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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 6: Inhaled Iodomethane: A Focused Research Program & Health-Based Risk Assessment
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Research Article

Prenatal developmental toxicity studies of inhaled methyl iodide vapor in rabbits reveal a susceptible window of exposure inducing late gestational fetotoxicity

M. NemecWIL Research Laboratories, LLC, Ashland, OhioCorrespondence[email protected]
,
E. SloterWIL Research Laboratories, LLC, Ashland, Ohio
,
D. StumpWIL Research Laboratories, LLC, Ashland, Ohio
,
J. HolsonWIL Research Laboratories, LLC, Ashland, Ohio
,
D. KirkpatrickWIL Research Laboratories, LLC, Ashland, Ohio
&
J. KinzellArysta LifeScience Corporation, Cary, North Carolina, USA
Pages 449-461 | Received 15 Oct 2008, Accepted 04 Nov 2008, Published online: 01 May 2009

References

  • Appel, G.B., Galen, R., O’Brien, J., and Schoenfeldt, R. 1975. Methyl iodide intoxication. A case report. Ann. Intern. Med. 82(4):534–536.
  • AWA. 1966. The Animal Welfare Act, 7 U.S.C. 2131–2159 (9 CFR, chapter, I, subchapter, A, parts 1, 2, and 3). Public Law 89-544, amended by Pub. L. 91-579, Pub. L. 94-279, and Pub. L. 99-198. US Congress.
  • Chameides, W.L., and Davis, D.D. 1980. Iodine: Its possible role in tropospheric photochemistry. J. Geophys. Res. 85:7383–7398.
  • Dunnett, C.W. 1964. New tables for multiple comparisons with a control. Biometrics 20:482–491.
  • Hermouet, C., Garnier, R., Efthymiou, M., and Fournier, P. 1996. Methyl iodide poisoning: Report of two cases. Am. J. Ind. Med. 30(6):759–764.
  • Holson, J.F., Nemec, M.D., Stump, D.G., Kaufman, L.E., Lindstro¨m, P., and Varsho, B.J. 2005. Significance, reliability, and interpretation of developmental and reproductive toxicity study findings. In Developmental and reproductive toxicology: A practical approach, 2nd ed., ed R.D. Hood, pp. 329–424. Boca Raton, FL: CRC Press.
  • Institute of Laboratory Animal Resources, Commission on Life Sciences, and the National Research Council. 1996. Guide for the care and use of laboratory animals. Washington, DC: National Academy Press.
  • Kruskal, W.H., and Wallis, W.A. 1952. Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 47:583–621.
  • MAFF. 1999. 11 Nousan Number 6283. Good laboratory practice standards. Tokyo: Japanese Ministry of Agriculture, Forestry and Fisheries.
  • MAFF. 2000. 12 Nousan Number 8147. Developmental toxicity testing guidelines. Tokyo: Japanese Ministry of Agriculture, Forestry and Fisheries.
  • Moore, R.M., and Groszko, W. 1999. Methyl iodide distribution in the ocean and fluxes to the atmosphere. J. Geophys. Res. 104:11163–11171.
  • Organisation for Economic Cooperation and Development. 1997. Principles of good laboratory practice, C(97)186/Final. Paris: Organisation for Economic Cooperation and Development.
  • Organisation for Economic Cooperation and Development. 2001. Test no. 414. Guidelines for the testing of chemicals. Prenatal developmental toxicity study. Paris: Organisation for Economic Cooperation and Development.
  • Schwartz, M.D., Obamwonyi, A.O., Thomas, J.D., Moorhead, J.F., and Morgan, B.W. 2005. Acute methyl iodide exposure with delayed neuropsychiatric sequelae: Report of a case. Am. J. Ind. Med. 47(6):550–556.
  • Singh, H.B., Salas, L.J., and Stiles, R.E. 1983. Methyl halides in and over the eastern Pacific (40°N–32°S). J. Geophys. Res. 88:3684–3690.
  • Sloter, E., Nemec, M., Stump, D., Holson, J., Kirkpatrick, D., Gargas, M., Kinzell, J., and Kaufman, J. 2009. Mode of action: Methyl iodide-induced fetal hypothyroidism implicated in late-stage L. fetal rabbit deaths. Inhal. Toxicol. 21: 462–479.
  • Snedecor, G.W., and Cochran, W.G. 1989. One way classifications: analysis of variance. In Statistical methods, 8th ed., pp. 217–236. Ames: Iowa State University Press.
  • Stuckhardt, J.L., and Poppe, S.M. 1984. Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratogen. Carcinogen. Mutagen. 4:181–188.
  • U.S. Environmental Protection Agency. 1989. Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Good Laboratory Practice Standards (GLPs) Final rule. 40 CFR Part 160 Available at: www.fda.gov.
  • U.S. Environmental Protection Agency. 1998. Health effects test guidelines for prenatal developmental toxicity study. OPPTS 870.3700 Available at: www.fda.gov.
  • Zhang, W., McGiffen, M.E. Jr., Becker, J.O., Ohr, H.D., Sims, J.J., and Campbell, S.D. 1998. Effect of soil physical factors on methyl iodide and methyl bromide. Pestic. Sci. 53:71–79.

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