137
Views
31
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Erythropoietin Stimulates Wound Healing and Angiogenesis in Mice

, PhD, , MD, PhD, , MD, , MD & , MD
Pages 163-173 | Received 09 Aug 2005, Accepted 19 Oct 2005, Published online: 09 Jul 2009

REFERENCES

  • Altavilla D, Saitta A, Cucinotta D, Galeano M, Deodato B, Colonna M, Torre V, Russo G, Sardella A, Urna G, Campo G M, Cavallari V, Squadrito G, Squadrito F. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 2001; 50(3)667–674, [INFOTRIEVE], [CSA]
  • Stallmeyer B, Kampfer H, Kolb N, Pfeilschifter J, Frank S. The function of nitric oxide in wound repair: Inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization. J Invest Dermatol. 1999; 113(6)1090–1098, [INFOTRIEVE], [CSA], [CROSSREF]
  • Steiling H, Munz B, Werner S, Brauchle M. Different types of ROS-scavenging enzymes are expressed during cutaneous wound repair. Exp Cell Res. 1999; 247: 484–494, [INFOTRIEVE], [CSA], [CROSSREF]
  • Sen C K, Khanna S, Venojarvi M, Trikha P, Ellison E C, Hunt T K, Roy S. Copper-induced vascular endothelial growth factor expression and wound healing. Am J Physiol Heart Circ Physiol. 2002; 282: H1821–H1827, [INFOTRIEVE], [CSA]
  • Swift M E, Kleinman H K, Di Pietro L A. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest. 1999; 79(12)1479–1487, [INFOTRIEVE], [CSA]
  • McCourt M, Wang J H, Sookhai S, Redmond H P. Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Arch. Surg 1999; 134: 1325–1332, [INFOTRIEVE], [CSA], [CROSSREF]
  • Corral C J, Siddiqui A, Wu L, Farrel C L, Lyons D, Mustoe T A. Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing. Arch Surg. 1999; 134: 200–205, [INFOTRIEVE], [CSA], [CROSSREF]
  • Howdieshell T R, Riegner C, Gupta V, Callaway D, Grembowicz K, Sathyanarayana McNeil P L. Normoxic wound fluid contains high levels of vascular endothelial growth factor. Ann Surg. 1998; 228(5)707–715, [INFOTRIEVE], [CSA], [CROSSREF]
  • Nissen N N, Polverini P J, Koch A E, Volin M V, Gamelli R L, Di Pietro L A. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol. 1998; 152(6)1445–1452, [INFOTRIEVE], [CSA]
  • Sheikh A Y, Gibson J J, Rollins M D, Hopf H W, Hussain Z, Hunt T K. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch. Surg. 2000; 135: 1293–1297, [INFOTRIEVE], [CSA], [CROSSREF]
  • Xiong M, Elson G, Legarda D, Leibovich S J. Production of vascular endothelial growth factor by murine macrophages. Am J Pathol. 1998; 153(2)587, [INFOTRIEVE], [CSA]
  • Buemi M, Aloisi C, Cavallaro E, Corica F, Floccari F, Grasso G, Lasco A, Pettinato G, Ruello A, Sturiale A, Frisina N. Recombinant human erythropoietin (rHuEPO): More than just the correction of uremic anemia. J Nephrol. 2002; 15(2)97–103, [INFOTRIEVE], [CSA]
  • Siren A L, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Nat Acad Sci. USA 2001; 98(7)4044–4049, [INFOTRIEVE], [CSA], [CROSSREF]
  • Buemi M, Cavallaro E, Floccari F, Sturiale A, Aloisi C, Trimarchi M, Grasso G, Corica F, Frisina N. Erythropoietin and the brain: From neurodevelopment to neuroprotection. Clin Sci. 2002; 103: 275–282, [INFOTRIEVE], [CSA]
  • Sadamoto Y, Igase K, Sakanaka M, Sato K, Otsuka H, Sakaki S, Masuda S, Sasaki R. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of middle cerebral artery. Biochem Biophys Res Commun. 1998; 253: 26–32, [INFOTRIEVE], [CSA], [CROSSREF]
  • Celik M, Gokmen N, Erbayraktar S, Akhisaroglu M, Konakci S, Ulukus C, Genc S, Genc K, Sagiroglu E, Cerami A, Brines A. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci, USA. 2002; 99(4)2258–2263, [INFOTRIEVE], [CSA], [CROSSREF]
  • Ribatti D, Presta M, Vacca A, Ria R, Giuliani R, Dell'Era P, Nico B, Roncali L, Dammacco F. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood. 1999; 93(8)2627–2636, [INFOTRIEVE], [CSA]
  • Jaquet K, Krause K, Tawakol-Khodai M, Geidel S, Kuck K H. Erythropoietin and VEGF exhibit equal angiogenic potential. Microvasc Res. 2002; 64: 326–333, [INFOTRIEVE], [CSA], [CROSSREF]
  • Haroon Z A, Amin K, Jiang X, Arcasoy M O. A novel role for erythropoietin during fibrin-induced wound healing response. Am J Pathol. 2003; 163(3)993–1000, [INFOTRIEVE], [CSA]
  • Calapai G, Marciano M C, Corica F, Allegra A, Parisi A, Frisina N, Caputi A P, Buemi M. Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation. Eur J Pharmacol. 2000; 401: 349–356, [INFOTRIEVE], [CSA], [CROSSREF]
  • Buemi M, Grasso G, Corica F, Calapai G, Salpietro F M, Casuscelli T, Sfacteria A, Aloisi C, Concetta A, Sturiale A, Frisina N, Tomasello F. In vivo evidence that erythropoietin has a neuroprotective effect during subarachnoid hemorrhage. Eur J Pharmacol. 2000; 392: 31–34, [INFOTRIEVE], [CSA], [CROSSREF]
  • Sakanaka M, Wen T C, Matsuda S, Masuda S, Morishita E, Nagao M, Sasaki R. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA. 1998; 95: 4635–4640, [INFOTRIEVE], [CSA], [CROSSREF]
  • Alafaci C, Salpietro F, Grasso G, Sfacteria A, Passalacqua M, Morabito A, Tripodo E, Calapai G, Buemi M, Tomasello F. Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage. Eur J Pharmacol. 2000; 406: 219–225, [INFOTRIEVE], [CSA], [CROSSREF]
  • Brines M L, Ghezzi P, Keenan S, Agnello D, de Lanerolle N C, Cerami C, Itri L M, Cerami A. Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury. Proc Acad Natl Acad Sci USA. 2000; 97(19)10526–10531, [CSA], [CROSSREF]
  • Çelebi N, Erden N, Gönül B, Koz M. Effect of epidermal growth factor dosage forms on dermal wound strength in mice. J Pharm Pharmacol. 1994; 46(5)386–387, [CSA]
  • Casini A, Ferrali M, Pampella A, Maellaro E, Comporti M. Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice. Am J Pathol. 1989; 123(3)520–531, [CSA]
  • Aykac G, Uysal M, Yalan A S, Kocak Toker N, Sivas A, Oz H. The effect of chronic ethanol injection on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats. Toxicology. 1985; 36(1)71–76, [INFOTRIEVE], [CSA], [CROSSREF]
  • Woessner J F, Jr. The determination of hydroxyproline in tissue and protein samples containing small proportion of this imino acid. Arch Biochem Biophys. 1961; 93: 440–447, [INFOTRIEVE], [CSA], [CROSSREF]
  • Fatouros M, Dalekos G N, Mylonakis E, Vekinis G, Kappas A M. Alterations in body weight, breaking strength, and wound healing in wistar rats treated pre- and postoperatively with erythropoietin or granulocyte macrophage-colony stimulating factor: Evidence of a previously unknown anabolic effect of erythropoietin?. J Lab Clin Med. 1999; 133: 253–259, [INFOTRIEVE], [CSA], [CROSSREF]
  • Fatouros M S, Vekinis G, Bourantas K L, Mylonakis E P, Scopelitou A S, Malamou-Mitsis V D, Kappas A M. Influence of growth factors erythropoietin and granulocyte macrophage colony stimulating factor on mechanical strength and healing of colonic anastomoses in rats. Eur J Surg. 1999; 165: 986–992, [INFOTRIEVE], [CSA], [CROSSREF]
  • Galeano M, Altavilla D, Cucinotta D, Russo G T, Calo M, Bitto A, Marini H, Marini R, Adamo E B, Seminara P, Minutoli L, Torre V, Squadrito F. Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes. 2004; 53(9)2509–2517, [INFOTRIEVE], [CSA]
  • Degim Z, Celebi N, Sayan H, Babul A, Erdogan D, Take G. An investigation of skin wound healing in mice with a taurine–chitosan gel formulation. Amino Acids. 2002; 22(2)187–198, [INFOTRIEVE], [CSA], [CROSSREF]
  • Kaptanoglu E, Solaroglu I, Okutan O, Surucu H S, Akbiyik F, Beskonakli E. Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: Effect on lipid peroxidation and early ultrastructural findings. Neurosurg Rev. 2004; 27(2)113–120, [INFOTRIEVE], [CSA], [CROSSREF]
  • Solaroglu I, Solaroglu A, Kaptanoglu E, Dede S, Haberal A, Beskonakli E, Kilinc K. Erythropoietin prevents ischemia-reperfusion from inducing oxidative damage in fetal rat brain. Childs Nerv Syst. 2003; 19(1)19–22, [INFOTRIEVE], [CSA]
  • Akisu M, Kullahcioglu Girgin F, Baka M, Husseyinov A, Kultursay N. The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. Eur J Pediatr Surg. 2001; 11(3)167–172, [INFOTRIEVE], [CSA], [CROSSREF]
  • Kilic D, Sayan H, Gonul B, Egehan I. The effect of granulocyte macrophage-colony stimulating factor on glutathione and lipid peroxidation in a rat model. Eur J Surg Oncol. 2000; 26(7)701–704, [INFOTRIEVE], [CSA], [CROSSREF]
  • Shi H P, Efron D T, Most D, Barbul A. The role of iNOS in wound healing. Surgery. 2001; 130: 225–229, [INFOTRIEVE], [CSA], [CROSSREF]
  • Adamson B, Schwarz D, Klugston P, Gilmont R, Perry L, Fisher J, Lindblad W, Rees R. Delayed repair: The role of glutathione in a rat incisional wound model. J Surg Res. 1996; 62: 159–164, [INFOTRIEVE], [CSA], [CROSSREF]
  • Shukla A, Rasik A M, Patnaik G K. Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defense enzymes in a healing cutaneous wound. Free Radical Res. 1997; 26(2)93–101, [CSA]
  • Genc S, Akhisaroglu M, Kuralay F, Genc K. Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro. Neurosci Lett. 2002; 321: 73–76, [INFOTRIEVE], [CSA], [CROSSREF]
  • Steinbrech D S, Longaker M T, Mehrara B J, Saadeh P B, Chin G S, Gerrets R P, Chau D C, Rowe N M, Gittes G K. Fibroblast response to hypoxia: The relationship between angiogenesis and matrix regulation. J Surg Res. 1999; 84 127–133, [INFOTRIEVE], [CSA], [CROSSREF]
  • Lee P C, Salyapongse N, Bragdon G A, Shears L L, II, Watkins S C, Edington H DJ, Billiar T R. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol Heart Circ Physiol. 1999; 277: H1600–H1608, [CSA]
  • Marti H H, Bernaudin M, Petit E, Bauer C. Neuroprotection and angiogenesis: Dual role of erythropoietin in brain ischemia. News Physiol Sci. 2000; 15: 225–229, [INFOTRIEVE], [CSA]
  • Buemi M, Vaccaro M, Sturiale A, Galeano M R, Sansotta C, Cavallari V, Floccari F, D'Amico D, Torre V, Calapai G, Frisina N, Guarneri F, Vermiglio G. Recombinant human erythropoietin influences revascularization and healing in a rat model of random ischaemic flaps. Acta Derm Venereol. 2002; 82(6)411–417, [INFOTRIEVE], [CSA], [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.