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Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 7
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Letter to the Editor

Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics

Allison J. Burbanka Department of Pediatrics, Division of Allergy, Immunology, & Rheumatology, University of North Carolina, Chapel Hill, NC, USA;b Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, USACorrespondence[email protected]
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,
Michelle L. Hernandeza Department of Pediatrics, Division of Allergy, Immunology, & Rheumatology, University of North Carolina, Chapel Hill, NC, USA;b Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, USAView further author information
,
Carole Robinetteb Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, USAView further author information
,
Ting Wangc Department of Biostatistics, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USAView further author information
,
Haibo Zhouc Department of Biostatistics, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USAView further author information
,
Neil Alexisb Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, USAView further author information
,
William D. Bennettb Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, USAView further author information
&
David B. Pedena Department of Pediatrics, Division of Allergy, Immunology, & Rheumatology, University of North Carolina, Chapel Hill, NC, USA;b Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, USAView further author information
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Pages 279-281 | Received 29 Apr 2020, Accepted 17 Jul 2020, Published online: 30 Jul 2020

References

  • Bennett WD, Alexis NE, Almond M, Herbst M, Zeman KL, Peden DB. 2014. Effect of inhaled endotoxin on mucociliary clearance and airway inflammation in mild smokers and nonsmokers. J Aerosol Med Pulm Drug Deliv. 27(6):459–465.
  • Bennett WD, Herbst M, Alexis NE, Zeman KL, Wu J, Hernandez ML, Peden DB. 2011. Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics. Clin Exp Allergy. 41(12):1719–1728.
  • Bennett WD, Wu J, Fuller F, Balcazar JR, Zeman KL, Duckworth H, Donn KH, O'Riordan TG, Boucher RC, Donaldson SH. 2015. Duration of action of hypertonic saline on mucociliary clearance in the normal lung. J Appl Physiol. 118(12):1483–1490.
  • Bromberg PA. 2016. Mechanisms of the acute effects of inhaled ozone in humans. Biochim Biophys Acta. 1860(12):2771–2781.
  • Burbank AJ, Duran CG, Almond M, Wells H, Jenkins S, Jiang Q, Yang C, Wang T, Zhou H, Hernandez ML, et al. 2017. A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo. J Allergy Clin Immunol. 140(4):1179–1181e4.
  • Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, Yang C, Jenkins S, Wells H, Alexis N, et al. 2018. Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. J Allergy Clin Immunol. 141(4):1231–1238e1.
  • Foster WM, Stetkiewicz PT. 1996. Regional clearance of solute from the respiratory epithelia: 18–20 h postexposure to ozone. J Appl Physiol. 81(3):1143–1149.
  • Gerrity TR, Bennett WD, Kehrl H, DeWitt PJ. 1993. Mucociliary clearance of inhaled particles measured at 2 h after ozone exposure in humans. J Appl Physiol. 74(6):2984–2989.
  • Hernandez ML, Lay JC, Harris B, Esther CR Jr, Brickey WJ, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Alexis NE, et al. 2010. Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone. J Allergy Clin Immunol. 126(3):537–544e1.
  • Lay JC, Alexis NE, Kleeberger SR, Roubey RA, Harris BD, Bromberg PA, Hazucha MJ, Devlin RB, Peden DB. 2007. Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals. J Allergy Clin Immunol. 120(3):719–722.
  • Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, Peden DB. 2007. Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol. Free Radic Biol Med. 43(8):1176–1188.

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