References
- Akhurst RJ, Hata A. 2012. Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov. 11(10):790–811.
- Asiedu-Gyekye IJ, Mahmood SA, Awortwe C, Nyarko AK. 2014. A preliminary safety evaluation of polyhexamethylene guanidine hydrochloride. Int J Toxicol. 33(6):523–531.
- Border WA, Noble NA. 1994. Transforming growth factor beta in tissue fibrosis. N Engl J Med. 331(19):1286–1292.
- Chang HR, Yang KW, Kim YH. 2006. Environmental risk assessment of polyhexamethyleneguanidine phosphate by soil adsorption/desorption coefficient. Korean J Environ Agric. 25(4):365–370.
- Chang MH, Park H, Ha M, Kim Y, Hong YC, Ha EH. 2012. Characteristics of humidifier use in Korean pregnant women: the mothers and children's environmental health (MOCEH) study. Environ Health Toxicol. 27:e2012003.
- Chaudhary NI, Schnapp A, Park JE. 2006. Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med. 173(7):769–776.
- Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, Du Bois RM, Jeffery PK, McAnulty RJ. 1997. Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol. 150(3):981–991.
- Datta A, Scotton CJ, Chambers RC. 2011. Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol. 163(1):141–172.
- Garamszegi N, Garamszegi SP, Samavarchi-Tehrani P, Walford E, Schneiderbauer MM, Wrana JL, Scully SP. 2010. Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics. Oncogene. 29(16):2368–2380.
- Gleizes PE, Munger JS, Nunes I, Harpel JG, Mazzieri R, Noguera I, Rifkin DB. 1997. TGF-beta latency: biological significance and mechanisms of activation. Stem Cells. 15(3):190–197.
- Grotendorst GR, Smale G, Pencev D. 1989. Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils. J Cell Physiol. 140(2):396–402.
- Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, et al. 2008. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68(12):4774–4782.
- Hinz B, Phan SH, Thannickal VJ, Prunotto M, Desmoulière A, Varga J, De Wever O, Mareel M, Gabbiani G. 2012. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol. 180(4):1340–1355.
- Hong SB, Kim HJ, Huh JW, Do KH, Jang SJ, Song JS, Choi SJ, Heo Y, Kim YB, Lim CM, Korean Study Group of Respiratory Failure, et al. 2014. A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome. Thorax. 69(8):694–702.
- Janick-Buckner D, Ranges GE, Hacker MP. 1989. Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice. Toxicol Appl Pharmacol. 100(3):465–473.
- Khalil N, O'Connor RN, Flanders KC, Unruh H. 1996. TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol. 14(2):131–138.
- Kim HJ, Lee MS, Hong SB, Huh JW, Do KH, Jang SJ, Lim CM, Chae EJ, Lee H, Jung M, et al. 2014. A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation. Thorax. 69(8):703–708.
- Kim HR, Hwang GW, Naganuma A, Chung KH. 2016. Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate. J Toxicol Sci. 41(6):711–717.
- Kim HR, Lee K, Park CW, Song JA, Shin DY, Park YJ, Chung KH. 2016. Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses. Arch Toxicol. 90(3):617–632.
- Kim KW, Ahn K, Yang HJ, Lee S, Park JD, Kim WK, Kim JT, Kim HH, Rha YH, Park YM. 2014. Humidifier disinfectant-associated children's interstitial lung disease. Am J Respir Crit Care Med. 189(1):48–56.
- Kim MS, Han JY, Kim SH, Jeon D, Kim HY, Lee SW, Rho MC, Lee K. 2018b. Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice. Respir Physiol Neurobiol. 252–253:1–9.
- Kim MS, Kim SH, Jeon D, Kim HY, Lee K. 2018a. Changes in expression of cytokines in polyhexamethylene guanidine-induced lung fibrosis in mice: Comparison of bleomycin-induced lung fibrosis. Toxicology. 393:185–192.
- King TE, Pardo A, Selman M. 2011. Idiopathic pulmonary fibrosis. Lancet. 378(9807):1949–1961.
- Kulkarni AB, Karlsson S. 1993. Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. Am J Pathol. 143(1):3–9.
- Lee JH, Kang HJ, Seol HS, Kim CK, Yoon SK, Gwack J, Kim YH, Kwon JH. 2013. Refined Exposure Assessment for Three Active Ingredients of Humidifier Disinfectants. Environ Eng Res. 18(4):253–257.
- Lee JH, Yu IJ. 2017. Human exposure to polyhexamethylene guanidine phosphate from humidifiers in residential settings: Cause of serious lung disease. Toxicol Ind Health. 33(11):835–842.
- Lee SJ, Park JH, Lee JY, Jeong YJ, Song JA, Lee K, Kim DJ. 2016. Establishment of a mouse model for pulmonary inflammation and fibrosis by intratracheal instillation of polyhexamethyleneguanidine phosphate. J Toxicol Pathol. 29(2):95–102. 2):
- Li MO, Wan YY, Sanjabi S, Robertson AKL, Flavell RA. 2006. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 24:99–146.
- Liu G, Friggeri A, Yang YP, Milosevic J, Ding Q, Thannickal VJ, Kaminski N, Abraham E. 2010. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med. 207(8):1589–1597.
- Meng XM, Nikolic-Paterson DJ, Lan HY. 2016. TGF-β: the master regulator of fibrosis. Nat Rev Nephrol. 12(6):325–338.
- Mikawa K, Nishina K, Takao Y, Obara H. 2003. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 97(6):1751–1755.
- Oh H, Kim CY, Ryu B, Kim U, Kim J, Lee JM, Lee BH, Moon J, Jung CR, Park JH. 2018. Respiratory toxicity of polyhexamethylene guanidine phosphate exposure in zebrafish. Zebrafish. 15(5):460–472.
- Oulé MK, Quinn K, Dickman M, Bernier AM, Rondeau S, De Moissac D, Boisvert A, Diop L. 2012. Akwaton, polyhexamethylene-guanidine hydrochloride-based sporicidal disinfectant: a novel tool to fight bacterial spores and nosocomial infections. J Med Microbiol. 61(Pt 10):1421–1427.
- Paek D, Koh Y, Park DU, Cheong HK, Do KH, Lim CM, Hong SJ, Kim YH, Leem JH, Chung KH, et al. 2015. Nationwide study of humidifier disinfectant lung injury in South Korea, 1994-2011. Incidence and dose-response relationships. Ann Am Thorac Soc. 12(12):1813–1821.
- Park DU, Friesen MC, Roh HS, Choi YY, Ahn JJ, Lim HK, Kim SK, Koh DH, Jung HJ, Lee JH, et al. 2015. Estimating retrospective exposure of household humidifier disinfectants. Indoor Air. 25(6):631–640.
- Park DU, Ryu SH, Lim HK, Kim SK, Choi YY, Ahn JJ, Lee E, Hong SB, Do KH, Cho JL, et al. 2017. Types of household humidifier disinfectant and associated risk of lung injury (HDLI) in South Korea. Sci Total Environ. 596-597:53–60.
- Park DU, Ryu SH, Roh HS, Lee E, Cho HJ, Yoon J, Lee SY, Cho YA, Do KH, Hong SJ. 2018. Association of high-level humidifier disinfectant exposure with lung injury in preschool children. Sci Total Environ. 616-617:855–862.
- Park JH, Kim HJ, Kwon GY, Gwack J, Park YJ, Youn SK, Kwon JW, Yang BG, Lee MS, Jung M, et al. 2016. Humidifier disinfectants are a cause of lung injury among adults in south korea: a community-based case-control study. PLoS ONE. 11(3):e0151849
- Park S, Lee K, Lee EJ, Lee SY, In KH, Kim HK, Kang MS. 2014. Humidifier disinfectant-associated interstitial lung disease in an animal model induced by polyhexamethylene guanidine aerosol. Am J Respir Crit Care Med. 190(6):706–708.
- Parsons CJ, Takashima M, Rippe RA. 2007. Molecular mechanisms of hepatic fibrogenesis. J Gastroen Hepatol. 22 Suppl 1:S79–S84.
- Rosin M, Welk A, Bernhardt O, Ruhnau M, Pitten FA, Kocher T, Kramer A. 2001. Effect of a polyhexamethylene biguanide mouthrinse on bacterial counts and plaque. J Clin Periodontol. 28(12):1121–1126.
- Shim HE, Lee JY, Lee CH, Mushtaq S, Song HY, Song L, Choi SJ, Lee K, Jeon J. 2018. Quantification of inhaled aerosol particles composed of toxic household disinfectant using radioanalytical method. Chemosphere. 207:649–654.
- Song J, Jung KJ, Yoon SJ, Lee K, Kim B. 2019. Polyhexamethyleneguanidine phosphate induces cytotoxicity through disruption of membrane integrity. Toxicology. 414:35–44.
- Song J, Kim W, Kim Y-B, Kim B, Lee K. 2018. Time course of polyhexamethyleneguanidine phosphate-induced lung inflammation and fibrosis in mice. Toxicol Appl Pharmacol. 345:94–102.
- Song JA, Park HJ, Yang MJ, Jung KJ, Yang HS, Song CW, Lee K. 2014. Polyhexamethyleneguanidine phosphate induces severe lung inflammation, fibrosis, and thymic atrophy. Food Chem Toxicol. 69:267–275.
- Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. 2002. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 3(5):349–363.
- Van Hoecke L, Job ER, Saelens X, Roose K. 2017. Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration. J Vis Exp. 123: 55398.
- Yoon HM, Lee E, Lee JS, Do KH, Jung AY, Yoon CH, Kim SO, Jang SJ, Hong SJ, Cho YA. 2016. Humidifier disinfectant-associated children's interstitial lung disease: Computed tomographic features, histopathologic correlation and comparison between survivors and non-survivors. Eur Radiol. 26(1):235–243.
- Zhang HY, Phan SH. 1999. Inhibition of myofibroblast apoptosis by transforming growth factor beta(1). Am J Respir Cell Mol Biol. 21(6):658–665.
- Zhou ZX, Wei DF, Guan Y, Zheng AN, Zhong JJ. 2010. Damage of Escherichia coli membrane by bactericidal agent polyhexamethylene guanidine hydrochloride: micrographic evidences. J Appl Microbiol. 108(3):898–907.