350
Views
6
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology

Protamine may have anti-atherogenic potential by inhibiting the binding of oxidized-low density lipoprotein to LOX-1

, , , &
Pages 1094-1101 | Received 28 Nov 2018, Accepted 07 Feb 2019, Published online: 15 Mar 2019

References

  • Steinberg D. The LDL modification hypothesis of atherogenesis: an update. J Lipid Res. 2008;50:S376–S381.
  • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317–325.
  • Di Pietro N, Formoso G, Pandolfi A. Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis. Vascul Pharmacol. 2016;84:1–7.
  • Moore KJ, Freeman MW. Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol. 2006;26:1702–1711.
  • Pirillo A, Norata GD, Catapano AL. LOX-1, oxLDL, and atherosclerosis. Mediators Inflamm. 2013;2013:152786.
  • Lubrano V, Balzan S. Roles of LOX-1 in microvascular dysfunction. Microvasc Res. 2016;105:132–140.
  • Chistiakov DA, Orekhov AN, Bobryshev YV. LOX-1-mediated effects on vascular cells in atherosclerosis. Cell Physiol Biochem. 2016;38:1851–1859.
  • Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386:73–77.
  • Khaidakov M, Mitra S, Wang X, et al. Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. PLoS One. 2012;7:e47421.
  • Chen M, Narumiya S, Masaki T, et al. Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem J. 2001;355:289–296.
  • Chen MY, Inoue K, Narumiya S, et al. Requirements of basic amino acid residues within the lectin- like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett. 2001;499:215–219.
  • Park H, Adsit FG, Boyington JC. The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1. J Biol Chem. 2005;280:13593–13599.
  • Ohki I, Ishigaki T, Oyama T, et al. Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure. 2005;13:905–917.
  • Steinbrecher UP. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J Biol Chem. 1987;262:3603–3608.
  • Zhang H, Yang Y, Steinbrecher UP. Structural requirements for the binding of modified proteins to the scavenger receptor of macrophages. J Biol Chem. 1993;268:5535–5542.
  • Levi M, Eerenberg E, Kamphuisen PW. Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents. J Thromb Haemost. 2011;9:1705–1712.
  • Baracchini C, Ballotta E. The benefit of heparin reversal with protamine during carotid endarterectomy. JAMA Surg. 2016;151:255–256.
  • Nybo M, Madsen JS. Serious anaphylactic reactions due to protamine sulfate: a systematic literature review. Basic Clin Pharmacol Toxicol. 2008;103:192–196.
  • Kusuhara M, Chait A, Cader A, et al. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol. 1997;17:141–148.
  • Apostolov EO, Basnakian AG, Yin X, et al. Modified LDLs induce proliferation-mediated death of human vascular endothelial cells through MAPK pathway. Am J Physiol Heart Circ Physiol. 2007;292:H1836–H1846.
  • Tanigawa H, Miura S, Zhang B, et al. Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1. Atherosclerosis. 2006;188:245–250.
  • Biocca S, Falconi M, Filesi I, et al. Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity. PLoS One. 2009;4:e4648.
  • Zhang Z, Zhang M, Li Y, et al. Simvastatin inhibits the additive activation of ERK1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stress and oxLDL through LOX-1 pathway. Cell Signal. 2013;25:332–340.
  • Tsai KL, Chang YL, Huang PH, et al. Ginkgo biloba extract inhibits oxidized low-density lipoprotein (oxLDL)-induced matrix metalloproteinase activation by the modulation of the lectin-like oxLDL receptor 1-regulated signaling pathway in human umbilical vein endothelial cells. J Vasc Surg. 2016;63:204–215.e1.
  • Shojima K, Sato A, Hanaki H, et al. Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci Rep. 2015;5:8042.
  • Kumano-Kuramochi M, Shimozu Y, Wakita C, et al. Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Biochem J. 2012;442:171–180.
  • Vohra RS, Murphy JE, Walker JH, et al. Functional refolding of a recombinant C-type lectin-like domain containing intramolecular disulfide bonds. Protein Expr Purif. 2007;52:415–421.
  • Sato Y, Nishimichi N, Nakano A, et al. Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB. Atherosclerosis. 2008;200:303–309.
  • Kar NS, Ashraf MZ, Valiyaveettil M, et al. Mapping and characterization of the binding site for specific oxidized phospholipids and oxidized low density lipoprotein of scavenger receptor CD36. J Biol Chem. 2008;283:8765–8771.
  • Doi T, Higashino KI, Kurihara Y, et al. Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors. J Biol Chem. 1993;268:2126–2133.
  • Platt N, Gordon S. Is the class A macrophage scavenger receptor (SR-A) multifunctional? — the mouse ’ s tale. J Clin Investig. 2001;108:649–654.
  • Kajikawa M, Ohta T, Takase M, et al. Lactoferrin inhibits cholesterol accumulation in macrophages mediated by acetylated or oxidized low-density lipoproteins. Biochim Biophys Acta. 1994;1213:82–90.
  • Kakino A, Fujita Y, Nakano A, et al. Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice. Circ J. 2016;80:2541–2549.
  • Suginohara Y, Miyazaki A, Hakamata H, et al. The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages. Atherosclerosis. 1996;120:167–179.
  • Francone OL, Tu M, Royer LJ, et al. The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding. J Lipid Res. 2009;50:546–555.
  • Falconi M, Ciccone S, D’Arrigo P, et al. Design of a novel LOX-1 receptor antagonist mimicking the natural substrate. Biochem Biophys Res Commun. 2013;438:340–345.
  • Thakkar S, Wang X, Khaidakov M, et al. Structure-based design targeted at LOX-1, a receptor for oxidized low-density lipoprotein. Sci Rep. 2015;5:16740.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.