293
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Sulforaphane alleviates LPS-induced inflammatory injury in ARPE-19 cells by repressing the PWRN2/NF-kB pathway

, , &
Pages 868-876 | Received 09 Oct 2021, Accepted 12 Jun 2022, Published online: 29 Jun 2022

References

  • Blitzer AL, Ham SA, Colby KA, et al. Association of metformin use with age-related macular degeneration: a case-control study. JAMA Ophthalmol. 2021;139(3):302–309.
  • Caceres PS, Rodriguez-Boulan E. Retinal pigment epithelium polarity in health and blinding diseases. Curr Opin Cell Biol. 2020;62:37–45.
  • Fuhrmann S, Zou C, Levine EM. Retinal pigment epithelium development, plasticity, and tissue homeostasis. Exp Eye Res. 2014;123:141–150.
  • Ly A, Nivison-Smith L, Hennessy M, et al. Pigmented lesions of the retinal pigment epithelium. Optom Vis Sci. 2015;92(8):844–857.
  • Jo DH, Yun JH, Cho CS, et al. Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood-retinal barrier in diabetic retinopathy. Glia. 2019;67(2):321–331.
  • Dolcet X, Llobet D, Pallares J, et al. NF-kB in development and progression of human cancer. Virchows Arch. 2005;446(5):475–482.
  • Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651.
  • Lai JL, Liu YH, Liu C, et al. Indirubin inhibits LPS-induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways. Inflammation. 2017;40(1):1–12.
  • He R, Li Y, Han C, et al. L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation. Int Immunopharmacol. 2019;73:379–388.
  • Zhang L, Previn R, Lu L, et al. Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway. Brain Res Bull. 2018;142:352–359.
  • Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19(3):143–157.
  • Sanchez Calle A, Kawamura Y, Yamamoto Y, et al. Emerging roles of long non-coding RNA in cancer. Cancer Sci. 2018;109(7):2093–2100.
  • Wan X, Tian X, Du J, et al. Long non-coding RNA H19 deficiency ameliorates bleomycin-induced pulmonary inflammation and fibrosis. Respir Res. 2020;21(1):290.
  • Wang D, Zhang J, Sun Y, et al. Long non-coding RNA NKILA weakens TNF-alpha-induced inflammation of MRC-5 cells by miR-21 up-regulation. Artif Cells Nanomed Biotechnol. 2020;48(1):498–505.
  • Buiting K, Nazlican H, Galetzka D, et al. C15orf2 and a novel noncoding transcript from the Prader-Willi/angelman syndrome region show monoallelic expression in fetal brain. Genomics. 2007;89(5):588–595.
  • Yu X, Luo Y, Chen G, et al. Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration. Biochem Biophys Res Commun. 2021;535:39–46.
  • Vanduchova A, Anzenbacher P, Anzenbacherova E. Isothiocyanate from broccoli, sulforaphane, and its properties. J Med Food. 2019;22(2):121–126.
  • Subedi L, Lee JH, Yumnam S, et al. Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK/AP-1/NF-kappaB inhibition and Nrf2/HO-1 activation. Cells. 2019;8(2):194.
  • Sim H, Lee W, Choo S, et al. Sulforaphane alleviates particulate matter-induced oxidative stress in human retinal pigment epithelial cells. Front Med (Lausanne). 2021;8:685032.
  • Rao X, Huang X, Zhou Z, et al. An improvement of the 2^(-Delta Delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 2013;3(3):71–85.
  • Wang Z, Yang B, Zhang M, et al. lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer. Canc Cell. 2018;33:e709.
  • Ammar MJ, Hsu J, Chiang A, et al. Age-related macular degeneration therapy: a review. Curr Opin Ophthalmol. 2020;31(3):215–221.
  • Tawarayama H, Suzuki N, Inoue-Yanagimachi M, et al. Glutathione trisulfide prevents lipopolysaccharide-induced inflammatory gene expression in retinal pigment epithelial cells. Ocul Immunol Inflamm. 2020;20:1–12.
  • Wu JH, Batist G. Glutathione and glutathione analogues; therapeutic potentials. Biochim Biophys Acta. 2013;1830(5):3350–3353.
  • Sujithra K, Srinivasan S, Indumathi D, et al. Allyl methyl sulfide, an organosulfur compound alleviates hyperglycemia mediated hepatic oxidative stress and inflammation in streptozotocin-induced experimental rats. Biomed Pharmacother. 2018;107:292–302.
  • Kong L, Liu B, Zhang C, et al. The therapeutic potential of sulforaphane on light-induced photoreceptor degeneration through antiapoptosis and antioxidant protection. Neurochem Int. 2016;100:52–61.
  • Ye L, Yu T, Li Y, et al. Sulforaphane enhances the ability of human retinal pigment epithelial cell against oxidative stress, and its effect on gene expression profile evaluated by microarray analysis. Oxid Med Cell Longev. 2013;2013:413024.
  • del V Cano M, Reyes JM, Park CY, et al. Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci. 2008;49(6):2606–2612.
  • Gao X, Talalay P. Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proc Natl Acad Sci USA. 2004;101(28):10446–10451.
  • Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. Proc Natl Acad Sci USA. 2001;98(26):15221–15226.
  • Yang PM, Cheng KC, Huang JY, et al. Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1alpha/Nrf2 pathway and autophagy in retinal pigment epithelial cells. Toxicol Appl Pharmacol. 2021;421:115545.
  • Lv J, Bao S, Liu T, et al. Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration. Cell Tissue Res. 2020;382(3):477–486.
  • Wang ZC, Chen Q, Wang J, et al. Sulforaphane mitigates LPS-induced neuroinflammation through modulation of cezanne/NF-kappaB signalling. Life Sci. 2020;262:118519.
  • Patel B, Mann GE, Chapple SJ. Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. Free Radic Biol Med. 2018;122:150–160.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.