Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice

References

• Aimé P, Duchamp-Viret P, Chaput MA, Savigner A, Mahfouz M, Julliard AK. 2007. Fasting increases and satiation decreases olfactory detection for a neutral odor in rats. Behav Brain Res. 179(2):258–264.
   PubMed Web of Science ®Google Scholar
• ATSDR. 2005. Health consultation: Cooper’s Poynt Elementary School, Camden, Camden County, New Jersey. Atlanta (GA): CDC.
   Google Scholar
• ATSDR. 2007. Toxicological profile for xylene. Atlanta (GA): CDC.
   Google Scholar
• Borriston. 1983. Thirteen week gavage administration of PET (MEHSL sample No. 700811) to rats. Washington (DC): USEPA.
   Google Scholar
• Brautbar N, Williams J, 2nd. 2002. Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. Int J Hyg Environ Health. 205(6):479–491.
   PubMed Web of Science ®Google Scholar
• Brittebo EB. 1993. Metabolism of xenobiotics in the nasal olfactory mucosa: implications for local toxicity. Pharmacol Toxicol. 72(3):50–52.
   PubMedGoogle Scholar
• Cheng YS, Bowen L, Rando RJ, Postlethwait EM, Squadrito GL, Matalon S. 2010. Exposing animals to oxidant gases: nose only vs. whole body. Proc Am Thorac Soc. 7(4):264–268.
   PubMedGoogle Scholar
• Danish EPA. 2016. Survey and risk assessment of toluene and other neurotoxic substances in children’s rooms. København (Denmark): Danish EPA.
   Google Scholar
• Devor M, Murphy MR. 1973. The effect of peripheral olfactory blockade on the social behavior of the male golden hamster. Behav Biol. 9(1):31–42.
   PubMedGoogle Scholar
• Dixon WJ, Massey FJ. 1957. Introduction to statistical analysis. 2nd ed. New York (NY): McGraw-Hill Book Company, Inc.
   Google Scholar
• Dunn OJ. 1964. Multiple comparisons using rank sums. Technometrics. 6(3):241–252.
   Web of Science ®Google Scholar
• Dunnett CW. 1955. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc. 50(272):1096–1122.
   Web of Science ®Google Scholar
• Elovaara E, Zitting A, Nickels J, Aitio A. 1987. m-Xylene inhalation destroys cytochrome P-450 in rat lung at low exposure. Arch Toxicol. 61(1):21–26.
   PubMed Web of Science ®Google Scholar
• EPA. 2003. Toxicological review of xylenes. Washington (DC): USEPA.
   Google Scholar
• EPA. 2010. Hydrocarbon composition of gasoline vapor emissions from enclosed fuel tanks. Washington (DC): USEPA.
   Google Scholar
• EPA. 2016a. Chemical data reporting for benzene, ethylmethyl. Washington (DC): USEPA.
   Google Scholar
• EPA. 2016b. Toxicological review of trimethylbenzenes. Washington (DC): USEPA.
   Google Scholar
• Fleming AS, Rosenblatt JS. 1974. Olfactory regulation of maternal behavior in rats. I. Effects of olfactory bulb removal in experienced and inexperienced lactating and cycling females. J Comp Physiol Psychol. 86(2):221–232.
   PubMed Web of Science ®Google Scholar
• Gart JJ, Chu KC, Tarone RE. 1979. Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J Natl Cancer Inst. 62(4):957–974.
   PubMedGoogle Scholar
• Genter MB, Owens DM, Deamer NJ. 1995. Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants. Chem Senses. 20(4):385–392.
   PubMed Web of Science ®Google Scholar
• Gralewicz S, Wiaderna D. 2001. Behavioral effects following subacute inhalation exposure to m-xylene or trimethylbenzene in the rat: a comparative study. Neurotoxicology. 22(1):79–89.
   PubMed Web of Science ®Google Scholar
• Green T, Lee R, Toghill A, Meadowcroft S, Lund V, Foster J. 2001. The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans. Chem Biol Interact. 137(2):185–202.
   PubMed Web of Science ®Google Scholar
• Harding JW, Getchell TV, Margolis FL. 1978. Denervation of the primary olfactory pathway in mice. V. Long-term effect of intranasal ZnSO4 irrigation on behavior, biochemistry and morphology. Brain Res. 140(2):271–285.
   PubMed Web of Science ®Google Scholar
• Hazleton Labs. 1983. Two-week gavage administration of PET to rats- final report. Microfiche No. OTS 0206422. Obtained from the U.S. Environmental Protection Agency, Office of Pollution, Prevention and Toxic Substances.
   Google Scholar
• Hellén H, Hakola H, Laurila T, Hiltunen V, Koskentalo T. 2002. Aromatic hydrocarbon and methyl tert-butyl ether measurements in ambient air of Helsinki (Finland) using diffusive samplers. Sci Total Environ. 298(1–3):55–64.
   PubMed Web of Science ®Google Scholar
• Hsu JC. 1992. The factor analytic approach to simultaneous inference in the general linear models. J Comp Graph Stat. 1:151–168.
   Google Scholar
• Hurtt ME, Thomas DA, Working PK, Monticello TM, Morgan KT. 1988. Degeneration and regeneration of the olfactory epithelium following inhalation exposure to methyl bromide: Pathology, cell kinetics, and olfactory function. Toxicol Appl Pharmacol. 94(2):311–328.
   PubMed Web of Science ®Google Scholar
• IARC. 2000. Ethylbenzene. IARC monographs on the evaluation of carcinogenic risks to humans. Lyon (France): IARC.
   Google Scholar
• ICCA. 2012. Initial assessment profile for C9 aromatic hydrocarbon solvents category (screening initial data set [SIDS]). Amsterdam (The Netherlands): ICCA.
   Google Scholar
• IRDC. 1980. Pilot teratology study in rats (final report) with attachments and cover letter containing information from four other reports dated 022592. Indianapolis (IN): International Research and Development Corporation.
   Google Scholar
• IRDC. 1981. Teratology study in rabbits dosed with p-ethyl toluene by oral gavage with attachments. Indianapolis (IN): International Research and Development Corporation.
   Google Scholar
• Jonckheere AR. 1954. A test of significance for the relation between m rankings and k ranked categories. Br J Stat Psychol. 7(2):93–100.
   Google Scholar
• Korsak Z, Rydzyński K. 1996. Neurotoxic effects of acute and subchronic inhalation exposure to trimethylbenzene isomers (pseudocumene, mesitylene, hemimellitene) in rats. Int J Occup Med Environ Health. 9(4):341–349.
   PubMedGoogle Scholar
• Langman J. 1994. Xylene: its toxicity, measurement of exposure levels, absorption, metabolism and clearance. Pathology. 26(3):301–309.
   PubMed Web of Science ®Google Scholar
• McMullin TS, Bamber AM, Bon D, Vigil DI, Van Dyke M. 2018. Exposures and health risks from volatile organic compounds in communities located near oil and gas exploration and production activities in Colorado (U.S.A.). Int J Env Res Public Health. 15(7):1500.
   Web of Science ®Google Scholar
• NTP. 1999. Toxicology and carcinogenesis studies of ethylbenzene (CAS No.100-41-4) in F344/N rats and B6C3F1 mice. Research Triangle Park (NC): US Department of Health and Human Services, Public Health Service, National Institutes of Health.
   Google Scholar
• NTP. 2009. Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice. Research Triangle Park (NC): US Department of Health and Human Services, Public Health Service, National Institutes of Health.
   Google Scholar
• NTP. 2013. N.T.P. report on carcinogens: monograph on cumene. Research Triangle Park (NC): US Department of Health and Human Services, Public Health Service, National Institutes of Health.
   Google Scholar
• Patel JM, Harper C, Drew RT. 1978. The biotransformation of p-xylene to a toxic aldehyde. Drug Metabol Disp. 6(4):368–374.
   PubMed Web of Science ®Google Scholar
• Pauluhn J, Mohr U. 2000. Inhalation studies in laboratory animals-current concepts and alternatives. Toxicol Pathol. 28(5):734–753.
   PubMed Web of Science ®Google Scholar
• Reed CJ. 1993. Drug metabolism in the nasal cavity: relevance to toxicology. Drug Metab Rev. 25(1–2):173–205.
   PubMed Web of Science ®Google Scholar
• Roberts GK, Willson CJ, Olivera DS, Malarkey DE, Morgan DL. 2017. Comparative inhalation toxicity of ethyltoluene isomers in rats and mice. Inhal Toxicol. 29(12–14):577–585.
   PubMed Web of Science ®Google Scholar
• Saghir SA, Rick DL, McClymont EL, Zhang F, Bartels MJ, Bus JS. 2009. Mechanism of ethylbenzene-induced mouse-specific lung tumor: metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes. Toxicol Sci. 107(2):352–366.
   PubMed Web of Science ®Google Scholar
• Shi J, Deng H, Bai Z, Kong S, Wang X, Hao J, Han X, Ning P. 2015. Emission and profile characteristic of volatile organic compounds emitted from coke production, iron smelt, heating station and power plant in Liaoning Province, China. Sci Total Environ. 515–516:101–108.
   PubMed Web of Science ®Google Scholar
• Shirley E. 1977. A non-parametric equivalent of Williams’ test for contrasting increasing dose levels of a treatment. Biometrics. 33(2):386–389.
   PubMed Web of Science ®Google Scholar
• Smith BR, Plummer JL, Wolf CR, Philpot RM, Bend JR. 1982. p-Xylene metabolism by rabbit lung and liver and its relationship to the selective destruction of pulmonary cytochrome P-450. J Pharmacol Exp Ther. 223(3):736–742.
   PubMed Web of Science ®Google Scholar
• Swiercz R, Rydzyński K, Jajte J, Stetkiewicz J, Majcherek W. 2000. Studies on dermal, ocular and respiratory effects of 4-ethyltoluene in experimental animals. Int J Occup Med Environ Health. 13(4):307–315.
   PubMedGoogle Scholar
• Tardif R, Charest-Tardif G, Brodeur J. 1996. Comparison of the influence of binary mixtures versus a ternary mixture of inhaled aromatic hydrocarbons on their blood kinetics in the rat. Arch Toxicol. 70(7):405–413.
   PubMed Web of Science ®Google Scholar
• Thornton-Manning JR, Dahl AR. 1997. Metabolic capacity of nasal tissue: interspecies comparisons of xenobiotic-metabolizing enzymes. Mutat Res. 380(1–2):43–59.
   PubMed Web of Science ®Google Scholar
• Tukey JW. 1977. Exploratory data analysis. Reading (MA): Addison-Wesley.
   Google Scholar
• Upadhyay UD, Holbrook EH. 2004. Olfactory loss as a result of toxic exposure. Otolaryngol Clin North Am. 37(6):1185–1207.
   PubMed Web of Science ®Google Scholar
• Wang G, Cheng S, Lang J, Li S, Tian L. 2016. On-board measurements of gaseous pollutant emission characteristics under real driving conditions from light-duty diesel vehicles in Chinese cities. J Environ Sci. 46:28–37.
   Google Scholar
• Williams DA. 1971. A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics. 27(1):103–117.
   PubMed Web of Science ®Google Scholar
• Williams DA. 1972. The comparison of several dose levels with a zero dose control. Biometrics. 28(2):519–531.
   PubMed Web of Science ®Google Scholar
• Williams DA. 1986. A note on Shirley’s nonparametric test for comparing several dose levels with a zero-dose control. Biometrics. 42(1):183–186.
   PubMed Web of Science ®Google Scholar
• Zhang M, Wang Y, Yang D, Zhang J, Gu Q. 2015. Roles of oxidative damage and mitochondria-mediated apoptosis in ethylbenzene-induced hepatotoxic effects in rat. Inhal Toxicol. 27(1):64–73.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wang H, Chen D, Li Q, Thai P, Gong D, Li Y, Zhang C, Gu Y, Zhou L, et al. 2017. Emission characteristics of volatile organic compounds and their secondary organic aerosol formation potentials from a petroleum refinery in Pearl River Delta, China. Sci Total Environ. 584–585:1162–1174.
   PubMed Web of Science ®Google Scholar