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Review Articles

Prospects for the application of growth factors in wound healing

, , , , &
Pages 25-34 | Received 09 Aug 2020, Accepted 31 Aug 2020, Published online: 05 Nov 2020

References

  • Adeli-Sardou, M., M. M. Yaghoobi, M. Torkzadeh-Mahani, and M. Dodel. 2019. “Controlled Release of Lawsone from Polycaprolactone/Gelatin Electrospun Nano Fibers for Skin Tissue Regeneration.” International Journal of Biological Macromolecules 124: 478–491. doi:10.1016/j.ijbiomac.2018.11.237.
  • Awada, H. K., N. R. Johnson, and Y. Wang. 2014. “Dual Delivery of Vascular Endothelial Growth Factor and Hepatocyte Growth Factor Coacervate Displays Strong Angiogenic Effects.” Macromolecular Bioscience 14 (5): 679–686. doi:10.1002/mabi.201300486.
  • Balaji, S., S. G. Keswani, and T. M. Crombleholme. 2012. “The Role of Mesenchymal Stem Cells in the Regenerative Wound Healing Phenotype.” Advances in Wound Care 1 (4): 159–165. doi:10.1089/wound.2012.0361.
  • Barrientos, S., H. Brem, O. Stojadinovic, and M. Tomic‐Canic. 2014. “Clinical Application of Growth Factors and Cytokines in Wound Healing.” Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 22 (5): 569–578. doi:10.1111/wrr.12205.
  • Belair, D. G., M. J. Miller, S. Wang, S. R. Darjatmoko, B. Y. Binder, N. Sheibani, and W. L. Murphy. 2016. “Differential Regulation of Angiogenesis Using Degradable VEGF-Binding Microspheres.” Biomaterials 93: 27–37. doi:10.1016/j.biomaterials.2016.03.021.
  • Boateng, J., and O. Catanzano. 2015. “Advanced Therapeutic Dressings for Effective Wound Healing – A Review.” Journal of Pharmaceutical Sciences 104 (11): 3653–3680. doi:10.1002/jps.24610.
  • Borena, B. M., A. Martens, S. Y. Broeckx, E. Meyer, K. Chiers, L. Duchateau, and J. H. Spaas. 2015. “Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments.” Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 36 (1): 1–23. doi:10.1159/000374049.
  • Chen, Y.-C., H.-O. Ho, D.-Z. Liu, W.-S. Siow, and M.-T. Sheu. 2015. “Swelling/Floating Capability and Drug Release Characterizations of Gastroretentive Drug Delivery System Based on a Combination of Hydroxyethyl Cellulose and Sodium Carboxymethyl Cellulose.” PLoS One 10 (1): e0116914. doi:10.1371/journal.pone.0116914.
  • Cho, K.-H., B. Singh, S. Maharjan, Y. Jang, Y.-J. Choi, and C.-S. Cho. 2017. “Local Delivery of CTGF siRNA with Poly(Sorbitol-co-PEI) Reduces Scar Contraction in Cutaneous Wound Healing.” Tissue Engineering and Regenerative Medicine 14 (3): 211–220. doi:10.1007/s13770-017-0059-9.
  • Chong, D. L., S. Trinder, M. Labelle, M. Rodriguez‐Justo, S. Hughes, A. M. Holmes, C. J. Scotton, and J. C. Porter. 2020. “Platelet‐Derived Transforming Growth Factor‐β1 Promotes Keratinocyte Proliferation in Cutaneous Wound Healing.” Journal of Tissue Engineering and Regenerative Medicine 14 (4): 645–649. doi:10.1002/term.3022.
  • Chu, Y., D. Yu, P. Wang, J. Xu, D. Li, and M. Ding. 2010. “Nanotechnology Promotes the Full-Thickness Diabetic Wound Healing Effect of Recombinant Human Epidermal Growth Factor in Diabetic Rats.” Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 18 (5): 499–505. doi:10.1111/j.1524-475X.2010.00612.x.
  • Das, S., G. Singh, M. Majid, M. B. Sherman, S. Mukhopadhyay, C. S. Wright, P. E. Martin, A. K. Dunn, and A. B. Baker. 2016. “Syndesome Therapeutics for Enhancing Diabetic Wound Healing.” Advanced Healthcare Materials 5 (17): 2248–2260. doi:10.1002/adhm.201600285.
  • Demidova-Rice, T. N., M. R. Hamblin, and I. M. Herman. 2012. “Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care.” Advances in Skin & Wound Care 25 (7): 304–314. doi:10.1097/01.ASW.0000416006.55218.d0.
  • Dolati, S., M. Ahmadi, R. Rikhtegar, Z. Babaloo, H. Ayromlou, L. Aghebati-Maleki, M. Nouri, and M. Yousefi. 2018a. “Changes in Th17 Cells Function after Nanocurcumin Use to Treat Multiple Sclerosis.” International Immunopharmacology 61: 74–81. doi:10.1016/j.intimp.2018.05.018.
  • Dolati, S., F. Marofi, Z. Babaloo, L. Aghebati-Maleki, L. Roshangar, M. Ahmadi, R. Rikhtegar, and M. Yousefi. 2018b. “Dysregulated Network of miRNAs Involved in the Pathogenesis of Multiple Sclerosis.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 104: 280–290. doi:10.1016/j.biopha.2018.05.050.
  • Dolati, S., M. Yousefi, M. Mahdipour, A. Afrasiabi Rad, A. Pishgahi, M. Nouri, and A. R. Jodati. 2019. “Mesenchymal Stem Cell and Bone Marrow Mononuclear Cell Therapy for Cardiomyopathy: From Bench to Bedside.” Journal of Cellular Biochemistry 120 (1): 45–55. doi:10.1002/jcb.27531.
  • Dubay, D. A., and M. G. Franz. 2003. “Acute Wound Healing: The Biology of Acute Wound Failure.” The Surgical Clinics of North America 83 (3): 463–481. doi:10.1016/S0039-6109(02)00196-2.
  • Eming, S. A., T. Krieg, and J. M. Davidson. 2007. “Inflammation in Wound Repair: Molecular and Cellular Mechanisms.” The Journal of Investigative Dermatology 127 (3): 514–525. doi:10.1038/sj.jid.5700701.
  • Falanga, V. 2005. “Wound Healing and Its Impairment in the Diabetic Foot.” The Lancet 366 (9498): 1736–1743. doi:10.1016/S0140-6736(05)67700-8.
  • Fernández-Montequín, J. I., B. Y. Betancourt, G. Leyva-Gonzalez, E. L. Mola, K. Galán-Naranjo, M. Ramírez-Navas, S. Bermúdez-Rojas, et al. 2009. “Intralesional Administration of Epidermal Growth Factor-Based Formulation (Heberprot-P) in Chronic Diabetic Foot Ulcer: Treatment Up to Complete Wound Closure.” International Wound Journal 6 (1): 67–72. doi:10.1111/j.1742-481X.2008.00561.x.
  • Fitzpatrick, L. E., and T. C. McDevitt. 2015. “Cell-Derived Matrices for Tissue Engineering and Regenerative Medicine Applications.” Biomaterials Science 3 (1): 12–24. doi:10.1039/C4BM00246F.
  • Fotouhi, A., A. Maleki, S. Dolati, A. Aghebati-Maleki, and L. Aghebati-Maleki. 2018. “Platelet Rich Plasma, Stromal Vascular Fraction and Autologous Conditioned Serum in Treatment of Knee Osteoarthritis.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 104: 652–660. doi:10.1016/j.biopha.2018.05.019.
  • Gainza, G., D. C. Bonafonte, B. Moreno, J. J. Aguirre, F. B. Gutierrez, S. Villullas, J. L. Pedraz, M. Igartua, and R. M. Hernandez. 2015a. “The Topical Administration of rhEGF-Loaded Nanostructured Lipid Carriers (rhEGF-NLC) Improves Healing in a Porcine Full-Thickness Excisional Wound Model.” Journal of Controlled Release: Official Journal of the Controlled Release Society 197: 41–47. doi:10.1016/j.jconrel.2014.10.033.
  • Gainza, G., M. Pastor, J. J. Aguirre, S. Villullas, J. L. Pedraz, R. M. Hernandez, and M. Igartua. 2014. “A Novel Strategy for the Treatment of Chronic Wounds Based on the Topical Administration of rhEGF-Loaded Lipid Nanoparticles: In Vitro Bioactivity and in Vivo Effectiveness in Healing-Impaired db/db Mice.” Journal of Controlled Release: Official Journal of the Controlled Release Society 185: 51–61. doi:10.1016/j.jconrel.2014.04.032.
  • Gainza, G., S. Villullas, J. L. Pedraz, R. M. Hernandez, and M. Igartua. 2015b. “Advances in Drug Delivery Systems (DDSs) to Release Growth Factors for Wound Healing and Skin Regeneration.” Nanomedicine: Nanotechnology, Biology, and Medicine 11 (6): 1551–1573. doi:10.1016/j.nano.2015.03.002.
  • Garcia-Orue, I., G. Gainza, F. B. Gutierrez, J. J. Aguirre, C. Evora, J. L. Pedraz, R. M. Hernandez, A. Delgado, and M. Igartua. 2017. “Novel Nanofibrous Dressings Containing rhEGF and Aloe Vera for Wound Healing Applications.” International Journal of Pharmaceutics 523 (2): 556–566. doi:10.1016/j.ijpharm.2016.11.006.
  • Goldman, R. 2004. “Growth Factors and Chronic Wound Healing: Past, Present, and Future.” Advances in Skin & Wound Care 17 (1): 24–35. doi:10.1097/00129334-200401000-00012.
  • Gomez‐Villa, R., Aguilar‐Rebolledo, F., A. Lozano‐Platonoff, J. M. Teran‐Soto, M. R. Fabian‐Victoriano, N. S. Kresch‐Tronik, X Garrido‐Espíndola, et al. 2014. “Efficacy of Intralesional Recombinant Human Epidermal Growth Factor in Diabetic Foot Ulcers in M Exican Patients: A Randomized Double‐Blinded Controlled Trial.” Wound Repair and Regeneration 22: 497–503.
  • Gorkun, A., A. Shpichka, I. Zurina, A. Koroleva, N. Kosheleva, D. Nikishin, D. Butnaru, P. Timashev, V. Repin, and I. Saburina. 2018. “Angiogenic Potential of Spheroids from Umbilical Cord and Adipose-Derived Multipotent Mesenchymal Stromal Cells within Fibrin Gel.” Biomedical Materials (Bristol, England) 13 (4): 044108. doi:10.1088/1748-605X/aac22d.
  • Greenhalgh, D. G. 2005. “Models of Wound Healing.” The Journal of Burn Care & Rehabilitation 26 (4): 293–305. doi:10.1097/01.bcr.0000169885.66639.b5.
  • Hanft, J., R. Pollak, A. Barbul, C. v. Gils, P. Kwon, S. Gray, C. Lynch, C. Semba, and T. Breen. 2008. “Phase I Trial on the Safety of Topical rhVEGF on Chronic Neuropathic Diabetic Foot Ulcers.” Journal of Wound Care 17 (1): 30–37. doi:10.12968/jowc.2008.17.1.27917.
  • Hong, J. P., H. D. Jung, and Y. W. Kim. 2006. “Recombinant Human Epidermal Growth Factor (EGF) to Enhance Healing for Diabetic Foot Ulcers.” Annals of Plastic Surgery 56 (4): 394–398. doi:10.1097/01.sap.0000198731.12407.0c.
  • Hong, J. P., Y. W. Kim, S. K. Lee, S. H. Kim, and K. H. Min. 2008. “The Effect of Continuous Release of Recombinant Human Epidermal Growth Factor (rh-EGF) in Chitosan Film on Full Thickness Excisional Porcine Wounds.” Annals of Plastic Surgery 61: 457–462.
  • Hu, L., J. Wang, X. Zhou, Z. Xiong, J. Zhao, R. Yu, F. Huang, H. Zhang, and L. Chen. 2016. “Exosomes Derived from Human Adipose Mensenchymal Stem Cells Accelerates Cutaneous Wound Healing via Optimizing the Characteristics of Fibroblasts.” Scientific Reports 6: 32993. doi:10.1038/srep32993.
  • Jackson, W. M., L. J. Nesti, and R. S. Tuan. 2012. “Mesenchymal Stem Cell Therapy for Attenuation of Scar Formation during Wound Healing.” Stem Cell Research & Therapy 3 (3): 20. doi:10.1186/scrt111.
  • Jetten, N., S. Verbruggen, M. J. Gijbels, M. J. Post, M. P. De Winther, and M. M. Donners. 2014. “Anti-Inflammatory M2, But Not Pro-Inflammatory M1 Macrophages Promote Angiogenesis In Vivo.” Angiogenesis 17 (1): 109–118. doi:10.1007/s10456-013-9381-6.
  • Johnson, N. R., T. Ambe, and Y. Wang. 2014. “Lysine-Based Polycation: Heparin Coacervate for Controlled Protein Delivery.” Acta Biomaterialia 10 (1): 40–46. doi:10.1016/j.actbio.2013.09.012.
  • Johnson, N. R., and Y. Wang. 2015. “Coacervate Delivery of HB-EGF Accelerates Healing of Type 2 Diabetic Wounds .” Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 23 (4): 591–600. doi:10.1111/wrr.12319.
  • Kim, H. S., X. Sun, J.-H. Lee, H.-W. Kim, X. Fu, and K. W. Leong. 2019. “Advanced Drug Delivery Systems and Artificial Skin Grafts for Skin Wound Healing.” Advanced Drug Delivery Reviews 146: 209–239. doi:10.1016/j.addr.2018.12.014.
  • Kim, J., W. -G. Bae, Y. J. Kim, H. Seonwoo, H. -W. Choung, K. -J. Jang, S. Park, et al. 2017. “Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing.” Advanced Healthcare Materials 6 (19): 1700297. doi:10.1002/adhm.201700297.
  • Koob, T. J., R. Rennert, N. Zabek, M. Massee, J. J. Lim, J. S. Temenoff, W. W. Li, and G. Gurtner. 2013. “Biological Properties of Dehydrated Human Amnion/Chorion Composite Graft: Implications for Chronic Wound Healing.” International Wound Journal 10 (5): 493–500. doi:10.1111/iwj.12140.
  • Lai, H.-J., C.-H. Kuan, H.-C. Wu, J.-C. Tsai, T.-M. Chen, D.-J. Hsieh, and T.-W. Wang. 2014. “Tailored Design of Electrospun Composite Nanofibers with Staged Release of Multiple Angiogenic Growth Factors for Chronic Wound Healing.” Acta Biomaterialia 10 (10): 4156–4166. doi:10.1016/j.actbio.2014.05.001.
  • Laiva, A. L., F. J. O'Brien, and M. B. Keogh. 2018. “Innovations in Gene and Growth Factor Delivery Systems for Diabetic Wound Healing.” Journal of Tissue Engineering and Regenerative Medicine 12 (1): e296–e312. doi:10.1002/term.2443.
  • Larouche, J., S. Sheoran, K. Maruyama, and M. M. Martino. 2018. “Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.” Advances in Wound Care 7 (7): 209–231. doi:10.1089/wound.2017.0761.
  • Le, T. M., N. Morimoto, T. Mitsui, S. C. Notodihardjo, M. C. Munisso, N. Kakudo, and K. Kusumoto. 2019. “The Sustained Release of Basic Fibroblast Growth Factor Accelerates Angiogenesis and the Engraftment of the Inactivated Dermis by High Hydrostatic Pressure.” PLoS One 14 (2): e0208658. doi:10.1371/journal.pone.0208658.
  • Lee, J. H., I.-H. Bae, J. K. Choi, and J. W. Park. 2013. “Evaluation of a Highly Skin Permeable Low-Molecular-Weight Protamine Conjugated Epidermal Growth Factor for Novel Burn Wound Healing Therapy.” Journal of Pharmaceutical Sciences 102 (11): 4109–4120. doi:10.1002/jps.23725.
  • Lei, Z., G. Singh, Z. Min, C. Shixuan, K. Xu, X. Pengcheng, W. Xueer, C. Yinghua, Z. Lu, and Z. Lin. 2018. “Bone Marrow-Derived Mesenchymal Stem Cells Laden Novel Thermo-Sensitive Hydrogel for the Management of Severe Skin Wound Healing.” Materials Science & Engineering. C, Materials for Biological Applications 90: 159–167. doi:10.1016/j.msec.2018.04.045.
  • Li, M., Y. Zhao, H. Hao, W. Han, and X. Fu. 2017. “Theoretical and Practical Aspects of Using Fetal Fibroblasts for Skin Regeneration.” Ageing Research Reviews 36: 32–41. doi:10.1016/j.arr.2017.02.005.
  • Lin, J., and A. P. Sclafani. 2018. “Platelet-Rich Plasma for Skin Rejuvenation and Tissue Fill.” Facial Plastic Surgery Clinics of North America 26 (4): 439–446. doi:10.1016/j.fsc.2018.06.005.
  • Liu, L., Y. Yu, Y. Hou, J. Chai, H. Duan, W. Chu, H. Zhang, Q. Hu, and J. Du. 2014. “Human Umbilical Cord Mesenchymal Stem Cells Transplantation Promotes Cutaneous Wound Healing of Severe Burned Rats.” PLoS One 9 (2): e88348. doi:10.1371/journal.pone.0088348.
  • Long, D. W., N. R. Johnson, E. M. Jeffries, H. Hara, and Y. Wang. 2017. “Controlled Delivery of Platelet-Derived Proteins Enhances Porcine Wound Healing.” Journal of Controlled Release: Official Journal of the Controlled Release Society 253: 73–81. doi:10.1016/j.jconrel.2017.03.021.
  • Lorenti, A. 2012. Wound healing: from epidermis culture to tissue engineering. CellBio 1 (2): 17–29.
  • Makarevich, P., A. Y. Efimenko, and V. Tkachuk. 2020. “Biochemical Regulation of Regenerative Processes by Growth Factors and Cytokines: Basic Mechanisms and Relevance for Regenerative Medicine.” Biochemistry Biokhimiia 85 (1): 11–26. doi:10.1134/S0006297920010022.
  • Martin, P., and S. J. Leibovich. 2005. “Inflammatory Cells during Wound Repair: The Good, the Bad and the Ugly.” Trends in Cell Biology 15 (11): 599–607. doi:10.1016/j.tcb.2005.09.002.
  • Martinez-Martinez, A., F. Ruiz-Santiago, and J. Garcia-Espinosa. 2018. “Platelet-Rich Plasma: Myth or Reality?” Radiología (English Edition) 60 (6): 465–475. doi:10.1016/j.rxeng.2018.08.001.
  • Martinez‐Zapata, M. J., A. J. Martí‐Carvajal, I. Solà, J. A. Expósito, I. Bolíbar, L. Rodríguez, J. Garcia, and C. Zaror. 2016. “Autologous Platelet‐Rich Plasma for Treating Chronic Wounds.” Cochrane Database of Systematic Reviews. 5: CD006899.
  • Mascré, G., S. Dekoninck, B. Drogat, K. K. Youssef, S. Brohée, P. A. Sotiropoulou, B. D. Simons, and C. Blanpain. 2012. “Distinct Contribution of Stem and Progenitor Cells to Epidermal Maintenance.” Nature 489 (7415): 257–262. doi:10.1038/nature11393.
  • McCollum, P., J. Bush, G. James, T. Mason, S. O'Kane, C. McCollum, D. Krievins, S. Shiralkar, and M. Ferguson. 2011. “Randomized Phase II Clinical Trial of Avotermin Versus Placebo for Scar Improvement.” The British Journal of Surgery 98 (7): 925–934. doi:10.1002/bjs.7438.
  • McGrath, J., R. Eady, and F. Pope. 2004. “Anatomy and Organization of Human Skin.” In Rook’s Textbook of Dermatology, edited by Burns, T., S. Breathnach, N. Cox, C. Griffiths, 3.1–3.84. Oxford: Blackwell Science Ltd Oxford.
  • Mizuno, K., K. Yamamura, K. Yano, T. Osada, S. Saeki, N. Takimoto, T. Sakurai, and Y. Nimura. 2003. “Effect of Chitosan Film Containing Basic Fibroblast Growth Factor on Wound Healing in Genetically Diabetic Mice.” Journal of Biomedical Materials Research. Part A 64 (1): 177–181. doi:10.1002/jbm.a.10396.
  • Murray, P. J., J. E. Allen, S. K. Biswas, E. A. Fisher, D. W. Gilroy, S. Goerdt, S. Gordon, et al. 2014. “Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines.” Immunity 41 (1): 14–20. doi:10.1016/j.immuni.2014.06.008.
  • Murray, P. J., and T. A. Wynn. 2011. “Protective and Pathogenic Functions of Macrophage Subsets.” Nature Reviews. Immunology 11 (11): 723–737. doi:10.1038/nri3073.
  • Ohura, T., T. Nakajo, T. Moriguchi, H. Oka, M. Tachi, N. Ohura, Jr., R. Nogami, and S. Murayama. 2011. “Clinical Efficacy of Basic Fibroblast Growth Factor on Pressure Ulcers: Case-Control Pairing Study Using a New Evaluation Method.” Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 19 (5): 542–551. doi:10.1111/j.1524-475X.2011.00726.x.
  • Park, J. W., S. R. Hwang, and I.-S. Yoon. 2017. “Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration.” Molecules 22 (8): 1259. doi:10.3390/molecules22081259.
  • Park, K. H., S. H. Han, J. P. Hong, S.-K. Han, D.-H. Lee, B. S. Kim, J. H. Ahn, and J. W. Lee. 2018. “Topical Epidermal Growth Factor Spray for the Treatment of Chronic Diabetic Foot Ulcers: A Phase III Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.” Diabetes Research and Clinical Practice 142: 335–344. doi:10.1016/j.diabres.2018.06.002.
  • Penn, J. W., A. O. Grobbelaar, and K. J. Rolfe. 2012. “The Role of the TGF-β Family in Wound Healing, Burns and Scarring: A Review.” International Journal of Burns and Trauma 2 (1): 18–28.
  • Porporato, P. E., V. L. Payen, C. J. De Saedeleer, V. Préat, J.-P. Thissen, O. Feron, and P. Sonveaux. 2012. “Lactate Stimulates Angiogenesis and Accelerates the Healing of Superficial and Ischemic Wounds in Mice.” Angiogenesis 15 (4): 581–592. doi:10.1007/s10456-012-9282-0.
  • Pu, C.-M., C.-W. Liu, C.-J. Liang, Y.-H. Yen, S.-H. Chen, Y.-F. Jiang-Shieh, C.-L. Chien, Y.-C. Chen, and Y.-L. Chen. 2017. “Adipose-Derived Stem Cells Protect Skin Flaps against Ischemia/Reperfusion Injury via IL-6 Expression.” The Journal of Investigative Dermatology 137 (6): 1353–1362. doi:10.1016/j.jid.2016.12.030.
  • Richardson, R., K. Slanchev, C. Kraus, P. Knyphausen, S. Eming, and M. Hammerschmidt. 2013. “Adult Zebrafish as a Model System for Cutaneous Wound-Healing Research.” The Journal of Investigative Dermatology 133 (6): 1655–1665. doi:10.1038/jid.2013.16.
  • Rikhtegar, R., M. Yousefi, S. Dolati, H. D. Kasmaei, S. Charsouei, M. Nouri, and S. K. Shakouri. 2019. “Stem Cell-Based Cell Therapy for Neuroprotection in Stroke: A Review.” Journal of Cellular Biochemistry 120 (6): 8849–8862. doi:10.1002/jcb.28207.
  • Rippon, M. G., K. Ousey, and K. Cutting. 2016. “Wound Healing and Hyper-Hydration: A Counterintuitive Model.” Journal of Wound Care 25 (2): 68–75. doi:10.12968/jowc.2016.25.2.68.
  • Rostamzadeh, D., S. R. Razavi, S. Esmaeili, S. Dolati, M. Ahmahi, S. Sadreddini, F. Jadidi-Niaragh, and M. Yousefi. 2016. “Application of Nanoparticle Technology in the Treatment of Systemic Lupus Erythematous.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 83: 1154–1163. doi:10.1016/j.biopha.2016.08.020.
  • Sasaki, M., R. Abe, Y. Fujita, S. Ando, D. Inokuma, and H. Shimizu. 2008. “Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type.” Journal of Immunology (Baltimore, Md.: 1950) 180 (4): 2581–2587. doi:10.4049/jimmunol.180.4.2581.
  • Schreml, S., R.-M. Szeimies, L. Prantl, M. Landthaler, and P. Babilas. 2010. “Wound Healing in the 21st Century.” Journal of the American Academy of Dermatology 63 (5): 866–881. doi:10.1016/j.jaad.2009.10.048.
  • Sen, C. K., G. M. Gordillo, S. Roy, R. Kirsner, L. Lambert, T. K. Hunt, F. Gottrup, G. C. Gurtner, and M. T. Longaker. 2009. “Human Skin Wounds: A Major and Snowballing Threat to Public Health and the Economy.” Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 17 (6): 763–771. doi:10.1111/j.1524-475X.2009.00543.x.
  • Seonwoo, H., B. Shin, K. ‐J. Jang, M. Lee, O. ‐S. Choo, S. ‐B. Park, Y. C. Kim, et al. 2019. “Epidermal Growth Factor–Releasing Radially Aligned Electrospun Nanofibrous Patches for the Regeneration of Chronic Tympanic Membrane Perforations.” Advanced Healthcare Materials 8 (2): 1801160. doi:10.1002/adhm.201801160.
  • Sheikh, E. S., E. S. Sheikh, and D. E. Fetterolf. 2014. “Use of Dehydrated Human Amniotic Membrane Allografts to Promote Healing in Patients with Refractory Non Healing Wounds.” International Wound Journal 11 (6): 711–717. doi:10.1111/iwj.12035.
  • Shpichka, A., D. Butnaru, E. A. Bezrukov, R. B. Sukhanov, A. Atala, V. Burdukovskii, Y. Zhang, and P. Timashev. 2019. “Skin Tissue Regeneration for Burn Injury.” Stem Cell Research & Therapy 10 (1): 94. doi:10.1186/s13287-019-1203-3.
  • Singer, A. J., and A. B. Dagum. 2008. “Current Management of Acute Cutaneous Wounds.” The New England Journal of Medicine 359 (10): 1037–1046. doi:10.1056/NEJMra0707253.
  • Smiell, J. M., T. Treadwell, H. D. Hahn, and M. H. Hermans. 2015. “Real-World Experience with a Decellularized Dehydrated Human Amniotic Membrane Allograft.” Wounds: A Compendium of Clinical Research and Practice 27 (6): 158–169.
  • Suh, A., A. Pham, M. J. Cress, T. Pincelli, S. P. TerKonda, A. J. Bruce, A. C. Zubair, J. Wolfram, and S. A. Shapiro. 2019. “Adipose-Derived Cellular and Cell-Derived Regenerative Therapies in Dermatology and Aesthetic Rejuvenation.” Ageing Research Reviews 54: 100933. doi:10.1016/j.arr.2019.100933.
  • Takeo, M., W. Lee, and M. Ito. 2015. “Wound Healing and Skin Regeneration.” Cold Spring Harbor Perspectives in Medicine 5 (1): a023267. doi:10.1101/cshperspect.a023267.
  • Tan, Q., B. Chen, X. Yan, Y. Lin, Z. Xiao, X. Hou, and J. Dai. 2014. “Promotion of Diabetic Wound Healing by Collagen Scaffold with Collagen-Binding Vascular Endothelial Growth Factor in a Diabetic Rat Model.” Journal of Tissue Engineering and Regenerative Medicine 8 (3): 195–201. doi:10.1002/term.1513.
  • Tiaka, E. K., N. Papanas, A. C. Manolakis, and G. S. Georgiadis. 2012. “Epidermal Growth Factor in the Treatment of Diabetic Foot Ulcers: An Update.” Perspectives in Vascular Surgery and Endovascular Therapy 24 (1): 37–44. doi:10.1177/1531003512442093.
  • Todorović, V., P. Peško, M. Micev, M. Bjelović, M. Budeč, M. Mićić, D. Brašanac, and O. Ilić-Stojanović. 2008. “Insulin-like Growth Factor-I in Wound Healing of Rat Skin.” Regulatory Peptides 150 (1–3): 7–13. doi:10.1016/j.regpep.2008.05.006.
  • Walraven, M., J. Akershoek, R. Beelen, and M. Ulrich. 2017. “In Vitro Cultured Fetal Fibroblasts Have Myofibroblast-Associated Characteristics and Produce a Fibrotic-Like Environment upon Stimulation with TGF-β1: Is There a Thin Line between Fetal Scarless Healing and Fibrosis?” Archives of Dermatological Research 309 (2): 111–121. doi:10.1007/s00403-016-1710-3.
  • Wang, J. H.-C., B. P. Thampatty, J.-S. Lin, and H.-J. Im. 2007. “Mechanoregulation of Gene Expression in Fibroblasts.” Gene 391 (1–2): 1–15. doi:10.1016/j.gene.2007.01.014.
  • Wilgus, T. A., S. Roy, and J. C. McDaniel. 2013. “Neutrophils and Wound Repair: Positive Actions and Negative Reactions.” Advances in Wound Care 2 (7): 379–388. doi:10.1089/wound.2012.0383.
  • Willenborg, S., and S. A. Eming. 2014. “Macrophages – Sensors and Effectors Coordinating Skin Damage and Repair.” Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG 12 (3): 214–221. doi:10.1111/ddg.12290.
  • Wu, J., J. Ye, J. Zhu, Z. Xiao, C. He, H. Shi, Y. Wang, et al. 2016. “Heparin-Based Coacervate of FGF2 Improves Dermal Regeneration by Asserting a Synergistic Role with Cell Proliferation and Endogenous Facilitated VEGF for Cutaneous Wound Healing.” Biomacromolecules 17 (6): 2168–2177. doi:10.1021/acs.biomac.6b00398.
  • Xie, Y., Z. Upton, S. Richards, S. C. Rizzi, and D. I. Leavesley. 2011. “Hyaluronic Acid: Evaluation as a Potential Delivery Vehicle for Vitronectin: Growth Factor Complexes in Wound Healing Applications.” Journal of Controlled Release: Official Journal of the Controlled Release Society 153 (3): 225–232. doi:10.1016/j.jconrel.2011.03.021.
  • Xu, H., H. Zhang, and Y. Ding. 2017. “Platelet-Derived Growth Factor and Stromal Cell-Derived Factor-1 Promote the Skin Wound Repairing Effect of Bone Mesenchymal Stem Cells: A Key Role of Matrix Metalloproteinase 1 and Collagens.” International Journal of Clinical and Experimental Pathology 10 (8): 8253–8262.
  • Xu, H. L., P. P. Chen, D. L. ZhuGe, Q. Y. Zhu, B. H. Jin, B. X. Shen, J. Xiao, and Y. Z. Zhao. 2017a. “Liposomes with Silk Fibroin Hydrogel Core to Stabilize bFGF and Promote the Wound Healing of Mice with Deep Second‐Degree Scald.” Advanced Healthcare Materials 6 (19): 1700344. doi:10.1002/adhm.201700344.
  • Xu, P., X. Fu, N. Xiao, Y. Guo, Q. Pei, Y. Peng, Y. Zhang, and M. Yao. 2017b. “Involvements of γδT Lymphocytes in Acute and Chronic Skin Wound Repair.” Inflammation 40 (4): 1416–1427. doi:10.1007/s10753-017-0585-6.
  • Xu, Q., S. A, Y. Gao, L. Guo, J. Creagh-Flynn, D. Zhou, U. Greiser, et al. 2018. “A Hybrid Injectable Hydrogel from Hyperbranched PEG Macromer as a Stem Cell Delivery and Retention Platform for Diabetic Wound Healing.” Acta Biomaterialia 75: 63–74. doi:10.1016/j.actbio.2018.05.039.
  • Yenilmez, E., E. Başaran, R. Arslan, M. Berkman, U. Güven, C. Baycu, and Y. Yazan. 2015. “Chitosan Gel Formulations Containing Egg Yolk Oil and Epidermal Growth Factor for Dermal Burn Treatment.” Die Pharmazie – An International Journal of Pharmaceutical Sciences 70: 67–73.
  • Yildirimer, L., N. T. Thanh, and A. M. Seifalian. 2012. “Skin Regeneration Scaffolds: A Multimodal Bottom-Up Approach.” Trends in Biotechnology 30 (12): 638–648. doi:10.1016/j.tibtech.2012.08.004.
  • Yoon, G., J. W. Park, and I.-S. Yoon. 2013. “Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs): Recent Advances in Drug Delivery.” Journal of Pharmaceutical Investigation 43 (5): 353–362. doi:10.1007/s40005-013-0087-y.

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