Flurbiprofen-loaded interpenetrating polymer network beads based on alginate, polyvinyl alcohol and methylcellulose: design, characterization and in-vitro evaluation

References

• Vijay S, Sati OP, Majumdar DK. Acrylic acid–methyl methacrylate (2.5:7.5/2:8) enteric copolymer for colon targeted drug delivery. J Mater Sci Mater Med. 2011;22(1):125–135.
   PubMed Web of Science ®Google Scholar
• Malipeddi VR, Dua K, Awasthi R. Development and characterization of solid dispersion-microsphere controlled release system for poorly water-soluble drug. Drug Deliv Transl Res. 2016;6(5):540–550.
   PubMed Web of Science ®Google Scholar
• Kawadkar J, Chauhan MK. Intra-articular delivery of genipin cross-linked chitosan microspheres of flurbiprofen: preparation, characterization, in vitro and in vivo studies. Eur J Pharm Biopharm. 2012;81(3):563–572.
   PubMed Web of Science ®Google Scholar
• Kausalya J, Eswari JL, Priya SP, et al. Design, development and evaluation of pulsatile drug delivery of flurbiprofen microspheres. J Pharm Res. 2011;4(6):1614–1616.
   Google Scholar
• Insel PA. Analgesic-Antipyretic and anti-inflammatory agents and drug employed in the treatment of gout. In: Hardman JG, Limbird LE, editors. Goodman & Gilman’s the pharmacological basis of therapeutics. New York: McGraw-Hill;1996. p. 617–665.
   Google Scholar
• Coimbra PA, De Sousa HC, Gil MH. Preparation and characterization of flurbiprofen-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microspheres. J Microencapsul. 2008;25(3):170–178.
   PubMed Web of Science ®Google Scholar
• Naeem M, Rahman NU, Tavares G, et al. Physicochemical, in vitro and in vivo evaluation of flurbiprofen microemulsion. An Acad Bras Cienc. 2015;87(3):1823–1831.
   PubMed Web of Science ®Google Scholar
• Kawadkar J, Jain R, R, Kishore R, et al. Formulation and evaluation of flurbiprofen-loaded genipin cross-linked gelatin microspheres for intra-articular delivery. J Drug Target. 2013;21(2):200–210.
   PubMed Web of Science ®Google Scholar
• Lu Y, Zhang G, Sun D, et al. Preparation and evaluation of biodegradable flubiprofen gelatin micro-spheres for intra-articular administration. J Microencap. 2007;24(6):515–524.
   PubMed Web of Science ®Google Scholar
• Akyüz L, Duman F, Kaya M. Encapsulation of flurbiprofen by chitosan using a spray-drying method with in vitro drug releasing and molecular docking. TJPS. 2017;14(1):34–39.
   Google Scholar
• Bae YH, Kim SW. Hydrogel delivery systems based on polymer blends, block copolymers, and interpenetrating networks. Adv Drug Delivery Rev. 1993;11(1-2):109–135.
   Web of Science ®Google Scholar
• Pulat M, Uğurlu N. Preparation and characterization of biodegradable gelatin-PAAm-based IPN hydrogels for controlled release of maleic acid to improve the solubility of phosphate fertilizers. Soft Mater. 2016;14(4):217–227.
   Web of Science ®Google Scholar
• Bhattacharya SS, Mishra A, Pal D, et al. Synthesis and characterization of poly(acrylic acid)/poly(vinyl alcohol)-xanthan gum interpenetrating network (IPN) superabsorbent polymeric composites. Polym Plast Technol Eng. 2012;51(9):878–884.
   Web of Science ®Google Scholar
• Krishna Rao KSV, Naidu BVK, Subha MCS, et al. Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil. Carbohydr Polym. 2006;66(3):333–344.
   Web of Science ®Google Scholar
• Rokhade AP, Patil SA, Aminabhavi TM. Synthesis and characterization of semi-interpenetrating polymer network microspheres of acrylamide grafted dextran and chitosan for controlled release of acyclovir. Carbonhydr. Polym. 2007;67(4):605–613.
   Web of Science ®Google Scholar
• AL-Kahtani Ahmed A, Naik HSB, Sherigara BS. Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium. Carbohydr. Res. 2009;344(5):699–706.
   PubMed Web of Science ®Google Scholar
• Kajjari PB, Manjeshwar LS, Aminabhavi TM. Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline. Ind Eng Chem Res. 2011;50(13):7833–7840.
   Web of Science ®Google Scholar
• Wang Q, Wang W, Wu J, et al. Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac. J Appl Polym Sci. 2012;124:4424–4432.
   Web of Science ®Google Scholar
• Maiti S, Singha K, Ray S, et al. Adipic acid dihydrazide treated partially oxidized alginate beads for sustained oral delivery of flurbiprofen. Pharm Dev Technol. 2009;14(5):461–470.
   PubMed Web of Science ®Google Scholar
• Babu R, Sairam M, Hosamani KM, et al. Preparation of sodium alginate–methylcellulose blend microspheres for controlled release of nifedipine. Carbohydr Polym. 2007;69(2):241–250.
   Web of Science ®Google Scholar
• Bulut E, Şanlı O. Optimization of release conditions of Alzheimer’s drug donepezil hydrochloride from sodium alginate/sodium carboxymethyl cellulose blend microspheres. J Macromol Sci B Phys. 2014;53(5):902–917.
   Web of Science ®Google Scholar
• Şanlı O, Biçer E, Işıklan N. In vitro release study of diltiazem hydrochloride from poly(vinyl pyrrolidone)/sodium alginate blend microspheres. J Appl Polym Sci. 2008;107(3):1973–1980.
   Web of Science ®Google Scholar
• Sullad AG, Manjeshwar LS, Aminabhavi TM. Controlled release of theophylline from interpenetrating blend microspheres of poly(vinyl alcohol) and methyl cellulose. J Appl Polym Sci. 2010;116:1226–1235.
   Web of Science ®Google Scholar
• Ray R, Maity S, Mandal S, et al. Studies on the release of ibuprofen from Al3+ ion cross-linked homopolymeric and interpenetrating network hydrogel beads of carboxymethyl xanthan and sodium alginate. Adv Polym. Technol. 2011;30(1):1–11.
   Web of Science ®Google Scholar
• Mandal S, Basu SK, Sa B. Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydr Polym. 2010;82(3):867–873.
   Web of Science ®Google Scholar
• Ramesh Babu V, Krishna Rao KSV, Sairam M, et al. pH sensitive interpenetrating network microgels of sodium alginate-acrylic acid for the controlled release of ibuprofen. J Appl Polym Sci. 2006;99(5):2671–2678.
   Web of Science ®Google Scholar
• Angadi SC, Manjeshwar LS, Aminabhavi TM. Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin. Int J Biol Macromol. 2012;51(1-2):45–55.
   PubMed Web of Science ®Google Scholar
• Bulut E, Dilek M. Development and characterization of pH-sensitive locust bean gum-alginate microspheres for controlled release of ibuprofen. J Drug Del Sci Tech. 2014;24(6):613–619.
   Web of Science ®Google Scholar
• Zheng CH, Gao JQ, Zhang YP, et al. A protein delivery system: biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres. Biochem Biophys Res Commun. 2004;323(4):1321–1327.
   PubMed Web of Science ®Google Scholar
• Tahtat D, Mahlous M, Benamer S, et al. Oral delivery of insulin from alginate/chitosan crosslinked by glutaraldehyde . Int J Biol Macromol. 2013;58:160–168.
   PubMed Web of Science ®Google Scholar
• Ghosal K, Adak S, Agatemor C, et al. Novel interpenetrating polymeric network based microbeads for delivery of poorly water soluble drug. J Polymer Res. 2020;27:98.
   Web of Science ®Google Scholar
• Park J-S, Park J-W, Ruckenstein E. Thermal and dynamic mechanical analysis of PVA/MC blend hydrogels. Polymer. 2001;42(9):4271–4280.
   Web of Science ®Google Scholar
• Xiong L, He Z. Release behavior and cytotoxicity of poly(vinyl alcohol)/chitosan blend microspheres containing 2,4-dihydroxy-5-fluoropyrimidine. Polym Plast Technol Eng. 2012;51(7):729–733.
   Web of Science ®Google Scholar
• Bulut E. Chitosan coated- and uncoated-microspheres of sodium carboxymethyl cellulose/polyvinyl alcohol crosslinked with ferric ion: flurbiprofen loading and in vitro drug release study. J Macromol Sci Part A Pure Appl Chem. 2020;57(1):72–82.
   Google Scholar
• Sullad AG, Manjeshwar LS, Aminabhavi TM. Novel semi-interpenetrating microspheres of Dextran-grafted-acrylamide and poly(vinyl alcohol) for controlled release of abacavir sulfate. Ind Eng Chem Res. 2011;50(21):11778–11784.
   Web of Science ®Google Scholar
• Ganguly K, Aminabhavi TM, Kulkarni AR. Colon targeting of 5-fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate. Ind Eng Chem Res. 2011;50(21):11797–11807.
   Web of Science ®Google Scholar
• Phadke KV, Manjeshwar LS, Aminabhavi TM, et al. Cellulose acetate butyrate bilayer coated microspheres for controlled release of ciprofloxacin. Polym Bull. 2018;75(3):1329–1348.
   Web of Science ®Google Scholar
• Peppas NA. Analysis of Fickian and non-Fickian drug release from polymer. Pharm Acta Helv. 1985;60(4):110–111.
   PubMedGoogle Scholar
• Bulut E. In-vitro evaluation of ibuprofen-loaded microspheres prepared from novel chitosan/poly(vinyl alcohol) interpenetrating polymer network. Polym Plast Technol Eng. 2014;53(4):371–378.
   Web of Science ®Google Scholar
• Bulut E, Şanlı O. Novel ionically crosslinked acrylamide-grafted poly(vinyl alcohol)/sodium alginate/sodium carboxymethyl cellulose pH-sensitive microspheres for delivery of Alzheimer's drug donepezil hydrochloride: preparation and optimization of release conditions. Artif Cells Nanomed Biotechnol. 2016;44(2):431–442.
   PubMed Web of Science ®Google Scholar
• Sanli O, Ay N, Işiklan N. Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads. Eur J Pharm Biopharm. 2007;65(2):204–214.
   PubMed Web of Science ®Google Scholar
• Kurkuri MD, Aminabhavi TM. Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. J Control Release. 2004;96(1):9–20.
   PubMed Web of Science ®Google Scholar
• Güncüm E, Işıklan N, Anlaş C, et al. Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin - an antimicrobial drug. Artif Cells Nanomed Biotechnol. 2018;46(sup2):964–973.
   PubMed Web of Science ®Google Scholar
• Rastogi R, Sultana Y, Aqil M, et al. Alginate microspheres of isoniazid for oral sustained drug delivery. Int J Pharm. 2007;334(1-2):71–77.
   PubMed Web of Science ®Google Scholar
• Bhattacharya SS, Ghosh AK, Banerjee S, et al. Al3+ ion cross-linked interpenetrating polymeric network microbeads from tailored natural polysaccharides. Int J Biol Macromol. 2012;51(5):1173–1184.
   PubMed Web of Science ®Google Scholar
• Dadsetan M, Taylor KE, Yong C, et al. Controlled release of doxorubicin from pH-responsive microgels. Acta Biomater. 2013;9(3):5438–5446.
   PubMed Web of Science ®Google Scholar
• Ritger PL, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release. 1987;5(1):37–42.
   Google Scholar