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Inhalation Toxicology
International Forum for Respiratory Research
Volume 34, 2022 - Issue 5-6
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Research Articles

A procedure to detect and identify specific chemicals of potential inhalation toxicity concern in aerosols

Pages 120-134 | Received 01 Oct 2021, Accepted 06 Mar 2022, Published online: 28 Mar 2022

References

  • Bastos PM, Haglund P. 2012. The use of comprehensive two-dimensional gas chromatography and structure–activity modeling for screening and preliminary risk assessment of organic contaminants in soil, sediment, and surface water. J Soils Sediments. 12(7):1079–1088.
  • Becker RA, Friedman KP, Simon TW, Marty MS, Patlewicz G, Rowlands JC. 2015. An exposure: activity profiling method for interpreting high-throughput screening data for estrogenic activity—proof of concept. Regul Toxicol Pharmacol. 71(3):398–408.
  • Bentley MC, Almstetter M, Arndt D, Knorr A, Martin E, Pospisil P, Maeder S. 2020. Comprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening. Anal Bioanal Chem. 412(11):2675–2685.
  • Blum KM, Andersson PL, Renman G, Ahrens L, Gros M, Wiberg K, Haglund P. 2017. Non-target screening and prioritization of potentially persistent, bioaccumulating and toxic domestic wastewater contaminants and their removal in on-site and large-scale sewage treatment plants. Sci Total Environ. 575:265–275.
  • Booyens W, Van Zyl PG, Beukes JP, Ruiz-Jimenez J, Kopperi M, Riekkola ML, Josipovic M, Venter AD, Jaars K, Laakso L, et al. 2015. Size-resolved characterisation of organic compounds in atmospheric aerosols collected at Welgegund, South Africa. J Atmos Chem. 72(1):43–64.
  • Brokl M, Bishop L, Wright CG, Liu C, McAdam K, Focant JF. 2013. Analysis of mainstream tobacco smoke particulate phase using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. J Sep Sci. 36(6):1037–1044.
  • Caesar LK, Kvalheim OM, Cech NB. 2018. Hierarchical cluster analysis of technical replicates to identify interferents in untargeted mass spectrometry metabolomics. Anal Chim Acta. 1021:69–77.
  • Cohen J. 1992. A power primer. Psychol Bull. 112(1):155–159.
  • CORESTA. 2019. Determination of selected carbonyls in mainstream cigarette smoke by HPLC. Paris (France): Cooperation Centre for Scientific Research Relative to Tobacco. CORESTA Recommended Method No. 74.
  • Crosswhite MR, Bailey PC, Jeong LN, Lioubomirov A, Yang C, Ozvald A, Jameson JB, Gillman IG. 2021. Non-targeted chemical characterization of JUUL Virginia Tobacco flavored aerosols using liquid and gas chromatography. Separations. 8(9):130.
  • Eggers ME, Lee YO, Jackson K, Wiley JL, Porter L, Nonnemaker JM. 2017. Youth use of electronic vapor products and blunts for administering cannabis. Addict Behav. 70:79–82.
  • Fairman BJ. 2015. Cannabis problem experiences among users of the tobacco–cannabis combination known as blunts. Drug Alcohol Depend. 150:77–84.
  • Gröger T, Welthagen W, Mitschke S, Schäffer M, Zimmermann R. 2008. Application of comprehensive two-dimensional gas chromatography mass spectrometry and different types of data analysis for the investigation of cigarette particulate matter. J Sep Sci. 31(19):3366–3374.
  • Hecht SS. 1998. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol. 11(6):559–603.
  • ISO. 2000. Cigarettes — Determination of total and nicotine-free dry particulate matter using a routine analytical smoking machine, 3rd ed. Geneva (Switzerland): International Organization for Standardization. International Standard ISO 4387:2000(E).
  • ISO. 2008. Cigarettes — Determination of total and nicotine-free dry particulate matter using a routine analytical smoking machine, 3rd ed.: Amendment 1. Geneva (Switzerland): International Organization for Standardization. International Standard ISO 4387:2000/Amd.1:2008(E).
  • ISO. 2012. Routine analytical cigarette-smoking machine — Definitions and standard conditions. Geneva (Switzerland): International Organization for Standardization. International Standard ISO 3308:2012.
  • Klupinski TP, Strozier ED, Friedenberg DA, Brinkman MC, Gordon SM, Clark PI. 2016. Identification of new and distinctive exposures from little cigars. Chem Res Toxicol. 29(2):162–168.
  • Klupinski TP, Strozier ED, Makselan SD, Buehler SS, Peters EN, Lucas EA, Casbohm JS, Friedenberg DA, Landgraf AJ, Frank AJ, et al. 2020. Chemical characterization of marijuana blunt smoke by non-targeted chemical analysis. Inhal Toxicol. 32(4):177–187.
  • Krewski D, Acosta D, Jr., Andersen M, Anderson H, Bailar JC, III, Boekelheide K, Brent R, Charnley G, Cheung VG, Green S, Jr., et al. 2010. Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B. 13(2-4):51–138.
  • Manzano C, Hoh E, Massey Simonich SL. 2012. Improved separation of complex polycyclic aromatic hydrocarbon mixtures using novel column combinations in GC × GC/ToF-MS. Environ Sci Technol. 46(14):7677–7684.
  • McGregor LA, Gauchotte-Lindsay C, Daéid NN, Thomas R, Daly P, Kalin RM. 2011. Ultra resolution chemical fingerprinting of dense non-aqueous phase liquids from manufactured gas plants by reversed phase comprehensive two-dimensional gas chromatography. J Chromatogr A. 1218(29):4755–4763.
  • Moir D, Rickert WS, Levasseur G, Larose Y, Maertens R, White P, Desjardins S. 2008. A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions. Chem Res Toxicol. 21(2):494–502.
  • Muscalu AM, Górecki T. 2018. Comprehensive two-dimensional gas chromatography in environmental analysis. Trends Anal Chem. 106:225–245.
  • National Research Council. 2001. Standing operating procedures for developing Acute Exposure Guideline Levels for hazardous chemicals. Washington, DC (U.S.): The National Academies Press. https://doi.org/https://doi.org/10.17226/10122. [accessed 2021 Sep 14]
  • National Research Council. 2007. Toxicity testing in the 21st century: A vision and a strategy. Chapter 2. Washington, DC (U.S.): The National Academies Press. https://doi.org/https://doi.org/10.17226/11970. [accessed 2022 Feb 09]
  • NIST. 2017. NIST/EPA/NIH Mass Spectral Library (NIST 17) and NIST Mass Spectral Search Program, version 2.3. Gaithersburg, MD (U.S.): National Institute of Standards and Technology, U.S. Department of Commerce.
  • OEHHA. 2021. Chemicals: Toxicity criteria on chemicals evaluated by OEHHA. Sacramento, CA (U.S.): Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. https://oehha.ca.gov/chemicals. [accessed 2021 Jul 15]
  • Piersanti A, Adani M, Briganti G, Cappelletti A, Ciancarella L, Cremona G, D'Isidoro M, Lombardi C, Pacchierotti F, Russo F, et al. 2018. Air quality modeling and inhalation health risk assessment for a new generation coal-fired power plant in Central Italy. Sci Total Environ. 644:884–898.
  • Prebihalo SE, Berrier KL, Freye CE, Bahaghighat HD, Moore NR, Pinkerton DK, Synovec RE. 2018. Multidimensional gas chromatography: advances in instrumentation, chemometrics, and applications. Anal Chem. 90(1):505–532.
  • R Core Team. 2017. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. https://www.R-project.org/.
  • Raies AB, Bajic VB. 2016. In silico toxicology: computational methods for the prediction of chemical toxicity. Wiley Interdiscip Rev Comput Mol Sci. 6(2):147–172.
  • Rosenberry ZR, Schauer GL, Kim H, Peters EN. 2017. The use of flavored cigars to smoke marijuana in a sample of US adults co-using cigarettes and marijuana. Tob Regul Sci. 3(2 Suppl 1):S94–S100.
  • Ruiz-Hernández V, Roca MJ, Egea-Cortines M, Weiss J. 2018. A comparison of semi-quantitative methods suitable for establishing volatile profiles. Plant Methods. 14:67.
  • Samokhin A, Sotnezova K, Lashin V, Revelsky I. 2015. Evaluation of mass spectral library search algorithms implemented in commercial software. J Mass Spectrom. 50(6):820–825.
  • Schauer GL, Berg CJ, Kegler MC, Donovan DM, Windle M. 2016. Differences in tobacco product use among past month adult marijuana users and nonusers: findings from the 2003–2012 National Survey on Drug Use and Health. Nicotine Tob Res. 18(3):281–288.
  • Seeley JV, Bates CT, McCurry JD, Seeley SK. 2012. Stationary phase selection and comprehensive two-dimensional gas chromatographic analysis of trace biodiesel in petroleum-based fuel. J Chromatogr A. 1226:103–109.
  • Seeley JV, Seeley SK. 2013. Multidimensional gas chromatography: fundamental advances and new applications. Anal Chem. 85(2):557–578.
  • Sobus JR, Grossman JN, Chao A, Singh R, Williams AJ, Grulke CM, Richard AM, Newton SR, McEachran AD, Ulrich EM. 2019. Using prepared mixtures of ToxCast chemicals to evaluate non-targeted analysis (NTA) method performance. Anal Bioanal Chem. 411(4):835–851.
  • Sobus JR, Wambaugh JF, Isaacs KK, Williams AJ, McEachran AD, Richard AM, Grulke CM, Ulrich EM, Rager JE, Strynar MJ, et al. 2018. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA. J Expo Sci Environ Epidemiol. 28(5):411–426.
  • Soldz S, Huyser DJ, Dorsey E. 2003. The cigar as a drug delivery device: youth use of blunts. Addiction. 98(10):1379–1386.
  • Spicer R, Salek RM, Moreno P, Cañueto D, Steinbeck C. 2017. Navigating freely-available software tools for metabolomics analysis. Metabolomics. 13(9):106.
  • Stefanuto PH, Smolinska A, Focant JF. 2021. Advanced chemometric and data handling tools for GC × GC-TOF-MS: application of chemometrics and related advanced data handling in chemical separations. Trends Anal Chem. 139:116251.
  • Stein SE. 1994. Estimating probabilities of correct identification from results of mass spectral library searches. J Am Soc Mass Spectrom. 5(4):316–323.
  • Stuard SB, Heinonen T. 2018. Relevance and application of read-across – mini review of European Consensus Platform for Alternatives and Scandinavian Society for Cell Toxicology 2017 workshop session. Basic Clin Pharmacol Toxicol. 123:37–41.
  • Su M, Sun R, Zhang X, Wang S, Zhang P, Yuan Z, Liu C, Wang Q. 2018. Assessment of the inhalation risks associated with working in printing rooms: a study on the staff of eight printing rooms in Beijing, China. Environ Sci Pollut Res. 25(17):17137–17143.
  • Szöcs E, Stirling T, Scott ER, Scharmüller A, Schäfer RB. 2020. webchem: an R package to retrieve chemical information from the web. J Stat Softw. 93(13):1–17.
  • U.S. EPA. 1985. Development of statistical distributions or ranges of standard factors used in exposure assessments. Washington, DC (U.S.): Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency. https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/1005783. [accessed 2021 Sep 14]
  • U.S. EPA. 1999a. Compendium of methods for the determination of toxic organic compounds in ambient air (Second edition): Compendium Method TO-9A: Determination of polychlorinated, polybrominated and brominated/chlorinated dibenzo-p-dioxins And dibenzofurans in ambient air. Cincinnati, OH (U.S.): Center for Environmental Research Information, Office of Research and Development, U.S. Environmental Protection Agency. https://www.epa.gov/sites/production/files/2019-11/documents/to-9arr.pdf. [accessed 2021 Jul 05]
  • U.S. EPA. 1999b. Compendium of methods for the determination of toxic organic compounds in ambient air (Second edition): Compendium Method TO-13A: Determination of polycyclic aromatic hydrocarbons (PAHs) in ambient air using gas chromatography/mass spectrometry (GC/MS). Cincinnati, OH (U.S.): Center for Environmental Research Information, Office of Research and Development, U.S. Environmental Protection Agency. https://www.epa.gov/sites/production/files/2019-11/documents/to-13arr.pdf. [accessed 2021 Jul 05]
  • U.S. EPA. 2002. A review of the reference dose and reference concentration processes. Page 4-4. Washington, DC (U.S.): Risk Assessment Forum, U.S. Environmental Protection Agency. https://www.epa.gov/sites/default/files/2014-12/documents/rfd-final.pdf. [accessed 2021 Jul 30]
  • U.S. EPA. 2011a. An overview of methods for EPA’s national-scale air toxics assessment. Section 6: Characterizing risks and hazards in NATA. Research Triangle Park, NC (U.S.): Office of Air Quality, Planning, and Standards, U.S. Environmental Protection Agency. https://www.epa.gov/sites/default/files/2015-10/documents/2005-nata-tmd.pdf. [accessed 2021 Jun 17]
  • U.S. EPA. 2011b. Exposure Factors Handbook 2011 edition (final report). Chapter 6—Inhalation rates. Washington, DC (U.S.): U.S. Environmental Protection Agency. https://cfpub.epa.gov/si/si_public_file_download.cfm?p_download_id=526167. [accessed 2021 Jun 22]
  • U.S. EPA. 2021. CompTox Chemicals Dashboard. Research Triangle Park, NC (U.S.): Center for Computational Toxicology and Exposure, Office of Research & Development, U.S. Environmental Protection Agency. https://comptox.epa.gov/dashboard. [accessed 2021 Sep 13]
  • U.S. EPA. 2022. CompTox Chemicals Dashboard. Research Triangle Park, NC (U.S.): Center for Computational Toxicology and Exposure, Office of Research & Development, U.S. Environmental Protection Agency. https://comptox.epa.gov/dashboard/about. [accessed 2022 Feb 13]
  • U.S. FDA. 2012. Harmful and potentially harmful constituents in tobacco products and tobacco smoke; established list. U.S. Food and Drug Administration (Docket No. FDA-2012-N-0143). U.S. Federal Register. 77:20034–20037. https://www.federalregister.gov/documents/2012/04/03/2012-7727/harmful-and-potentially-harmful-constituents-in-tobacco-products-and-tobacco-smoke-established-list. [accessed 2021 Sep 09]
  • Williams AJ, Grulke CM, Edwards J, McEachran AD, Mansouri K, Baker NC, Patlewicz G, Shah I, Wambaugh JF, Judson RS, et al. 2017. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry. J Cheminform. 9(1):61.
  • Xie J, Marano KM, Wilson CL, Liu H, Gan H, Xie F, Naufal ZS. 2012. A probabilistic risk assessment approach used to prioritize chemical constituents in mainstream smoke of cigarettes sold in China. Regul Toxicol Pharmacol. 62(2):355–362.

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