Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages

References

• Akurugu WA, Van Heerden CJ, Mulder N, et al. Hypothalamic-pituitary-adrenal axis suppression in asthma: a glucocorticoid receptor polymorphism may protect. Pediatr Allergy Immunol. 2021;32(2):273–279. doi: 10.1111/pai.13379.
   PubMed Web of Science ®Google Scholar
• Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233–247. doi: 10.1038/nri.2017.1.
   PubMed Web of Science ®Google Scholar
• Ivy JR, Carter RN, Zhao J-F, et al. Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes. J Physiol. 2021;599(21):4901–4924. doi: 10.1113/JP281860.
   PubMed Web of Science ®Google Scholar
• Bridges JP, Sudha P, Lipps D, et al. Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function. Am J Physiol Lung Cell Mol Physiol. 2020;319(2):L239–L255. doi: 10.1152/ajplung.00459.2019.
   PubMed Web of Science ®Google Scholar
• Reichardt SD, Amouret A, Muzzi C, et al. The Role of Glucocorticoids in Inflammatory Diseases. Cells. 2021;10(11):2921. doi: 10.3390/cells10112921.
   PubMed Web of Science ®Google Scholar
• Neeck G, Renkawitz R, Eggert M. Molecular aspects of glucocorticoid hormone action in rheumatoid arthritis. Cytokines Cell Mol Ther. 2002;7(2):61–69. doi: 10.1080/13684730412331302081.
   PubMed Web of Science ®Google Scholar
• Pofi R, Caratti G, Ray DW, et al. Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad? Endocr Rev. 2023;44(6):975–1011. doi: 10.1210/endrev/bnad016.
   PubMed Web of Science ®Google Scholar
• Kokkinopoulou I, Moutsatsou P. Mitochondrial Glucocorticoid Receptors and Their Actions. Int J Mol Sci. 2021;22(11):6054. doi: 10.3390/ijms22116054.
   PubMed Web of Science ®Google Scholar
• Kovacs JJ, Murphy PJM, Gaillard S, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell. 2005;18(5):601–607. doi: 10.1016/j.molcel.2005.04.021.
   PubMed Web of Science ®Google Scholar
• Shen S, Svoboda M, Zhang G, et al. Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor. ACS Med Chem Lett. 2020;11(5):706–712. doi: 10.1021/acsmedchemlett.9b00560.
   PubMed Web of Science ®Google Scholar
• Li ZY, Li QZ, Chen L, et al. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochem Int. 2016;99:239–251. doi: 10.1016/j.neuint.2016.08.004.
   PubMed Web of Science ®Google Scholar
• Guo J, Yang N, Zhang J, et al. Neurotoxicity study of ethyl acetate extract of Zanthoxylum armatum DC. on SH-SY5Y based on ROS mediated mitochondrial apoptosis pathway. J Ethnopharmacol. 2024;319(Pt 3):117321. doi: 10.1016/j.jep.2023.117321.
   PubMedGoogle Scholar
• Yan Z, He Z, Jiang H, et al. TRPV4-mediated mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via the Drp1-HK2 axis. Int Immunopharmacol. 2023;123:110651. doi: 10.1016/j.intimp.2023.110651.
   PubMed Web of Science ®Google Scholar
• Li JY, Sun XA, Wang X, et al. PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release. Acta Pharmacol Sin. 2023;45(1):125–136. doi: 10.1038/s41401-023-01151-1.
   PubMed Web of Science ®Google Scholar
• Roussel D, Dumas J-F, Simard G, et al. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment. Biochem J. 2004;382(Pt 2):491–499. doi: 10.1042/BJ20040696.
   PubMedGoogle Scholar
• Fink BD, Yu L, Coppey L, et al. Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect. 2021;9(1):e00701. doi: 10.1002/prp2.701.
   PubMed Web of Science ®Google Scholar
• Gruber J, Fong S, Chen C-B, et al. Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnol Adv. 2013;31(5):563–592. doi: 10.1016/j.biotechadv.2012.09.005.
   PubMed Web of Science ®Google Scholar
• Victorelli S, Lagnado A, Halim J, et al. Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. Embo J. 2019;38(23):e101982. doi: 10.15252/embj.2019101982.
   PubMed Web of Science ®Google Scholar
• Sulaimon LA, Afolabi LO, Adisa RA, et al. Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases. Advances in Redox Research. 2022 ;2022/07/01/5:100037. doi: 10.1016/j.arres.2022.100037.
   Google Scholar
• Murphy MP, Smith RAJ. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol. 2007;47(1):629–656. doi: 10.1146/annurev.pharmtox.47.120505.105110.
   PubMed Web of Science ®Google Scholar
• Smith RAJ, Murphy MP. Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci. 2010;1201·(1):96–103. doi: 10.1111/j.1749-6632.2010.05627.x.
   PubMedGoogle Scholar
• Ehrchen JM, Roth J, Barczyk-Kahlert K. More than suppression: glucocorticoid action on monocytes and macrophages. Front Immunol. 2019;10:2028. doi: 10.3389/fimmu.2019.02028.
   PubMed Web of Science ®Google Scholar
• Weinstein RS, Chen J-R, Powers CC, et al. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest. 2002;109(8):1041–1048. doi: 10.1172/JCI14538.
   PubMed Web of Science ®Google Scholar
• Zeng S, Qiao H, Lv X-W, et al. High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis. Drug Des Devel Ther. 2017;11:3097–3104. doi: 10.2147/DDDT.S147014.
   PubMed Web of Science ®Google Scholar
• Tao R, Zhao Y, Chu H, et al. Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. Nat Methods. 2017;14(7):720–728. doi: 10.1038/nmeth.4306.
   PubMed Web of Science ®Google Scholar
• Huang X, Yan J, Zhang M, et al. Targeting epigenetic crosstalk as a therapeutic strategy for EZH2-aberrant solid tumors. Cell. 2018;175(1):186–199.e19. doi: 10.1016/j.cell.2018.08.058.
   PubMed Web of Science ®Google Scholar
• Crochemore C, Lu J, Wu Y, et al. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry. 2005;10(8):790–798. doi: 10.1038/sj.mp.4001679.
   PubMed Web of Science ®Google Scholar
• Cari L, De Rosa F, Nocentini G, et al. Context-dependent effect of glucocorticoids on the proliferation, differentiation, and apoptosis of regulatory T cells: a review of the empirical evidence and clinical applications. Int J Mol Sci. 2019;20(5):1142. doi: 10.3390/ijms20051142.
   PubMed Web of Science ®Google Scholar
• Gupta SK, Patel SK, Tomar MS, et al. Long-term exposure of 2450 MHz electromagnetic radiation induces stress and anxiety like behavior in rats. Neurochem Int. 2019;128·:1–13. doi: 10.1016/j.neuint.2019.04.001.
   PubMed Web of Science ®Google Scholar
• Prenek L, Boldizsár F, Kugyelka R, et al. The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells. Apoptosis. 2017;22(2):239–253. doi: 10.1007/s10495-016-1320-8.
   PubMed Web of Science ®Google Scholar
• Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14(6):392–404. doi: 10.1038/nri3671.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Chen H, Duan P, et al. Early depletion of M1 macrophages retards the progression of glucocorticoid-associated osteonecrosis of the femoral head. Int Immunopharmacol. 2023;122:110639. doi: 10.1016/j.intimp.2023.110639.
   PubMed Web of Science ®Google Scholar
• Nakamura R, Bing R, Gartling GJ, et al. Dose-dependent glucocorticoid regulation of transcription factors in vocal fold fibroblasts and macrophages. Laryngoscope. 2023;133(10):2704–2711. doi: 10.1002/lary.30594.
   PubMed Web of Science ®Google Scholar
• Czar MJ, Lyons RH, Welsh MJ, et al. Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus. Mol Endocrinol. 1995;9(11):1549–1560.
   PubMedGoogle Scholar
• Denis M, Gustafsson JA, Wikström AC. Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor. J Biol Chem. 1988;263(34):18520–18523.
   PubMed Web of Science ®Google Scholar
• Howard KJ, Holley SJ, Yamamoto KR, et al. Mapping the HSP90 binding region of the glucocorticoid receptor. J Biol Chem. 1990;265(20):11928–11935.
   PubMed Web of Science ®Google Scholar
• Chevallet M, Lescuyer P, Diemer H, et al. Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: a proteomic view. Electrophoresis. 2006;27(8):1574–1583. doi: 10.1002/elps.200500704.
   PubMed Web of Science ®Google Scholar
• Simon N, Jolliet P, Morin C, et al. Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondria. FEBS Lett. 1998;435(1):25–28. doi: 10.1016/s0014-5793(98)01033-3.
   PubMed Web of Science ®Google Scholar
• Sekeris CE. The mitochondrial genome: a possible primary site of action of steroid hormones. In Vivo. 1990;4(5):317–320.
   PubMedGoogle Scholar
• Baumgardt SL, Fang J, Fu X, et al. Augmentation of histone deacetylase 6 activity impairs mitochondrial respiratory complex I in ischemic/reperfused diabetic hearts. bioRxiv: the preprint server for biology, 2023.02.21.529462. doi: 10.1101/2023.02.21.529462.
   Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–950. doi: 10.1152/physrev.00026.2013.
   PubMed Web of Science ®Google Scholar