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Article

A novel theory on the predictive value of variation in the β-endorphin system on the risk and severity of PTSD

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Pages 247-260 | Received 31 Mar 2019, Accepted 18 Sep 2019, Published online: 25 Feb 2020

References

  • Adams Pangkahila, E., Adiputra, N., Pangkahila, W., Putu, I. W., & Yasa, S. (2016). Balanced physical exercise increase physical fitness, optimize endorphin levels, and decrease malondialdehyde levels. Bali Medicine Journal, 5(3), 493–496. doi:10.15562/bmj.v5i3.337
  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th). American Journal of Psychiatry, doi:10.1176/appi.books.9780890425596.744053
  • Amin, F. M., Aristeidou, S., Baraldi, C., Czapinska-Ciepiela, E. K., Ariadni, D. D., Di Lenola, D., … Linde, M. (2018). The association between migraine and physical exercise. The Journal of Headache and Pain, 19(1), 83. doi:10.1186/s10194-018-0902-y
  • Amstadter, A. B., Nugent, N. R., & Koenen, K. C. (2009). Genetics of PTSD: Fear conditioning as a model for future research. Psychiatric Annals, 71(2), 233–236. doi:10.1038/mp.2011.182.doi
  • Anderson, E., & Shivakumar, G. (2013, April). Effects of exercise and physical activity on anxiety. Frontiers in Psychiatry, 4, 10–13. doi:10.3389/fpsyt.2013.00027
  • Andrews, B., Brewin, C. R., Philpott, R., & Stewart, L. (2007). Delayed-onset posttraumatic stress disorder: A systematic review of the evidence. American Journal of Psychiatry, 164(9), 1319–1326. doi:10.1176/appi.ajp.2007.06091491
  • Balchin, R., Linde, J., Blackhurst, D., Rauch, H. L., & Schönbächler, G. (2016). Sweating away depression? The impact of intensive exercise on depression. Journal of Affective Disorders, 200, 218–221. doi:10.1016/j.jad.2016.04.030
  • Bali, A., Randhawa, P. K., & Jaggi, A. S. (2015). Stress and opioids: Role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference. Neuroscience and Biobehavioral Reviews, 51, 138–150. doi:10.1016/j.neubiorev.2014.12.018
  • Bandelow, B., Schmahl, C., Falkai, P., & Wedekind, D. (2010). Borderline personality disorder: A dysregulation of the endogenous opioid system? Psychological Review, 117(2), 623–636. doi:10.1037/a0018095
  • Bandelow, B., & Wedekind, D. (2015). Possible role of a dysregulation of the endogenous opioid system in antisocial personality disorder. Human Psychopharmacology, 30, 393–415.
  • Bartone, P. T., Roland, R. R., Picano, J. J., & Williams, T. J. (2008). Psychological hardiness predicts success in US Army special forces candidates. International Journal of Selection and Assessment, 16(1), 78–81. doi:10.1111/j.1468-2389.2008.00412.x
  • Bodnar, R. J. (2018, January). Endogenous opiates and behavior: 2016. Peptides, 101, 167–212. doi:10.1016/j.peptides.2018.01.011
  • Boehnlein, J. K., & Kinzie, J. D. (2007). Pharmacologic reduction of CNS noradrenergic activity in PTSD: The case for clonidine and prazosin. Journal of Psychiatric Practice, 13(2), 72–78. doi:10.1097/01.pra.0000265763.79753.c1
  • Bouvard, M. P., Leboyer, M., Launay, J. M., Recasens, C., Plumet, M. H., Waller-Perotte, D., … Panksepp, J. (1995). Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: A double-blind, placebo-controlled study. Psychiatry Research, 58(3), 191–201. doi:10.1016/0165-1781(95)02601-R
  • Brailey, K., Vasterling, J. J., Proctor, S. P., Constans, J. I., & Friedman, M. J. (2007). PTSD symptoms, life events, and unit cohesion in US soldiers: Baseline findings from the neurocognition deployment health study. Journal of Traumatic Stress, 20(4), 495–503. doi:10.1002/(ISSN)1573-6598
  • Bremner, J. D., & Pearce, B. (2016). Neurotransmitter, neurohormonal, and neuropeptidal function in stress and PTSD. In J. D. Bremner (Ed.), Posttraumatic stress disorder: From neurobiology to treatment (pp. 181–232). doi:10.1002/9781118356142
  • Brewin, C. R., Andrews, B., Hejdenberg, J., & Stewart, L. (2012). Objective predictors of delayed-onset post-traumatic stress disorder occurring after military discharge. Psychological Medicine, 42(10), 2119–2126. doi:10.1017/S0033291712000189
  • Brockway, S. S. (1987). Group treatment of combat nightmares in post-traumatic stress disorder. Journal of Contemporary Psychotherapy, 17(4), 270–284. doi:10.1007/BF00949026
  • Broekman, B. F. P., Olff, M., & Boer, F. (2007). The genetic background to PTSD. Neuroscience and Biobehavioral Reviews, 31(3), 348–362. doi:10.1016/j.neubiorev.2006.10.001
  • Bryant, R. A., Creamer, M., O’Donnell, M., Silove, D., & McFarlane, A. C. (2009). A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder. Biological Psychiatry, 65(5), 438–440. doi:10.1016/j.biopsych.2008.10.032
  • Clark, H. W., Masson, C. L., Delucchi, K. L., Hall, S. M., & Sees, K. L. (2001). Violent traumatic events and drug abuse severity. Journal of Substance Abuse Treatment, 20(2), 121–127. doi:10.1016/S0740-5472(00)00156-2
  • Cohen, E. E. A., Ejsmond-frey, R., Knight, N., & Dunbar, R. I. M. (2010, September). Rowers ’ high: Behavioural synchrony is correlated with elevated pain thresholds subject collections. Differences, 106–108. doi:10.1098/rsbl.2009.0670
  • Cohen, S., & Wills, T. A. (1985). Stress, social support, and the buffering hypothesis: A theoretical analysis. Psychological Bulletin, 98(2), 310–357. doi:10.1037/0033-2909.98.2.310
  • Comings, B. G., Muhleman, D., Dietz, G., Shahbahrami, B., Tast, D., Knell, E., … Steven, D. (2012). The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. Human Genetics, 266(13), 1793–1800.
  • Comings, D. E., Muhleman, D., & Gysin, R. (1996). Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication. Biological Psychiatry, 40(5), 368–372. doi:10.1016/0006-3223(95)00519-6
  • Corder, G., Castro, D. C., Bruchas, M. R., & Scherrer, G. (2018). Endogenous and exogenous opioids in pain. Annual Review of Neuroscience, 41(1), 453–473. doi:10.1146/annurev-neuro-080317-061522
  • Daskalakis, N. P., Rijal, C. M., King, C., Huckins, L. M., & Ressler, K. J. (2018). Recent genetics and epigenetics approaches to PTSD. Current Psychiatry Reports, 20(5). doi:10.1007/s11920-018-0898-7
  • Davis, A., Taylor, J., Cohen, E., & Mesoudi, A. (2015). Social bonds and exercise: Evidence for a reciprocal relationship. PLoS ONE, 10(8), 1–14. doi:10.1371/journal.pone.0136705
  • De Dreu, C. K. W., Greer, L. L., Van Kleef, G. A., Shalvi, S., & Handgraaf, M. J. J. (2011). Oxytocin promotes human ethnocentrism. Proceedings of the National Academy of Sciences, 108(4), 1262–1266. doi:10.1073/pnas.1015316108
  • Delahanty, D. L., Nugent, N. R., Christopher, N. C., & Walsh, M. (2005). Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims. Psychoneuroendocrinology, 30(2), 121–128. doi:10.1016/j.psyneuen.2004.06.004
  • Diamond, D. M., & Zoladz, P. R. (2016). Dysfunctional or hyperfunctional? The amygdala in posttraumatic stress disorder is the bull in the evolutionary china shop. Journal of Neuroscience Research, 94(6), 437–444. doi:10.1002/jnr.23684
  • Duncan, L. E., Cooper, B. N., & Shen, H. (2018). Robust findings from 25 years of PSTD genetics research. Current Psychiatry Reports, 20(12), 1–9. doi:10.1007/s11920-018-0980-1
  • Duncan, L. E., Ratanatharathorn, A., Aiello, A. E., Almli, L. M., Amstadter, A. B., Ashley-Koch, A. E., … Koenen, K. C. (2018). Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Molecular Psychiatry, 23(3), 666–673. doi:10.1038/mp.2017.77
  • El-Solh, A. A. (2018). Management of nightmares in patients with posttraumatic stress disorder: Current perspectives. Nature and Science of Sleep, 10, 409–417. doi:10.2147/NSS.S166089
  • Engert, V., Koester, A. M., Riepenhausen, A., & Singer, T. (2016). Boosting recovery rather than buffering reactivity: Higher stress-induced oxytocin secretion is associated with increased cortisol reactivity and faster vagal recovery after acute psychosocial stress. Psychoneuroendocrinology, 74, 111–120. doi:10.1016/j.psyneuen.2016.08.029
  • File, S. E. (1980). Naloxone reduces social and exploratory activity in the rat. Psychopharmacology, 71(1), 41–44. doi:10.1007/BF00433250
  • Fillingim, R. B., Kaplan, L., Staud, R., Ness, T. J., Glover, T. L., Campbell, C. M., … Wallace, M. R. (2005). The A118G single nucleotide polymorphism of the μ-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. Journal of Pain, 6(3), 159–167. doi:10.1016/j.jpain.2004.11.008
  • Frewen, P. A., & Lanius, R. A. (2006). Neurobiology of dissociation: Unity and disunity in mind-body-brain. Psychiatric Clinics of North America, 29(1), 113–128. doi:10.1016/j.psc.2005.10.016
  • Fulton, J. J., Calhoun, P. S., Wagner, H. R., Schry, A. R., Hair, L. P., Feeling, N., … Beckham, J. C. (2015). The prevalence of posttraumatic stress disorder in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans: A meta-analysis. Journal of Anxiety Disorders, 31, 98–107. doi:10.1016/j.janxdis.2015.02.003
  • Garfinkel, S. N., & Liberzon, I. (2009). Neurobiology of PTSD: A review of neuroimaging findings. Psychiatric Annals, 39(6), 370–381. doi:10.3928/00485713-20090527-01
  • Giesen, E. S., Deimel, H., & Bloch, W. (2015). Clinical exercise interventions in alcohol use disorders: A systematic review. Journal of Substance Abuse Treatment, 52, 1–9. doi:10.1016/j.jsat.2014.12.001
  • Gregory, A. M., Caspi, A., Moffitt, T. E., Koenen, K., Eley, T. C., & Poulton, R. (2007). Juvenile mental health histories of adults with anxiety disorders. American Journal of Psychiatry, 164(2), 301–308. doi:10.1176/ajp.2007.164.2.301
  • Haerian, B. S., & Haerian, M. S. (2013). OPRM1 rs1799971 polymorphism and opioid dependence: Evidence from a meta-analysis. Pharmacogenomics, 14(7), 813–824. doi:10.2217/pgs.13.57
  • Hallgren, M., Vancampfort, D., Giesen, E. S., Lundin, A., & Stubbs, B. (2017). Exercise as treatment for alcohol use disorders: Systematic review and meta-analysis. British Journal of Sports Medicine, 51(14), 1058–1064. doi:10.1136/bjsports-2016-096814
  • Hansen, M., Műllerová, J., Elklit, A., & Armour, C. (2016). Can the dissociative PTSD subtype be identified across two distinct trauma samples meeting caseness for PTSD? Social Psychiatry and Psychiatric Epidemiology, 51(8), 1159–1169. doi:10.1007/s00127-016-1235-2
  • Hansen, M., Ross, J., & Armour, C. (2017, February). Evidence of the dissociative PTSD subtype: A systematic literature review of latent class and profile analytic studies of PTSD. Journal of Affective Disorders, 213, 59–69. doi:10.1016/j.jad.2017.02.004
  • Hanwella, R., & De Silva, V. (2012). Mental health of special forces personnel deployed in battle. Social Psychiatry and Psychiatric Epidemiology, 47(8), 1343–1351. doi:10.1007/s00127-011-0442-0
  • Harber, V. J., & Sutton, J. R. (1984). Endorphins and exercise. Sports Medicine: an International Journal of Applied Medicine and Science in Sport and Exercise, 1(2), 154–171. doi:10.2165/00007256-198401020-00004
  • Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12), 1389–1398. doi:10.1016/S0006-3223(03)00465-7
  • Herman, B. H., & Panksepp, J. (1978). Effects of morphine and naloxone on separation distress and approach attachment: Evidence for opiate mediation of social affect. Pharmacology, Biochemistry and Behavior, 9(2), 213–220. doi:10.1016/0091-3057(78)90167-3
  • Hoge, C. W. (2010). Once a warrior always a warrior (pp. 1–303). Retrieved from https://books.google.at/books?hl=de‎&id=zx1UM5j7FNkC&oi=fnd&pg=PP1&dq=hoge++ptsd&ots=OjGXCnS6dP&sig=7tL894LQv21_V5bP2Ik8AM7adig
  • Hoge, C. W. H. (2011). Interventions for war-related posttraumatic stress disorder. JAMA - Journal of the American Medical Association, 306(5), 549–551. doi:10.1001/jama.2011.1096
  • Holbrook, T. L., Galarneau, M. R., Dye, J. L., Quinn, K., & Dougherty, A. L. (2010). Morphine use after combat injury in Iraq and post-traumatic stress disorder. The New England Journal of Medicine, 362(2), 110–117. doi:10.1016/s0084-3970(10)79337-3
  • Holden, J. E., Jeong, Y., & Forrest, J. M. (2005). The endogenous opioid system and clinical pain management. AACN Clinical Issues, 16(3), 291–301. doi:10.1097/00044067-200507000-00003
  • Horton, E. G., Diaz, N., Peluso, P. R., Mullaney, D., Weiner, M., & McIlveen, J. W. (2009). Relationships between trauma, posttraumatic stress disorder symptoms, dissociative symptoms, and lifetime heroin use among individuals who abuse substances in residential treatment. Journal of Addictions & Offender Counseling, 29(2), 81–95. doi:10.1002/j.2161-1874.2009.tb00047.x
  • Inagaki, T. K. (2018). Opioids and social connection. Current Directions in Psychological Science, 27(2), 85–90. doi:10.1177/0963721417735531
  • Inagaki, T. K., Irwin, M. R., & Eisenberger, N. I. (2015). Blocking opioids attenuates physical warmth-induced feelings of social connection. Emotion, 15(4), 494–500. doi:10.1002/cncr.27633
  • Johnson, K. V. A., & Dunbar, R. I. M. (2016, April). Pain tolerance predicts human social network size. Scientific Reports, 6, 1–5. doi:10.1038/srep25267
  • Jones, N., Seddon, R., Fear, N. T., McAllister, P., Wessely, S., & Greenberg, N. (2012). Leadership, cohesion, morale, and the mental health of UK Armed Forces in Afghanistan. Psychiatry: Interpersonal and Biological Processes, 75(1), 49–59. doi:10.1521/psyc.2012.75.1.49
  • Kang, Y. S., & Park, J. H. (2000). Brain uptake and the analgesic effect of oxytocin – Its usefulness as an analgesic agent. Archives of Pharmacal Research, 23(4), 391–395. doi:10.1007/BF02975453
  • Kelmendi, B., Adams, T. G., Yarnell, S., Abdallah, C. G., Krystal, J. H., Kelmendi, B., … Krystal, J. H. (2016). PTSD: From neurobiology to pharmacological treatments. European journal of psychotraumatology, 7, 31858.
  • Kiefer, F., Horntrich, M., Jahn, H., & Wiedemann, K. (2002). Is withdrawal-induced anxiety in alcoholism based on β-endorphin deficiency? Psychopharmacology, 162(4), 433–437. doi:10.1007/s00213-002-1118-y
  • Kikusui, T., Winslow, J. T., & Mori, Y. (2006). Social buffering: Relief from stress and anxiety. Philosophical Transactions of the Royal Society B: Biological Sciences, 361(1476), 2215–2228. doi:10.1098/rstb.2006.1941
  • Kilpatrick, D. G., Koenen, K. C., Ruggiero, K. J., Acierno, R., Galea, S., Resnick, H. S., & Gelernter, J. (2007, November). The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. American Journal of Psychiatry, 164, 1693–1699. doi:10.1176/appi.ajp.2007.06122007
  • Kiyokawa, Y., & Hennessy, M. B. (2018). Comparative studies of social buffering: A consideration of approaches, terminology, and pitfalls. Neuroscience and Biobehavioral Reviews, 86, 131–141. doi:10.1016/j.neubiorev.2017.12.005
  • Koenen, K. C., Fu, Q. J., Lyons, M. J., Toomey, R., Goldberg, J., Eisen, S. A., … Tsuang, M. (2005). Juvenile conduct disorder as a risk factor for trauma exposure and posttraumatic stress disorder. Journal of Traumatic Stress, 18(1), 23–32. doi:10.1002/jts.20010
  • Koenen, K. C., Hitsman, B., Lyons, M. J., Niaura, R., McCaffery, J., Goldberg, J., … Tsuang, M. (2005). A twin registry study of the relationship between posttraumatic stress disorder and nicotine dependence in men. Archives of General Psychiatry, 62(11), 1258–1265. doi:10.1001/archpsyc.62.11.1258
  • Kolmen, B. K., Feldman, H. M., Handen, B. L., & Janosky, J. E. (1995). Naltrexone in young autistic children: A double-blind, placebo-controlled crossover study. Journal of the American Academy of Child and Adolescent Psychiatry, 34(2), 223–231. doi:10.1097/00004583-199502000-00018
  • Konvalinka, I., Xygalatas, D., Bulbulia, J., Schjodt, U., Jegindo, E.-M., Wallot, S., … Roepstorff, A. (2011). Synchronized arousal between performers and related spectators in a fire-walking ritual. Proceedings of the National Academy of Sciences, 108(20), 8514–8519. doi:10.1073/pnas.1016955108
  • Kroslak, T., Laforge, K. S., Gianotti, R. J., Ho, A., Nielsen, D. A., & Kreek, M. J. (2007). The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. Journal of Neurochemistry, 103(1), 77–87. doi:10.1111/j.1471-4159.2007.04738.x
  • Lang, M., Bahna, V., Shaver, J. H., Reddish, P., & Xygalatas, D. (2017, June). Sync to link: Endorphin-mediated synchrony effects on cooperation. Biological Psychology, 127, 191–197. doi:10.1016/j.biopsycho.2017.06.001
  • Latt, H. M., Matsushita, H., Morino, M., Koga, Y., Michiue, H., Nishiki, T., … Matsui, H. (2018). Oxytocin inhibits corticosterone-induced apoptosis in primary hippocampal neurons. Neuroscience, 379, 383–389. doi:10.1016/j.neuroscience.2018.03.025
  • Lee, H. J., Kwak, S. K., Paik, J. W., Kang, R. H., & Lee, M. S. (2007). Association between serotonin 2A receptor gene polymorphism and posttraumatic stress disorder. Psychiatry Investigation, 4(2), 104–108.
  • Lovallo, W. R., Enoch, M. A., Acheson, A., Cohoon, A. J., Sorocco, K. H., Hodgkinson, C. A., … Goldman, D. (2015a). Cortisol stress response in men and women modulated differentially by the mu-opioid receptor gene polymorphism OPRM1 A118G. Neuropsychopharmacology, 40(11), 2546–2554. doi:10.1038/npp.2015.101
  • Lovallo, W. R., Enoch, M. A., Acheson, A., Cohoon, A. J., Sorocco, K. H., Hodgkinson, C. A., … Goldman, D. (2015b). Cortisol stress response in men and women modulated differentially by the mu-opioid receptor gene polymorphism OPRM1 A118G. Neuropsychopharmacology, 40(11), 2546–2554. doi:10.1038/npp.2015.101
  • Love, T. M. (2018). The impact of oxytocin on stress : The role of sex. Cobeha, 23, 136–142. doi:10.1016/j.cobeha.2018.06.018
  • Lu, A. T., Ogdie, M. N., Jarvelin, M.-R., Moilanen, I. K., Loo, S. K., McCracken, J. T., … Cantor, R. M. (2008). Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 147(8), 1488–1494. doi:10.1002/ajmg.b.30693
  • Lubin, G., Weizman, A., Shmushkevitz, M., & Valevski, A. (2002). Short-term treatment of post-traumatic stress disorder with naltrexone: An open-label preliminary study. Human Psychopharmacology, 17(4), 181–185. doi:10.1002/hup.395
  • Lutz, P. E., Courtet, P., & Calati, R. (2018, February). The opioid system and the social brain: Implications for depression and suicide. Journal of Neuroscience Research, 1–13. doi:10.1002/jnr.24269
  • Machin, A. A. J., & Dunbar, R. I. M. (2011). The brain opioid theory of social attachment : A review of the evidence. Behaviour, 148(9), 985–1025. doi:10.1163/000579511X596624
  • MacNair, R. M. (2002). Perpetration-induced traumatic stress in combat veterans. Peace and Conflict, 8(1), 63–72. doi:10.1207/S15327949PAC0801_6
  • Maguen, S., & Burkman, K. (2013). Combat-related killing: expanding evidence-based treatments for PTSD. Cognitive and Behavioral Practice, 20(4), 476–479. doi:10.1016/j.cbpra.2013.05.003
  • Manthou, E., Georgakouli, K., & Fatouros, I. G. (2016). Role of exercise in the treatment of alcohol use disorders (Review). Biomedical reports, 4, 535–545. doi:10.3892/br.2016.626
  • Master, S. L., Eisenberger, N. I., Taylor, S. E., Naliboff, B. D., Shirinyan, D., & Lieberman, M. D. (2009). A picture’s worth: Partner photographs reduce experimentally induced pain. Psychological Science, 20(11), 1316–1318. doi:10.1111/j.1467-9280.2009.02444.x
  • Masters, K. S. (1992). Hypnotic susceptibility, cognitive dissociation, and runner’s high in a sample of marathon runners. American Journal of Clinical Hypnosis, 34(3), 193–201. doi:10.1080/00029157.1992.10402844
  • McQuaid, R. J., McInnis, O. A., Paric, A., Al-Yawer, F., Matheson, K., & Anisman, H. (2016a). Relations between plasma oxytocin and cortisol: The stress buffering role of social support. Neurobiology of Stress, 3, 52–60. doi:10.1016/j.ynstr.2016.01.001
  • McQuaid, R. J., McInnis, O. A., Paric, A., Al-Yawer, F., Matheson, K., & Anisman, H. (2016b). Relations between plasma oxytocin and cortisol: The stress buffering role of social support. Neurobiology of Stress, 3, 52–60. doi:10.1016/j.ynstr.2016.01.001
  • Merenlender-wagner, A., Dikshtein, Y., & Yadid, G. (2009). The beta-endorphin role in stress-related psychiatric disorders. Current Drug Targets, 10, 1096–1108.
  • Miller, M. W., & Resick, P. A. (2007). Internalizing and externalizing subtypes in female sexual assault survivors: Implications for the understanding of complex PTSD. Behavior Therapy, 38(1), 58–71. doi:10.1016/j.beth.2006.04.003
  • Mills, K. L., Lynskey, M., Teesson, M., Ross, J., & Darke, S. (2005). Post-traumatic stress disorder among people with heroin dependence in the Australian treatment outcome study (ATOS): Prevalence and correlates. Drug and Alcohol Dependence, 77(3), 243–249. doi:10.1016/j.drugalcdep.2004.08.016
  • Morrison, I. (2016). Keep calm and cuddle on: Social touch as a stress buffer. Adaptive Human Behavior and Physiology, 2(4), 344–362. doi:10.1007/s40750-016-0052-x
  • Naegeli, C., Zeffiro, T., Piccirelli, M., Jaillard, A., Weilenmann, A., Hassanpour, K., … Mueller-Pfeiffer, C. (2018). Locus coeruleus activity mediates hyperresponsiveness in posttraumatic stress disorder. Biological Psychiatry, 83(3), 254–262. doi:10.1016/j.biopsych.2017.08.021
  • Nawijn, L., Van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2017). Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder. Social Cognitive and Affective Neuroscience, 12, 212–223. doi:10.1093/scan/nsw123
  • Nentwig, T. B., Wilson, D. E., Rhinehart, E. M., & Grisel, J. E. (2018). Sex differences in binge-like EtOH drinking, corticotropin-releasing hormone and corticosterone: Effects of β-endorphin. Addiction Biology. doi:10.1111/adb.12610
  • Nijenhuis, E. R. S., Van der Hart, O., & Steele, K. (2002). The emerging psychobiology of trauma-related dissociation and dissociative disorders. Biological Psychiatry, 2, 1079–1098. doi:10.1002/0470854871.chxxi
  • Nogueira, A., Molinero, O., Salguero, A., & Márquez, S. (2018, August). Exercise addiction in practitioners of endurance sports: A literature review. Frontiers in Psychology, 9. doi:10.3389/fpsyg.2018.01484
  • Nugent, N. R., Lally, M. A., Brown, L., Knopik, V. S., & McGeary, J. E. (2012). OPRM1 and diagnosis-related posttraumatic stress disorder in binge-drinking patients living with HIV. AIDS and Behavior, 16(8), 2171–2180. doi:10.1007/s10461-011-0095-8
  • Nummenmaa, L., Tuominen, L., Dunbar, R., Hirvonen, J., Manninen, S., Arponen, E., … Sams, M. (2016). Social touch modulates endogenous μ-opioid system activity in humans. NeuroImage, 138, 242–247. doi:10.1016/j.neuroimage.2016.05.063
  • O’Donnell, T., Hegadoren, K. M., & Coupland, N. C. (2004). Noradrenergic mechanisms in the pathophysiology of post-traumatic stress disorder. Neuropsychobiology, 50(4), 273–283. doi:10.1159/000080952
  • Oae, H. (2009). Dissociation and the dissociative disorders. Ryoikibetsu Shokogun Shirizu. doi:10.4324/9780203893920
  • Osório, C., Carvalho, C., Fertout, M., & Maia, Â. (2012). Prevalence of post-traumatic stress disorder and physical health complaints among portuguese army special operations forces deployed in Afghanistan. Military Medicine, 177(8), 957–962. doi:10.7205/milmed-d-12-00024
  • Osório, C., Greenberg, N., Jones, N., Goodwin, L., Fertout, M., & Maia, Â. (2013). Combat exposure and posttraumatic stress disorder among portuguese special operation forces deployed in afghanistan. Military Psychology, 25(1), 70–81. doi:10.1037/h0094758
  • Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016). The analgesic effect of oxytocin in humans: A double-blind, placebo-controlled cross-over study using laser-evoked potentials. Journal of Neuroendocrinology, 28(4). doi:10.1111/jne.12347
  • Panksepp, J. (1979). A neurochemical theory of autism. Trends in Neurosciences, 2, 174–177. doi:10.1016/0166-2236(79)90071-7
  • Panksepp, J. (2016). Etiological pathways toward autism and diversities of treatments: From unimodal to multidimensional approaches. Commentary on “An integrative model of autism spectrum disorder: ASD as a neurobiological disorder of experienced environmental deprivation, early life stress, and allostatic overload” by William M. Singletary, M.D. Neuropsychoanalysis, 18(1), 19–23. doi:10.1080/15294145.2016.1156388
  • Panksepp, J., Bean, N. J., Bishop, P., Vilberg, T., & Sahley, T. L. (1980). Opioid blockade and social comfort in chicks. Pharmacology Biochemistry and Behavior, 13(5), 673–683. doi:10.1016/0091-3057(80)90011-8
  • Panksepp, J., Herman, B. H., Vilberg, T., Bishop, P., & DeEskinazi, F. G. (1980). Endogenous opioids and social behavior. Neuroscience and Biobehavioral Reviews, 4(4), 473–487. doi:10.1016/0149-7634(80)90036-6
  • Panksepp, J., Najam, N., & Soares, F. (1979). Morphine reduces social cohesion in rats. Pharmacology, Biochemistry and Behavior, 11(2), 131–134. doi:10.1016/0091-3057(79)90002-9
  • Panksepp, J., Nelson, E., & Bekkedal, M. (1997). Brain systems for the mediation of social separation-distress and social-reward. Evolutionary antecedents and neuropeptide intermediaries. Annals of the New York Academy of Sciences, 807, 78–100. doi:10.1111/j.1749-6632.1997.tb51914.x
  • Pearce, E., Wlodarski, R., Machin, A., & Dunbar, R. I. M. (2017). Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality. Proceedings of the National Academy of Sciences, 114(20), 5300–5305. doi:10.1073/pnas.1700712114
  • Peciña, M., Love, T., Stohler, C. S., Goldman, D., & Zubieta, J. K. (2015). Effects of the mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures. Neuropsychopharmacology, 40(4), 957–965. doi:10.1038/npp.2014.272
  • Pescosolido, F. J. (1993). Clinical considerations related to victimization dynamics and post-traumatic stress in the group treatment of sexually abused boys. Journal of Child and Adolescent Group Therapy, 3(1), 49–73. doi:10.1007/BF00973643
  • Petrakis, I. L., Desai, N., Gueorguieva, R., Arias, A., O’Brien, E., Jane, J. S., … Ralevski, E. (2016). Prazosin for veterans with posttraumatic stress disorder and comorbid alcohol dependence: A clinical trial. Alcoholism: Clinical and Experimental Research, 40(1), 178–186. doi:10.1111/acer.12926
  • Petrakis, I. L., Ralevski, E., Desai, N., Trevisan, L., Gueorguieva, R., Rounsaville, B., & Krystal, J. H. (2012). Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology, 37(4), 996–1004. doi:10.1038/npp.2011.283
  • Philipsen, A., Schmahl, C., & Lieb, K. (2004). Naloxone in the treatment of acute dissociative states in female patients with borderline personality disorder. Pharmacopsychiatry, 37(5), 196–199. doi:10.1055/s-2004-827243
  • Pitts, B. L., Chapman, P., Safer, M. A., Unwin, B., Figley, C., & Russell, D. W. (2014). Killing versus witnessing trauma: Implications for the development of PTSD in combat medics. Military Psychology, 25(6), 537–544. doi:10.1037/mil0000025
  • Roche, D. J. O., King, A. C., Cohoon, A. J., & Lovallo, W. R. (2013). Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women. Pharmacology Biochemistry and Behavior, 109, 84–90. doi:10.1016/j.pbb.2013.05.007.Hormonal
  • Rosenbaum, S., Vancampfort, D., Steel, Z., Newby, J., Ward, P. B., & Stubbs, B. (2015). Physical activity in the treatment of post-traumatic stress disorder: A systematic review and meta-analysis. Psychiatry Research, 230(2), 130–136. doi:10.1016/j.psychres.2015.10.017
  • Roy, A., Roy, M., Deb, S., Unwin, G., & Roy, A. (2015). Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: A systematic review. Journal of Intellectual Disability Research, 59(4), 293–306. doi:10.1111/jir.12122
  • Rucklidge, J., Johnstone, J., Harrison, R., & Boggis, A. (2011). Micronutrients reduce stress and anxiety in adults with attention-deficit/hyperactivity disorder following a 7.1 earthquake. Psychiatry Research, 189(2), 281–287. doi:10.1016/j.psychres.2011.06.016
  • Sack, W. H., Clark, G. N., & Seeley, J. (1995). Posttraumatic stress disorder across two generations of cambodian refugees. Journal of the American Academy of Child and Adolescent Psychiatry, 34(9), 1160–1166. doi:10.1097/00004583-199509000-00013
  • Salmon, P. (2001). ScienceDirect – Clinical psychology review : Effects of physical exercise on anxiety, depression, and sensitivity to stress: A unifying theory. Clinical Psychology Review, 21(1), 33–61. doi:10.1016/S0272-7358(99)00032-X
  • Savic, D., Knezevic, G., Matic, G., Damjanovic, S., & Spiric, Z. (2015). Posttraumatic and depressive symptoms in β-endorphin dynamics. Journal of Affective Disorders, 181, 61–66. doi:10.1016/j.jad.2015.03.063
  • Saxe, G., Stoddard, F., Courtney, D., Cunningham, K., Chawla, N., Sheridan, R., … King, L. (2001). Relationship between acute morphine and the course of PTSD in children with burns. Journal of the American Academy of Child and Adolescent Psychiatry, 40(8), 915–921. doi:10.1097/00004583-200108000-00013
  • Schiavone, F. L., Frewen, P., McKinnon, M., & Lanius, R. A. (2018). The dissociative subtype of PTSD: An update of the literature. PTSD Research Quarterly, 29(3), 1–13.
  • Schlumpf, Y. R., Reinders, A. A. T. S., Nijenhuis, E. R. S., Luechinger, R., Van Osch, M. J. P., & Jäncke, L. (2014). Dissociative part-dependent resting-state activity in dissociative identity disorder: A controlled fMRI perfusion study. PLoS ONE, 9(6), e98795. doi:10.1371/journal.pone.0098795
  • Schmahl, C., Kleindienst, N., Limberger, M., Ludäscher, P., Mauchnik, J., Deibler, P., … Bohus, M. (2012). Evaluation of naltrexone for dissociative symptoms in borderline personality disorder. International Clinical Psychopharmacology, 27(1), 61–68. doi:10.1097/YIC.0b013e32834d0e50
  • Segman, R. H., Cooper-Kazaz, R., Macciardi, F., Goltser, T., Halfon, Y., Dobroborski, T., & Shalev, A. Y. (2002). Association between the dopamine transporter gene and posttraumatic stress disorder. Molecular Psychiatry, 7(8), 903–907. doi:10.1038/sj.mp.4001085
  • Serrano-Sevillano, Á., González-Ordi, H., Corbí-Gran, B., & Vallejo-Pareja, M. Á. (2017). Psychological characteristics of dissociation in general population. Clinica y Salud, 28(3), 101–106. doi:10.1016/j.clysa.2017.09.003
  • Setiawan, E., Pihl, R. O., Benkelfat, C., & Leyton, M. (2012). Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone. Pharmacogenomics, 13(10), 1161–1172. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=2012497148
  • Sharifi, M., Hamedinia, M. R., & Hosseini-Kakhak, S. A. (2018). The effect of an exhaustive aerobic, anaerobic and resistance exercise on serotonin, beta-endorphin and BDNF in students. Physical Education of Students, 22(5), 272–277. doi:10.15561/20755279.2018.0507
  • Sia, A. T., Lim, Y., Lim, E. C. P., Goh, R. W. C., Law, H. Y., Landau, R., … Tan, E. C. (2008). A118G single nucleotide polymorphism of human μ-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology, 109(3), 520–526. doi:10.1097/ALN.0b013e318182af21
  • Sierra, M. (2008). Depersonalization disorder: Pharmacological approaches. Expert Review of Neurotherapeutics, 8(1), 19–26. Retrieved from http://linker2.worldcat.org/?rft.institution_id=129658&spage=19&pkgName=nhshospital&PQUEST.WAYFlessID=47848&issn=1473-7175&linkclass=to_article&jKey=54578&issue=1&provider=PQUEST&date=2008-01&aulast=Sierra+M.&atitle=Depersonalization+disorder%3A+Pharmacol
  • Simeon, D., & Knutelska, M. (2005). An open trial of naltrexone in the treatment of depersonalization disorder. Journal of Clinical Psychopharmacology, 25(3), 267–270. doi:10.1097/01.jcp.0000162803.61700.4f
  • Skelton, K., Ressler, K. J., Norrholm, S. D., Jovanovic, T., & Bradley-Davino, B. (2012). PTSD and gene variants: New pathways and new thinking. Neuropharmacology, 62(2), 628–637. doi:10.1016/j.neuropharm.2011.02.013
  • Slutsky, A. B., Diekfuss, J. A., Janssen, J. A., Berry, N. T., Shih, C. H., Raisbeck, L. D., … Etnier, J. L. (2017, August). The effects of low-intensity cycling on cognitive performance following sleep deprivation. Physiology and Behavior, 180, 25–30. doi:10.1016/j.physbeh.2017.07.033
  • Somer, E. (2009). Opioid use disorder, and dissociation. Dissociation and the Dissociative Disorders: DSM-V, 1–8. Retrieved from http://www.somer.co.il/articles/Opiods&Dissociation.pdf
  • Somer, E., Altus, L., & Ginzburg, K. (2010). Dissociative psychopathology among opioid use disorder patients: Exploring the “chemical dissociation” hypothesis. Comprehensive Psychiatry, 51(4), 419–425. doi:10.1016/j.comppsych.2009.09.007
  • Southwick, S. M., Southwick, S. M., Bremner, J. D., Bremner, J. D., Rasmusson, A., Rasmusson, A., … Charney, D. S. (1999). Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biological Psychiatry, 46(9), 1192–1204. Retrieved from papers2://publication/uuid/14E45257-F4BA-4D41-8650-12EB7E9155F9
  • Spiegel, D., Loewenstein, R. J., Lewis-Fernández, R., Sar, V., Simeon, D., Vermetten, E., … Dell, P. F. (2011). Dissociative disorders in DSM-5. Depression and Anxiety, 28(9), 824–852. doi:10.1002/da.20874
  • Sprouse-Blum, A. S., Smith, G., Sugai, D., & Parsa, F. D. (2010). Understanding endorphins and their importance in pain management. Hawaii Medical Journal, 69(3), 70–71. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104618/pdf/hmj6903_0070.pdf%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/20397507
  • Stein, D. J., Koenen, K. C., Friedman, M. J., Hill, E., McLaughlin, K. A., Petukhova, M., … Kessler, R. C. (2013). Dissociation in posttraumatic stress disorder: Evidence from the world mental health surveys. Biological Psychiatry, 73(4), 302–312. doi:10.1016/j.biopsych.2012.08.022
  • Stein, M. B., Jang, K. L., Taylor, S., Vernon, P. A., & Livesley, W. J. (2002). Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: A twin study. American Journal of Psychiatry, 159(10), 1675–1681. doi:10.1176/appi.ajp.159.10.1675
  • Steinman, M. Q., Duque-Wilckens, N., Greenberg, G. D., Hao, R., Campi, K. L., Laredo, S. A., … Trainor, B. C. (2016). Sex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin. Biological Psychiatry, 80(5), 406–414. doi:10.1016/j.biopsych.2015.10.007
  • Steuwe, C., Lanius, R. A., & Frewen, P. A. (2012). Evidence for a dissociative subtype of PTSD by latent profile and confirmatory factor analyses in a civilian sample. Depression and Anxiety, 29(8), 689–700. doi:10.1002/da.21944
  • Stoddard, F. J., Sorrentino, E. A., Ceranoglu, T. A., Saxe, G., Murphy, J. M., Drake, J. E., … Tompkins, R. G. (2009). Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns. Journal of Burn Care and Research, 30(5), 836–843. doi:10.1097/BCR.0b013e3181b48102
  • Stults-Kolehmainen, M. A., & Sinha, R. (2013). The effects of stress on physical activity and exercise. Sports Medicine, 44. doi:10.1007/s40279-013-0090-5
  • Szabo, A. (1995). The impact of exercise deprivation on well-being of habitual exercisers. The Australian Journal of Science and Medicine in Sport, 27(3), 68–75.
  • Szabo, A., Griffiths, M. D., & Demetrovics, Z. (2013). Psychology and exercise. In Acute and chronic psychological effects of exercise (pp. 65–73). doi:10.1016/B978-0-12-396454-0.00006-0
  • Szczytkowski-Thomson, J. L., Lebonville, C. L., & Lysle, D. T. (2013). Morphine prevents the development of stress-enhanced fear learning. Pharmacology Biochemistry and Behavior, 103(3), 672–677. doi:10.1016/j.pbb.2012.10.013
  • Tarr, B., Launay, J., Benson, C., & Dunbar, R. I. M. (2017). Naltrexone blocks endorphins released when dancing in synchrony. Adaptive Human Behavior and Physiology, 3(3), 241–254. doi:10.1007/s40750-017-0067-y
  • Tarr, B., Launay, J., Cohen, E., & Dunbar, R. (2015). Synchrony and exertion during dance independently raise pain threshold and encourage social bonding. Biology Letters, 11(10), 0–3. doi:10.1098/rsbl.2015.0767
  • Tarr, B., Launay, J., & Dunbar, R. I. M. (2014, September). Music and social bonding: “Self-other” merging and neurohormonal mechanisms. Frontiers in Psychology, 5, 1–10. doi:10.3389/fpsyg.2014.01096
  • Tarr, B., Launay, J., & Dunbar, R. I. M. (2016). Silent disco: Dancing in synchrony leads to elevated pain thresholds and social closeness. Evolution and Human Behavior, 37(5), 343–349. doi:10.1016/j.evolhumbehav.2016.02.004
  • Torrecilla, M., Marker, C. L., Cintora, S. C., Stoffel, M., Williams, J. T., & Wickman, K. (2002). G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. Journal of Neuroscience, 22(11), 4328–4334.
  • True, W. R., Rice, J., Eisen, S. A., Heath, A. C., Goldberg, J., Lyons, M. J., & Nowak, J. (1993). A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Archives of General Psychiatry, 50(4), 257–264. doi:10.1001/archpsyc.1993.01820160019002
  • Voisey, J., Swagell, C. D., Hughes, I. P., Morris, C. P., Van Daal, A., Noble, E. P., … Lawford, B. R. (2009). The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans. Depression and Anxiety, 26(1), 28–33. doi:10.1002/da.20517
  • Way, B. M., Taylor, S. E., & Eisenberger, N. I. (2009). Variation in the -opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proceedings of the National Academy of Sciences, 106(35), 15079–15084. doi:10.1073/pnas.0812612106
  • Whitworth, J. W., & Ciccolo, J. T. (2016). Exercise and post-traumatic stress disorder in military veterans: A systematic review. Military Medicine, 181(9), 953–960. doi:10.7205/milmed-d-15-00488
  • Williamson, G. R. (1999). The effectiveness of a group approach to clinical supervision in reducing stress: A review of the literature. Journal of Clinical Nursing, 8(4), 338–344. doi:10.1046/j.1365-2702.1999.00274.x
  • Wolf, E. J., Miller, M. W., Krueger, R. F., Lyons, M. J., Tsuang, M. T., & Koenen, K. C. (2010). Posttraumatic stress disorder and the genetic structure of comorbidity. Journal of Abnormal Psychology, 119(2), 320–330. doi:10.1037/a0019035
  • Wolf, E. J., Miller, M. W., Reardon, A. F., Ryabchenko, K. A., Castillo, D., & Freund, R. (2012). A latent class analysis of dissociation and posttraumatic stress disorder. Archives of General Psychiatry, 69(7), 698–705. doi:10.1001/archgenpsychiatry.2011.1574
  • Wood, M. D., Foran, H. M., Britt, T. W., & Wright, K. M. (2012). The impact of benefit finding and leadership on combat-related PTSD symptoms. Military Psychology, 24(6), 529–541. doi:10.1080/08995605.2012.736321
  • World Health Organization. (1993). The ICD-10 classification of mental and behavioural disorders: Diagnostic criteria for research (pp. 155–157). doi:10.1002/1520-6505(2000)9:5<201::AID-EVAN2>3.3.CO;2-P
  • Yehuda, R., Halligan, S. L., & Bierer, L. M. (2001). Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring. Journal of Psychiatric Research, 35(5), 261–270. doi:10.1016/S0022-3956(01)00032-2
  • Younger, J., Aron, A., Parke, S., Chatterjee, N., & Mackey, S. (2010). Viewing pictures of a romantic partner reduces experimental pain: Involvement of neural reward systems. PLoS ONE, 5(10), e13309. doi:10.1371/journal.pone.0013309
  • Zalewska-kaszubska, J., & Czarnecka, E. (2005). Deficit in beta-endorphin peptide and tendency to alcohol abuse. Peptides, 26, 701–705. doi:10.1016/j.peptides.2004.11.010

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