522
Views
3
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology

Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ

, , , , , ORCID Icon, , , , , & show all
Pages 243-250 | Received 03 Aug 2018, Accepted 03 Oct 2018, Published online: 21 Oct 2018

References

  • Canessa CM, Horisberger JD, Rossier BC. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 1993;361(6411):467.
  • Canessa CM, Schild L, Buell G, et al. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994;367(6462):463.
  • Kellenberger S, Gautschi I, Schild L. An external site controls closing of the epithelial Na+ channel ENaC. J Physiol. 2002;543(2):413–424.
  • Waldmann R, Champigny G, Bassilana F, et al. Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem. 1995;270(46):27411–27414.
  • Yamamura H, Ugawa S, Ueda T, et al. Protons activate the δ-subunit of the epithelial Na+ channel in humans. J Biol Chem. 2004;279(13):12529–12534.
  • Staruschenko A, Adams E, Booth RE, et al. Epithelial Na+ channel subunit stoichiometry. Biophys J. 2005;88(6):3966–3975.
  • Kretz O, Barbry P, Bock R, et al. Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat. J Histochem Cytochemistry. 1999;47(1):51–64.
  • Lin W, Finger TE, Rossier BC, et al. Epithelial Na+ channel subunits in rat taste cells: localization and regulation by aldosterone. J Comp Neurol. 1999;405(3):406–420.
  • Brand JG, Teeter JH, Silver WL. Inhibition by amiloride of chorda tympani responses evoked by monovalent salts. Brain Res. 1985;334(2):207–214.
  • Ninomiya Y, Funakoshi M. Amiloride inhibition of responses of rat single chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res. 1988;451(1–2):319–325.
  • Chandrashekar J, Kuhn C, Oka Y, et al. The cells and peripheral representation of sodium taste in mice. Nature. 2010;464(7286):297.
  • Geller DS, Rodriguez-Soriano J, Boado AV, et al. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat Genet. 1998;19(3):279.
  • Kellenberger S, Gautschi I, Rossier BC, et al. Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system. J Clin Invest. 1998;101(12):2741–2750.
  • Mall M, Grubb BR, Harkema JR, et al. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med. 2004;10(5):487.
  • Baker E, Jeunemaitre X, Portal AJ, et al. Abnormalities of nasal potential difference measurement in Liddle’s syndrome. J Clin Invest. 1998;102(1):10–14.
  • Lu M, Echeverri F, Kalabat D, et al. Small molecule activator of the human epithelial sodium channel. J Biol Chem. 2008;283(18):11981–11994.
  • Chang, SS, Grunder, S, et al. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet. 1996;12(3):248.
  • Zhang JH, Chung TD, Oldenburg KR. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen. 1999;4(2):67–73.
  • Michael. L, Eleanor W, Sommerville J. Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes. Nucleic Acids Res. 1997;25(5):965–973.
  • Rauh R, Soell D, Haerteis S, et al. A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect. Am J Physiology-Lung Cell Mol Physiol. 2012;304(1):L43–L55.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.