Effect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model

REFERENCES

• Hızlı D, Hızlı F, Köşüş A, Yılmaz N, Haltaş, et al. Effect of hypericumperforatum on intraperitoneal adhesion formation in rats. Arch Med Sci. 2014;10:396–400.
   PubMed Web of Science ®Google Scholar
• Parker MC, Wilson MS, Menzies D, et al. Surgical and clinical adhesions research (SCAR) group. Colorectal surgery: the risk and burden of adhesion-related complications. Colorectal Dis. 2004;6:506–511.
   PubMedGoogle Scholar
• Liakakos T, Thomakos N, Fine PM, et al. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001;18:260–273.
   PubMed Web of Science ®Google Scholar
• Hindocha A, Beere L, Dias S, et al. Adhesion prevention agents for gynaecological surgery: an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015;1: CD011254.
   Google Scholar
• Hisatomi K, Mukae H, Sakamoto N, et al. Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells. BMC Pulm Med. 2012;12:24.
   PubMed Web of Science ®Google Scholar
• Leask A. Potential therapeutic targets for cardiac fibrosis:TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res. 2010;106:1675–1680.
   PubMed Web of Science ®Google Scholar
• Rodrigues-Díez R, Aroeira LS, Orejudo M, et al. IL-17A is a novel player in dialysis-induced peritoneal damage. Kidney Int. 2014;86:303–315.
   PubMed Web of Science ®Google Scholar
• Al-Took S, Murray C, Tulandi T. Effects of pirfenidone and dermoid cyst fluid on adhesion formation. Fertil Steril. 1998;69:341–343.
   PubMed Web of Science ®Google Scholar
• Salazar-Montes A, Ruiz-Corro L, López-Reyes A, et al. Potent antioxidant role of pirfenidone in experimental cirrhosis. Eur J Pharmacol. 2008;595:69–77.
   PubMed Web of Science ®Google Scholar
• Keskin HL, Sirin YS, Keles H, Turgut O, Ide T, Avsar AF. The aromatase inhibitor letrozole reduces adhesion formation after intraperitoneal surgery in a rat uterine horn model. Eur J Obstet Gynecol Reprod Biol. 2013;167: 199–204.
   PubMed Web of Science ®Google Scholar
• Shirakawa T, Miyahara Y, Tanimura K, et al. Expression of epithelial-mesenchymaltransition-related factors in Adherent Placenta. Int J GynecolPathol. 2015;34:584–589.
   Web of Science ®Google Scholar
• Cheong YC, Laird SM, Li TC, et al. Peritoneal healing and adhesion formation/reformation. Hum Reprod Update. 2001;7:556–566.
   PubMed Web of Science ®Google Scholar
• Nakayama S, Mukae H, Sakamoto N, et al. Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts. Life Sci. 2008;82: 210–217.
   PubMed Web of Science ®Google Scholar
• Conte E, Gili E, Fagone E, et al. Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts. Eur J Pharm Sci. 2014;58:13–19.
   PubMed Web of Science ®Google Scholar
• Myllärniemi M, Kaarteenaho R. Pharmacological treatment of idiopathic pulmonary fibrosis - preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine. Eur Clin Respir J. 2015;10:2.
   Google Scholar
• Ji X, Naito Y, Weng H, et al. Renoprotective mechanisms of pirfenidone in hypertension-induced renal injury: through anti-fibrotic and anti-oxidative stress pathways. Biomed Res. 2013;34:309–319.
   PubMed Web of Science ®Google Scholar
• Di Sario A, Bendia E, Macarri G, et al. The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagenalpha1(I), TIMP-1 and MMP-2. Dig Liver Dis. 2004;36:744–751.
   PubMedGoogle Scholar
• Suga H, Teraoka S, Ota K, et al. Preventive effect of pirfenidone against experimental sclerosing peritonitis in rats. Exp Toxicol Pathol. 1995;47:287–291.
   PubMed Web of Science ®Google Scholar
• Ignotz RA, Massagué J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem. 1986;261:4337–4345.
   PubMed Web of Science ®Google Scholar
• Shah M, Foreman DM, Ferguson MW. Neutralisation of TGFbeta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci. 1995;108:985–1002.
   PubMed Web of Science ®Google Scholar
• Krause TJ, Katz D, Wheeler CJ, et al. Increased levels of surgical adhesions in TGFbeta1 heterozygous mice. J Invest Surg. 1999;12:31–38.
   PubMed Web of Science ®Google Scholar
• Guler S, Cimen S, Hu Q, et al. Effects of mTOR inhibitors in prevention of abdominal adhesions. J Invest Surg. 2016;16:1–7.
   Web of Science ®Google Scholar
• Mi S, Li Z, Yang HZ, et al. Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol. 2011;187:3003-3014.
   PubMed Web of Science ®Google Scholar
• Wang G, Wu K, Li W, et al. Role of IL-17 and TGF-β in peritoneal adhesion formation after surgical trauma. Wound Repair Regen. 2014;22:631–639.
   PubMed Web of Science ®Google Scholar
• Vittal R, Fan L, Greenspan DS, et al. IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis. Am J Physiol Lung Cell Mol Physiol. 2013;304:401–414.
   Web of Science ®Google Scholar
• Iyer SN, Wild JS, Schiedt MJ, et al. Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. J Lab Clin Med. 1995;125:779–785.
   PubMed Web of Science ®Google Scholar
• Lundorff P, Hahlin M, Källfelt B, et al. Adhesion formation after laparoscopic surgery in tubal pregnancy: a randomized trial versus laparotomy. Fertil Steril. 1991;55: 911–915.
   PubMed Web of Science ®Google Scholar
• Boland GM, Weigel RJ. Formation and prevention of postoperative abdominal adhesions. J Surg Res. 2006;132:3–12.
   PubMed Web of Science ®Google Scholar
• King TE Jr, Bradford WZ, Castro-Bernardini S, et al; ASCEND study group. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2083–2092.
   PubMed Web of Science ®Google Scholar