Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3

References

• Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001 Apr;81:629–683.
   PubMed Web of Science ®Google Scholar
• Kosfeld M, Heinrichs M, Zak PJ, et al. Oxytocin increases trust in humans. Nature. 2005 Jun;435:673–676.
   PubMed Web of Science ®Google Scholar
• Jones C, Barrera I, Brothers S, et al. Oxytocin and social functioning. Dialogues Clin Neurosci. 2017 Jun;19:193–201.
   PubMed Web of Science ®Google Scholar
• Maejima Y, Sakuma K, Santoso P, et al. Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett. 2014 Nov;588:4404–4412.
   PubMed Web of Science ®Google Scholar
• Maejima Y, Rita RS, Santoso P, et al. Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology. 2015 Jan;101:35–44.
   PubMed Web of Science ®Google Scholar
• Maejima Y, Iwasaki Y, Yamahara Y, et al. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY). 2011 Dec;3:1169–1177.
   PubMedGoogle Scholar
• Lawson EA, Marengi DA, Desanti RL, et al. Schoenfeld DA and Tolley CJ. Oxytocin reduces caloric intake in men. Obesity (Silver Spring). 2015 May;23:950–956.
   PubMed Web of Science ®Google Scholar
• Zhang H, Wu C, Chen Q, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One. 2013 May;8:e61477.
   PubMed Web of Science ®Google Scholar
• Ludwig M, Leng G. Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci. 2006 Feb;7:126–136.
   PubMed Web of Science ®Google Scholar
• Rudy B, Maffie J, Amarillo Y, et al. Voltage gated potassium channels: structure and function of Kv1 to Kv9 Subfamilies. In: Editor Larry R, editor. Squire editor. encyclopedia of neuroscience. Massachusetts: Academic Press; 2009. p. 397–425.
   Google Scholar
• Fisher TE, Voisin DL, Bourque CW. Density of transient K+ current influences excitability in acutely isolated vasopressin and oxytocin neurones of rat hypothalamus. J Physiol. 1998 Sep;511:423–432.
   PubMed Web of Science ®Google Scholar
• Serôdio P, Rudy B. Differential expression of Kv4 K+ channel subunits mediating subthreshold transient K+ (A-type) currents in rat brain. J Neurophysiol. 1998 Feb;79:1081–1091.
   PubMed Web of Science ®Google Scholar
• Lee SK, Lee S, Shin SY, et al. Single cell analysis of voltage-gated potassium channels that determines neuronal types of rat hypothalamic paraventricular nucleus neurons. Neuroscience. 2012 Mar;205:49–62.
   PubMed Web of Science ®Google Scholar
• Bondy CA, Gainer H, Russell JT. Effects of stimulus frequency and potassium channel blockade on the secretion of vasopressin and oxytocin from the neurohypophysis. Neuroendocrinology. 1987 Sep;46:258–267.
   PubMed Web of Science ®Google Scholar
• Racké K, Altes U, Baur AM, et al. Differential effects of potassium channel blockers on neurohypophysial release of oxytocin and vasopressin. Evidence for frequency-dependent interaction with the endogenous opioid inhibition of oxytocin release. Naunyn Schmiedebergs Arch Pharmacol. 1988 Nov;338:560–566.
   PubMed Web of Science ®Google Scholar
• Katoh A, Fujihara H, Ohbuchi T, et al. Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats. Endocrinology. 2011 Jul;152:2768–2774.
   PubMed Web of Science ®Google Scholar
• Diochot S, Drici M-D, Moinier D, et al. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol. 1999 Jan;126:251–263.
   PubMed Web of Science ®Google Scholar
• Maejima Y, Takahashi S, Takasu K, et al. Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus. Neuroreport. 2017 Apr;28:360–366.
   PubMed Web of Science ®Google Scholar
• Sonner PM, Stern JE. Functional role of A-type potassium currents in rat presympathetic PVN neurones. J Physiol. 2007 Aug;582:1219–1238.
   PubMed Web of Science ®Google Scholar
• Carrasquillo Y, Burkhalter A, Nerbonne JM. A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons. J Physiol. 2012 Aug;590:3877–3890.
   PubMed Web of Science ®Google Scholar
• Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest. 2005 Aug;115:2047–2058.
   PubMed Web of Science ®Google Scholar
• MacDonald PE, Wheeler MB. Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. Diabetologia. 2003 Aug;46:1046–1062.
   PubMed Web of Science ®Google Scholar
• Rita RS, Dezaki K, Kurashina T, et al. Partial blockade of Kv2.1 channel potentiates GLP-1’s insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice. Endocrinology. 2015 Jan;156:114–123.
   PubMed Web of Science ®Google Scholar
• Maejima Y, Horita S, Kobayashi D, et al. Nesfatin-1 inhibits voltage gated K+ channels in pancreatic beta cells. Peptides. 2017 Sep;95:10–15.
   PubMed Web of Science ®Google Scholar
• Jerng HH, Pfaffinger PJ. Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci. 2004 Dec;27:343–369.
   PubMed Web of Science ®Google Scholar
• Liss B, Franz O, Sewing S, et al. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. Embo J. 2001 Oct;20:5715–5724.
   PubMed Web of Science ®Google Scholar
• Brimble MJ, Dyball REJ, Forsling ML. Oxytocin release following osmotic activation of oxytocin neurones in the paraventricular and supraoptic nuclei. J Physiol. 1978 May;278:69–78.
   PubMed Web of Science ®Google Scholar
• Hoffman DA, Magee JC, Colbert CM, et al. K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 1997 Jun;387:869–875.
   PubMed Web of Science ®Google Scholar
• Chen C. beta-Amyloid increases dendritic Ca2+ influx by inhibiting the A-type K+ current in hippocampal CA1 pyramidal neurons. Biochem Biophys Res Commun. 2005 Dec;338:1913–1919.
   PubMed Web of Science ®Google Scholar
• Sah P, Davies P. Calcium-activated potassium currents in mammalian neurons. Clin Exp Pharmacol Physiol. 2000 Sep;27:657–663.
   PubMed Web of Science ®Google Scholar