A novel osmoprotective liposomal formulation from synthetic phospholipids to reduce in vitro hyperosmolar stress in dry eye treatments

References

• Abal, P.P., 2016. Pharmaceutical microscale and nanoscale approaches for efficient treatment of ocular diseases. Drug delivery and translational research, 6 (6), 686-707.
   Web of Science ®Google Scholar
• Acar, D., et al., 2018. Novel liposome-based and in situ gelling artificial tear formulation for dry eye disease treatment. Contact lens & anterior eye, 41 (1), 93–96.
   PubMed Web of Science ®Google Scholar
• Afri, M., et al., 2004. Active oxygen chemistry within the liposomal bilayer. Part III: locating vitamin E, ubiquinol and ubiquinone and their derivatives in the lipid bilayer. Chemistry and physics of lipids, 131 (1), 107–121.
   PubMed Web of Science ®Google Scholar
• Anderson, M. and Omri, A., 2004. The effect of different lipid components on the in vitro stability and release kinetics of liposome formulations. Drug delivery, 11 (1), 33–39.
   PubMed Web of Science ®Google Scholar
• Attwood, S.J., Choi, Y., and Leonenko, Z., 2013. Preparation of DOPC and DPPC supported planar lipid bilayers for atomic force microscopy and atomic force spectroscopy. International journal of molecular sciences, 14 (2), 3514–3539.
   PubMed Web of Science ®Google Scholar
• Blalock, T.D., et al., 2008. Release of membrane-associated mucins from ocular surface epithelia. Investigative ophthalmology & visual science, 49 (5), 1864–1871.
   PubMed Web of Science ®Google Scholar
• Bron, A.J., et al., 2017. TFOS DEWS II pathophysiology report. The ocular surface, 15 (3), 438–510.
   PubMed Web of Science ®Google Scholar
• Bron, A.J., et al., 2009. Predicted phenotypes of dry eye: proposed consequences of its natural history. The ocular surface, 7 (2), 78–92.
   PubMed Web of Science ®Google Scholar
• Bucolo, C., et al., 2018. Antioxidant and osmoprotecting activity of taurine in dry eye models. Journal of ocular pharmacology and therapeutics, 34 (1–2), 188–194.
   PubMed Web of Science ®Google Scholar
• Butovich, I.A., Millar, T.J., and Ham, B.M., 2008. Understanding and analyzing meibomian lipids—a review. Current eye research, 33 (5–6), 405–420.
   PubMed Web of Science ®Google Scholar
• Chandrinos, A. and Tzamouranis, D.-D., 2020. Dry eye, contact lenses and preservatives in glaucoma medication. The clinical ophthalmologist journal, 1 (1), 1003.
   Google Scholar
• Chávez-Hurtado, P., et al., 2022. Physicochemical characterization of a DMPC-based nanoemulsion for dry eye and compatibility test with soft contact lenses in vitro. Contact lens and anterior eye, 45 (2), 101428.
   PubMed Web of Science ®Google Scholar
• Chen, W., et al., 2018. Determination of the main phase transition temperature of phospholipids by nanoplasmonic sensing. Scientific reports, 8 (1), 1–11.
   PubMedGoogle Scholar
• Cher, I., 2014. Ocular surface concepts: development and citation. The ocular surface, 12 (1), 10–13.
   PubMed Web of Science ®Google Scholar
• Contreras-Ruiz, L., et al., 2010. Ocular tolerance to a topical formulation of hyaluronic acid and chitosan-based nanoparticles. Cornea, 29 (5), 550–558.
   PubMed Web of Science ®Google Scholar
• Corrales, R.M., et al., 2008. Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells. Cornea, 27 (5), 574–579.
   PubMed Web of Science ®Google Scholar
• Davidson, H.J. and Kuonen, V.J., 2004. The tear film and ocular mucins. Veterinary ophthalmology, 7 (2), 71–77.
   PubMed Web of Science ®Google Scholar
• Davies, N.M., 2000. Biopharmaceutical considerations in topical ocular drug delivery. Clinical and experimental pharmacology & physiology, 27 (7), 558–562.
   PubMed Web of Science ®Google Scholar
• Deng, R., et al., 2014. Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells. Molecular vision, 20, 1243–1252.
   PubMed Web of Science ®Google Scholar
• Dilly, P. N. (1994). Structure and function of the tear film. In D. A. Sullivan (Ed.), Lacrimal gland, tear film, and dry eye syndromes (pp. 239–247). Springer.
   Google Scholar
• Eibl, H., and Kaufmann-Kolle, P., 1995. Medical application of synthetic phospholipids as liposomes and drugs. Journal of liposome research, 5 (1), 131–148.
   Google Scholar
• Enrı, A., et al., 2006. Chitosan nanoparticles as a potential drug delivery system for the ocular surface: toxicity, uptake mechanism and in vivo tolerance. Investigative ophthalmology & visual science, 47 (4), 1416–1425.
   PubMed Web of Science ®Google Scholar
• Epstein, S.P., Chen, D., and Asbell, P.A., 2009. Evaluation of biomarkers of inflammation in response to benzalkonium chloride on corneal and conjunctival epithelial cells. Journal of ocular pharmacology and therapeutics, 25 (5), 415–424.
   PubMed Web of Science ®Google Scholar
• Essmer, E.L.M.M., et al., 2013. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. The ocular surface, 11 (4), 246–258.
   PubMed Web of Science ®Google Scholar
• Freeberg, F.E., et al., 1986. Human and rabbit eye responses to chemical insult. Toxicological sciences, 7 (4), 626–634.
   Google Scholar
• Fresta, M., et al., 1999. Characterization and in-vivo ocular absorption of liposome-encapsulated acyclovir. The journal of pharmacy and pharmacology, 51 (5), 565–576.
   PubMed Web of Science ®Google Scholar
• Garrigue, J.S., et al., 2017. Relevance of lipid-based products in the management of dry eye disease. Journal of ocular pharmacology and therapeutics, 33 (9), 647–661.
   PubMed Web of Science ®Google Scholar
• Gómez-Ballesteros, M., et al., 2019. Osmoprotectants in hybrid liposome/HPMC systems as potential glaucoma treatment. Polymers, 11 (6), 929.
   PubMed Web of Science ®Google Scholar
• González, M.Á.C., 2020. Estudio de formulaciones liposomales oftálmicas. Aplicación en la enfermedad de ojo seco.
   Google Scholar
• Gonzalez Gomez, A., et al., 2019. Liposomal nanovesicles for efficient encapsulation of staphylococcal antibiotics. ACS Omega, 4 (6), 10866–10876.
   PubMed Web of Science ®Google Scholar
• Grassiri, B., Zambito, Y., and Bernkop-Schnürch, A., 2021. Strategies to prolong the residence time of drug delivery systems on ocular surface. Advances in colloid and interface science, 288, 102342.
   PubMed Web of Science ®Google Scholar
• Gulsen, D., Li, C.C., and Chauhan, A., 2005. Dispersion of DMPC liposomes in contact lenses for ophthalmic drug delivery. Current eye research, 30 (12), 1071–1080.
   PubMed Web of Science ®Google Scholar
• Hájek, J., et al., 2009. Cryoproective role of ribitol in Xanthoparmelia somloensis. Biologia plantarum, 53 (4), 677–684.
   Web of Science ®Google Scholar
• Herrero-Vanrell, R., et al., 2013. Nano and microtechnologies for ophthalmic administration, an overview. Journal of drug delivery science and technology, 23 (2), 75–102.
   Web of Science ®Google Scholar
• Houlsby, R.D., Ghajar, M., and Chavez, G., 1986. Antimicrobial activity of borate-buffered solutions. Antimicrobial agents and chemotherapy, 89 (5), 803–806.
   Google Scholar
• Hubrecht, R.C. and Carter, E., 2019. The 3Rs and humane experimental technique: implementing change. Animals, 9 (10), 754.
   Web of Science ®Google Scholar
• Jones, L., et al., 2017. TFOS DEWS II management and therapy report. The ocular surface, 15 (3), 575–628.
   PubMed Web of Science ®Google Scholar
• José, A., et al., 2018. Combination of hyaluronic acid, carmellose, and osmoprotectants for the treatment of dry eye disease. Clinical ophthalmology, 12, 453–461.
   PubMed Web of Science ®Google Scholar
• Li, D., et al., 2006. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Experimental eye research, 82 (4), 588–596.
   PubMed Web of Science ®Google Scholar
• Links, D.A., 2012. The impact of lipid composition on the stability of the tear fluid lipid layer. Soft matter, 8 (21), 5826–5834.
   Web of Science ®Google Scholar
• Liu, H., et al., 2009. A link between tear instability and hyperosmolarity in dry eye. Investigative ophthalmology & visual science, 50 (8), 3671–3679.
   PubMed Web of Science ®Google Scholar
• López-Cano, J.J., et al., 2021a. Combined hyperosmolarity and inflammatory conditions in stressed human corneal epithelial cells and macrophages to evaluate osmoprotective agents as potential DED treatments. Experimental eye research, 211, 108723.
   PubMed Web of Science ®Google Scholar
• López-Cano, J.J., et al., 2021b. Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection. Expert opinion on drug delivery, 18 (7), 819–848.
   PubMed Web of Science ®Google Scholar
• Loss, E., 2009. Inputs and outputs of the lacrimal system: review of production and evaporative loss. The ocular surface, 7 (4), 186–198.
   PubMed Web of Science ®Google Scholar
• Luo, L., Li, D.Q., and Pflugfelder, S.C., 2007. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea, 26 (4), 452–460.
   PubMed Web of Science ®Google Scholar
• Luo, L., et al., 2004. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Investigative ophthalmology & visual science, 45 (12), 4293–4301.
   PubMed Web of Science ®Google Scholar
• Meng, T., et al., 2019. Therapeutic implications of nanomedicine for ocular drug delivery. Drug discovery today, 24 (8), 1524–1538.
   PubMed Web of Science ®Google Scholar
• Naguib, Y.W., et al., 2021. Biomaterials solubilized ubiquinol for preserving corneal function. Biomaterials, 275, 120842.
   PubMed Web of Science ®Google Scholar
• OECD Guidelines for the Testing of Chemicals, n.d.
   Google Scholar
• Partenhauser, A. and Bernkop-schnu, A., 2016. Mucoadhesive polymers in the treatment of dry X syndrome. Drug discovery today, 21 (7), 1051–1062.
   PubMed Web of Science ®Google Scholar
• Refai, H., et al., 2017. Development and characterization of polymer- coated liposomes for vaginal delivery of sildenafil citrate. Drug delivery, 24 (1), 278–288.
   PubMed Web of Science ®Google Scholar
• Schniertshauer, D., et al., 2020. The activity of the DNA repair enzyme hOGG1 can be directly modulated by ubiquinol. DNA repair, 87, 102784.
   PubMed Web of Science ®Google Scholar
• Schuett, B.S. and Millar, T.J., 2012. Lipid component contributions to the surface activity of meibomian lipids. Investigative ophthalmology & visual science, 53 (11), 7208–7219.
   PubMed Web of Science ®Google Scholar
• Shahraki, K., et al., 2016. Effects of topical 1% sodium hyaluronate and hydroxypropyl methylcellulose in treatment of corneal epithelial defects. Medical hypothesis, discovery & innovation ophthalmology journal, 5 (4), 136–144. http://www.ncbi.nlm.nih.gov/pubmed/28293662%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5346304
   PubMedGoogle Scholar
• Singh, M., et al., 2015. Roles of osmoprotectants in improving salinity and drought tolerance in plants: a review. Reviews in environmental science and bio/technology, 14 (3), 407–426.
   Web of Science ®Google Scholar
• Stapleton, F., et al., 2017. TFOS DEWS II epidemiology report. The ocular surface, 15 (3), 334–365.
   PubMed Web of Science ®Google Scholar
• Stoll, C., et al., 2012. Synergistic effects of liposomes, trehalose, and hydroxyethyl starch for cryopreservation of human erythrocytes. Biotechnology progress, 28 (2), 364–371.
   PubMed Web of Science ®Google Scholar
• Taha, E.I., et al., 2014. Design of liposomal colloidal systems for ocular delivery of ciprofloxacin. Saudi pharmaceutical journal, 22 (3), 231–239.
   PubMed Web of Science ®Google Scholar
• OECD, 2021. Test No. 405: acute eye irritation/corrosion. OECD.
   Google Scholar
• The Association for Research in Vision and Ophthalmology, n.d. Statement for the use of animals in ophthalmic and vision research. Available from: https://www.arvo.org/About/policies/statement-for-the-use-of-animals-in-ophthalmic-and-vision-research/ [Accessed 23 June 2021].
   Google Scholar
• Tiffany, J.M., 2008. The normal tear film. Surgery for the dry eye, 41, 1–20.
   Google Scholar
• Tirpack, A.R., et al., 2019. Dry eye symptoms and ocular pain in veterans with glaucoma. Journal of clinical medicine, 8 (7), 1076.
   Web of Science ®Google Scholar
• Tomlinson, A., et al., 2006. Tear film osmolarity: Determination of a referent for dry eye diagnosis. Investigative ophthalmology & visual science, 47 (10), 1–7.
   PubMed Web of Science ®Google Scholar
• Tran, K.N., et al., 2020. Purification and characterization of a novel medium-chain ribitol dehydrogenase from a lichen-associated bacterium Sphingomonas sp. PLOS one, 15 (7), e0235718.
   PubMed Web of Science ®Google Scholar
• Vicario-de-la-Torre, M., et al., 2014. Design and characterization of an ocular topical liposomal preparation to replenish the lipids of the tear film. Investigative ophthalmology & visual science, 55 (12), 7839–7847.
   PubMed Web of Science ®Google Scholar
• Vicario-de-la-Torre, M., et al., 2018. Novel nano-liposome formulation for dry eyes with components similar to the preocular tear film. Polymers, 10 (4), 425–413.
   PubMed Web of Science ®Google Scholar
• Bollag, W.B., et al., 2020. Dioleoylphosphatidylglycerol accelerates corneal epithelial wound healing. Investigative ophthalmology & visual science, 3 (29), 1–4.
   Google Scholar
• Willcox, M.D.P., et al., 2017. TFOS DEWS II tear film report. The ocular surface, 15 (3), 366–403.
   PubMed Web of Science ®Google Scholar
• Wong, A.B.C., et al., 2018. Exploring topical anti-glaucoma medication effects on the ocular surface in the context of the current understanding of dry eye. The ocular surface, 16 (3), 289–293.
   PubMed Web of Science ®Google Scholar
• Yamauchi, M., et al., 2007. Release of drugs from liposomes varies with particle size. Biological & pharmaceutical bulletin, 30 (5), 963–966.
   PubMed Web of Science ®Google Scholar
• Ye, J., et al., 2012. Cytoprotective effect of hyaluronic acid and hydroxypropyl methylcellulose against DNA damage induced by thimerosal in Chang conjunctival cells. Graefe's archive for clinical and experimental ophthalmology, 250 (10), 1459–1466.
   PubMed Web of Science ®Google Scholar
• Zhan, C., et al., 2018. Long-acting liposomal corneal anesthetics. Biomaterials, 181, 372–377.
   PubMed Web of Science ®Google Scholar
• Zhang, F., et al., 2021. Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier. Experimental eye research, 202, 108313.
   PubMed Web of Science ®Google Scholar
• Zhang, R., et al., 2019. Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease. Ocular Surface, 18 (1), 158-169.
   PubMed Web of Science ®Google Scholar