Autophagy promotion enhances the protective effect of Morroniside on human OA chondrocyte

References

• Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010; 18: 476–499.
   PubMed Web of Science ®Google Scholar
• Matheson AJ, Perry CM. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging. 2003;20:1041–1060.
   PubMed Web of Science ®Google Scholar
• Kronenberg HM. Developmental regulation of the growth plate. Nature. 2003;423:332–336.
   PubMed Web of Science ®Google Scholar
• Hashimoto S, Nishiyama T, Hayashi S, et al. Role of p53 in human chondrocyte apoptosis in response to shear strain. Arthritis Rheum. 2009;60:2340–2349.
   PubMedGoogle Scholar
• Luo HR, Hattori H, Hossain MA, et al. Akt as a mediator of cell death. Proc Natl Acad Sci U S A. 2003;100:11712–11717.
   PubMed Web of Science ®Google Scholar
• Huang JG, Xia C, Zheng XP, et al. 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway. Cell Mol Biol Lett. 2011;16:564–575.
   PubMed Web of Science ®Google Scholar
• Cheng L, Zeng G, Liu Z, et al. Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes. J Cell Mol Med. 2015;19:1877–1886.
   PubMed Web of Science ®Google Scholar
• Michigami T. Current understanding on the molecular basis of chondrogenesis. Clin Pediatr Endocrinol. 2014;23:1–8.
   PubMedGoogle Scholar
• Shapiro IM, Adams CS, Freeman T, et al. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res C Embryo Today. 2005;75:330–339.
   PubMedGoogle Scholar
• Srinivas V, Bohensky J, Zahm AM, et al. Autophagy in mineralizing tissues: microenvironmental perspectives. Cell Cycle. 2009;8:391–393.
   PubMed Web of Science ®Google Scholar
• Bohensky J, Shapiro IM, Leshinsky S, et al. HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway. Autophagy. 2007;3:207–214.
   PubMed Web of Science ®Google Scholar
• Lian WS, Ko JY, Wu RW, et al. MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12. Cell Death Dis. 2018;9:919.
   PubMed Web of Science ®Google Scholar
• Bouderlique T, Vuppalapati KK, Newton PT, et al. Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis. Ann Rheum Dis. 2016;75:627–631.
   PubMed Web of Science ®Google Scholar
• Fullgrabe J, Klionsky DJ, Joseph B. The return of the nucleus: transcriptional and epigenetic control of autophagy. Nat Rev Mol Cell Biol. 2014;15:65–74.
   PubMed Web of Science ®Google Scholar
• Attur MG, Dave M, Cipolletta C, et al. Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. J Biol Chem. 2000;275:40307–40315.
   PubMed Web of Science ®Google Scholar
• Zeng G, Cui X, Liu Z, et al. Disruption of phosphoinositide-specific phospholipases Cγ1 contributes to extracellular matrix synthesis of human osteoarthritis chondrocytes. Int J Mol Sci. 2014;15:13236–13246.
   PubMed Web of Science ®Google Scholar
• Saiki S, Sasazawa Y, Imamichi Y, et al. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy. 2011;7:176–187.
   PubMed Web of Science ®Google Scholar
• Wang X, Qi H, Wang Q, et al. FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia. Autophagy. 2015;11:1998–2013.
   PubMed Web of Science ®Google Scholar
• Ke D, Fu X, Xue Y, et al. IL-17A regulates the autophagic activity of osteoclast precursors through RANKL-JNK1 signaling during osteoclastogenesis in vitro. Biochem Biophys Res Commun. 2018;497:890–896.
   PubMed Web of Science ®Google Scholar
• Ni Z, Wang B, Dai X, et al. HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS-JNK-autophagy pathway. Free Radic Biol Med. 2014;70:194–203.
   PubMed Web of Science ®Google Scholar
• Wu X, Pan G, McKenna MA, et al. RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts. J Bone Miner Res. 2005;20:107–116.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1–222.
   PubMed Web of Science ®Google Scholar
• Wang B, Zhong Y, Li Q, et al. Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy. Aging (Albany NY). 2018;10:2772–2782.
   PubMedGoogle Scholar
• Xue JF, Shi ZM, Zou J, et al. Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacother. 2017;89:1252–1261.
   PubMed Web of Science ®Google Scholar
• Liu WJ, Luo MN, Tan J, et al. Autophagy activation reduces renal tubular injury induced by urinary proteins. Autophagy. 2014;10:243–256.
   PubMed Web of Science ®Google Scholar
• Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926–1945.
   PubMed Web of Science ®Google Scholar
• Yan B, Zhang Z, Jin D, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151.
   PubMed Web of Science ®Google Scholar
• Lai LP, Lilley BN, Sanes JR, et al. Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013;110:19450–19455.
   PubMed Web of Science ®Google Scholar