across the eukaryotic tree of life. PLoS One. 2014;9(3):e90859.
  • Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol. 2014;32(5):453–461.
  • Johnsson P, Ackley A, Vidarsdottir L, et al. A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol. 2013;20(4):440–446.
  • Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell. 2011;146(3):353–358.
  • Nie MW, Han YC, Shen ZJ, et al. Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide‐induced sepsis. J Cell Mol Med. 2020;24(14):7915–7927.
  • Beltrán-García J, Osca-Verdegal R, Nacher-Sendra E, et al. Circular RNAs in sepsis: biogenesis, function, and clinical significance. Cells. 2020;9(6):1544.
  • Bao X, Zhang Q, Liu N, et al. Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis‐induced acute lung injury. J Cell Mol Med. 2019;23(10):7111–7115.
  • Kewley RJ, Whitelaw ML, Chapman-Smith A. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int J Biochem Cell Biol. 2004;36(2):189–204.
  • Lin Y, Bloodgood BL, Hauser JL, et al. Activity-dependent regulation of inhibitory synapse development by Npas4. Nature. 2008;455(7217):1198–1204.
  • Ploski JE, Monsey MS, Nguyen T, et al. The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. PLoS One. 2011;6(8):e23760.
  • Ramamoorthi K, Fropf R, Belfort GM, et al. Npas4 regulates a transcriptional program in CA3 required for contextual memory formation. Science. 2011;334(6063):1669–1675.
  • Leong WK, Klaric TS, Lin Y, et al. Upregulation of the neuronal Per-Arnt-Sim domain protein 4 (Npas4) in the rat corticolimbic system following focal cerebral ischemia. Eur J Neurosci. 2013;37(11):1875–1884.
  • Shamloo M, Soriano L, Von Schack D, et al. Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. Eur J Neurosci. 2006;24(10):2705–2720.
  • Ooe N, Motonaga K, Kobayashi K, et al. Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an "on demand" neuroprotection system. J Biol Chem. 2009;284(2):1057–1063.
  • Hester I, McKee S, Pelletier P, et al. Transient expression of Nxf, a bHLH-PAS transactivator induced by neuronal preconditioning, confers neuroprotection in cultured cells. Brain Res. 2007;1135(1):1–11.
  • Flood WD, Moyer RW, Tsykin A, et al. Nxf and Fbxo33: novel seizure-responsive genes in mice. Eur J Neurosci. 2004;20(7):1819–1826.
  • Friedman RC, Farh KK-H, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105.
  • Jang JC, Li J, Gambini L, et al. Human resistin protects against endotoxic shock by blocking LPS–TLR4 interaction. Proc Natl Acad Sci U S A. 2017;114(48):E10399–E10408.
  • Langkamp-Henken B, Donovan TB, Pate LM, et al. Increased intestinal permeability following blunt and penetrating trauma. Crit Care Med. 1995;23(4):660–664.
  • Fang J, Qiao F, Tu J, et al. High expression of long non-coding RNA NEAT1 indicates poor prognosis of human cancer. Oncotarget. 2017;8(28):45918–45927.
  • Zhang Z, Yang T, Xiao J. Circular RNAs: promising biomarkers for human diseases. EBioMedicine. 2018;34:267–274.
  • Wang F, Chen X, Han Y, et al. circRNA CDR1as regulated the proliferation of human periodontal ligament stem cells under a lipopolysaccharide-induced inflammatory condition. Mediators Inflamm. 2019;2019:1–9.
  • Li B, Xie F, Zheng F-x, et al. Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer. J Huazhong Univ Sci Technol Med Sci. 2017;37(6):886–890.
  • Zhang Z-C, Guo X-L, Li X. The novel roles of circular RNAs in metabolic organs. Genes Dis. 2018;5(1):16–23.
  • Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017;39(5):517–528.
  • Wang H, He P, Pan H, et al. Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. Exp Mol Med. 2018;50(4):1–14.
  • Sheng Y-J, Gao J-P, Li J, et al. Follow-up study identifies two novel susceptibility loci PRKCB and 8p11. 21 for systemic lupus erythematosus. Rheumatology. 2011;50(4):682–688.
  • Deng T, Yang L, Zheng Z, et al. Calcitonin gene-related peptide induces IL-6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893 . Mol Med Rep. 2017;16(6):9367–9374.
  • Wu Y, Zhang Y, Zhang Y, et al. CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a. Cell Biol Int. 2017;41(12):1283–1289.
  • Choy FC, Klarić TS, Koblar SA, et al. The role of the neuroprotective factor Npas4 in cerebral ischemia. Int J Mol Sci. 2015;16(12):29011–29028.
  • Choy FC, Klarić TS, Leong WK, et al. Reduction of the neuroprotective transcription factor Npas4 results in increased neuronal necrosis, inflammation and brain lesion size following ischaemia. J Cereb Blood Flow Metab. 2016;36(8):1449–1463.
  • Funahashi Y, Ariza A, Emi R, et al. Phosphorylation of Npas4 by MAPK regulates reward-related gene expression and behaviors. Cell Rep. 2019;29(10):3235–3252.e9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.