Interval Debulking Surgery for Advanced Ovarian Cancer in Elderly Patients (≥70 y): Does the Age Matter?

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.
   PubMed Web of Science ®Google Scholar
• Malvezzi M, Carioli G, Rodriguez T, et al. Global trends and predictions in ovarian cancer mortality. Ann Oncol. 2016;27(11):2017–2025.
   PubMed Web of Science ®Google Scholar
• Pallis AG, Fortpied C, Wedding U, et al. EORTC elderly task force position paper: approach to the older cancer patient. Eur J Cancer. 2010;46(9):1502–1513. doi:10.1016/j.ejca.2010.02.022.
   PubMed Web of Science ®Google Scholar
• Gibson SJ, Fleming GF, Temkin SM, et al. The application and outcome of standard of care treatment in elderly women with ovarian cancer: a literature review over the last 10 years. Front Oncol. 2016; 6:63. doi:10.3389/fonc.2016.00063.
   PubMed Web of Science ®Google Scholar
• van Walree IC, van Soolingen NJ, Hamaker ME, et al. Treatment decision-making in elderly women with ovarian cancer: an age-based comparison. Int J Gynecol Cancer. 2019;29(1):158–165. doi:10.1136/ijgc-2018-000026.
   PubMed Web of Science ®Google Scholar
• Kim J, Chang Y, Kim TJ, et al. Optimal cutoff age for predicting prognosis associated with serous epithelial ovarian cancer: what is the best age cutoff? J Gynecol Oncol. 2019;30(1):e11. doi:10.3802/jgo.2019.30.e11.
   PubMed Web of Science ®Google Scholar
• Nadaraja S, Jorgensen TL, Matzen LE, et al. Impact of age, comorbidity, and FIGO stage on treatment choice and mortality in older Danish patients with gynecological cancer: a retrospective register-based cohort study. Drugs Real World Outcomes. 2018;5(4):225–235. doi:10.1007/s40801-018-0145-x.
   PubMedGoogle Scholar
• Jorgensen TL, Hallas J, Friis S, et al. Comorbidity in elderly cancer patients in relation to overall and cancer-specific mortality. Br J Cancer. 2012;106:1353–1360. doi:10.1038/bjc.2012.46.
   PubMed Web of Science ®Google Scholar
• Sabatier R, Calderon B, Jr., Lambaudie E, et al. Prognostic factors for ovarian epithelial cancer in the elderly: a case-control study. Int J Gynecol Cancer. 2015;25(5):815–822. doi:10.1097/IGC.0000000000000418.
   PubMed Web of Science ®Google Scholar
• Morotti M, Becker CM, Menada MV, et al. Targeting tyrosine-kinases in ovarian cancer. Expert Opin Investig Drugs. 2013;22(10):1265–1279. doi:10.1517/13543784.2013.816282.
   PubMed Web of Science ®Google Scholar
• Tortorella L, Vizzielli G, Fusco D, et al. Ovarian cancer management in the oldest old: improving outcomes and tailoring treatments. Aging Dis. 2017;8(5):677–684. doi:10.14336/AD.2017.0607.
   PubMed Web of Science ®Google Scholar
• Du Bois A, Reuss A, Pujade-Lauraine E, et al. Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d’Investigateurs Nationaux Pour les Etudes des Cancers de l’Ovaire (GINECO). Cancer. 2009;115:1234–1244. doi:10.1002/cncr.24149.
   PubMed Web of Science ®Google Scholar
• Vergote I, Trope CG, Amant F, et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med. 2010;363(10):943–953. doi:10.1056/NEJMoa0908806.
   PubMed Web of Science ®Google Scholar
• Kehoe S, Hook J, Nankivell M, et al. Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial. Lancet. 2015;386(9990):249–257. doi:10.1016/S0140-6736(14)62223-6.
   PubMed Web of Science ®Google Scholar
• McLean KA, Shah CA, Thompson SA, et al. Ovarian cancer in the elderly: outcomes with neoadjuvant chemotherapy or primary cytoreduction. Gynecol Oncol. 2010;118(1):43–46. doi:10.1016/j.ygyno.2010.03.002.
   PubMed Web of Science ®Google Scholar
• Tozzi R, Casarin J, Garruto-Campanile R, et al. Morbidity and reversal rate of ileostomy after bowel resection during Visceral-Peritoneal Debulking (VPD) in patients with stage IIIC-IV ovarian cancer. Gynecol Oncol. 2018;148(1):74–78. doi:10.1016/j.ygyno.2017.11.017.
   PubMed Web of Science ®Google Scholar
• Tozzi R, Hardern K, Gubbala K, et al. En-bloc resection of the pelvis (EnBRP) in patients with stage IIIC-IV ovarian cancer: a 10 steps standardised technique. Surgical and survival outcomes of primary vs. interval surgery. Gynecol Oncol. 2017;144(3):564–570. doi:10.1016/j.ygyno.2016.12.019.
   PubMed Web of Science ®Google Scholar
• Tozzi R, Ferrari F, Nieuwstad J, et al. Tozzi classification of diaphragmatic surgery in patients with stage IIIC-IV ovarian cancer based on surgical findings and complexity. J Gynecol Oncol. 2020;31(2):e14. doi:10.3802/jgo.2020.31.e14.
   PubMed Web of Science ®Google Scholar
• Pinelli C, Morotti M, Casarin J, et al. The feasibility of cardiophrenic lymphnode assessment and removal in patients requiring diaphragmatic resection during interval debulking surgery for ovarian cancer. J Invest Surg. 2019:1–7.
   PubMed Web of Science ®Google Scholar
• Tozzi R, Casarin J, Baysal A, et al. Bowel resection rate but not bowel related morbidity is decreased after interval debulking surgery compared to primary surgery in patents with stage IIIC-IV ovarian cancer. J Gynecol Oncol. 2019;30(2):e25. doi:10.3802/jgo.2019.30.e101.
   PubMed Web of Science ®Google Scholar
• Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187–196. doi:10.1097/SLA.0b013e3181b13ca2.
   PubMed Web of Science ®Google Scholar
• Papadia A, Morotti M. Diaphragmatic surgery during cytoreduction for primary or recurrent epithelial ovarian cancer: a review of the literature. Arch Gynecol Obstet. 2013;287(4):733–741. doi:10.1007/s00404-013-2715-1.
   PubMed Web of Science ®Google Scholar
• Heilmann T, Pfisterer J, Hempel AM, et al. Early treatment modifications improve chemotherapy adherence in ovarian cancer patients >/=70 years. Gynecol Oncol. 2019;153(3):616–624. doi:10.1016/j.ygyno.2019.02.015.
   PubMed Web of Science ®Google Scholar
• Langstraat C, Aletti GD, Cliby WA. Morbidity, mortality and overall survival in elderly women undergoing primary surgical debulking for ovarian cancer: a delicate balance requiring individualization. Gynecol Oncol. 2011;123(2):187–191. doi:10.1016/j.ygyno.2011.06.031.
   PubMed Web of Science ®Google Scholar
• Thrall MM, Goff BA, Symons RG, et al. Thirty-day mortality after primary cytoreductive surgery for advanced ovarian cancer in the elderly. Obstet Gynecol. 2011;118(3):537–547. doi:10.1097/AOG.0b013e31822a6d56.
   PubMed Web of Science ®Google Scholar
• Di Donato V, Kontopantelis E, Aletti G, et al. Trends in mortality after primary cytoreductive surgery for ovarian cancer: a systematic review and metaregression of randomized clinical trials and observational studies. Ann Surg Oncol. 2017;24(6):1688–1697. doi:10.1245/s10434-016-5680-7.
   PubMed Web of Science ®Google Scholar
• Meyer LA, He W, Sun CC, et al. Neoadjuvant chemotherapy in elderly women with ovarian cancer: rates of use and effectiveness. Gynecol Oncol. 2018;150(3):451–459. doi:10.1016/j.ygyno.2018.06.020.
   PubMed Web of Science ®Google Scholar
• Meyer LA, Cronin AM, Sun CC, et al. Use and effectiveness of neoadjuvant chemotherapy for treatment of ovarian cancer. JCO. 2016;34(32):3854–3863. doi:10.1200/JCO.2016.68.1239.
   PubMed Web of Science ®Google Scholar
• Bogani G, Matteucci L, Tamberi S, et al. The impact of number of cycles of neoadjuvant chemotherapy on survival of patients undergoing interval debulking surgery for stage IIIC-IV unresectable ovarian cancer: results from a multi-institutional study. Int J Gynecol Cancer. 2017;27(9):1856–1862. doi:10.1097/IGC.0000000000001108.
   PubMed Web of Science ®Google Scholar
• Levett DZ, Grocott MP. Cardiopulmonary exercise testing, prehabilitation, and Enhanced Recovery After Surgery (ERAS). Can J Anesth/J Can Anesth. 2015;62(2):131–142. doi:10.1007/s12630-014-0307-6.
   PubMed Web of Science ®Google Scholar
• Katsura M, Kuriyama A, Takeshima T, et al. Preoperative inspiratory muscle training for postoperative pulmonary complications in adults undergoing cardiac and major abdominal surgery. Cochrane Database Syst Rev. 2015;(10):CD010356.
   Google Scholar
• Escayola C, Torrent JJ, Ferron G, et al. When and who should perform epithelial ovarian cancer surgery? Int J Gynecol Cancer. 2018;28(3):594–599. doi:10.1097/IGC.0000000000001188.
   PubMed Web of Science ®Google Scholar