Dietary daidzein, but not genistein, has a hypocholesterolemic effect in non-ovariectomized and ovariectomized female Sprague-Dawley rats on a cholesterol-free diet

References

• Lissin LW, Cooke JP. Phytoestrogens and cardiovascular health. J Am Coll Cardiol. 2000;35:1403–1410.10.1016/S0735-1097(00)00590-8
   PubMed Web of Science ®Google Scholar
• Setchell KD. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy phytoestrogens. Am J Clin Nutr. 1998;68(6 suppl):1333S–1348S.
   PubMed Web of Science ®Google Scholar
• Messina MJ. Legumes and soybeans: overview of their nutritional profiles and health effects. Am J Clin Nutr. 1999;70(3 suppl):439S–450S.
   PubMed Web of Science ®Google Scholar
• F.l.h.c.s.p.a.c.h. Food and Drug Administration, HHS Final Rule. Fed Regist. 1999;64:57700–57733.
   PubMedGoogle Scholar
• Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333(5):276–282.10.1056/NEJM199508033330502
   PubMed Web of Science ®Google Scholar
• Cederroth CR, Nef S. Soy, phytoestrogens and metabolism: A review. Mol Cell Endocrinol. 2009;304:30–42.10.1016/j.mce.2009.02.027
   PubMed Web of Science ®Google Scholar
• Gu L, House SE, Prior RL, et al. Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J Nutr. 2006;136(5):1215–1221.
   PubMed Web of Science ®Google Scholar
• Legette LL, Lee WH, Martin BR, et al. Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects. Menopause. 2011;18(8):923–931.10.1097/gme.0b013e3182116e81
   PubMed Web of Science ®Google Scholar
• Cassidy A, Bingham S, Setchell K. Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products. Br J Nutr. 1995;74:587–601.10.1079/BJN19950160
   PubMed Web of Science ®Google Scholar
• Kirk EA, Sutherland P, Wang SA, et al. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J Nutr. 1998;128:954–959.
   PubMed Web of Science ®Google Scholar
• Pilšáková L, Riečanský I, Jagla F. The physiological actions of isoflavone phytoestrogens. Physiol Res. 2010;59:651–664.
   PubMed Web of Science ®Google Scholar
• Anthony MS, Clarkson TB, Bullock BC, et al. Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys. Arteriosler Thromb Vasc Biol. 1997;17:2524–2531.10.1161/01.ATV.17.11.2524
   PubMed Web of Science ®Google Scholar
• Kritchevsky D. Dietary protein, cholesterol and atherosclerosis: a review of the early history. J Nutr. 1995;125:589S–593S.
   PubMed Web of Science ®Google Scholar
• Lucas EA, Khalil DA, Daggy BP, et al. Ethanol-extracted soy protein isolate does not modulate serum cholesterol in golden Syrian hamsters: a model of postmenopausal hypercholesterolemia. J Nutr. 2001;131:211–214.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Ide T. Effects of soy protein in isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor γ in adipose tissues of rats. J Nutr Biochem. 2008;19:682–693.10.1016/j.jnutbio.2007.09.003
   PubMed Web of Science ®Google Scholar
• Ross-Viola JS, Mezei O, Welsh J, et al. Effects of low- and high- isoflavone soy protein-based diets on cholesterol metabolism and enterohepatic bile salt recirculation in mice. FASEB J. 2006;20:A854.
   Web of Science ®Google Scholar
• Kishida T, Mizushige T, Nagamoto M, et al. Lowering effect of an isoflavone-rich fermented soybean extract on the serum cholesterol concentration in female rats with or without ovariectomy but not in male rats. Biosci Biotechnol Biochem. 2006;70(7):1547–1556.10.1271/bbb.50008
   PubMed Web of Science ®Google Scholar
• Lee SO, Renouf M, Ye Z, et al. Isoflavone glycitein diminished plasma cholesterol in female golden syrian hamsters. J Agric Food Chem. 2007;55:11063–11067.10.1021/jf070972r
   PubMed Web of Science ®Google Scholar
• Balmir F, Staack R, Jeffrey E, et al. An extract of soy flour influences serum cholesterol and thyroid hormones in rats and hamsters. J Nutr. 1996;126(12):3046–3053.
   PubMed Web of Science ®Google Scholar
• Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology. 1998;139(10):4252–4263.10.1210/endo.139.10.6216
   PubMed Web of Science ®Google Scholar
• Yuan JP, Wang JH, Liu X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora–implications for health. Mol Nutr Food Res. 2007;51:765–781.10.1002/(ISSN)1613-4133
   PubMed Web of Science ®Google Scholar
• Ricketts ML, Moore DD, Banz WJ, et al. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. J Nutr Biochem. 2005;16(6):321–330.10.1016/j.jnutbio.2004.11.008
   PubMed Web of Science ®Google Scholar
• Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226(1):497–509.
   PubMed Web of Science ®Google Scholar
• Sheltawy MJ, Losowsky MS. Determination of faecal bile acids by an enzymic method. Clin Chim Acta. 1975;64:127–132.10.1016/0009-8981(75)90194-1
   PubMed Web of Science ®Google Scholar
• Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156–159.10.1016/0003-2697(87)90021-2
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:2002–2007.
   Web of Science ®Google Scholar
• Geahlen RL, Koonchanok NM, McLaughlin JL, et al. Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds. J Nat Prod. 1989;52(5):982–986.10.1021/np50065a011
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Odbayar TO, Ide TA. A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver. J Clin Biochem Nutr. 2009;44(3):223–230.10.3164/jcbn.08-211
   PubMed Web of Science ®Google Scholar
• Su Y, Shankar K, Simmen RC. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr. 2009;139(5):945–951.10.3945/jn.108.103820
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Sobue T, Sasaki S, et al. Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records and blood and urine isoflavones. J Nutr. 2001;131(10):2741–2747.
   PubMed Web of Science ®Google Scholar
• Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol – a clue to the effectiveness of soy and its isoflavones. J Nutr. 2002;132(12):3577–3584.
   PubMed Web of Science ®Google Scholar
• Kishida T, Mizushige T, Ohtsu Y, et al. Dietary soy isoflavone-aglycone lowers food intake in female rats with and without ovariectomy. Obesity (Silver Spring). 2008;16(2):290–297.10.1038/oby.2007.68
   PubMed Web of Science ®Google Scholar
• Fujitani M, Mizushige T, Bhattarai K, et al. Dynamics of appetite-mediated gene expression in daidzein-fed female rats in the meal-feeding method. Biosci Biotechnol Biochem. 2015;79(8):1342–1349.10.1080/09168451.2015.1025034
   PubMed Web of Science ®Google Scholar
• Rachon D, Vortherms T, Seidlova-Wuttke D, et al. Effects of dietary equol on body weight gain, intra-abdominal fat accumulation, plasma lipids, and glucose tolerance in ovariectomized Sprague-Dawley rats. Menopause. 2007;14(5):925–932.10.1097/gme.0b013e31802d979b
   PubMed Web of Science ®Google Scholar
• Lu TT, Makishima M, Repa JJ, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 2000;6:507–515.10.1016/S1097-2765(00)00050-2
   PubMed Web of Science ®Google Scholar
• Pandak WM, Schwarz C, Hylemon PB, et al. Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis. Am J Physiol Gastrointest Liver Physiol. 2001;281(4):G878–G889.
   PubMed Web of Science ®Google Scholar
• Bjorkhem I, Andersson U, Sudjama-Sugiaman E, et al. Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in lymph-fistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids. J Lipid Res. 1993;34(9):1497–1503.
   PubMed Web of Science ®Google Scholar
• Kang SK, Davis RA. Cholesterol and hepatic lipoprotein assembly and secretion. Biochim Biophys Acta. 2000;1529(1–3):223–230.10.1016/S1388-1981(00)00151-7
   PubMed Web of Science ®Google Scholar
• Clarkson TB, Adams MR, Kaplan JR, et al. Psychosocial and reproductive influences on plasma lipids, lipoproteins and atherosclerosis in nonhuman primates. J Lipids Res. 1984;25:1629–1634.
   PubMed Web of Science ®Google Scholar
• Lee RG, Shah R, Sawyer JK, et al. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl esters to LDL in mice. J Lipid Res. 2005;46(6):1205–1212.10.1194/jlr.M500018-JLR200
   PubMed Web of Science ®Google Scholar
• Thompson GR, Naoumova RP, Watts GF. Role of cholesterol in regulating apolipoprotein B secretion by the liver. J Lipid Res. 1996;37(3):439–447.
   PubMed Web of Science ®Google Scholar
• Istvan ES, Palnitkar M, Buchanan SK, et al. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 2000;19(5):819–830.10.1093/emboj/19.5.819
   PubMed Web of Science ®Google Scholar
• Xu G, Pan LX, Li H, et al. Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits. J Biol Chem. 2002;277(52):50491–50496.10.1074/jbc.M209176200
   PubMed Web of Science ®Google Scholar