800
Views
23
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology

Production of lycopene by metabolically engineered Pichia pastoris

, , , , &
Pages 463-470 | Received 24 Jun 2019, Accepted 04 Nov 2019, Published online: 22 Nov 2019

References

  • Grether-Beck S, Marini A, Jaenicke T, et al. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study. Br J Dermatol. 2017 May;176(5):1231–1240.
  • Lee PC, Momen AZ, Mijts BN, et al. Biosynthesis of structurally novel carotenoids in Escherichia coli. Chem Biol. 2003;10(5):453–462.
  • Sies H, Stahl W. Lycopene: antioxidant and biological effects and its bioavailability in the human. Pro Soc Exp Biol Med. 1998;218(2):121–124.
  • Sun T, Miao L, Li Q, et al. Production of lycopene by metabolically-engineered Escherichia coli. Biotechnol Lett. 2014 Jul;36(7):1515–1522.
  • Levesque F, Seeberger PH. Continuous-flow synthesis of the anti-malaria drug artemisinin. Angew Chem. 2012 Feb 13;51(7):1706–1709.
  • Araya-Garay JM, Feijoo-Siota L, Rosa-dos-Santos F, et al. Construction of new Pichia pastoris X-33 strains for production of lycopene and beta-carotene. Appl Microbiol Biotechnol. 2012 Mar;93(6):2483–2492.
  • Xie W, Lv X, Ye L, et al. Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering. Metab Eng. 2015 July 1;30:69–78.
  • Zhu F, Lu L, Fu S, et al. Targeted engineering and scale up of lycopene overproduction in Escherichia coli. Process Biochem. 2015;50(3):341–346.
  • Macauley-Patrick S, Fazenda ML, McNeil B, et al. Heterologous protein production using the Pichia pastoris expression system. Yeast. 2005 Mar;22(4):249–270.
  • Ramon A, Marin M. Advances in the production of membrane proteins in Pichia pastoris. Biotechnol J. 2011 Jun;6(6):700–706.
  • Wriessnegger T, Augustin P, Engleder M, et al. Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastoris. Metab Eng. 2014 Jul;24:18–29.
  • Jeong E, Shim WY, Kim JH. Metabolic engineering of Pichia pastoris for production of hyaluronic acid with high molecular weight. J Biotechnol. 2014 Sep;20(185):28–36.
  • Bhataya A, Schmidt-Dannert C, Lee PC. Metabolic engineering of Pichia pastoris X-33 for lycopene production. Process Biochem. 2009;44(10):1095–1102.
  • Cregg JM, Tolstorukov I, Kusari A, et al. Expression in the yeast pichia pastoris. Methods Enzymol. 2009;463:169-189.
  • Li C, Lin Y, Zheng X, et al. Recycling of a selectable marker with a self-excisable plasmid in Pichia pastoris. Sci Rep. 2017 Sep 11;7(1):11113.
  • Li X, Wang Z, Zhang G, et al. Improving lycopene production in Saccharomyces cerevisiae through optimizing pathway and chassis metabolism. Chem Eng Sci. 2019;193:364–369.
  • Misawa N. Pathway engineering for functional isoprenoids. Curr Opin Biotechnol. 2011 Oct;22(5):627–633.
  • Paradise EM, Kirby J, Chan R, et al. Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. Biotechnol Bioeng. 2008 Jun 1;100(2):371–378.
  • Rico J, Pardo E, Orejas M. Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae. Appl Environ Microbiol. 2010 Oct;76(19):6449–6454.
  • Ma T, Shi B, Ye Z, et al. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metab Eng. 2019 Mar;52:134–142.
  • Verwaal R, Jiang Y, Wang J, et al. Heterologous carotenoid production in Saccharomyces cerevisiae induces the pleiotropic drug resistance stress response. Yeast. 2010 Dec;27(12):983–998.
  • Song MC, Kim EJ, Kim E, et al. Microbial biosynthesis of medicinally important plant secondary metabolites. Nat Prod Rep. 2014 Nov;31(11):1497–1509.
  • Mantzouridou F, Tsimidou MZ. Lycopene formation in Blakeslea trispora chemical aspects of a bioprocess. Trends Food Sci Technol. 2008;19(7):363–371.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.