Dexmedetomidine alleviates hyperalgesia in arthritis rats through inhibition of the p38MAPK signaling pathway

References

• Hong Y, Palaksha K, Reproductive SLJ, et al. Morphological changes of bones and joints with rheumatoid arthritis and osteoarthritis. Reprod Dev Biol. 2011;35(2):143–149.
   Google Scholar
• Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012;8(7):390–398.
   PubMed Web of Science ®Google Scholar
• Ji D, Zhou Y, Li S, et al. Anti-nociceptive effect of dexmedetomidine in a rat model of monoarthritis via suppression of the TLR4/NF-kappaB p65 pathway. Exp Ther Med. 2017;14(5):4910–4918.
   PubMed Web of Science ®Google Scholar
• Chien SY, Huang CY, Tsai CH, et al. Interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes. Clin Sci (Lond). 2016;130(9):667–681.
   PubMedGoogle Scholar
• Shimode N, Fukuoka T, Tanimoto M, et al. The effects of dexmedetomidine and halothane on fos expression in the spinal dorsal horn using a rat postoperative pain model. Neurosci Lett. 2003;343(1):45–48.
   PubMedGoogle Scholar
• Xu B, Zhang WS, Yang JL, et al. Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis. Acta Pharmacol Sin. 2010;31(5):523–530.
   PubMedGoogle Scholar
• Motawea HKB, Chotani MA, Ali M, et al. Human placenta expresses α2-adrenergic receptors and may be implicated in pathogenesis of preeclampsia and fetal growth restriction. Am J Pathol. 2018;188(12):2774–2785.
   PubMedGoogle Scholar
• Patel R, Qu C, Xie JY, et al. Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone. Pain. 2018;159(9):1887–1899.
   PubMedGoogle Scholar
• Zhang WS, Xu H, Xu B, et al. Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. Brain Res. 2009;1264:57–66.
   PubMed Web of Science ®Google Scholar
• Hajialilo M, Ghorbanihaghjo A, Valaee L, et al. A double-blind randomized comparative study of triamcinolone hexacetonide and dexamethasone intra-articular injection for the treatment of knee joint arthritis in rheumatoid arthritis. Clin Rheumatol. 2016;35(12):2887–2891.
   PubMed Web of Science ®Google Scholar
• Wang ZC, Lu H, Zhou Q, et al. MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38MAPK signaling pathway. Int J Clin Exp Pathol. 2015;8(11):14562–14567.
   PubMed Web of Science ®Google Scholar
• Liu S, Feng G, Wang GL, et al. p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway. Eur J Pharmacol. 2008;584(1):159–165.
   PubMed Web of Science ®Google Scholar
• Clark AR, Dean JL. The p38 MAPK pathway in rheumatoid arthritis: a sideways look. Open Rheumatol J. 2012;6:209–219.
   PubMedGoogle Scholar
• Noh ASM, Chuan TD, Khir NAM, et al. Effects of different doses of complete Freund’s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis. PLoS One. 2021;16(12):e0260423.
   PubMedGoogle Scholar
• Schett G, Zwerina J, Firestein G. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis. 2008;67(7):909–916.
   PubMed Web of Science ®Google Scholar
• Wood MW, Segal JA, Mark RJ, et al. Inflammatory cytokines enhance muscarinic-mediated arachidonic acid release through p38 mitogen-activated protein kinase in A2058 cells. J Neurochem. 2000;74(5):2033–2040.
   PubMedGoogle Scholar
• Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58(1):15–25.
   PubMed Web of Science ®Google Scholar
• Shi M, Wang A, Prescott D, et al. Infection with an intestinal helminth parasite reduces Freund’s complete adjuvant-induced monoarthritis in mice. Arthritis Rheum. 2011;63(2):434–444.
   PubMedGoogle Scholar
• Keeble J, Russell F, Curtis B, et al. Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation. Arthritis Rheum. 2005;52(10):3248–3256.
   PubMedGoogle Scholar
• Kelso EB, Dunning L, Lockhart JC, et al. Strain dependence in murine models of monoarthritis. Inflamm Res. 2007;56(12):511–514.
   PubMedGoogle Scholar
• Xu B, Zhang WS, Yang JL, et al. Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis. Clin Exp Pharmacol Physiol. 2010;37(10):e158–e166.
   PubMed Web of Science ®Google Scholar
• Fang JQ, Du JY, Liang Y, et al. Intervention of electroacupuncture on spinal p38 MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats. Mol Pain. 2013;9:13.
   PubMedGoogle Scholar
• Kumar S, Boehm J, Lee JC. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov. 2003;2(9):717–726.
   PubMed Web of Science ®Google Scholar
• Matsuda M, Huh Y, Ji RR. Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. J Anesth. 2019;33(1):131–139.
   PubMed Web of Science ®Google Scholar
• Ji RR, Gereau R, Malcangio M, et al. MAP kinase and pain. Brain Res Rev. 2009;60(1):135–148.
   PubMedGoogle Scholar
• Boyle DL, Jones TL, Hammaker D, et al. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006;3(9):e338.
   PubMedGoogle Scholar
• Akhtari Z, Zaringhalam J, Eidi A, et al. Bidirectional effects of serum TNF alpha level and spinal p38MAPK phosphorylation on hyperalgesia variation during CFA-induced arthritis. Excli J. 2012;11:373–385.
   PubMedGoogle Scholar
• Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 2007;1773(8):1358–1375.
   PubMed Web of Science ®Google Scholar
• Yamakita S, Matsuda M, Yamaguchi Y, et al. Dexmedetomidine prolongs levobupivacaine analgesia via inhibition of inflammation and p38 MAPK phosphorylation in rat dorsal root ganglion. Neuroscience. 2017;361:58–68.
   PubMed Web of Science ®Google Scholar
• Wang Q, Tan Y, Zhang N, et al. Dexmedetomidine inhibits activation of the MAPK pathway and protects PC12 and NG108-15 cells from lidocaine-induced cytotoxicity at its maximum safe dose. Biomed Pharmacother. 2017;91:162–166.
   PubMedGoogle Scholar