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Bioscience, Biotechnology, and Biochemistry Volume 79, 2015 - Issue 12
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Microbiology & Fermentation Technology(Note)

Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis

Masafumi TokuokaFaculty of Applied Bioscience, Department of Fermentation Science and Technology, Tokyo University of Agriculture, Tokyo, JapanCorrespondence[email protected]
,
Tomoki KikuchiFaculty of Applied Bioscience, Department of Fermentation Science and Technology, Tokyo University of Agriculture, Tokyo, Japan
,
Yasutomo ShinoharaNoda Institute for Scientific Research, Noda, Japan
,
Akifumi KoyamaFaculty of Applied Bioscience, Department of Fermentation Science and Technology, Tokyo University of Agriculture, Tokyo, Japan
,
Shin-ichiro IioFaculty of Applied Bioscience, Department of Fermentation Science and Technology, Tokyo University of Agriculture, Tokyo, Japan
,
Takaaki KubotaGraduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan;Showa Pharmaceutical University, Tokyo, Japan
,
Jun’ichi KobayashiGraduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
,
Yasuji KoyamaNoda Institute for Scientific Research, Noda, Japan
,
Akira TotsukaResearch Institute of KANSEI science, Yokohama, Japan
,
Hitoshi ShindoFaculty of Applied Bioscience, Department of Fermentation Science and Technology, Tokyo University of Agriculture, Tokyo, Japan
&
Kazuo SatoFaculty of Applied Bioscience, Department of Fermentation Science and Technology, Tokyo University of Agriculture, Tokyo, Japan
 show all
Pages 2081-2085 | Received 26 Feb 2015, Accepted 27 May 2015, Published online: 24 Jul 2015

References

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  • Goeger DE, Riley RT, Dorner JW, Cole RJ. Cyclopiazonic acid inhibition of the Ca2+-transport ATPase in rat skeletal muscle sarcoplasmic reticulum vesicles. Biochem. Pharmacol. 1988;37:978–981. 10.1016/0006-2952(88)90195-5
  • Chang PK, Ehrlich K, Fujii I. Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. Toxins. 2009;1:74–99.10.3390/toxins1020074
  • Kato N, Tokuoka M, Shinohara Y, et al. Genetic safeguard against mycotoxin cyclopiazonic acid production in Aspergillus oryzae. ChemBioChem. 2011;12:1376–1382.10.1002/cbic.v12.9
  • Tsuda M, Mugishima T, Komatsu K, et.al. Speradine A, a new pentacyclic oxindole alkaloid from a marine-derived fungus Aspergillus tamarii. Tetrahedron. 2003;59:3227–3230.10.1016/S0040-4020(03)00413-7
  • Tokuoka M, Seshime Y, Fujii I, Kitamoto K, Takahashi T, Koyama Y. Identification of a novel polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae. Fungal Genet. Biol. 2008;45:1608–1615.10.1016/j.fgb.2008.09.006
  • Seshime Y, Juvvadi PR, Tokuoka M, et al. Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid. Bioorg. Med. Chem. Lett. 2009;19:3288–3292.10.1016/j.bmcl.2009.04.073
  • Chang PK, Horn BW, Dorner JW. Clustered genes involved in cyclopiazonic acid production are next to the aflatoxin biosynthesis gene cluster in Aspergillus flavus. Fungal Genet. Biol. 2009;46:176–182.10.1016/j.fgb.2008.11.002
  • Kubodera T, Yamashita N, Nishimura A. Pyrithiamine resistance gene (ptrA) of Aspergillus oryzae: cloning, characterization and application as a dominant selectable marker for transformation. Biosci. Biotechnol. Biochem. 2000;64:1416–1421.10.1271/bbb.64.1416
  • Gomi K, Iimura Y, Hara S. Integrative transformation of Aspergillus oryzae with a plasmid containing the Aspergillus nidulans argB gene. Agric. Biol. Chem. 1987;51:2549–2555.10.1271/bbb1961.51.2549
  • Hu X, Xia QW, Zhao YY, et al. Speradines F–H, three new oxindole alkaloids from the marine-derived fungus Aspergillus oryzae. Chem. Pharm. Bull. 2014;62:942–946.10.1248/cpb.c14-00312

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