Allyl isothiocyanate suppresses the proteolytic activation of sterol regulatory element-binding proteins and de novo fatty acid and cholesterol synthesisFootnote

Abbreviations: ACC1, acetyl-CoA carboxylase 1; AITC, allyl isothiocyanate; AMPK, AMP-activated kinase; COP II, coated protein II; DMEM, Dulbecco’s modified Eagle’s medium; ER, endoplasmic reticulum; FAS, fatty acid synthase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; 25-HC, 25-Hydroxycholesterol; 4′-HF, 4′-hydroxyflavanone; HMGCR, HMG-CoA reductase; HMGCS, HMG-CoA synthase; Insigs, insulin-induced genes; LPDS, lipoprotein-deficient serum; SCAP, SREBP cleavage-activating protein; SCD1, stearoyl-CoA desaturase 1; S1P, site-1 protease; S2P, site-2 protease; SQS, squalene synthase; SREBPs, sterol regulatory element-binding proteins; XN, xanthohumol.

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