Cardenolide glycosides from the seeds of Digitalis purpurea exhibit carcinoma-specific cytotoxicity toward renal adenocarcinoma and hepatocellular carcinoma cells

References

• Kuroda M, Kubo S, Matsuo Y, Atou T, Satoh J, Fujino T, Hayakawa M, Mimaki Y. New cardenolide glycosides from the seeds of Digitalis purpurea and their cytotoxic activity. Biosci. Biotechnol. Biochem. 2013;77:1186–1192.10.1271/bbb.120922
   PubMed Web of Science ®Google Scholar
• Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev. 2004;18:157–169.10.1101/gad.1138104
   PubMed Web of Science ®Google Scholar
• Fujino T, Takeuchi A, Maruko-Ohtake A, Ohtake Y, Satoh J, Kobayashi T, Tanaka T, Ito H, Sakamaki R, Kashimura R, Ando K, Nishimaki-Mogami T, Ohkubo Y, Kitamura N, Sato R, Kikugawa K, Hayakawa M. Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation. J. Biochem. 2012;152:577–586.10.1093/jb/mvs101
   PubMed Web of Science ®Google Scholar
• Zhang DM, Liu JS, Tang MK, Yiu A, Cao HH, Jiang L, Yuet-Wa Chan JY, Tian HY, Fung KP, Ye WC. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. Eur. J. Pharmacol. 2012;692:19–28.10.1016/j.ejphar.2012.06.045
   PubMed Web of Science ®Google Scholar
• Hwang-Verslues WW, Sladek FM. Nuclear receptor hepatocyte nuclear factor 4α1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter. Mol. Endocrinol. 2008;22:78–90.10.1210/me.2007-0298
   PubMed Web of Science ®Google Scholar
• Chiba H, Itoh T, Satohisa S, Sakai N, Noguchi H, Osanai M, Kojima T, Sawada N. Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α. Exp. Cell Res. 2005;302:11–21.10.1016/j.yexcr.2004.08.014
   PubMed Web of Science ®Google Scholar
• Lu D, Han C, Wu T. 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1. Oncogene. 2014;33:1101–1112.10.1038/onc.2013.69
   PubMed Web of Science ®Google Scholar
• Wang X, Kiyokawa H, Dennewitz MB, Costa RH. The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc. Nat. Acad. Sci. USA. 2002;99:16881–16886.10.1073/pnas.252570299
   PubMed Web of Science ®Google Scholar
• Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799–1805.
   PubMed Web of Science ®Google Scholar
• Sugars KL, Budhram-Mahadeo V, Packham G, Latchman DS. A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53. Nucleic Acids Res. 2001;29:4530–4540.10.1093/nar/29.22.4530
   PubMed Web of Science ®Google Scholar
• Pietrzak M, Puzianowska-Kuznicka M. p53-dependent repression of the human MCL-1 gene encoding an antiapoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter. Biol. Chem. 2008;389:383–393.
   PubMed Web of Science ®Google Scholar
• Hiyoshi H, Abdelhady S, Segerström L, Sveinbjörnsson B, Nuriya M, Lundgren TK, Desfrere L, Miyakawa A, Yasui M, Kogner P, Johnsen JI, Andäng M, Uhlén P. Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase. Br. J. Cancer. 2012;106:1807–1815.10.1038/bjc.2012.159
   PubMed Web of Science ®Google Scholar
• Xu ZW, Wang FM, Gao MJ, Chen XY, Shan NN, Cheng SX, Mai X, Zala GH, Hu WL, Xu RC. Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth. J. Steroid Biochem. Mol. Biol. 2011;125:181–191.10.1016/j.jsbmb.2010.12.016
   PubMed Web of Science ®Google Scholar
• Einbond LS, Wu HA, Su T, Chang T, Panjikaran M, Wang X, Goldsberry S. Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells. J. Carcinog. 2010 Nov 18;9:10.10.4103/1477-3163.72578
   PubMedGoogle Scholar
• Zhang DM, Liu JS, Tang MK, Yiu A, Cao HH, Jiang L, Yuet-Wa Chan JY, Tian HY, Fung KP, Ye WC. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant. HepG2 cells through G2/M cell cycle arrest and apoptosis. Eur. J. Pharmacol. 2012;692:19–28.10.1016/j.ejphar.2012.06.045
   PubMed Web of Science ®Google Scholar
• Kometiani P, Liu L, Askari A. Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. Mol. Pharmacol. 2005;67:929–936.
   PubMed Web of Science ®Google Scholar