References
- Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57(1):43–66. doi:https://doi.org/10.3322/canjclin.57.1.43. PMID: 17237035.
- Kianmanesh R, Regimbeau JM, Belghiti J. Selective approach to major hepatic resection for hepatocellular carcinoma in chronic liver disease. Surg Oncol Clin N Am. 2003;12(1):51–63. doi:https://doi.org/10.1016/S1055-3207(02)00090-X. PMID: 12735129.
- EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236. doi:https://doi.org/10.1016/j.jhep.2018.03.019. PMID: 29628281.
- Couri T, Pillai A. Goals and targets for personalized therapy for HCC. Hepatol Int. 2019;13(2):125–137. doi:https://doi.org/10.1007/s12072-018-9919-1. PMID: 30600478.
- Huang A, Yang XR, Chung WY, et al. Targeted therapy for hepatocellular carcinoma. Signal Transduct Target Ther. 2020;5(1):146. doi:https://doi.org/10.1038/s41392-020-00264-x. PMID: 32782275.
- Lev S. Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis. Biochem Soc Trans. 2020;48(2):657–665. doi:https://doi.org/10.1042/bst20191055. PMID: 32311020.
- Rankin EB, Giaccia AJ. Hypoxic control of metastasis. Science. 2016;352(6282):175–180. doi:https://doi.org/10.1126/science.aaf4405. PMID: 27124451.
- Zhao J, Xiao A, Liu C, et al. The HIF-1A/miR-17-5p/PDCD4 axis contributes to the tumor growth and metastasis of gastric cancer. Signal Transduct Target Ther. 2020;5(1):46. doi:https://doi.org/10.1038/s41392-020-0132-z. PMID: 32296039.
- Seeber LM, Horrée N, Vooijs MA, et al. The role of hypoxia inducible factor-1alpha in gynecological cancer. Crit Rev Oncol Hematol. 2011;78(3):173–184. doi:https://doi.org/10.1016/j.critrevonc.2010.05.003. PMID: 20627616.
- Jiang L, Li Y, He Y, et al. Knockdown of m6A reader IGF2BP3 inhibited hypoxia-induced cell migration and angiogenesis by regulating hypoxia inducible factor-1α in stomach cancer. Front Oncol. 2021;11:711207. doi:https://doi.org/10.3389/fonc.2021.711207. PMID: 34621671.
- Chen J, Chen J, Huang J, et al. HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway. Aging (Albany NY). 2019;11(23):10839–10860. doi:https://doi.org/10.18632/aging.102488. PMID: 31796646.
- Jeng KS, Jeng CJ, Jeng WJ, et al. Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma. Oncol Lett. 2019;18(5):4377–4384. doi:https://doi.org/10.3892/ol.2019.10826. PMID: 31611946.
- Li HY, Yin FF, Li XY, et al. Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma. Biosens Bioelectron. 2021;174:112738. doi:https://doi.org/10.1016/j.bios.2020.112738. PMID: 33257185.
- Leung HW, Lau EYT, Leung CON, et al. NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma. Cancer Lett. 2020;476:48–56. doi:https://doi.org/10.1016/j.canlet.2020.02.008. PMID: 32061952.
- Hou W, Xie Y, Song X, et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12(8):1425–1428. doi:https://doi.org/10.1080/15548627.2016.1187366. PMID: 27245739.
- Torii S, Shintoku R, Kubota C, et al. An essential role for functional lysosomes in ferroptosis of cancer cells. Biochem J. 2016;473(6):769–777. doi:https://doi.org/10.1042/bj20150658. PMID: 26759376.
- Wu G, Wang Q, Xu Y, et al. A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma. Aging (Albany NY). 2020;12(14):14933–14948. doi:https://doi.org/10.18632/aging.103553. PMID: 32688345.
- Yang L, Tian S, Chen Y, et al. Ferroptosis-related gene model to predict overall survival of ovarian carcinoma. J Oncol. 2021;2021:6687391. doi:https://doi.org/10.1155/2021/6687391. PMID: 33519933.
- Xu T, Ding W, Ji X, et al. Molecular mechanisms of ferroptosis and its role in cancer therapy. J Cell Mol Med. 2019;23(8):4900–4912. doi:https://doi.org/10.1111/jcmm.14511. PMID: 31232522.
- Kong N, Chen X, Feng J, et al. Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1. Acta Pharm Sin B. 2021;11(12):4045–4054. doi:https://doi.org/10.1016/j.apsb.2021.03.036. PMID: 35024325.
- Fuhrmann DC, Mondorf A, Beifuß J, et al. Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis. Redox Biol. 2020;36:101670. doi:https://doi.org/10.1016/j.redox.2020.101670. PMID: 32810738.
- Ni S, Yuan Y, Qian Z, et al. Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis. Free Radic Biol Med. 2021;169:271–282. doi:https://doi.org/10.1016/j.freeradbiomed.2021.04.027. PMID: 33895289.
- Chen M, Ye Y, Zou B, et al. C14orf166 is a high-risk biomarker for bladder cancer and promotes bladder cancer cell proliferation. J Transl Med. 2016;14(1):55. doi:https://doi.org/10.1186/s12967-016-0801-4. PMID: 26905879.
- Jin GZ, Yu WL, Dong H, et al. SUOX is a promising diagnostic and prognostic biomarker for hepatocellular carcinoma. J Hepatol. 2013;59(3):510–517. doi:https://doi.org/10.1016/j.jhep.2013.04.028. PMID: 23665285.
- Zhu XD, Zhang JB, Zhuang PY, et al. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol. 2008;26(16):2707–2716. doi:https://doi.org/10.1200/JCO.2007.15.6521. PMID: 18509183.
- Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004;10(21):7252–7259. doi:https://doi.org/10.1158/1078-0432.Ccr-04-0713. PMID: 15534099.
- Peer E, Tesanovic S, Aberger F. Next-generation Hedgehog/GLI pathway inhibitors for cancer therapy. Cancers (Basel). 2019;11(4):538. doi:https://doi.org/10.3390/cancers11040. PMID: 30991683.
- Jiang Y, Mao C, Yang R, et al. EGLN1/c-Myc induced lymphoid-specific helicase inhibits ferroptosis through lipid metabolic gene expression changes. Theranostics. 2017;7(13):3293–3305. doi:https://doi.org/10.7150/thno.19988. PMID: 28900510.
- Yang Y, Tang H, Zheng J, et al. The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma. Transl Oncol. 2022;18:101360. doi:https://doi.org/10.1016/j.tranon.2022.101360. PMID: 35134674.
- Jing X, Yang F, Shao C, et al. Role of hypoxia in cancer therapy by regulating the tumor microenvironment. Mol Cancer. 2019;18(1):157. doi:https://doi.org/10.1186/s12943-019-1089-9. PMID: 31711497.
- Spivak-Kroizman TR, Hostetter G, Posner R, et al. Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res. 2013;73(11):3235–3247. doi:https://doi.org/10.1158/0008-5472.Can-11-1433. PMID: 23633488.
- Lu JT, Zhao WD, He W, et al. Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway. Acta Pharmacol Sin. 2012;33(5):691–700. doi:https://doi.org/10.1038/aps.2012.24. PMID: 22543708.
- Liu J, Ma H, Meng L, et al. Construction and external validation of a ferroptosis-related gene signature of predictive value for the overall survival in bladder cancer. Front Mol Biosci. 2021;8(675651):1-18. doi:https://doi.org/10.3389/fmolb.2021.675651. PMID: 34095228.
- Miao H, Ren Q, Li H, et al. Comprehensive analysis of the autophagy-dependent ferroptosis-related gene FANCD2 in lung adenocarcinoma. BMC Cancer. 2022;22(1):225. doi:https://doi.org/10.1186/s12885-022-09314-9. PMID: 35236309.
- Fang Y, Chen X, Tan Q, et al. Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action. ACS Cent Sci. 2021;7(6):980–989. doi:https://doi.org/10.1021/acscentsci.0c01592. PMID: 34235259.