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Inhalation Toxicology
International Forum for Respiratory Research
Volume 36, 2024 - Issue 4
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Research Articles

Sinomenine attenuates bleomycin-induced pulmonary fibrosis, inflammation, and oxidative stress by inhibiting TLR4/NLRP3/TGFβ signaling

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Pages 217-227 | Received 20 Jan 2024, Accepted 15 Mar 2024, Published online: 07 May 2024

References

  • Bai S, Wen W, Hou X, Wu J, Yi L, Zhi Y, Lv Y, Tan X, Liu L, Wang P. 2021. Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor. J Leukoc Biol. 109(4):843–852. doi: 10.1002/JLB.6MA0720-344RRR.
  • Bhattacharyya S, Wang W, Tamaki Z, Shi B, Yeldandi A, Tsukimi Y, Yamasaki M, Varga J. 2018. Pharmacological inhibition of toll-like receptor-4 signaling by TAK242 prevents and induces regression of experimental organ fibrosis. Front Immunol. 9:2434. doi: 10.3389/fimmu.2018.02434.
  • Chen Y, Zhang W, Xin L, Wang Z, Zheng M, Vijayalakshmi A. 2022. Modulatory apoptotic effects of sinomenine on Mycoplasma pneumonia through the attenuation of inflammation via ERK/JNK/NF-κB signaling pathway. Arch Microbiol. 204(7):441. doi: 10.1007/s00203-022-03039-w.
  • D'Amelio M, Cavallucci V, Cecconi F. 2010. Neuronal caspase-3 signaling: not only cell death. Cell Death Differ. 17(7):1104–1114. doi: 10.1038/cdd.2009.180.
  • Della Latta V, Cecchettini A, Del Ry S, Morales MA. 2015. Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions. Pharmacol Res. 97:122–130. doi: 10.1016/j.phrs.2015.04.012.
  • Glass DS, Grossfeld D, Renna HA, Agarwala P, Spiegler P, DeLeon J, Reiss AB. 2022. Idiopathic pulmonary fibrosis: current and future treatment. Clin Respir J. 16(2):84–96. doi: 10.1111/crj.13466.
  • Holm Nielsen S, Willumsen N, Leeming DJ, Daniels SJ, Brix S, Karsdal MA, Genovese F, Nielsen MJ. 2019. Serological assessment of activated fibroblasts by alpha-smooth muscle actin (α-SMA): a noninvasive biomarker of activated fibroblasts in lung disorders. Transl Oncol. 12(2):368–374. doi: 10.1016/j.tranon.2018.11.004.
  • Ishida Y, Kuninaka Y, Mukaida N, Kondo T. 2023. Immune mechanisms of pulmonary fibrosis with bleomycin. Int J Mol Sci. 24(4):3149.
  • Jaganjac M, Milkovic L, Zarkovic N, Zarkovic K. 2022. Oxidative stress and regeneration. Free Radic Biol Med. 181:154–165. doi: 10.1016/j.freeradbiomed.2022.02.004.
  • Jia L, Sun P, Gao H, Shen J, Gao Y, Meng C, Fu S, Yao H, Zhang G. 2019. Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF-β1/Smad2/3 pathway. J Pharm Pharmacol. 71(6):1017–1028. doi: 10.1111/jphp.13077.
  • Kaňuchová M, Urban L, Melegová N, Čoma M, Dvořánková B, Smetana K, Gál P. 2021. Genistein does not inhibit TGF-beta1-induced conversion of human dermal fibroblasts to myofibroblasts. Physiol Res. 70(5):815–820. doi: 10.33549/physiolres.934666.
  • King TE, Jr., Pardo A, Selman M. 2011. Idiopathic pulmonary fibrosis. Lancet. 378(9807):1949–1961. doi: 10.1016/S0140-6736(11)60052-4.
  • Lasithiotaki I, Giannarakis I, Tsitoura E, Samara KD, Margaritopoulos GA, Choulaki C, Vasarmidi E, Tzanakis N, Voloudaki A, Sidiropoulos P, et al. 2016. NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung. Eur Respir J. 47(3):910–918. doi: 10.1183/13993003.00564-2015.
  • Li L, Fang P, Chen J, Zhang C, Tao H. 2021. Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice. J Appl Biomed. 19(3):142–148. doi: 10.32725/jab.2021.014.
  • Li XX, Jiang DY, Huang XX, Guo SL, Yuan W, Dai HP. 2015. Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice. Genet Mol Res. 14(4):17391–17398. doi: 10.4238/2015.December.21.8.
  • Li Y, Xie H, Zhang H. 2021. Protective effect of sinomenine against inflammation and oxidative stress in gestational diabetes mellitus in female rats via TLR4/MyD88/NF-κB signaling pathway. J Food Biochem. 45(11):e13952. doi: 10.1111/jfbc.13952.
  • Liu B, Lü W, Ge H, Tang H, Li R, Zhang C. 2019. Protective effect of the traditional Chinese patent medicine qing-xuan granule against bleomycin-induced pulmonary fibrosis in mice. Chem Biodivers. 16(12):e1900467.
  • Liu S, Xu S, Wang Z, Guo Y, Pan W, Shen Z. 2018. Anti-depressant-like effect of sinomenine on chronic unpredictable mild stress-induced depression in a mouse model. Med Sci Monit. 24:7646–7653. doi: 10.12659/MSM.908422.
  • Liu W, Han X, Li Q, Sun L, Wang J. 2022. Iguratimod ameliorates bleomycin-induced pulmonary fibrosis by inhibiting the EMT process and NLRP3 inflammasome activation. Biomed Pharmacother. 153:113460. doi: 10.1016/j.biopha.2022.113460.
  • Nakai K, Tsuruta D. 2021. What are reactive oxygen species, free radicals, and oxidative stress in skin diseases? Int J Mol Sci. 22(19):10799.
  • Park MW, Cha HW, Kim J, Kim JH, Yang H, Yoon S, Boonpraman N, Yi SS, Yoo ID, Moon J-S, et al. 2021. NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases. Redox Biol. 41:101947. doi: 10.1016/j.redox.2021.101947.
  • Pauklin P, Zilmer M, Eha J, Tootsi K, Kals M, Kampus P. 2022. Markers of inflammation, oxidative stress, and fibrosis in patients with atrial fibrillation. Oxid Med Cell Longev. 2022:4556671.
  • Phan THG, Paliogiannis P, Nasrallah GK, Giordo R, Eid AH, Fois AG, Zinellu A, Mangoni AA, Pintus G. 2021. Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis. Cell Mol Life Sci. 78(5):2031–2057. doi: 10.1007/s00018-020-03693-7.
  • Qin T, Yin S, Yang J, Zhang Q, Liu Y, Huang F, Cao W. 2016. Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling. Toxicol Appl Pharmacol. 304:1–8. doi: 10.1016/j.taap.2016.05.009.
  • Richeldi L, Collard HR, Jones MG. 2017. Idiopathic pulmonary fibrosis. Lancet. 389(10082):1941–1952. doi: 10.1016/S0140-6736(17)30866-8.
  • Rostami A, Taleahmad F, Haddadzadeh-Niri N, Joneidi E, Afshin-Majd S, Baluchnejadmojarad T, Roghani M. 2022. Sinomenine attenuates trimethyltin-induced cognitive decline via targeting hippocampal oxidative stress and neuroinflammation. J Mol Neurosci. 72(8):1609–1621. doi: 10.1007/s12031-022-02021-x.
  • Samareh Fekri M, Poursalehi HR, Sharififar F, Mandegary A, Rostamzadeh F, Mahmoodi R. 2021. The effects of methanolic extract of Glycyrrhiza glabra on the prevention and treatment of bleomycin-induced pulmonary fibrosis in rat: experimental study. Drug Chem Toxicol. 44(4):365–371. doi: 10.1080/01480545.2019.1606232.
  • Song J-X, An J-R, Chen Q, Yang X-Y, Jia C-L, Xu S, Zhao Y-S, Ji E-S. 2022. Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice. Bioengineered. 13(4):8334–8348. doi: 10.1080/21655979.2022.2051858.
  • Spagnolo P, Kropski JA, Jones MG, Lee JS, Rossi G, Karampitsakos T, Maher TM, Tzouvelekis A, Ryerson CJ. 2021. Idiopathic pulmonary fibrosis: disease mechanisms and drug development. Pharmacol Ther. 222:107798. doi: 10.1016/j.pharmthera.2020.107798.
  • Stacchiotti A, Favero G, Giugno L, Golic I, Korac A, Rezzani R. 2017. Melatonin efficacy in obese leptin-deficient mice heart. Nutrients. 9(12):1323. doi: 10.3390/nu9121323.
  • Suzuki Y, Aono Y, Kono M, Hasegawa H, Yokomura K, Naoi H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, et al. 2021. Cause of mortality and sarcopenia in patients with idiopathic pulmonary fibrosis receiving antifibrotic therapy. Respirology. 26(2):171–179. doi: 10.1111/resp.13943.
  • Tian R, Zhu Y, Yao J, Meng X, Wang J, Xie H, Wang R. 2017. NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis. Exp Cell Res. 357(2):328–334. doi: 10.1016/j.yexcr.2017.05.028.
  • Tsung A, Hoffman RA, Izuishi K, Critchlow ND, Nakao A, Chan MH, Lotze MT, Geller DA, Billiar TR. 2005. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol. 175(11):7661–7668. doi: 10.4049/jimmunol.175.11.7661.
  • Walton KL, Johnson KE, Harrison CA. 2017. Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis. Front Pharmacol. 8:461. doi: 10.3389/fphar.2017.00461.
  • Wang J, Wang H, Fang F, Fang C, Wang S, Lu C, Liu N. 2021. Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis by suppressing the TLR4/NLRP3 signaling pathway in rats. Evid Based Complement Alternat Med. 2021:8030143. doi: 10.1155/2021/8030143.
  • Wang J, Zhao H, Xu F, Zhang P, Zheng Y, Jia N. 2019. Human epididymis protein 4 (HE4) protects against cystic pulmonary fibrosis associated-inflammation through inhibition of NF-κB and MAPK singnaling. Genes Genomics. 41(9):1045–1053. doi: 10.1007/s13258-019-00836-4.
  • Wei Z, Sun X, Xu Q, Zhang Y, Tian F, Sun H, Zheng H, Dai J. 2016. TAK-242 suppresses lipopolysaccharide-induced inflammation in human coronary artery endothelial cells. Pharmazie. 71(10):583–587.
  • Willis S, Day CL, Hinds MG, Huang DCS. 2003. The Bcl-2-regulated apoptotic pathway. J Cell Sci. 116(Pt 20):4053–4056. doi: 10.1242/jcs.00754.
  • Wu X, Zhi F, Lun W, Deng Q, Zhang W. 2018. Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis. Int J Mol Med. 41(4):1992–2002. doi: 10.3892/ijmm.2018.3427.
  • Yanagihara T, Tsubouchi K, Gholiof M, Chong SG, Lipson KE, Zhou Q, Scallan C, Upagupta C, Tikkanen J, Keshavjee S, et al. 2022. Connective-tissue growth factor contributes to TGF-β1-induced lung fibrosis. Am J Respir Cell Mol Biol. 66(3):260–270. doi: 10.1165/rcmb.2020-0504OC.
  • Yang H-Z, Wang J-P, Mi S, Liu H-Z, Cui B, Yan H-M, Yan J, Li Z, Liu H, Hua F, et al. 2012. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol. 180(1):275–292. doi: 10.1016/j.ajpath.2011.09.019.
  • Yang X, Walton W, Cook DN, Hua X, Tilley S, Haskell CA, Horuk R, Blackstock AW, Kirby SL. 2011. The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 45(1):127–135. doi: 10.1165/rcmb.2010-0265OC.
  • Zhang M-W, Wang X-H, Shi J, Yu J-G. 2021. Sinomenine in cardio-cerebrovascular diseases: potential therapeutic effects and pharmacological evidences. Front Cardiovasc Med. 8:749113. doi: 10.3389/fcvm.2021.749113.
  • Zhang X, Rui L, Wang M, Lian H, Cai L. 2018. Sinomenine attenuates chronic intermittent hypoxia-induced lung injury by inhibiting inflammation and oxidative stress. Med Sci Monit. 24:1574–1580. doi: 10.12659/msm.906577.
  • Zhao H, Li C, Li L, Liu J, Gao Y, Mu K, Chen D, Lu A, Ren Y, Li Z. 2020. Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway. Mol Med Rep. 21(6):2321–2334.
  • Zhao M-M, Yang B, Zhang Q, Wang J-H, Zhao J-N, Zhang Y. 2017. Sinomenine hydrochloride attenuates renal fibrosis by inhibiting excessive autophagy induced by adriamycin: an experimental study. Evid Based Complement Alternat Med. 2017:6878795–6878796. doi: 10.1155/2017/6878795.
  • Zheng R, Tao L, Jian H, Chang Y, Cheng Y, Feng Y, Zhang H. 2018. NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter. Ecotoxicol Environ Saf. 163:612–619. doi: 10.1016/j.ecoenv.2018.07.076.
  • Zhu M, Wang H, Chen J, Zhu H. 2021. Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2/STAT3/SOCS1 pathway in streptozotocin-induced diabetic rats. Life Sci. 265:118855. doi: 10.1016/j.lfs.2020.118855.

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