References
- Aghazadeh R, Zali MR, Bahari A, et al. Inflammatory bowel disease in Iran: a review of 457 cases. J Gastroenterol Hepatol. 2005;20(11):1691–1695.
- Nahon S, Ramtohul T, Paupard T, et al. Evolution in clinical presentation of inflammatory bowel disease over time at diagnosis: a multicenter cohort study. Eur J Gastroenterol Hepatol. 2018;30(10):1125–1129.
- Perler BK, Ungaro R, Baird G, et al. Presenting symptoms in inflammatory bowel disease: descriptive analysis of a community-based inception cohort. BMC Gastroenterol. 2019;19(1):47.
- Vegni E, Gilardi D, Bonovas S, et al. Illness perception in inflammatory bowel disease patients is different between patients with active disease or in remission: a prospective cohort study. J Crohns Colitis. 2019;13(4):417–423.
- Palm O, Moum B, Jahnsen J, et al. Fibromyalgia and chronic widespread pain in patients with inflammatory bowel disease: a cross sectional population survey. J Rheumatol. 2001;28(3):590–594.
- Foy R, Leaman B, McCrorie C, et al. Prescribed opioids in primary care: cross-sectional and longitudinal analyses of influence of patient and practice characteristics. BMJ Open. 2016;6(5):e010276.
- Okie S. A flood of opioids, a rising tide of deaths. N Engl J Med. 2010;363(21):1981–1985.
- Rudd RA, Seth P, David F, et al. Increases in drug and opioid-involved overdose deaths – United States, 2010–2015. MMWR Morb Mortal Wkly Rep. 2016;65(50-51):1445–1452.
- Burr NE, Smith C, West R, et al. Increasing prescription of opiates and mortality in patients with inflammatory bowel diseases in England. Clin Gastroenterol Hepatol. 2018;16(4):534–541.e6.
- Targownik LE, Nugent Z, Singh H, et al. The prevalence and predictors of opioid use in inflammatory bowel disease: a population-based analysis. Am J Gastroenterol. 2014;109(10):1613–1620.
- Grunkemeier DM, Cassara JE, Dalton CB, et al. The narcotic bowel syndrome: clinical features, pathophysiology, and management. Clin Gastroenterol Hepatol. 2007;5(10):1126–1139.
- Holzer P. Opioid receptors in the gastrointestinal tract. Regul Pept. 2009;155(1–3):11–17.
- Pauly NJ, Michailidis L, Kindred MG, et al. Predictors of chronic opioid use in newly diagnosed Crohn's disease. Inflamm Bowel Dis. 2017;23(6):1004–1010.
- Banta-Green CJ, Von Korff M, Sullivan MD, et al. The prescribed opioids difficulties scale: a patient-centered assessment of problems and concerns. Clin J Pain. 2010;26(6):489–947.
- Reid MC, Henderson CR, Jr, Papaleontiou M, et al. Characteristics of older adults receiving opioids in primary care: treatment duration and outcomes. Pain Med. 2010;11(7):1063–1071.
- Solomon DH, Rassen JA, Glynn RJ, et al. The comparative safety of opioids for nonmalignant pain in older adults. Arch Intern Med. 2010;170(22):1979–1986.
- Liang X, Liu R, Chen C, et al. Opioid system modulates the immune function: a review. Transl Perioper Pain Med. 2016;1(1):5–13.
- Sobczak M, Sałaga M, Storr MA, et al. Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives. J Gastroenterol. 2014;49(1):24–45.
- Al-Hashimi M, Scott SW, Thompson JP, et al. Opioids and immune modulation: more questions than answers. Br J Anaesth. 2013;111(1):80–88.
- Tomassini N, Renaud FL, Roy S, et al. Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages. J Neuroimmunol. 2003;136(1–2):9–16.
- Cornwell WD, Lewis MG, Fan X, et al. Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques. J Neuroimmunol. 2013;265(1–2):43–50.
- Filipczak-Bryniarska I, Nowak B, Sikora E, et al. The influence of opioids on the humoral and cell-mediated immune responses in mice. The role of macrophages. Pharmacol Rep. 2012;64(5):1200–1215.
- Liu Z, Gao F, Tian Y. Effects of morphine, fentanyl and tramadol on human immune response. J Huazhong Univ Sci Technolog Med Sci. 2006;26(4):478–481.
- Cooper HS, Murthy SN, Shah RS, et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69(2):238–249.
- Obermeier F, Kojouharoff G, Hans W, et al. Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice. Clin Exp Immunol. 1999;116(2):238–245.
- Melhem H, Spalinger MR, Cosin-Roger J, et al. Prdx6 deficiency ameliorates DSS colitis: relevance of compensatory antioxidant mechanisms. J Crohns Colitis. 2017;11(7):871–884.
- Lippold KM, Jones CM, Olsen EO, et al. Racial/ethnic and age group differences in opioid and synthetic opioid-involved overdose deaths among adults aged ≥18 years in metropolitan areas - United States, 2015–2017. MMWR Morb Mortal Wkly Rep. 2019;68(43):967–973.
- Smith BH, Fletcher EH, Colvin LA. Opioid prescribing is rising in many countries. BMJ. 2019;367:l5823.
- Zöllner C, Stein C. Opioids. Handb Exp Pharmacol. 2007;177:31–63.
- Chen W, Jin N, Lin Y, et al. Immunomodulatory effects of fentanyl or dexmedetomidine hydrochloride infusion after allogeneic heart transplantation in mice. Reg Anesth Pain Med. 2018;43(5):509–515.
- Molina-Martínez LM, González-Espinosa C, Cruz SL. Dissociation of immunosuppressive and nociceptive effects of fentanyl, but not morphine, after repeated administration in mice: fentanyl-induced sensitization to LPS. Brain Behav Immun. 2014;42:60–64.
- Newton PM, Kim JA, McGeehan AJ, et al. Increased response to morphine in mice lacking protein kinase C epsilon. Genes Brain Behav. 2007;6(4):329–338.
- Vuong C, Van Uum SH, O’Dell LE, et al. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010;31(1):98–132.
- Facchinetti F, Grasso A, Petraglia F, et al. Impaired circadian rhythmicity of beta-lipotrophin, beta-endorphin and ACTH in heroin addicts. Acta Endocrinol. 1984;105(2):149–155.
- Yeager MP, Procopio MA, DeLeo JA, et al. Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans. Anesth Analg. 2002;94(1):94–99.
- House RV, Thomas PT, Bhargava HN. In vitro evaluation of fentanyl and meperidine for immunomodulatory activity. Immunol Lett. 1995;46(1-2):117–124.
- Yardeni IZ, Beilin B, Mayburd E, et al. Relationship between fentanyl dosage and immune function in the postoperative period. J Opioid Manag. 2008;4(1):27–33.
- Philippe D, Dubuquoy L, Groux H, et al. Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. J Clin Invest. 2003;111(9):1329–1338.