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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 36, 2023 - Issue 5
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Original Research - Obstetrics

Comparison of clinical outcomes and biochemical markers in normal and preeclamptic pregnancies: a prospective cohort study

Niraj Voraa Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center – Temple, Temple, Texas, USACorrespondence[email protected]
View further author information
, MD,
Ram R. Kalagiria Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center – Temple, Temple, Texas, USAView further author information
, MD,
Kushi Shettyb McNeil High School, Austin, Texas, USAView further author information
,
Yara Mustafab McNeil High School, Austin, Texas, USAView further author information
,
Waverly Kundysekc Department of Medical Physiology, Texas A&M University College of Medicine, College Station, Texas, USAView further author information
, BS,
Muppala Rajua Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center – Temple, Temple, Texas, USAView further author information
, MD,
Vinayak Govandea Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center – Temple, Temple, Texas, USAView further author information
, MD,
Madhava Beerama Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center – Temple, Temple, Texas, USAView further author information
, MD &
Mohammad Nasir Uddina Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center – Temple, Temple, Texas, USA;c Department of Medical Physiology, Texas A&M University College of Medicine, College Station, Texas, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1170-7805View further author information
, PhDORCID Icon show all
Pages 572-577 | Received 23 Feb 2023, Accepted 05 Jun 2023, Published online: 22 Jun 2023

  • Anderson UD, Olsson MG, Kristensen KH, Åkerström B, Hansson SR. Review: biochemical markers to predict preeclampsia. Placenta. 2012;33(suppl):S42–S47. doi:10.1016/j.placenta.2011.11.021.
  • Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ. Maternal preeclampsia and neonatal outcomes. J Pregnancy. 2011;2011:214365. doi:10.1155/2011/214365.
  • Cunningham FG, Leveno KJ, Bloom SL, et al. Hypertensive disorders. In: Williams Obstetrics. 24th ed. New York: McGraw-Hill Education Medical; 2014:728–779.
  • Lin S, Leonard D, Co MAM, et al. Pre-eclampsia has an adverse impact on maternal and fetal health. Transl Res. 2015;165:449–463. doi:10.1016/j.trsl.2014.10.006.
  • Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785–799. doi:10.1016/s0140-6736(05)17987-2.
  • Wenger NK. Recognizing pregnancy-associated cardiovascular risk factors. Am J Cardiol. 2014;113:406–409. doi:10.1016/j.amjcard.2013.08.054.
  • Ehrig JC, Horvat D, Allen SR, Jones RO, Kuehl TJ, Uddin MN. Cardiotonic steroids induce anti-angiogenic and anti-proliferative profiles in first trimester extravillous cytotrophoblast cells. Placenta. 2014;35:932–936. doi:10.1016/j.placenta.2014.07.014.
  • LaMarca B. IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate? Int J Interferon Cytokine Mediat Res. 2011;2011:59–64. doi:10.2147/ijicmr.s16320.
  • Hermes W, Van Kesteren F, De Groot CJM. Preeclampsia and cardiovascular risk. Minerva Ginecol. 2012;64:281–292.
  • Staff AC, Dechend R, Redman CWG. Review: Preeclampsia, acute atherosis of the spiral arteries and future cardiovascular disease: two new hypotheses. Placenta. 2013;34(suppl):S73–S78. doi:10.1016/j.placenta.2012.11.022.
  • Xia Y, Kellems RE. Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond. Circ Res. 2013;113:78–87. doi:10.1161/circresaha.113.300752.
  • Andraweera PH, Dekker GA, Roberts CT. The vascular endothelial growth factor family in adverse pregnancy outcomes. Hum Reprod Update. 2012;18:436–457. doi:10.1093/humupd/dms011.
  • Nagamatsu T, Fujii T, Kusumi M, et al. Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology. 2004;145:4838–4845. doi:10.1210/en.2004-0533.
  • Redman CWG, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response—a review. Placenta. 2003;24(suppl A):S21–S7. doi:10.1053/plac.2002.0930.
  • Agarwal I, Karumanchi SA. Preeclampsia and the anti-angiogenic state. Pregnancy Hypertens. 2011;1:17–21. doi:10.1016/j.preghy.2010.10.007.
  • Hakim J, Senterman MK, Hakim AM. Preeclampsia is a biomarker for vascular disease in both mother and child: the need for a medical alert system. Int J Pediatr 2013;2013:953150. doi:10.1155/2013/953150.
  • Levine RJ, Karumanchi SA. Circulating angiogenic factors in preeclampsia. Clin Obstet Gynecol. 2005;48:372–386. doi:10.1097/01.grf.0000160313.82606.d7.
  • Young BC, Levine RJ, Karumanchi SA. Pathogenesis of preeclampsia. Annu Rev Pathol. 2010;5:173–192. doi:10.1146/annurev-pathol-121808-102149.
  • Tal R. The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis. Biol Reprod. 2012;87:134. doi:10.1095/biolreprod.112.102723.
  • Xia Y, Kellems RE. Is preeclampsia an autoimmune disease? Clin Immunol. 2009;133:1–12. doi:10.1016/j.clim.2009.05.004.
  • Uddin MN, Allen SR, Jones RO, Zawieja DC, Kuehl TJ. Pathogenesis of pre-eclampsia: marinobufagenin and angiogenic imbalance as biomarkers of the syndrome. Transl Res. 2012;160:99–113. doi:10.1016/j.trsl.2012.01.005.
  • Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–1408. doi:10.1056/nejmra000763.
  • Wang Y, Alexander JS. Placental pathophysiology in preeclampsia. Pathophysiology. 2000;6(4):261–270. doi:10.1016/s0928-4680(99)00026-7.
  • Afroze SH, Kalagiri RR, Reyes M, et al. Apoptotic and stress signaling markers are augmented in preeclamptic placenta and umbilical cord. BBA Clin. 2016;6:25–30. doi:10.1016/j.bbacli.2016.05.003.
  • Bevilacqua MP. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol. 1993;11:767–804. doi:10.1146/annurev.iy.11.040193.004003.
  • Granger JP, LaMarca BBD, Cockrell K, et al. Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia. Methods Mol Med. 2006;122:383–392. doi:10.1385/1-59259-989-3:381.
  • Gilbert JS, Babcock SA, Granger JP. Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression. Hypertension. 2007;50:1142–1147. doi:10.1161/hypertensionaha.107.096594.
  • Steegers EAP, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet. 2010;376:631–644. doi:10.1016/s0140-6736(10)60279-6.
  • Das UN. Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids in preeclampsia. Nutrition. 2015;31:1083–1095. doi:10.1016/j.nut.2015.03.013.
  • Malshe AK, Sibai BM. Angiogenic and antiangiogenic markers for prediction and risk classification of preeclampsia. Clin Obstet Gynecol. 2017;60:134–140. doi:10.1097/grf.0000000000000267.
  • Pinheiro CC, Rayol P, Gozzani L, et al. The relationship of angiogenic factors to maternal and neonatal manifestations of early-onset and late-onset preeclampsia. Prenat Diagn. 2014;34(11):1084–1092. doi:10.1002/pd.4432.
  • Soto E, Romero R, Kusanovic JP, et al. Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion. J Matern Fetal Neonatal Med. 2012;25:498–507. doi:10.3109/14767058.2011.591461.
  • Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T. Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction. Hypertens Res. 2017;40:305–310. doi:10.1038/hr.2016.152.
  • Yelumalai S, Subramanian K, Omar SZ, Qvist R, Muniandy S. Angiogenic factors in the pathogenesis and pathophysiology of preeclampsia: a mini review. Biomedical Research. 2010;21:246–251.
  • Ahmad S, Ahmed A. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ Res. 2004;95:884–891. doi:10.1161/01.res.0000147365.86159.f5.
  • Jayet PY, Rimoldi SF, Stuber T, et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation. 2010; 122:488–494. doi:10.1161/CIRCULATIONAHA.110.941203.
  • Kendall RL, Wang G, Thomas KA. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun. 1996;226:324–328. doi:10.1006/bbrc.1996.1355.
  • Landmesser U, Drexler H. The clinical significance of endothelial dysfunction. Curr Opin Cardiol. 2005;20:547–551. doi:10.1097/01.hco.0000179821.11071.79.
  • Thadhani R, Mutter WP, Wolf M, et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab. 2004;89:770–775. doi:10.1210/jc.2003-031244.
  • Rajakumar A, Michael HM, Rajakumar PA, et al. Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. Placenta. 2005;26:563–573. doi:10.1016/j.placenta.2004.09.001.
  • Bergmann A, Ahmad S, Cudmore M, et al. Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. J Cell Mol Med. 2010;14:1857–1867. doi:10.1111/j.1582-4934.2009.00820.x.
  • Carmeliet P, Moons L, Luttun A, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med. 2001;7:575–583. doi:10.1038/87904.
  • Zhou Y, McMaster M, Woo K, et al. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002;160:1405–1423. doi:10.1016/s0002-9440(10)62567-9.
  • Li DY, Sorensen LK, Brooke BS, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534–1537. doi:10.1126/science.284.5419.1534.
  • López-Novoa JM. Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia. Nephrol Dial Transplant. 2007;22:712–714. doi:10.1093/ndt/gfl768.
  • Hayman R, Brockelsby J, Kenny L, Baker P. Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J Soc Gynecol Investig. 1999;6:3–10. doi:10.1177/107155769900600103.
  • Maharaj ASR, Walshe TE, Saint-Geniez M, et al. VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma. J Exp Med. 2008;205:491–501. doi:10.1084/jem.20072041.
  • Roberts J, Taylor R, Musci T, Rodgers G, Hubel C, Mclaughlin M. Preeclampsia: an endothelial cell disorder. Int J Gynecol Obstet. 1990;32(3):299. doi:10.1016/0020-7292(90)90402-7.
  • Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649–658. doi:10.1172/JCI17189.
  • Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12:642–649. doi:10.1038/nm1429.
  • Autiero M, Luttun A, Tjwa M, Carmeliet P. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost. 2003;1:1356–1370. doi:10.1046/j.1538-7836.2003.00263.x.
  • Agunanne EE, Uddin MN, Horvat D, Puschett JB. Contribution of angiogenic factors in a rat model of pre-eclampsia. Am J Nephrol. 2010;32:332–339. doi:10.1159/000319463.
  • Shibata E, Rajakumar A, Powers RW, et al. Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor. J Clin Endocrinol Metab. 2005;90:4895–4903. doi:10.1210/jc.2004-1955.
  • Kalagiri RR, Carder T, Choudhury S, et al. Inflammation in complicated pregnancy and its outcome. Am J Perinatol. 2016;33:1337–1356. doi:10.1055/s-0036-1582397.
  • Buhimschi CS, Norwitz ER, Funai E, et al. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol. 2005;192:734–741. doi:10.1016/j.ajog.2004.12.052.
  • De Vivo A, Baviera G, Giordano D, Todarello G, Corrado F, D’anna R. Endoglin, PlGF and sFlt-1 as markers for predicting pre-eclampsia. Acta Obstet Gynecol Scand. 2008;87:837–842. doi:10.1080/00016340802253759.
  • Lam C, Lim KH, Karumanchi SA. Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension. 2005;46:1077–1085. doi:10.1161/01.hyp.0000187899.34379.b0.
  • Verlohren S, Galindo A, Schlembach D, et al. An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol. 2010;202:161.e.1–11. doi:10.1016/j.ajog.2009.09.016.

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