2,300
Views
0
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology (Note)

Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

, , , , , & show all
Pages 510-513 | Received 24 Jul 2015, Accepted 31 Aug 2015, Published online: 13 Oct 2015

References

  • Uekawa A, Katsushima K, Ogata A, et al. Change of epigenetic control of cystathionine beta-synthase gene expression through dietary vitamin B12 is not recovered by methionine supplementation. J. Nutrigenet. Nutrigenomics. 2009;2:29–36.
  • Vacek TP, Kalani A, Voor MJ, et al. The role of homocysteine in bone remodeling. Clin. Chem. Lab. Med. 2013;51:579–590.
  • Vaes BL, Lute C, Blom HJ, et al. Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif. Tissue Int. 2009;84:413–422.
  • Herrmann M, Wildemann B, Wagner A, et al. Experimental folate and vitamin B12 deficiency does not alter bone quality in rats. J. Bone Miner. Res. 2009;24:589–596.
  • Tucker KL, Hannan MT, Qiao N, et al. Low plasma vitamin B12 is associated with lower BMD: the framingham osteoporosis study. J. Bone Miner. Res. 2005; 20: 152–158.
  • Berndt T, Kumar R. Phosphatonins and the regulation of phosphate homeostasis. Annu. Rev. Physiol. 2007;69:341–359.
  • Moe S, Drüeke T, Cunningham J, et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–1953.
  • Beck L, Karaplis AC, Amizuka N, et al. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc. Natl. Acad. Sci. USA. 1998;95:5372–5377.
  • Custer M, Lötscher M, Biber J, et al. Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am. J. Physiol. 1994;266:F767–F774.
  • Takahiro S, Tetsunori K, Tadasu F, et al. Elevation of urinary methylmolonic acid induces the suppression of megalin-mediated endocytotic cycles during vitamin B12 deficiency. Biochem. Biophys. Res. Commun. 2015;465:206–212.
  • Melton ME, Kochman ML. Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious anemia. Metabolism. 1994;43:468–469.
  • Fukumoto S. Phosphate metabolism and vitamin D. Bonekey Rep. 2014;3:497.
  • Ito M, Sakurai A, Hayashi K, et al. An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells. Am. J. Physiol. Renal Physiol. 2010;299:F243–F254.
  • Bachmann S, Schlichting U, Geist B, et al. Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J. Am. Soc. Nephrol. 2004; 15: 892–900.
  • Bacic D, LeHir M, Biber J, et al. The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Kidney Int. 2006; 69: 495–503.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.