Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 11, 1999 - Issue 2
136
Views
27
CrossRef citations to date
0
Altmetric
Research Article

INFLAMMATORY RESPONSE IN HUMANS EXPOSED TO 2.0 PPM NITROGEN DIOXIDE

Pages 89-109 | Published online: 01 Oct 2008

References

  • Amoruso, M. A., Witz, G., and Goldstein, B. D. 1981. Decreased superoxide anion radical production by rat alveolar macrophages following inhalation of ozone or nitrogen dioxide. Life Sci. 28(20): 2215–2221.
  • Anderson, M. E. 1985. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113:548–555.
  • Balmes, J. R., Chen, L. L., Scannell, C., Tager, I., Christian, D., Hearne, P. Q., Kelly, T., and Aris, R. M. 1996. Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am.]. Respir. Crit. Care Med. 153(3):904–909.
  • Bascom, R., Bromberg, P. A., Costa, D. L., Devlin, R. B., Dockery, D. W., Frampton, M. W., Lambert, W., Samet, J. M., Speizer, F. E., and Utell, M. A. 1996. Health effects of outdoor air pollution. Am.]. Respir. Crit. Care Med. 153:477–498.
  • Bauer, M. A., Utell, M. J., Morrow, P. E., Speers, D. M., and Gibb, F. R. 1986. 0.30 ppm Nitrogen dioxide inhalation potentiates exercise induced bronchospasm in asthmatics. Am. Rev. Respir. Dis. 134:1203–1208.
  • Bitterman, P. B., Rennard, S. I., Adelberg, S., and Crystal, R. G. 1983. Role of fibronectin as a growth factor for fibroblasts.]. Cell Biol. 97(6):1925–1932.
  • Bowen, R. M., Hoidal, J. R., and Estensen, R. D. 1985. Urokinase-type plasminogen activator in alve-olar macrophages and bronchoalveolar lavage fluid from normal and smoke-exposed hamsters and humans.]. Lab. Clin. Med. 106(6):667–673.
  • Brown, J. S., Gerrity, T. R., Bennett, W. D., Kim, C. S., and House, D. E. 1995. Dispersion of aerosol boluses in the human lung: Dependence on lung volume, bolus volume, and gender.]. AppL Physiol. 79(5):1787–1795.
  • Carson, J. L., Collier, A. M., Hu, S., and Devlin, R. B. 1993. Effect of nitrogen dioxide on human nasal epithelium. Am.]. Respir. Cell Mol. Biol. 9(3):264–270.
  • Devlin, R. B., McDonnell, W. F., Mann, R., Becker, S., House, D. E., Schreinemachers, D., and Koren, H. S. 1991. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am.]. Respir. Cell Mol. Biol. 4(1):72–81.
  • Devlin, R. B., Folinsbee, L. J., Biscardi, F., Hatch, G., Becker, S., Madden, M. C., Robbins, M., and Koren, H. S. 1997. Inflammation and cell damage induced by repeated exposure of humans to ozone. lnhal. Toxicol. 9:211–235.
  • Frampton, M. W., Finkelstein, J. N., Roberts, N. J., Jr., Smeglin, A. M., Morrow, P. E., and Utell, M. J. 1989a. Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans. Am. J. Respir. Cell Mol. Biol 1:499–505.
  • Frampton, M. W., Smeglin, A. M., Roberts, N. J., Jr., Finkelstein, J. N., Morrow, P. E., and Utell, M. J. 1989b. Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro. Environ. Res. 48(2):179–92.
  • Frampton, M. W., Morrow, P. E., Cox, C., Gibb, F. R., Speers, D. M., and Utell, M. J. 1991. Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am. Rev. Respir. Dis. 143:522–27.
  • Gardner, D. E. 1984. Oxidant-induced enhanced sensitivity to infection in animal models and their extrapolations to man.]. Toxicol. Environ. Health 13:423–439.
  • Gardner, D. E., Miller, F. J., Blommer, E. J., and Coffin, D. L. 1979. Influence of exposure mode on the toxicity of NO2. Environ. Health Perspect. 30:23–29.
  • Glover, D. E., Hernsten, J. H., Crider, W. L., and Strong, A. A. 1981. Design and performance of a system to control concentrations of common gaseous air pollutants within environmental labo-ratories used for human exposure studies.]. Environ. Health ScL 16:501–522.
  • Goings, S. A., Kulle, T. J., Bascom, R., Sauder, L. R., Green, D. J., Hebei, J. R., and Clements, M. L. 1989. Effect of nitrogen dioxide exposure on susceptibility to influenza A virus infection in healthy adults. Am. Rev. Respir. Dis. 139(5):1075–1081.
  • Goldstein, B., Eagle, M. C., and Hoeprich, P. D. 1973. Effect of nitrogen dioxide on pulmonary bac-teria] defense mechanisms. Arch. Environ. Health 26:202–204.
  • Goldstein, I. F., Lieber, K., Andrews, L. R., Foutrakis, G., Kazembe, F., Huange, P., and Hayes, C. 1988. Acute respiratory effects of short-term exposures to nitrogen dioxide. Arch. Environ. Health 43:138–142.
  • Hackney, J. D., Thiede, F. C., Linn, W. S., Pedersen, E. E., Spier, C. E., Law, D. C., and Fischer, D. A. 1978. Experimental studies on human health effects of air pollutants. IV. Short-term physiological and clinical effects of nitrogen dioxide exposure. Arch. Environ. Health 33(4): 176–180.
  • Hasselblad, V., Kotchmar, D. J., and Eddy, D. M. 1992. Synthesis of environmental evidence: Nitro-gen dioxide epidemiology studies.]. Air Waste Manage. Assoc. 42:662–671.
  • Helleday, R., Sandstrom, T., and Stjernberg, N. 1994. Differences in bronchoalveolar cell response to nitrogen dioxide exposure between smokers and nonsmokers. Eur. Respir.]. 7(7):1213–1220.
  • Helleday, R., Huberman, D., Blomberg, A., Stjernberg, N., and Sandstrom, T. 1995. Nitrogen dioxide exposure impairs the frequency of the mucociliary activity in healthy subjects. Eur. Respir. J. 8(10):1664–1668.
  • Horstman, D. H., Ball, B. A., Brown, J., Gerrity, T., and Folinsbee, L. J. 1995. Comparison of pul-monary responses of asthmatic and nonasthmatic subjects performing light exercise while exposed to a low level of ozone. Toxicol. Ind. Health 11(4):369–385.
  • Jakab, G. J. 1987. Modulation of pulmonary defense mechanisms by acute exposures to nitrogen dioxide. Environ. Res. 42:215–228.
  • Jorres, R., Nowak, D., Grimm inger, F., Seeger, W., Oldigs, M., and Magnussen, H. 1995. The effect of 1 ppm nitrogen dioxide on bronchoalveolar lavage cells and inflammatory mediators in nor-mal and asthmatic subjects. Eur. Respir.]. 8(3):416–424.
  • Keefe, M. J., Bennett, W. D., DeWitt, P., Seal, E., Strong, A. A., and Gerrity, T. R. 1991. The effect of ozone exposure on the dispersion of inhaled aerosol boluses in healthy human subjects. Am. Rev. Respir. Dis. 144(1):23–30.
  • Kelly, F. J., Blomberg, A., Frew, A., Holgate, S. T., and Sandstrom, T. 1996. Antioxidant kinetics in lung lavage fluid following exposure of humans to nitrogen dioxide. Am. J. Respir. Crit. Care Med. 154(6 Pt 1):1700–1705.
  • Kerr, H. D., Kulle, T. J., Mcllhany, M. L., and Swidersky, P. 1979. Effects of nitrogen dioxide on pul-monary function in human subjects: An environmental chamber study. Environ. Res. 19(2):392–404.
  • Kim, C. S., and Kang, C. W. 1997. Comparative measurement of lung deposition of inhaled particles in normals and patients with obstructive airway disease. Am.]. Respir. Crit. Care Med. 155:899–905.
  • Kim, C. S., Abraham, W. M., Chapman, G. A., and Sackner, M. 1989. Enhanced aerosol deposition in the lung with mild airways obstruction. Am. Rev. Respir. Dis. 139:422–426.
  • Kleinman, M. T., Bailey, R. M., Linn, W. S., Anderson, K. R., Whynot, J. D., Shamoo, D. A., and Hackney, J. D. 1983. Effects of 0.2 ppm nitrogen dioxide on pulmonary function and response to bronchoprovocation in asthmatics./ Toxicol. Environ. Health 12(4-6):815–26.
  • Koren, H. S., Devlin, R. B., Graham, D. E., Mann, R., McGee, M. P., Horstman, D. H., Kozumbo, W. J., Becker, S., House, D. E., McDonnell, W. F., et al. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139(2):407–415.
  • Kutnick, M. A., Hawkes, W. C., Schaus, E. E., and Omaye, S. T. 1987. An internal standard method for the unattended high-performance liquid chromatographic analysis of ascorbic acid in blood components. Anal. Biochem. 166(2):424–430.
  • Leaderer, B. P., Stolwijk, J. A. J., Zagraniski, R. T., and Quing-Shang, M. A. 1984. "Field study of indoor air contaminant levels associated with unvented combustion sources." (abstract). 77th Annual Meeting of the Air Pollution Control Association. 33.3.
  • Linn, W. S., Solomon, J. C., Trim, S. C., Spier, C. E., Shamoo, D. A., Venet, T. G., Avol, E. L., and Hackney, J. D. 1985. Effects of exposure to 4 ppm nitrogen dioxide in healthy and asthmatic volunteers. Arch. Environ. Health 40:234–238.
  • Matthay, M. A., Eschenbacher, W. L., and Goetzl, E. J. 1984. Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.]. Clin. Immunol. 4(6):479–83.
  • McDonnell, W. F., Horstman, D. H., Hazucha, M. J., Seal, E., Jr., Haak, E. D., Salaam, S. A., and House, D. E. 1983. Pulmonary effects of ozone exposure during exercise: Dose-response char-acteristics./ Appl. Physiol. Respir. Environ. Exercise Physiol. 54(5):1345–1352.
  • Melia, R. J., Florey, C. V., Altman, D. G., and Swan, A. V. 1977. Association between gas cooking and respiratory disease in children. Br. Med.]. 2:14–52.
  • Miller, F. J., Overton, J. H., Myers, E. T., and Graham, J. A. 1982. Pulmonary dosimetry of nitrogen dioxide in animals and man. In Air pollution by nitrogen oxides, eds. T. Schneider and L. Grant, pp. 377-386. Amsterdam: Elsevier.
  • Mohsen in, V. 1988. Airway responses to 2.0 ppm nitrogen dioxide in normal subjects. Arch. Environ. Health 43(3):242–246.
  • Neas, L. M., Dockery, D. W., Ware, J. H., Spengler, J. D., Speizer, F. E., and Ferris, B. G., Jr. 1991. Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children. Am.]. Epidemiol. 134(2):204–219.
  • Orehek, J., Massari, J. P., Gayrard, P., Grimaud, C., and Charpin, J. 1976. Effect of short-term, low-level nitrogen exposure on bronchial sensitivity of asthmatic patients. J. Clin. Invest. 57:301–307.
  • Overton, J. H., and Miller, F. J. 1988. Absorbtion of inhaled reactive gases. In Toxicologyof the lung, eds. D. E. Gardner, J. D. Crapo, and E. J. Massaro, pp. 477–508. New York: Raven Press.
  • Pick, E., and Keisari, Y. 1981. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages-Induction by multiple nonphagocytic stimuli. Cell. ImmunoL 59(2):301–318.
  • Rennard, S. I., Hunninghake, G. W., Bitterman, P. B., and Crystal, R. G. 1981. Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases. Proc. Natl. Acad. Sci. USA 78(11):7147–7151.
  • Rennard, S. I., Ghafouri, M., Thompson, A. B., Linder, J., Vaughn, W., Jones, K., Ertl, R. F., Christensen, K., Prince, A., Stahl, M. G., and Robbins, R. A. 1990. Fractional processing of sequential bronchoalveolar lavage to separate bronchial and alveolar samples. Am. Rev. Respir. Dis. 141:208–217.
  • Samet, J. M. 1989. Nitrogen dioxide and respiratory infection. Am. Rev. Respir. Dis. 139:1073-1074. Samet, J. M., and Utell, M. J. 1990. The risk of nitrogen dioxide: What have we learned from epi-demiological and clinical studies? [Review]. Toxicol. Ind. Health 6(2):247–262.
  • Samet, J. M., Lambert, W. E., Skipper, B. J., Cushing, A. H., Hunt, W. C., Young, S. A., McLaren, L. C., Schwab, M., and Spengler, J. M. 1993. Nitrogen dioxide and respiratory illness in infants. Am. Rev. Respir. Dis. 148:1258–1265.
  • Sandstrom, T., Andersson, M. C., Kolmodin-Hedman, B., Stjernberg, N., and Angstrom, T. 1990. Bronchoalveolar mastocytosis and lymphocytosis after nitrogen dioxide exposure in man: A time-kinetic study. Eur. Respir.]. 3(2):138–143.
  • Sandstrom, T., Stjernberg, N., Eklund, A., Ledin, M. C., Kolmodin-Hedman, B., Lindstrom, K., Rosenhall, L., and Angstrom, T. 1991. Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: A dose-response study. Eur. Respir.]. 4: 332–39.
  • Schlesinger, R. B. 1987. Intermittent inhalation of nitrogen dioxide: Effects on rabbit alveolar macro-phages.]. Toxicol. Environ. Health 21:127–139.
  • Slade, R., Crissman, K., Norwood, J., and Hatch, G. 1993. Comparison of antioxidant substances in bronchoalveolar lavage cells and fluid from humans, guinea pigs, and rats. Exp. Lung Res. 19(4): 469–484.
  • Smith, C. E., and Johnson, D. A. 1985. Human bronchial leucocyte proteinase inhibitor. Rapid isola- tion and kinetic analysis with human leucocyte proteinases. Biochem. J. 225(2):463-472. Speizer, F. E., Ferris, B., Jr., Bishop, Y. M. M., and Spengler, J. 1980. Respiratory disease rates and pulmonary function in children associated with NO2 exposure. Am. Rev. Respir. Dis. 121:3–10.
  • Strong, A. A. 1978. Description of the CLEANS Human Exposure System. EPA-600/1-78-064. U.S. EPA.
  • Thompson, A. B., Boh ling, T., Faribourz, P., and Rennard, S. I. 1990. Lower respiratory tract lactofer-rin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis.]. Lab. Clin. Med. 115:148–158.
  • Vagaggini, B., Paggiaro, P. L., Giannini, D., Franco, A. D., Cianchetti, S., Carnevali, S., Taccola, M., Bacci, E., Bancalari, L., Dente, F. L., and Giuntini, C. 1996. Effect of short-term NO2 exposure on induced sputum in normal, asthmatic and COPD subjects. Eur. Respir. J. 9(9):1852–1857.
  • Vandewoude, M., Claeys, M., and De Leeuw, I. 1984. Determination of alpha-tocopherol in human plasma by high-performance liquid chromatography with electrochemical detection./ Chromatogr. 311(1):176–182.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.