Design, formulation and optimization of topical ethosomes using full factorial design: in-vitro and ex-vivo characterization

References

• Abd-Elbary, A., El-Laithy, H.M., and Tadros, M.I., 2008. Sucrose stearate-based proniosome-derived niosomes for the nebulisable delivery of cromolyn sodium. International journal of pharmaceutics, 357 (1–2), 189–198.
   PubMed Web of Science ®Google Scholar
• Abdel Messih, H.A., et al., 2017. Nanoethosomes for transdermal delivery of tropisetron HCl: multi-factorial predictive modeling, characterization, and ex vivo skin permeation. Drug development and industrial pharmacy, 43 (6), 958–971.
   PubMed Web of Science ®Google Scholar
• Abdelbary, G., et al., 2011. Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization. International journal of research in pharmaceutical sciences, 2, 537–544.
   Google Scholar
• Abdelkader, H., Alani, A.W., and Alany, R.G., 2014a. Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations. Drug delivery, 21 (2), 87–100.
   PubMed Web of Science ®Google Scholar
• Abdelkader, H., Farghaly, U., and Moharram, H., 2014b. Effects of surfactant type and cholesterol level on niosomes physical properties and in vivo ocular performance using timolol maleate as a model drug. Journal of pharmaceutical investigation, 44 (5), 329–337.
   Google Scholar
• Abdulbaqi, I.M., et al., 2016. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. International Journal of Nanomedicine, 11, 2279–2304.
   PubMed Web of Science ®Google Scholar
• Abousamra, M.M., et al., 2019. A promising nystatin nanocapsular hydrogel as an antifungal polymeric carrier for the treatment of topical candidiasis. Journal of drug delivery science and technology, 49, 365–374.
   Web of Science ®Google Scholar
• Aditya, N.P., et al., 2013. Curcumin and genistein coloaded nanostructured lipid carriers: in vitro digestion and antiprostate cancer activity. Journal of agricultural and food chemistry, 61 (8), 1878–1883.
   PubMed Web of Science ®Google Scholar
• Ahad, A., et al., 2012. Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan. Nanomedicine: nanotechnology, biology, and medicine, 8 (2), 237–249.
   PubMed Web of Science ®Google Scholar
• Ahmed, T.A., 2020. Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity. BMC pharmacology & toxicology, 21 (1), 1–12.
   PubMed Web of Science ®Google Scholar
• Basha, M., et al., 2018. A potential antibacterial wound dressing of cefadroxil chitosan nanoparticles in situ gel: fabrication, in vitro optimization and in vivo evaluation. International journal of pharmaceutics, 544 (1), 129–140.
   PubMed Web of Science ®Google Scholar
• Beberok, A., et al., 2013. Cytotoxic effect of lomefloxacin in culture of human epidermal melanocytes. Pharmacological reports, 65 (3), 689–699.
   PubMed Web of Science ®Google Scholar
• Benson, H.A., 2009. Elastic liposomes for topical and transdermal drug delivery. Methods in molecular biology, 605, 77–86.
   Google Scholar
• Bragagni, M., et al., 2012. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib. Drug delivery, 19 (7), 354–361.
   PubMed Web of Science ®Google Scholar
• Celia, C., et al., 2012. Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders. Biomedical microdevices, 14 (1), 119–130.
   PubMed Web of Science ®Google Scholar
• Chandra, A., et al., 2019. Development of topical gel of methotrexate incorporated ethosomes and salicylic acid for the treatment of psoriasis. Pharmaceutical nanotechnology, 7 (5), 362–374.
   PubMedGoogle Scholar
• Chen, Z.X., et al., 2017. Evaluation of paeonol-loaded transethosomes as transdermal delivery carriers. European journal of pharmaceutical sciences, 99, 240–245.
   PubMed Web of Science ®Google Scholar
• Chhibber, T., Gondil, V.S., and Sinha, V.R., 2020. Development of chitosan-based hydrogel containing antibiofilm agents for the treatment of staphylococcus aureus-infected burn wound in mice. AAPS PharmSciTech, 21 (2), 1–12.
   Web of Science ®Google Scholar
• Choi, J.H., et al., 2015. Ethosomes and transfersomes for topical delivery of ginsenoside Rhl from red ginseng: characterization and in vitro evaluation. Journal of nanoscience and nanotechnology, 15 (8), 5660–5662.
   PubMed Web of Science ®Google Scholar
• Dubey, V., et al., 2010. Enhanced transdermal delivery of an anti-HIV agent via ethanolic liposomes. Nanomedicine, 6 (4), 590–596.
   PubMed Web of Science ®Google Scholar
• El-Laithy, H.M., Shoukry, O., and Mahran, L.G., 2011. Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies. European journal of pharmaceutics and biopharmaceutics, 77 (1), 43–55.
   PubMed Web of Science ®Google Scholar
• Elsayed, M.M., et al., 2006. Deformable liposomes and ethosomes: mechanism of enhanced skin delivery. International journal of pharmaceutics, 322 (1–2), 60–66.
   PubMed Web of Science ®Google Scholar
• Garg, B.J., et al., 2016. Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment. Journal of drug targeting, 24 (3), 233–246.
   PubMed Web of Science ®Google Scholar
• Garg, V., et al., 2017. Ethosomes and transfersomes: principles, perspectives and practices. Current drug delivery, 14 (5), 613–633.
   PubMed Web of Science ®Google Scholar
• Ghanbarzadeh, S. and Arami, S., 2013. Enhanced transdermal delivery of diclofenac sodium via conventional liposomes, ethosomes, and transfersomes. Biomed research international, 2013, 1–7.
   Web of Science ®Google Scholar
• Gomes, G.C. and Salgado, H.R.N., 2005. Validation of UV spectrophotometric method for determination of lomefloxacin in pharmaceutical dosage form. Acta farmaceutica bonaerense, 24, 406–408.
   Google Scholar
• Gonzalez-Mira, E., et al., 2010. Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC. Colloids and surfaces. B, Biointerfaces, 81 (2), 412–421.
   PubMed Web of Science ®Google Scholar
• Gorzelanny, C., et al., 2020. Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them? Pharmaceutics, 12 (7), 684.
   PubMed Web of Science ®Google Scholar
• Goyal, R., et al., 2016. Nanoparticles and nanofibers for topical drug delivery. Journal of controlled release, 240, 77–92.
   PubMed Web of Science ®Google Scholar
• Hallan, S.S., et al., 2020. Design and characterization of ethosomes for transdermal delivery of caffeic acid. Pharmaceutics, 12 (8), 1–19.
   Web of Science ®Google Scholar
• Ibrahim, T.M., et al., 2019. Transdermal ethosomal gel nanocarriers; a promising strategy for enhancement of anti-hypertensive effect of carvedilol. Journal of liposome research, 29 (3), 215–228.
   PubMed Web of Science ®Google Scholar
• Islam, M.T., et al., 2004. Rheological characterization of topical carbomer gels neutralized to different pH. Pharmaceutical research, 21 (7), 1192–1199.
   PubMed Web of Science ®Google Scholar
• Junyaprasert, V.B., et al., 2012. Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid. International journal of pharmaceutics, 423 (2), 303–311.
   PubMed Web of Science ®Google Scholar
• Khalil, R.M., et al., 2017a. Design and evaluation of proniosomes as a carrier for ocular delivery of lomefloxacin HCl. Journal of liposome research, 27 (2), 118–129.
   PubMed Web of Science ®Google Scholar
• Khalil, R.M., et al., 2017b. Enhancement of lomefloxacin Hcl ocular efficacy via niosomal encapsulation: in vitro characterization and in vivo evaluation. Journal of liposome research, 27 (4), 312–323.
   PubMed Web of Science ®Google Scholar
• Khalil, R.M., et al., 2019. Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization. Journal of liposome research, 29 (2), 171–182.
   PubMed Web of Science ®Google Scholar
• Khalil, R.M., et al., 2021. Development of tizanidine loaded aspasomes as transdermal delivery system: ex-vivo and in-vivo evaluation. Journal of liposome research, 31 (1), 19–29.
   PubMed Web of Science ®Google Scholar
• Kumar, R. and Philip, A., 2007. Modified transdermal technologies: breaking the barriers of drug permeation via the skin. Tropical journal of pharmaceutical research, 6, 633–644.
   Web of Science ®Google Scholar
• Limsuwan, T. and Amnuaikit, T., 2012. Development of ethosomes containing mycophenolic acid. Procedia chemistry, 4, 328–335.
   Google Scholar
• Lu, J., et al., 2020. Recent developments in the principles, modification and application prospects of functionalized ethosomes for topical delivery. Current drug delivery, 18 (5), 570–582.
   Web of Science ®Google Scholar
• Natsheh, H. and Touitou, E., 2020. Phospholipid vesicles for dermal/transdermal and nasal administration of active molecules: the effect of surfactants and alcohols on the fluidity of their lipid bilayers and penetration enhancement properties. Molecules, 25 (13), 1–42.
   Web of Science ®Google Scholar
• Peram, M.R., et al., 2019. Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: in vitro evaluation. Journal of liposome research, 29 (3), 291–311.
   PubMed Web of Science ®Google Scholar
• Rahman, S.A., et al., 2016. Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients. Drug delivery, 23 (4), 1184–1193.
   PubMed Web of Science ®Google Scholar
• Rushmi, Z.T., et al., 2017. The impact of formulation attributes and process parameters on black seed oil loaded liposomes and their performance in animal models of analgesia. Saudi pharmaceutical journal, 25 (3), 404–412.
   PubMed Web of Science ®Google Scholar
• Salama, A., Hegazy, R., and Hassan, A.J.P.O., 2016. Intranasal chromium induces acute brain and lung injuries in rats: assessment of different potential hazardous effects of environmental and occupational exposure to chromium and introduction of a novel pharmacological and toxicological animal model. PLoS One, 11 (12), 1–20.
   Web of Science ®Google Scholar
• Sato, H., et al., 1996. Pharmacokinetics of norfloxacin and lomefloxacin in aqueous humour analysed by microdialysis. Japanese journal of ophthalmology, 100, 513–519.
   Google Scholar
• Shah, P., et al., 2020. Evaluations of quality by design (QbD) elements impact for developing niosomes as a promising topical drug delivery platform. Pharmaceutics, 12 (3), 1–29.
   Web of Science ®Google Scholar
• Shen, L.N., et al., 2014. Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes. International journal of pharmaceutics, 460 (1–2), 280–288.
   PubMed Web of Science ®Google Scholar
• Touitou, E., et al., 1997. Ethosomes: novel lipid vesicular system for enhanced delivery. Pharmaceutical research, 14, 305–306.
   Google Scholar
• Touitou, E., et al., 2000. Ethosomes – novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. Journal of controlled release, 65 (3), 403–418.
   PubMed Web of Science ®Google Scholar
• Verma, P. and Pathak, K., 2010. Therapeutic and cosmeceutical potential of ethosomes: an overview. Journal of advanced pharmaceutical technology & research, 1 (3), 274–282.
   PubMedGoogle Scholar
• Verma, S., et al., 2009. Quality by design approach to understand the process of nanosuspension preparation. International journal of pharmaceutics, 377 (1–2), 185–198.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2020. Antifungal photodynamic activity of hexyl-aminolevulinate ethosomes against Candida albicans biofilm. Frontiers in microbiology, 11, 1–25.
   PubMed Web of Science ®Google Scholar
• Ying, L.Q. and Misran, M., 2017. Rheological and physicochemical characterization of alpha-tocopherol loaded lipid nanoparticles in thermoresponsive gel for topical application. Malaysian journal of fundamental and applied sciences, 13 (3), 248–252.
   Web of Science ®Google Scholar
• Yu, Z., et al., 2016. Ethosomes loaded with cryptotanshinone for acne treatment through topical gel formulation. PLoS One, 11 (7), 1–11.
   Web of Science ®Google Scholar
• Zhang, Y.T., et al., 2014. Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis. International journal of nanomedicine, 9, 669–678.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., et al., 2010. Synergistic penetration of ethosomes and lipophilic prodrug on the transdermal delivery of acyclovir. Archives of pharmacal research, 33 (4), 567–574.
   PubMed Web of Science ®Google Scholar