164
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Fentanyl alleviates intestinal mucosal barrier damage in rats with severe acute pancreatitis by inhibiting the MMP-9/FasL/Fas pathway

, , , , , & show all
Pages 757-765 | Received 01 Dec 2021, Accepted 21 May 2022, Published online: 06 Jun 2022

References

  • Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102–111.
  • Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet. 2015;386(9988):85–96.
  • Li X, He C, Li N, et al. The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice. Gut Microbes. 2020;11(6):1774–1789.
  • Deng W, Abliz A, Xu S, et al. Severity of pancreatitis-associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin. Mol Med Rep. 2016;14(4):3525–3534.
  • Capurso G, Zerboni G, Signoretti M, et al. Role of the gut barrier in acute pancreatitis. J Clin Gastroenterol. 2012;46:S46–S51.
  • Thomson JE, Nweke EE, Brand M, et al. Transient expression of interleukin-21 in the second hit of acute pancreatitis may potentiate immune paresis in severe acute pancreatitis. Pancreas. 2019;48(1):107–112.
  • Stanley TH. The fentanyl story. J Pain. 2014;15(12):1215–1226.
  • O’Donnell JK, Gladden RM, Seth P. Trends in deaths involving heroin and synthetic opioids excluding methadone, and law enforcement drug product reports, by census Region - United States, 2006-2015. MMWR Morb Mortal Wkly Rep. 2017;66(34):897–903.
  • Kamp-Jensen M, Clausen T, Eriksen J. [Methadone as an analgesic]. Ugeskr Laeger. 2000;162(2):163–166.
  • Stevens M, Elser R, Asher G. Transdermal fentanyl for the management of acute pancreatitis pain. Appl Nurs Res. 2002;15(2):102–110.
  • Wang Y, Chen M. Fentanyl ameliorates severe acute pancreatitis-induced myocardial injury in rats by regulating NF-κB signaling pathway. Med Sci Monit. 2017;23:3276–3283.
  • Li C, Qin Y, Zhong Y, et al. Fentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/akt signaling pathway. Ann Transl Med. 2020;8(4):118.
  • Zhang XL, Chen ML, Zhou SL. Fentanyl inhibits proliferation and invasion of colorectal cancer via β-catenin. Int J Clin Exp Pathol. 2015;8(1):227–235.
  • He G, Li LI, Guan E, et al. Fentanyl inhibits the progression of human gastric carcinoma MGC-803 cells by modulating NF-κB-dependent gene expression in vivo. Oncol Lett. 2016;12(1):563–571.
  • Klein T, Bischoff R. Physiology and pathophysiology of matrix metalloproteases. Amino Acids. 2011;41(2):271–290.
  • Huang H. Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances. Sensors. 2018;18(10):3249.
  • Backstrom JR, Lim GP, Cullen MJ, et al. Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40). J Neurosci. 1996;16(24):7910–7919.
  • Jobin PG, Butler GS, Overall CM. New intracellular activities of matrix metalloproteinases shine in the moonlight. Biochim Biophys Acta Mol Cell Res. 2017;1864(11 Pt A):2043–2055.
  • Mikami Y, Dobschütz EV, Sommer O, et al. Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis. Surgery. 2009;145(2):147–156.
  • Pinhu L, Qin Y, Xiong B, et al. Overexpression of fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes. Inflammation. 2014;37(4):1202–1212.
  • Liang Y, Yang C, Lin Y, et al. Matrix metalloproteinase 9 induces keratinocyte apoptosis through FasL/fas pathway in diabetic wound. Apoptosis. 2019;24(7–8):542–551.
  • Schmidt J, Rattner DW, Lewandrowski K, et al. A better model of acute pancreatitis for evaluating therapy. Ann Surg. 1992;215(1):44–56.
  • Ling X, Linglong P, Weixia D, et al. Protective effects of bifidobacterium on intestinal barrier function in LPS-Induced enterocyte barrier injury of CACO-2 monolayers and in a rat NEC model. PLoS One. 2016;11(8):e0161635.
  • Yu C, Yuan M, Yang H, et al. P-Glycoprotein on Blood-Brain barrier plays a vital role in fentanyl brain exposure and respiratory toxicity in rats. Toxicol Sci. 2018;164(1):353–362.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
  • Li XY, He C, Zhu Y, et al. Role of gut microbiota on intestinal barrier function in acute pancreatitis. World J Gastroenterol. 2020;26(18):2187–2193.
  • Werge M, Novovic S, Schmidt PN, et al. Infection increases mortality in necrotizing pancreatitis: a systematic review and Meta-analysis. Pancreatology. 2016;16(5):698–707.
  • Testoni PA, Caporuscio S, Bagnolo F, et al. Twenty-four-hour serum amylase predicting pancreatic reaction after endoscopic sphincterotomy. Endoscopy. 1999;31(2):131–136.
  • Testoni PA, Bagnolo F, Caporuscio S, et al. Serum amylase measured four hours after endoscopic sphincterotomy is a reliable predictor of postprocedure pancreatitis. Am J Gastroenterol. 1999;94(5):1235–1241.
  • Thomas PR, Sengupta S. Prediction of pancreatitis following endoscopic retrograde cholangiopancreatography by the 4-h post procedure amylase level. J Gastroenterol Hepatol. 2001;16(8):923–926.
  • Zhang JW, Zhang GX, Chen HL, et al. Therapeutic effect of qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury. World J Gastroenterol. 2015;21(12):3537–3546.
  • Srinivasan B, Kolli AR, Esch MB, et al. TEER measurement techniques for in vitro barrier model systems. J Lab Autom. 2015;20(2):107–126.
  • Sarmento B, Andrade F, da Silva SB, et al. Cell-based in vitro models for predicting drug permeability. Expert Opin Drug Metab Toxicol. 2012;8(5):607–621.
  • Matter K, Balda MS. Functional analysis of tight junctions. Methods. 2003;30(3):228–234.
  • Galipeau HJ, Verdu EF. The complex task of measuring intestinal permeability in basic and clinical science. Neurogastroenterol Motil. 2016;28(7):957–965.
  • Zhang J, Yu WQ, Wei T, et al. Effects of Short-Peptide-Based enteral nutrition on the intestinal microcirculation and mucosal barrier in mice with severe acute pancreatitis. Mol Nutr Food Res. 2020;64(5):e1901191.
  • Tornavaca O, Chia M, Dufton N, et al. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. J Cell Biol. 2015;208(6):821–838.
  • Su YR, Hong YP, Mei FC, et al. High-Fat diet aggravates the intestinal barrier injury via TLR4-RIP3 pathway in a rat model of severe acute pancreatitis. Med Inflamm. 2019;2019(2512687):1–13.
  • Zhao X, Xu XX, Liu Y, et al. The in vitro protective role of bovine lactoferrin on intestinal epithelial barrier. Molecules. 2019;24(1):148.
  • Chen P, Yuan Y, Wang S, et al. Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis. Tohoku J Exp Med. 2006;208(3):261–266.
  • Nighot P, Al-Sadi R, Rawat M, et al. Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis. Am J Physiol Gastrointest Liver Physiol. 2015;309(12):G988–97.
  • Nagata S, Golstein P. The fas death factor. Science. 1995;267(5203):1449–1456.
  • Strasser A, Jost PJ, Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity. 2009;30(2):180–192.
  • Ayala A, Chung CS, Xu YX, et al. Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by fas ligand and not endotoxin. Immunology. 1999;97(1):45–55.
  • Pardalis V, Palli E, Lambropoulou M, et al. Expression of Fas (CD95/APO-1) and Fas ligand (FasL) in experimentally-induced acute pancreatitis. J Invest Surg. 2014;27(2):65–72.
  • An S, Hishikawa Y, Koji T. Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and BCL-2/Bax systems depending upon cell types. Histochem Cell Biol. 2005;123(3):249–261.
  • Lin T, Brunner T, Tietz B, et al. Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J Clin Invest. 1998;101(3):570–577.
  • Pinkoski MJ, Brunner T, Green DR, et al. Fas and fas ligand in gut and liver. Am J Physiol Gastrointest Liver Physiol. 2000;278(3):G354–66.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.