Bacillus subtilis highly efficient protein expression systems that are chromosomally integrated and controllable by glucose and rhamnose

References

• Westers L, Westers H, Quax WJ. Bacillus subtilis as cell factory for pharmaceutical proteins: a biotechnological approach to optimize the host organism. Biochim Biophys Acta. 2004;1694:299–310.
   PubMed Web of Science ®Google Scholar
• Degering C, Eggert T, Puls M, et al Optimization of protease secretion in Bacillus subtilis and Bacillus licheniformis by screening of homologous and heterologous signal peptides. Appl Environ Microbiol. 2010;76:6370–6376.
   PubMed Web of Science ®Google Scholar
• Sak-Ubol S, Namvijitr P, Pechsrichuang P, et al Secretory production of a beta-mannanase and a chitosanase using a Lactobacillus plantarum expression system. Microb Cell Fact. 2016;15:81.
   PubMed Web of Science ®Google Scholar
• Zobel S, Kumpfmüller J, Süssmuth RD, et al Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin. Appl Microbiol Biotechnol. 2015;99:681–691.
   PubMed Web of Science ®Google Scholar
• Schumann W. Production of recombinant proteins in Bacillus subtilis. Adv Appl Microbiol. 2007;62:137–189.
   PubMed Web of Science ®Google Scholar
• Dong H, Zhang D. Current development in genetic engineering strategies of Bacillus species. Microb Cell Fact. 2014;13:63.
   PubMed Web of Science ®Google Scholar
• Song Y, Nikoloff JM, Zhang D. Improving protein production on the level of regulation of both expression and secretion pathways in Bacillus subtilis. J Microbiol Biotechnol. 2015;25:963–977.
   PubMed Web of Science ®Google Scholar
• Jarmer H, Larsen TS, Krogh A, et al Sigma A recognition sites in the Bacillus subtilis genome. Microbiology. 2001;147:2417–2424.
   PubMed Web of Science ®Google Scholar
• Petersohn A, Bernhardt J, Gerth U, et al Identification of σB-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization. J Bacteriol. 1999;181:5718–5724.
   PubMed Web of Science ®Google Scholar
• Wang PZ, Doi RH. Overlapping promoters transcribed by Bacillus subtilis σ55 and σ37 RNA polymerase holoenzymes during growth and stationary phases. J Biol Chem. 1984;259:8619–8625.
   PubMed Web of Science ®Google Scholar
• Yu X, Xu J, Liu X, et al Identification of a highly efficient stationary phase promoter in Bacillus subtilis. Sci Rep. 2015;5:18405.
   PubMed Web of Science ®Google Scholar
• Guan C, Cui W, Cheng J, et al Construction and development of an auto-regulatory gene expression system in Bacillus subtilis. Microb Cell Fact. 2015;14:150.
   PubMed Web of Science ®Google Scholar
• K, Kodoi Y, Satomura T, et al. Regulation of the rhaEWRBMA operon involved in L-rhamnose catabolism through two transcriptional factors, RhaR and CcpA, in Bacillus subtilis. J Bacteriol. 2016;198:830–845.
   Web of Science ®Google Scholar
• Fujita Y. Carbon catabolite control of the metabolic network in Bacillus subtilis. Biosci Biotechnol Biochem. 2009;73:245–259.
   PubMed Web of Science ®Google Scholar
• Wickstrum JR, Skredenske JM, Balasubramaniam V, et al The AraC/XylS family activator RhaS negatively autoregulates rhaSR expression by preventing cyclic AMP receptor protein activation. J Bacteriol. 2010;192:225–232.
   PubMed Web of Science ®Google Scholar
• Terpe K. Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems. Appl Microbiol Biotechnol. 2006;72:211–222.
   PubMed Web of Science ®Google Scholar
• Tojo S, Satomura T, Matsuoka H, et al Catabolite repression of the Bacillus subtilis FadR regulon, which is involved in fatty acid catabolism. J Bacteriol. 2011;193:2388–2395.
   PubMed Web of Science ®Google Scholar
• Fujita Y, Miwa Y. Identification of an operator sequence for the Bacillus subtilis gnt operon. J Biol Chem. 1989;264:4201–4206.
   PubMed Web of Science ®Google Scholar
• Tsien RY. The green fluorescent protein. Annu Rev Biochem. 1998;67:509–544.
   PubMed Web of Science ®Google Scholar
• Miwa Y, Fujita Y. Involvement of two distinct catabolite-responsive elements in catabolite repression of the Bacillus subtilis myo-inositol (iol) operon. J Bacteriol. 2001;183:5877–5884.
   PubMed Web of Science ®Google Scholar
• Yoshida K, Ishio I, Nagakawa E, et al Systematic study of gene expression and transcription organization in the gntZ-ywaA region of the Bacillus subtilis genome. Microbiology. 2000;146:573–579.
   PubMed Web of Science ®Google Scholar
• Atkinson MR, Wray LV Jr, Fisher SH. Regulation of histidine and proline degradation enzymes by amino acid availability in Bacillus subtilis. J Bacteriol. 1990;172:4758–4765.
   PubMed Web of Science ®Google Scholar
• Sambrook J, Russell DW. Molecular cloning: a laboratory manual. 3rd ed. Cold Spring Harbor, New York (NY): Cold Spring Harbor Laboratory Press; 2001.
   Google Scholar
• Blencke HM, Homuth G, Ludwig H, et al Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 2003;5:133–149.
   PubMed Web of Science ®Google Scholar
• Bron S, Luxen E, Swart P. Instability of recombinant pUB110 plasmids in Bacillus subtilis: plasmid-encoded stability function and effects of DNA inserts. Plasmid. 1988;19:231–241.
   PubMed Web of Science ®Google Scholar
• Band L, Henner DJ. Bacillus subtilis requires a “stringent” Shine-Dalgarno region for gene expression. DNA. 1984;3:17–21.
   PubMedGoogle Scholar