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Biochemistry & Molecular Biology

A designed cell-penetrating human SOCS2 protein suppresses GH-dependent cancer cell proliferation

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Pages 300-308 | Received 03 Sep 2018, Accepted 07 Oct 2018, Published online: 22 Oct 2018

References

  • Goldenberg N, Barkan A. Factors regulating growth hormone secretion in humans. Endocrinol Metabolism Clinics North America. 2007;36:37–55.
  • Boguszewski CL, Boguszewski MC, Kopchick JJ. Growth hormone, insulin-like growth factor system and carcinogenesis. Endokrynol Pol. 2016;67:414–426.
  • Chanson P, Salenava S, Kamenicky P. Acromegaly. Handb Clin Neurol. 2014;124:197–219.
  • Ahmed SF, Farquharson C. The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins. J Endocrinol. 2010;206:249–259.
  • Greenhalgh CJ, Bartolino P, Asa SL, et al. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol. 2002;16:1394–1406.
  • Greenhalgh CJ, Rico-Bautista E, Lorentzon M, et al. SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest. 2005;115:397–406.
  • Chen M, Wei L, Law C-T, et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Hepatology. 2018;67:2254–2270.
  • Cui M, Sun J, Hou J, et al. The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma. Tumour Biol. 2016;37:13521–13531.
  • Jiang C, Long J, Liu B, et al. miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma. J Exp Clin Cancer Res. 2017;36:99.
  • Zhou Y, Zhang Z, Wang N, et al. Suppressor of cytokine signalling-2 limits IGF1R-mediated regulation of epithelial-mesenchymal transition in lung adenocarcinoma. Cell Death Dis. 2018;9:429.
  • Haffner MC, Petridou B, Peyrat JP, et al. Favorable prognostic value of SOCS2 and IGF-I in breast cancer. BMC Cancer. 2007;7:136.
  • Farabegoli F, Ceccarelli C, Santini D, et al. Suppressor of cytokine signalling 2 (SOCS-2) expression in breast carcinoma. J Clin Pathol. 2005;58:1046–1050.
  • Iglesias-Gato D, Chuan YC, Wikström P, et al. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer. Carcinogenesis. 2014;35:24–33.
  • Hendriksen PJ, Dits NF, Kokame K, et al. Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Res. 2006;66:5012–5020.
  • Misawa A, Takayama K, Urano T, et al. Androgen-induced long noncoding RNA (lncRNA) SOCS2-AS1 promotes cell growth and inhibits apoptosis in prostate cancer cells. J Biol Chem. 2016;291:17861–17880.
  • Das R, Gregory PA, Fernandes RC, et al. MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2. Cancer Res. 2017;77:1021–1034.
  • Jo D, Liu D, Yao S, et al. Hawiger J Intercellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat Med. 2005;11:892–898.
  • Ohno Y, Suzuki-Takedachi K, Yasunaga S, et al. Manipulation of cell cycle and chromatin configuration by means of cell-penetrating geminin. PLoS One. 2016;11:e0155558.
  • Choi JM, Shin JH, Sohn MH, et al. Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation. Proc Natl Acad Sci USA. 2010;107:18575–18580.
  • Zhou H, Wu S, Joo JY, et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell. 2009;4:381–384.
  • Oho M, Nakano R, Nakayama R, et al. TIPE2 (tumor necrosis factor α-induced protein 8-like 2) is a novel negative regulator of TAK1 signal. J Biol Chem. 2016;291:22650–22660.
  • Masuhiro Y, Kayama K, Fukushima A, et al. SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell cycle progression via interaction with DP-1. J Biol Chem. 2008;283:31575–31583.
  • Greenhalgh CJ, Metcalf D, Thaus AL, et al. Biological evidence that SOCS-2 can ACT either as an enhancer or suppressor of growth hormone signaling. J Biol Chem. 2002;277:40181–40184.

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