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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 36, 2023 - Issue 2
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Editorials

Direct Oral Anticoagulants Versus Vitamin K Antagonist (Warfarin) For Stroke Prevention In Frail Patients With Atrial Fibrillation: A Meta-Analysis

Rupak Desaia Independent Outcomes Researcher, Atlanta, Georgia
, MBBS,
Aobo Lib Department of Internal Medicine, Beijing Anzhen Hospital, Beijing, China
, MD,
Avilash Mondalc Internal Medicine, Nazareth Hospital Philadelphia, Philadelphia, Pennsylvania
, MD,
Priya Shenwaid Department of Surgery, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York
, MD,
Bhavyasri Merugue Department of Medicine, Vydehi Institute of Medical Sciences and Research Centre, Karnataka, India
, MBBS,
Frailyn J. Nunez Guzmanf Department of Internal Medicine, St. Barnabas Hospital, Bronx, New York
, MD &
Akhil Jaing Department of Internal Medicine, Mercy Catholic Medical Center, Darby, PennsylvaniaORCID Iconhttps://orcid.org/0000-0001-7298-4246
, MDORCID Icon show all
Pages 274-275 | Received 07 Oct 2022, Accepted 29 Nov 2022, Published online: 22 Dec 2022

  • Wilkinson C, Todd O, Clegg A, Gale CP, Hall M. Management of atrial fibrillation for older people with frailty: a systematic review and meta-analysis. Age Ageing. 2019;48(2):196–203. doi:10.1093/ageing/afy180.
  • Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc. 2010;58(4):681–687. doi:10.1111/j.1532-5415.2010.02764.x.
  • Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. doi:10.1016/s0140-6736(12)62167-9.
  • Lip G, Freedman B, De Caterina R, Potpara TS. Stroke prevention in atrial fibrillation: past, present and future. Comparing the guidelines and practical decision-making. Thromb Haemost. 2017;117(7):1230–1239. doi:10.1160/th16-11-0876.
  • Hindricks G, Potpara T, Dagres N, et al; ESC Scientific Document Group. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021;42(5):373–498. doi:10.1093/eurheartj/ehaa612.
  • Kim DH, Pawar A, Gagne JJ, et al. Frailty and clinical outcomes of direct oral anticoagulants versus warfarin in older adults with atrial fibrillation: a cohort study. Ann Intern Med. 2021;174(9):1214–1223. doi:10.7326/m20-7141.
  • Lip GYH, Keshishian AV, Kang AL, et al. Oral anticoagulants for nonvalvular atrial fibrillation in frail elderly patients: insights from the ARISTOPHANES study. J Intern Med. 2021;289(1):42–52. doi:10.1111/joim.13140.
  • Wilkinson C, Wu J, Searle SD, et al. Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial. BMC Med. 2020;18(1):401. doi:10.1186/s12916-020-01870-w.
  • Shinohara M, Wada R, Yao S, et al. Evaluation of oral anticoagulants in atrial fibrillation patients over 80 years of age with nonsevere frailty. J Arrhythm. 2019;35(6):795–803. doi:10.1002/joa3.12231.
  • Hohmann C, Hohnloser SH, Jacob J, Walker J, Baldus S, Pfister R. Non-vitamin K oral anticoagulants in comparison to phenprocoumon in geriatric and non-geriatric patients with non-valvular atrial fibrillation. Thromb Haemost. 2019;119(6):971–980. doi:10.1055/s-0039-1683422.
  • Martinez BK, Sood NA, Bunz TJ, Coleman CI. Effectiveness and safety of apixaban, dabigatran, and rivaroxaban versus warfarin in frail patients with nonvalvular atrial fibrillation. JAHA. 2018;7(8):e008643. doi:10.1161/JAHA.118.008643.
  • Carnicelli AP, Hong H, Connolly SJ, et al. Direct oral anticoagulants versus warfarin in patients with atrial fibrillation: patient-level network meta-analyses of randomized clinical trials with interaction testing by age and sex. Circulation. 2022;145(4):242–255. doi:10.1161/circulationaha.121.056355.
  • Damanti S, Braham S, Pasina L. Anticoagulation in frail older people. J Geriatr Cardiol. 2019;16(11):844–846. doi:10.11909/j.issn.1671-5411.2019.11.005.

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