Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats

References

• Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in globocan. Int J Cancer. 2015;5:1–136.
   Google Scholar
• Cure E, Cure M, Kalkan Y, et al. Protective effect of infliximab on methotrexate-induced liver injury in rats: unexpected drug interaction. J Cancer Res Ther. 2015;11(1):164–169.
   PubMed Web of Science ®Google Scholar
• Samdanci E, Huz M, Ozhan O, et al. Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study. Drug Des Devel Ther. 2019;13:13–21.
   PubMed Web of Science ®Google Scholar
• Fuskevåg OM, Kristiansen C, Lindal S, et al. Leucovorin and maximum tolerated dose toxicity of methotrexate in rats. Pediatr Hematol Oncol. 2000; Dec; 17(8):651–658.
   PubMed Web of Science ®Google Scholar
• Tag HM. Hepatoprotective effect of mulberry (morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat. BMC Complement Altern Med. 2015; Jul 25; 15:252.
   PubMed Web of Science ®Google Scholar
• Conklin KA. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther. 2004;3(4):294–300.
   PubMedGoogle Scholar
• Moghadam A, Tutunchi S, Namvaran-Abbas-Abad A, et al. Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress. BMC Complement Altern Med. 2015;15:246.
   PubMed Web of Science ®Google Scholar
• Mahmoud A, Hussein O, Hozayen W, et al. Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPAR gamma and Nrf2: protective effect of 18beta-Glycyrrhetinic acid. Chem Biol Interact. 2017;270:59–72.
   PubMed Web of Science ®Google Scholar
• Rofaeil R, Kamel M, Abdelzaher W. Different effects of selective b1-adrenoceptor antagonists, nebivolol or atenolol in acetaminophen-induced hepatotoxicity of rats. Fundam Clin Pharmacol. 2017;31(2):165–173.
   PubMed Web of Science ®Google Scholar
• Wolburg H, Paulus W. Choroid plexus: biology and pathology. Acta Neuropathol. 2010;119(1):75–88.
   PubMed Web of Science ®Google Scholar
• Ogushi N, Sasaki K, Shimoda M. CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? -inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration. J Vet Med Sci. 2017;79(2):320–327.
   PubMed Web of Science ®Google Scholar
• Liu W, Li H, Zhang D, et al. Effects of the multidrug resistance-1 gene on drug resistance in primary immune thrombocytopenia. Autoimmunity. 2016;49(7):486–495.
   PubMed Web of Science ®Google Scholar
• He M, Shi W, Yu M, et al. Nicorandil attenuates LPS-Induced acute lung injury by pulmonary endothelial cell protection via NF-κB and MAPK pathways. Oxid Med Cell Longev. 2019;2019 :4957646.
   PubMed Web of Science ®Google Scholar
• Ahmed L, El-Maraghy S, Rizk S. Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats. Sci Rep. 2015;5:14043.
   PubMed Web of Science ®Google Scholar
• Satyanarayana S, Kilari E. Influence of nicorandil on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits. Mol Cell Biochem. 2006;291(1-2):101–105.
   PubMed Web of Science ®Google Scholar
• Abdel-Raheem I, Taye A, Abouzied M. Cardioprotective effects of nicorandil a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol. 2013;113(3):158–166.
   PubMed Web of Science ®Google Scholar
• Patel S, Patel N, Patel V. Anti-Fibrotic potential of nicorandil in the treatment of bleomycin induced pulmonary fibrosis. JYP. 2017;9(3):376–380.
   Google Scholar
• Khames A, Khalaf MM, Gad AM, et al. Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ- B signaling pathway. Chem Biol Interact. 2019; 311:108777.
   PubMed Web of Science ®Google Scholar
• El-Kashef DH. Nicorandil ameliorates pulmonary inflammation and fibrosis in a rat model of silicosis. Int Immunopharmacol. 2018; 64:289–297.
   PubMed Web of Science ®Google Scholar
• Tanabe K, Lanaspa M, Kitagawa W, et al. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse. Am J Physiol Renal Physiol. 2012;302(9):F1151–1160.
   PubMed Web of Science ®Google Scholar
• Akao M, Teshima Y, Marban E. Antiapoptotic effect of nicorandil mediated by mitochondrial ATP-sensitive potassium channels in cultured cardiac myocytes. J Am Coll Cardiol. 2002;40(4):803–810.
   PubMed Web of Science ®Google Scholar
• Yucel Y, Oguz E, Kocarslan S, et al. The effects of lycopene on methotrexate-induced liver injury in rats. Bratisl Lek Listy. 2017;118(4):212–216.
   PubMed Web of Science ®Google Scholar
• Mohamed Y, Ahmed L, Salem H, et al. Role of nitricoxide and KATP channel in the protective effect mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats. Biochem Pharmacol. 2018;151:135–142.
   PubMed Web of Science ®Google Scholar
• Sheikh S, Ikram H, Haleem D. Behavioral deficits in rats following acute administration of glimepiride: relationship with brain serotonin and dopamine. Pak J Pharm Sci. 2015;28(4):1181–1186.
   PubMed Web of Science ®Google Scholar
• Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978;86(1):271–278.
   PubMed Web of Science ®Google Scholar
• Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469–474.
   PubMedGoogle Scholar
• Sastry K, Moudgal R, Mohan J, et al. Spectrophotometric determination of serumnitrite and nitrate by copper-cadmium alloy. Anal Biochem. 2002;306(1):79–82.
   PubMed Web of Science ®Google Scholar
• Gunduz E, Dursun R, Zengin Y, et al. Lycium barbarum extract provides effective protection against paracetamol induced acute hepatotoxicity in rats. Int J Clin Exp Med. 2015;8:7898–7905.
   PubMed Web of Science ®Google Scholar
• Özen A, Ergün E, Öztaş E, et al. Imunohistochemical expression of nitric oxide synthase enzymes (iNOS, eNOS, nNOS) in the estrual and luteal phases of the sexual cycle in the cow oviduct. Anat Histol Embryol. 2013;42(5):384–393.
   PubMed Web of Science ®Google Scholar
• Zhang HY, Meng X, Du ZX, et al. Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma. Clin Exp Med. 2009;9(3):207–213.
   PubMed Web of Science ®Google Scholar
• Chladek J, Martinkova J, Sispera L. An in vitro study on methotrexate hydroxylation in rat and human liver. Physiol Res. 1997;46:371–379.
   PubMed Web of Science ®Google Scholar
• Vardi N, Parlakpinar H, Cetin A, et al. Protective effect of ß-carotene on methotrexate-induced oxidative liver damage. Toxicol Pathol. 2010;38(4):592–597. Jun
   PubMed Web of Science ®Google Scholar
• Hemeida R, Mohafez O. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. J Egypt Natl Canc Inst. 2008;20(2):141–148.
   PubMedGoogle Scholar
• Fan W, Huang C, Yang Y, et al. Serum pentraxin-3 and tumor necrosis factor-like weak inducer of apoptosis (TWEAK) predict severity of infections in acute decompensated cirrhotic patients. J Microbiol Immunol Infect. 2017;50(6):905–914.
   PubMedGoogle Scholar
• Sherif IO, Al-Shaalan NH, Sabry D. Ginkgo biloba extract alleviates Methotrexate-Induced renal injury: new impact on PI3K/akt/mTOR signaling and MALAT1 expression. Biomolecules. 2019; 9(11):691.
   PubMed Web of Science ®Google Scholar
• Zaitsev AV, Martinov MV, Vitvitsky VM, et al. Rat liver folate metabolism can provide an independent functioning of associated metabolic pathways. Sci Rep. 2019;9(1):7657.
   PubMedGoogle Scholar
• Tuncer A, Bozkurt M, Koken T, et al. The protective effects of alpha-lipoic acid and coenzyme Q10 combination on ovarian ischemia-reperfusion injury: an experimental study. Adv Med Sci. 2016;3415046:8.
   Google Scholar
• Refaie M, El-Hussieny M, Zenhom N. Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways. Environ Toxicol Pharmacol. 2018;58:212–219.
   PubMed Web of Science ®Google Scholar
• Whidden M, Kirichenko N, Halici Z, et al. Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of fischer 344_brown Norway rats. Biochem Biophys Res Commun. 2011;408(3):454–458.
   PubMed Web of Science ®Google Scholar
• Fukai T, Ushio-Fukai M. Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal. 2011;15(6):1583–1606.
   PubMed Web of Science ®Google Scholar
• Hamid A, Lee LS, Karim SR, et al. Hepatoprotective effects of zerumbone against Paracetamol-Induced acute hepatotoxicity in rats. Malays J Med Sci. 2018; 25(2):64–71.
   PubMed Web of Science ®Google Scholar
• Fu Y, Zheng S, Lin J, et al. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008;73(2):399–409.
   PubMed Web of Science ®Google Scholar
• Kelleni M, Ibrahim S, Abdelrahman A. Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis. Toxicol Mech Methods. 2016;26(5):371–377.
   PubMed Web of Science ®Google Scholar
• Owumi SE, Ajijola IJ, Agbeti OM. Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate. Hum Exp Toxicol. 2019;38(11):1254–1265.
   PubMed Web of Science ®Google Scholar
• Shibayama Y, Takeda Y, Yamada K. Effect of methotrexate treatment on expression levels of organic anion transporterpolypeptide 2, P-glycoprotein and bile salt export pump in rats. Biol Pharm Bull. 2009;32(3):493–496.
   PubMed Web of Science ®Google Scholar
• Fei M, Li N, Ze Y, et al. The mechanism of liver injury in mice caused by lanthanoids. Biol Trace Elem Res. 2011;140(3):317–329.
   PubMed Web of Science ®Google Scholar
• Elshazly S. Ameliorative effect of nicorandil on high fat diet induced non-alcoholic fatty liver disease in rats. Eur J Pharmacol. 2015;748:123–132.
   PubMed Web of Science ®Google Scholar
• Soliman GF, Rashed LA, Morsi H, et al. Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats. Life Sci. 2019; 222:175–182.
   PubMed Web of Science ®Google Scholar
• Li W, Wu N, Shu W, et al. Pharmacological preconditioning and postconditioning with nicorandil attenuates ischemia/reperfusion-induced myocardial necrosi sand apoptosis in hypercholesterolemic rats. Exp Ther Med. 2015;10(6):2197–2205.
   PubMed Web of Science ®Google Scholar
• Horinaka S, Kobayashi N, Higashi T, et al. Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J Cardiovasc Pharmacol. 2001;38(2):200–210.
   PubMed Web of Science ®Google Scholar