Virginia Pascual, MD: A Conversation with the Editor

Original Research

• Regueiro JR, Arnaiz-Villena A, Ortiz de Landázuri M, Martín Villa JM, Vicario JL, Pascual-Ruiz V, Guerra-Garcia F, Alcamí J, López-Botet M, Manzanares J. Familial defect of CD3 (T3) expression by T cells associated with rare gut epithelial cell autoantibodies. Lancet 1986;1 (8492): 1274–1245.
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• Pascual V, Randen I, Thompson K, Sioud M, Forre O, Natvig J, Capra JD. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus–transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes. J Clin Invest 1990;86 (4): 1320–1328.
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• Pascual V, Victor K, Lelsz D, Spellerberg MB, Hamblin TJ, Thompson KM, Randen I, Natvig J, Capra JD, Stevenson FK. Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J Immunol 1991;146 (12): 4385–4391.
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• Pascual V, Victor K, Spellerberg M, Hamblin TJ, Stevenson FK, Capra JD. VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 1992;149 (7): 2337–2344.
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• Pascual V, Victor K, Randen I, Thompson K, Steinitz M, F⊘rre O, Fu SM, Natvig JB, Capra JD. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3. Scand J Immunol 1992;36 (2): 349–362.
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• Randen I, Brown D, Thompson KM, Hughes-Jones N, Pascual V, Victor K, Capra JD, F⊘rre O, Natvig JB. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J Immunol 1992;148 (10): 3296–3301.
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• Potter KN, Li Y, Pascual V, Williams RC Jr, Byres LC, Spellerberg M, Stevenson FK, Capra JD. Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J Exp Med 1993;178 (4): 1419–1428.
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• Pascual V, Cha S, Gershwin ME, Capra JD, Leung PS. Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology. J Immunol 1994;152 (5): 2577–2585.
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• Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994;180 (1): 329–339.
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• Wilson PC, de Bouteiller O, Liu YJ, Potter K, Banchereau J, Capra JD, Pascual V. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med 1998;187 (1): 59–70.
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• Wilson PC, Wilson K, Liu YJ, Banchereau J, Pascual V, Capra JD. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J Exp Med 2000;191 (11): 1881–1894.
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• Wise CA, Bennett LB, Pascual V, Gillum JD, Bowcock AM. Localization of a gene for familial recurrent arthritis. Arthritis Rheum 2000;43 (9): 2041–2045.
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• Frazer JK, Jackson DG, Gaillard JP, Lutter M, Liu YJ, Banchereau J, Capra JD, Pascual V. Identification of centerin: a novel human germinal center B cell-restricted serpin. Eur J Immunol 2000;30 (10): 3039–3048.
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• Arce E, Jackson DG, Gill MA, Bennett LB, Banchereau J, Pascual V. Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. J Immunol 2001;167 (4): 2361–2369.
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• Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001;294 (5546): 1540–1543.
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• Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, Pascual V. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003;197 (6): 711–723.
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• Jego G, Palucka AK, Blanck JP, Chalouni C, Pascual V, Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 2003;19 (2): 225–234.
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• Stichweh DS, Punaro M, Pascual V. Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome. Pediatr Dermatol 2005;22 (3): 262–265.
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• Palucka AK, Blanck JP, Bennett L, Pascual V, Banchereau J. Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci U S A 2005;102 (9): 3372–3377.
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• Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V, Nussenzweig MC. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 2005;201 (5): 703–711.
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• Pascual V, Allantaz F, Arce E, Punaro M, Banchereau J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 2005;201 (9): 1479–1486.
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• Yurasov S, Tiller T, Tsuiji M, Velinzon K, Pascual V, Wardemann H, Nussenzweig MC. Persistent expression of autoantibodies in SLE patients in remission. J Exp Med 2006;203 (10): 2255–2261.
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• Chaussabel D, Allman W, Mejias A, Chung W, Bennett L, Ramilo O, Pascual V, Palucka AK, Banchereau J. Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes. Ann N Y Acad Sci 2005;1062: 146–154.
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• Allantaz F, Chaussabel D, Stichweh D, Bennett L, Allman W, Mejias A, Ardura M, Chung W, Wise C, Palucka K, Ramilo O, Punaro M, Banchereau J, Pascual V. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med 2007;204 (9): 2131–2144.
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• Chapters and reviews
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• Pascual V, Capra JD. Human heavy chain genes and autoimmunity. In Osterhaus ADME, Uytdehaag FGCM, eds. Idiotype Networks in Biology and Medicine. Amsterdam: Elsevier Science Publishers BV, 1990: 27–35.
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• Pascual V, Capra JD. Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Adv Immunol 1991;49: 1–74.
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• Pascual V, Capra JD. B-cell superantigens? Curr Biol 1991;1 (5): 315–317.
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• Pascual V, Capra JD. VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum 1992;35 (1): 11–18.
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• Pascual V, Capra JD. Immunoglobulin heavy chain variable region gene usage in human autoimmune diseases. In Aledort LM, Hoyer LW, Lusher JM, Reisner HM, White GC III. Inhibitors to Coagulation Factors [Advances in Experimental Medicine and Biology, vol 386]. New York: Plenum Publishing, 1995: 133–140.
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• Potter KN, Li Y, Pascual V, Capra JD. Staphylococcal protein A binding to VH3 encoded immunoglobulins. Int Rev Immunol 1997;14 (4): 291–308.
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• Wilson P, Liu YJ, Banchereau J, Capra JD, Pascual V. Amino acid insertions and deletions contribute to diversify the human Ig repertoire. Immunol Rev 1998;162: 143–151.
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• Palucka AK, Banchereau J, Blanco P, Pascual V. The interplay of dendritic cell subsets in systemic lupus erythematosus. Immunol Cell Biol 2002;80 (5): 484–488.
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• Pascual V, Banchereau J, Palucka AK. The central role of dendritic cells and interferon-alpha in SLE. Curr Opin Rheumatol 2003;15 (5): 548–556.
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• Banchereau J, Pascual V, Palucka AK. Autoimmunity through cytokine-induced dendritic cell activation. Immunity 2004;20 (5): 539–550.
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• Stichweh D, Arce E, Pascual V. Update on pediatric systemic lupus erythematosus. Curr Opin Rheumatol 2004;16 (5): 577–587.
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• Pascual V, Palucka K, Banchereau J. Role of innate immunity cytokines in systemic lupus and systemic onset arthritis. In Taniguchi M, Akira S, Nakayama T, eds. The Innate Immune System: Strategies for Disease Control [International Congress Series 1285]. Elsevier, 2005: 50–54.
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• Banchereau J, Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006;25 (3): 383–392.
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• Pascual V, Farkas L, Banchereau J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol 2006;18 (6): 676–682.
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• Ueno H, Klechevsky E, Morita R, Aspord C, Cao T, Matsui T, Di Pucchio T, Connolly J, Fay JW, Pascual V, Palucka AK, Banchereau J. Dendritic cell subsets in health and disease. Immunol Rev 2007;219: 118–142.
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