Development of functional agricultural products utilizing the new health claim labeling system in Japan

References

• Arai H, Ouchi Y, Toba K, et al. Japan as the front-runner of super-aged societies: perspectives from medicine and medical care in Japan. Geriatr Gerontol Int. 2015;15:673–687.10.1111/ggi.2015.15.issue-6
   PubMed Web of Science ®Google Scholar
• Overview of the system and the basic statics [Internet]. Tokyo: Ministry of Health, Labour and Welfare; [cited 2017 Aug 25]. Available from: http://www.mhlw.go.jp/english/wp/wp-hw9/dl/01e.pdf
   Google Scholar
• Nakanishi N, Nishina K, Okamoto M, et al. Clustering of components of the metabolic syndrome and risk for development of type 2 diabetes in Japanese male office workers. Diabetes Res Clin Pract. 2004;63:185–194.10.1016/j.diabres.2003.08.007
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Temba H, Horibe H, et al; Research group on serum lipid survey 1990 in Japan. Life style and cardiovascular risk factors in the Japanese population–from an epidemiological survey on serum lipid levels in Japan. Part 2: association of lipid parameters with hypertension. J Atheroscler Thromb. 1990;2003(10):176–185.
   Google Scholar
• Kanauchi M, Kanauchi K, Hashimoto T, et al. Metabolic syndrome and new category ‘pre-hypertension’ in a Japanese population. Curr Med Res Opin. 2004;20:1365–1370.10.1185/030079904X2042
   PubMed Web of Science ®Google Scholar
• Trends in national medical care expenditure [Internet]. Tokyo: Ministry of Health, Labour and Welfare; [cited 2017 Aug 25]. Available from: http://www.mhlw.go.jp/file/04-Houdouhappyou-12401000-Hokenkyoku-Soumuka/0000136497.pdf. Japanese.
   Google Scholar
• Chiba E, editor. Shokuhin no Seitaichosetsukinou [Physiological function of foods]. Tokyo: Gakkai Shuppan Center; 1992. Japanese.
   Google Scholar
• Asai S, editor. Kinouseishokuhin no Kenkyu [The studies of food function]. Tokyo: Gakkai Shuppan Center; 1995. Japanese.
   Google Scholar
• Fujimaki M, editor. Shokuhin no Kinousei [Functionality of foods]. Tokyo: Gakkai Shuppan Center; 1998. Japanese.
   Google Scholar
• Regulatory systems of health claims in Japan [Internet]. Tokyo: Consumer Affairs Agency; [cited 2017 Aug 25]. Available from: http://www.caa.go.jp/en/pdf/syokuhin338.pdf
   Google Scholar
• Foods with nutrient function claims [Internet]. Tokyo: Consumer Affairs Agency; [updated 2016 Oct 4; cited 2017 Aug 25]. Available from: http://www.caa.go.jp/foods/pdf/foods_161004_0004.pdf. Japanese.
   Google Scholar
• The system of “Foods with Function Claims” has been launched [Internet]. Tokyo: Consumer Affairs Agency; [updated 2015 Dec; cited 2017 Aug 25]. Available from: http://www.caa.go.jp/foods/pdf/151224_2.pdf
   Google Scholar
• What are “Foods with Function Claims” [Internet]. Tokyo: Consumer Affairs Agency; [updated 2015 Dec; cited 2017 Aug 25]. Available from: http://www.caa.go.jp/foods/pdf/151224_2.pdf
   Google Scholar
• Yamaguchi M, Igarashi A, Uchiyama S, et al. Effect of β-Crytoxanthin on circulating bone metabolic markers: intake of juice (Citrus Unshiu) supplemented with β-Cryptoxanthin has an effect in menopausal women. J Health Sci. 2006;52:758–768.10.1248/jhs.52.758
   Google Scholar
• Taku K, Melby MK, Takebayashi J, et al. Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. Asis Pac J Clin Nutr. 2010;19:33–42.
   PubMed Web of Science ®Google Scholar
• Ma FD, Qin LQ, Wang PY, et al. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J. Clin Nutr. 2008;62:155–161.10.1038/sj.ejcn.1602748
   PubMed Web of Science ®Google Scholar
• Li J, Kaneko T, Qin LQ, et al. Effects of barley intake on glucose tolerance, lipid metabolism, and bowel function in women. Nutrition. 2003;19:926–929.10.1016/S0899-9007(03)00182-5
   PubMed Web of Science ®Google Scholar
• Behall KM, Scholfield DJ, Hallfrisch J. Lipids significantly reduced by diets containing barley in moderately hypercholesterolemic men. J Am Coll Nutr. 2004;23:55–62.10.1080/07315724.2004.10719343
   PubMed Web of Science ®Google Scholar
• Nishimura M, Yoshida S, Haramoto M, et al. Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. J Tradit Complement Med. 2015;6:66–71.
   PubMedGoogle Scholar
• Uesugi S, Watanabe S, Ishiwata N, et al. Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women. Biofactors. 2004;22:221–228.10.1002/biof.v22:1/4
   PubMed Web of Science ®Google Scholar
• Yamori Y, Moriguchi EH, Teramoto T, et al. Soybean isoflavones reduce postmenopausal bone resorption in female Japanese immigrants in Brazil: a ten-week study. J Am Coll Nutr. 2002;21:560–563.10.1080/07315724.2002.10719255
   PubMed Web of Science ®Google Scholar
• Blum A, Merei M, Karem A, et al. Effect of tomatoes on the lipid profile. Clin Invest Med. 2006;29:298–300.
   PubMed Web of Science ®Google Scholar
• Kobayashi K, Hamazaki K, Fujioka S, et al. The effect of n-3 PUFA/γ-cyclodextrin complex on serum lipids in healthy volunteers: a randomized, placebo-controlled, double-blind trial. Asia Pac. J Clin. Nutr. 2007;16:429–434.
   PubMed Web of Science ®Google Scholar
• Matsumoto M, Matsunaga H, Nishimura T, et al. Effects of purified fish oil-containing dietary supplement on serum triglycerides, blood pressure, and cognitive function in healthy Japanese middle-agers: randomized, double-blind, placebo-controlled parallel-group trial. [ Yakuri to Chiryo] Jpn Pharmacol Ther. 2016;44:235–246. Japanese.
   Google Scholar
• Retrieval of ‘Foods with Function Claims’ [Internet]. Tokyo: Consumer Affairs Agency; [updated 2017 Jul 28; cited 2017 Aug 25]. Available from: https://www.fld.caa.go.jp/caaks/cssc01/. Japanese.
   Google Scholar
• Sugiura M, Nakamura M, Ogawa K, et al. High serum carotenoids associated with lower risk for bone loss and osteoporosis in post-menopausal Japanese female subjects: prospective cohort study. PLoS ONE. 2012;7:e52643.10.1371/journal.pone.0052643
   PubMed Web of Science ®Google Scholar
• Sugiura M, Nakamura M, Ogawa K, et al. High serum carotenoids are associated with lower risk for developing elevated serum alanine aminotransferase among Japanese subjects: the Mikkabi cohort study. Br J Nutr. 2016;115:1462–1469.10.1017/S0007114516000374
   PubMed Web of Science ®Google Scholar
• Sugiura M, Nakamura M, Ogawa K, et al. High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study. BMJ Open Diabetes Res Care. 2015;3:e000147.10.1136/bmjdrc-2015-000147
   PubMed Web of Science ®Google Scholar
• Nakamura M, Sugiura M, Ogawa K, et al. Serum β-cryptoxanthin and β-carotene derived from Satsuma mandarin and brachial-ankle pulse wave velocity: the Mikkabi cohort study. Nutr Metab Cardiovasc Dis. 2016;26:808–814.10.1016/j.numecd.2016.04.001
   PubMed Web of Science ®Google Scholar
• Sugiura M, Nakamura M, Ogawa K, et al. High serum carotenoids associated with lower risk for the metabolic syndrome and its components among Japanese subjects: Mikkabi cohort study. Br J Nutr. 2015;114:1674–1682.10.1017/S0007114515003268
   PubMed Web of Science ®Google Scholar
• Maeda-Yamamoto M, Kawahara H, Matsuda N, et al. Effects of tea infusions of various varieties or different manufacturing types on inhibition of mouse mast cell activation. Biosci. Biotech. Biochem. 1998;62:2277–2279.10.1271/bbb.62.2277
   PubMed Web of Science ®Google Scholar
• Sano M, Suzuki M, Miyase T, et al. Novel antiallergic catechin derivatives isolated from oolong tea. J. Agric. Food Chem. 1999;47:1906–1910.10.1021/jf981114 l
   PubMed Web of Science ®Google Scholar
• Tachibana H, Sunada Y, Miyase T, et al. Identification of a methylated tea catechin as an inhibitor of degranulation in human basophilic KU812 cells. Biosci. Biotech. Biochem. 2000;64:452–454.10.1271/bbb.64.452
   PubMed Web of Science ®Google Scholar
• Suzuki M, Yoshino K, Maeda-Yamamoto M, et al. Inhibitory effects of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate on mouse type-IV allergy. J Agric Food Chem. 2000;48:5649–5653.10.1021/jf000313d
   PubMed Web of Science ®Google Scholar
• Suzuki M, Sano M, Yoshida R, et al. Epimerization of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate: relationship between epimerization and chemical structure and epimerization of tea epicatechin during the extraction with hot water. J Agric Food Chem. 2003;51:510–514.10.1021/jf0210627
   PubMed Web of Science ®Google Scholar
• Maeda-Yamamoto M, Nagai H, Asai K, et al. Changes in epigallocatehin-3-O-(3-O-methyl) gallate and strictinin contents of tea (Camellia sinensis L.) cultivar ‘Benifuuki’ in various degree of maturity and leaf order. Food Sci Technol Res. 2004;10:186–190.10.3136/fstr.10.186
   Web of Science ®Google Scholar
• Maeda-Yamamoto M, Ema K, Tokuda Y, et al. Epicatechin-3-O-(3-O-methyl) gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release. J Agric Food Chem. 2012;60:2165–2170.10.1021/jf204497b
   PubMed Web of Science ®Google Scholar
• Yasue M, Nagai H, Maeda-Yamamoto M, et al. The clinical effects and the safety of the intakes of ‘Benifuuki’ green tea in patients with perennial allergic rhinitis. J Jpn Soc Clin Nutr. 2005;27:33–51. Japanese.
   Google Scholar
• Yasue M, Ohtake Y, Nagai H, et al. The efficacy and safety of ‘Benifuuki’ green tea containing O-methylated catechin: clinical study in patients with mild perennial allergic rhinitis. Nippon Shokuhin Shinsozaikenkyukaishi. 2005;8:65–80. Japanese.
   Google Scholar
• Maeda-Yamamoto M, Ema K, Shibuichi I. In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement. Cytotechnology. 2007;55:135–142.10.1007/s10616-007-9112-1
   PubMed Web of Science ®Google Scholar
• Masuda S, Maeda-Yamamoto M, Usui S, et al. ‘Benifuuki’ green tea containing O-methylated catechin reduces symptoms of Japanese cedar pollinosis: a randomized, double-blind, placebo-controlled trial. Allergology Int. 2014;63:211–217.10.2332/allergolint.13-OA-0620
   Web of Science ®Google Scholar
• Maeda-Yamamoto M, Ema K, Monobe M, et al. The efficacy of early treatment of seasonal allergic rhinitis with Benifuuki green tea containing O-methylated catechin before pollen exposure: an open randomized study. Allergology Int. 2009;58(3):437–444.10.2332/allergolint.08-OA-0066
   PubMedGoogle Scholar
• Maeda-Yamamoto M, Inagaki N, Kitaura J, et al. O-methylated catechins from tea leaves, inhibit multiple protein kinases in mast cells. J. Immunol. 2004;172:4486–4492.10.4049/jimmunol.172.7.4486
   PubMed Web of Science ®Google Scholar
• Fujimura Y, Umeda D, Yano S, et al. The 67 kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG. Biochem Biophys Res Commun. 2007;364:79–85.10.1016/j.bbrc.2007.09.095
   PubMed Web of Science ®Google Scholar
• Fujimura Y, Tachibana H, Maeda-Yamamoto M, et al. Antiallergic tea catechin: (-)-Epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses fcepsilonRI expression in human basophilic KU812 cells. J Agric Food Chem. 2002;50:5729–5734.10.1021/jf025680z
   PubMed Web of Science ®Google Scholar
• Research reviews of nine agricultural products [Internet]. Tsukuba: NARO; [cited 2017 Aug 25]. Available from: http://www.naro.affrc.go.jp/project/f_foodpro/2016/063236.html. Japanese.
   Google Scholar
• Aoe S, Ichinose Y, Kohyama N, et al. Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: a randomized, double-blind study. Nutrition. 2017;42:1–6. 10.1016/j.nut.2017.05.002
   PubMed Web of Science ®Google Scholar
• Nishimura M, Ohkawara T, Sato Y, et al. Improvement of triglyceride levels through the intake of enriched-β-conglycinin soybean (Nanahomare) revealed in a randomized, double-blind, placebo-controlled study. Nutrients. 2016;8:491–498.10.3390/nu8080491
   Web of Science ®Google Scholar
• Nishimura M, Ohkawara T, Sato Y, et al. Effectiveness of rutin-rich Tartary buckwheat ( Fagopyrum tataricum Gaertn.) ‘Manten-Kirari’ in body weight reduction related to its antioxidant properties: a randomised, double-blind, placebo-controlled study. J Funct Foods. 2016;26:460–469.10.1016/j.jff.2016.08.004
   Web of Science ®Google Scholar
• Nishimura M, Ohkawara T, Nakagawa T, et al. A randomized, double-blind, placebo-controlled study evaluating the effects of quercetin-rich onions on cognitive function in elderly subjects. Funct Foods Health Dis. 2017;7:353–374.
   Web of Science ®Google Scholar
• Shoji T, Yamada M, Miura T, et al. Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: a randomised, placebo-controlled trial. Diabetes Res Clin Pract. 2017;129:43–51.10.1016/j.diabres.2017.03.028
   PubMed Web of Science ®Google Scholar
• Imbe H, Sano H, Miyawaki M, et al. “Benifuuki” green tea, containing O-methylated EGCG, reduces serum low-density lipoprotein cholesterol and lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: a double-blind, placebo-controlled randomized trial. J Funct Foods. 2016;25:25–37.10.1016/j.jff.2016.05.004
   Web of Science ®Google Scholar
• Momose Y, Maeda-Yamamoto M, Nabetani H. Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans. Int J Food Sci Nutr. 2016;20:1–8.
   Google Scholar
• Noro W, Akaishi R, Nakamura S, et al. Prevention of abrupt increases in postprandial blood glucose levels by rice bread made with the novel rice cultivar “Konayukinomai”. Food Sci Technol Res. 2016;22:793–799.10.3136/fstr.22.793
   Web of Science ®Google Scholar
• Saito H, Cherasse Y, Suzuki R, et al. Zinc-rich oysters as well as zinc yeast- and astaxanthin-enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals. Mol Nutr Food Res. 2017;65. DOI:10.1002/mnfr.201600882
   Google Scholar
• Maeda-Yamamoto M, Hirosawa T, Mihara Y, et al. Randomized, placebo-controlled, clinical study to investigate anti-metabolic syndrome effects of functional foods in humans. Nippon Shokuhin Kagaku Kogaku Kaishi. 2017;64:23–33. Japanese.10.3136/nskkk.64.23
   Web of Science ®Google Scholar
• Technical Measures for Functional Labeling [Internet]. Tsukuba: NARO; [updated 2015 Aug 24; cited 2017 Aug 25]. Available from: http://www.s.affrc.go.jp/docs/kinousei_pro/reference.htm. Japanese.
   Google Scholar
• Watanabe J, Ayugase J. Effect of low temperature on flavonoids, oxygen radical absorbance capacity values and major components of winter sweet spinach (Spinacia oleracea L.). J Sci Food Agric. 2015;95:2095–2104.10.1002/jsfa.2015.95.issue-10
   PubMed Web of Science ®Google Scholar
• Schalch W, Cohn W, Barker FM, et al. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Arch Biochem Biophys. 2007;458:128–135.10.1016/j.abb.2006.09.032
   PubMed Web of Science ®Google Scholar