3D printing technology and applied materials in eardrum regeneration

References

• Kanemaru SI, Kanai R, Omori K, et al. Multicenter phase III trial of regenerative treatment for chronic tympanic membrane perforation. Auris Nasus Larynx. 2021;48(6):1054–1060.
   PubMed Web of Science ®Google Scholar
• Huang JT, Teh BM, Eikelboom RH, et al. The effectiveness of bFGF in the treatment of tympanic membrane perforations: a systematic review and meta-analysis. Otol Neurotol. 2020;41(6):782–790.
   PubMed Web of Science ®Google Scholar
• Jang CH, Kim W, Moon C, et al. Bioprinted collagen-based cell-laden scaffold with growth factors for tympanic membrane regeneration in chronic perforation model. IEEE Trans Nanobioscience. 2018;24(9):1536.
   Google Scholar
• Aleemardani M, Bagher Z, Farhadi M, et al. Can tissue engineering bring hope to the development of human tympanic membrane?. Tissue Eng Part B Rev. 2021;27(6):572–589.
   PubMed Web of Science ®Google Scholar
• Kuo CY, Wilson E, Fuson A, et al. Repair of tympanic membrane perforations with customized bioprinted ear grafts using chinchilla models. Tissue Eng Part A. 2018;24(5–6):527–535.
   PubMed Web of Science ®Google Scholar
• Kozin ED, Black NL, Cheng JT, et al. Design, fabrication, and in vitro testing of novel three-dimensionally printed tympanic membrane grafts. Hear Res. 2016;340:191–203.
   PubMed Web of Science ®Google Scholar
• Ali A, Hja B, Az C, et al. Experimentally validated vibro-acoustic modeling of 3D bio-printed grafts for potential use in human tympanic membrane regeneration. Bioprinting. 2022;25(3):e00186.
   Google Scholar
• Yao X, Teh BM, Li H, et al. Acellular collagen scaffold with basic fibroblast growth factor for repair of traumatic tympanic membrane perforation in a rat model. Otolaryngol Head Neck Surg. 2021;16(2):381–390.
   Google Scholar
• Ilhan E, Ulag S, Sahin A, et al. Fabrication of tissue-engineered tympanic membrane patches using 3D-Printing technology. J Mech Behav Biomed Mater. 2021;114:104219.
   PubMed Web of Science ®Google Scholar
• Jang CH, Ahn S, Lee JW, et al. Mesenchymal stem cell-laden hybrid scaffold for regenerating subacute tympanic membrane perforation. Mater Sci Eng C Mater Biol Appl. 2017;72:456–463.
   PubMed Web of Science ®Google Scholar
• Jang CH, Kim W, Moon C, et al. Bioprinted Collagen-Based Cell-Laden scaffold with growth factors for tympanic membrane regeneration in chronic perforation model. IEEE Trans Nanobioscience. 2022;21(3):370–379.
   PubMed Web of Science ®Google Scholar
• Anand S, Stoppe T, Lucena M, et al. Mimicking the human tympanic membrane: the significance of scaffold geometry. Adv Healthc Mater. 2021;10(11):e2002082.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim SW, Choi SJ, et al. A healing method of tympanic membrane perforations using three-dimensional porous chitosan scaffolds. Tissue Eng Part A. 2011;17(21–22):2763–2772.
   PubMed Web of Science ®Google Scholar
• Ali A, Hja B, Az C, et al. Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: a vibro-acoustic analysis. Compos C. 2021;10(6):100205.
   Google Scholar
• Danti S, Anand S, Azimi B, et al. Chitin nanofibril application in tympanic membrane scaffolds to modulate inflammatory and immune response. Pharmaceutics. 2021;13(9):1440–Published 2021 Sep 10.
   PubMed Web of Science ®Google Scholar
• Seonwoo H, Shin B, Jang KJ, et al. Epidermal growth Factor-Releasing radially aligned electrospun nanofibrous patches for the regeneration of chronic tympanic membrane perforations. Adv Healthc Mater. 2019;8(2):1–11.
   Web of Science ®Google Scholar
• Hussain Z, Ding P, Zhang L, et al. Multifaceted tannin crosslinked bioinspired dECM decorated nanofibers modulating cell-scaffold biointerface for tympanic membrane perforation bioengineering. Biomed Mater. 2022;17(3):10–1088.
   Web of Science ®Google Scholar
• Kim JY, Oh JH, Lee HH. Fascia versus cartilage graft in type I tympanoplasty: audiological outcome. J Craniofac Surg. 2012;23(6):605–608.
   PubMed Web of Science ®Google Scholar
• Parida PK, Nochikattil SK, Surianarayanan G, et al. A comparative study of temporalis fascia graft and vein graft in myringoplasty. Indian J Otolaryngol Head Neck Surg. 2013;65(Suppl 3):569–574.
   PubMedGoogle Scholar
• Kwong KM, Smith MM, Coticchia JM. Fat graft myringoplasty using umbilical fat. Int J Pediatr Otorhinolaryngol. 2012;76(8):1098–1101.
   PubMed Web of Science ®Google Scholar
• Chhapola S, Matta I. Cartilageperichondrium:-an ideal graft material?. Indian J Otolaryngol Head Neck Surg. 2012;64(3):208–213.
   PubMed Web of Science ®Google Scholar
• Ozgursoy OB, Yorulmaz I. Fat graft myringoplasty: a cost-effective but underused procedure. J Laryngol Otol. 2005;119(4):277–279.
   PubMed Web of Science ®Google Scholar
• Acar M, Yazıcı D, San T, et al. Fat-plug myringoplasty of ear lobule vs abdominal donor sites. Eur Arch Otorhinolaryngol. 2015;272(4):861–866.
   PubMed Web of Science ®Google Scholar
• Ilhan E, Ulag S, Sahin A, et al. Fabrication of tissue-engineered tympanic membrane patches using 3D-Printing technology. J Mech Behav Biomed Mater. 2021;11(4):104–119.
   Google Scholar
• Sagiv D, Chin OY, Diaz RC, et al. State of the art regeneration of the tympanic membrane. Curr Opin Otolaryngol Head Neck Surg. 2020;28(5):314–322.
   PubMed Web of Science ®Google Scholar
• Lee JM, Seo YJ, Shim DB, et al. Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study. Acta Otorhinolaryngol Ital. 2018;38(6):554–562.
   PubMed Web of Science ®Google Scholar
• Min J, Kim SH. Comparison of transcanal endoscopic tympanoplasty with sterile acellular dermal allograft to conventional endaural microscopic tympanoplasty with tragal perichondrium. Am J Otolaryngol. 2018;39(2):167–170.
   PubMed Web of Science ®Google Scholar
• Villar-Fernandez MA, Lopez-Escamez JA. Outlook for tissue engineering of the tympanic membrane. Audiol Res. 2015;5(1):117–124.
   PubMedGoogle Scholar
• Saeedi M, Ajalloueian M, Zare E, et al. The effect of PRP-enriched gelfoam on chronic tympanic membrane perforation: adouble-blind randomized clinical trial. Int Tinnitus J. 2017;21(2):108–111.
   PubMedGoogle Scholar
• Teh BM, Marano RJ, Shen Y, et al. Tissue engineering of the tympanic membrane. Tissue Eng B. 2013;19(11): 6–132.
   Google Scholar
• Lou ZC, He JG. A randomised controlled trial comparing spontaneous healing, gelfoam patching and edge-approximation plus gelfoam patching in traumatic tympanic membrane perforation with inverted or everted edges. Clin Otolaryngol. 2011;36(3):221–226.
   Web of Science ®Google Scholar
• Albera R, Dagna F, Lacilla M, et al. Equine versus bovine pericardium in transmeatal underlay myringoplasty. Ann Otol Rhinol Laryngol. 2009;118(4):287–291.
   PubMed Web of Science ®Google Scholar
• Miranda Araujo M, Tanaka Massuda E, Hyppolito M. Anatomical and functional evaluation of tympanoplasty using a transitory natural latex biomembrane implant from the rubber tree hevea brasiliensis. Acta Cirurgica Bras. 2012;27(8):566–571.
   Web of Science ®Google Scholar
• Huang, P, Zhang, S, Gong X, et al. Endoscopic observation of different repair patterns in human traumatic tympanic membrane perforations. Braz J Otorhinolaryngol. 2018;84(5):545–552.
   PubMed Web of Science ®Google Scholar
• Jin Z-H, Dong Y-H, Lou Z-H. The effects of fibroblast growth factor-2 delivered via a gelfoam patch on the regeneration of myringosclerotic traumatic eardrum perforations lying close to the malleus. Am J Otolaryngol. 2017;38(5):582–587.
   PubMed Web of Science ®Google Scholar
• Lou ZC, Lou Z. Efficacy of EGF and gelatin sponge for traumatic tympanic membrane perforations: a randomized controlled study. Otolaryngol Head Neck Surg. 2018;159(6):1028–1036.
   PubMed Web of Science ®Google Scholar
• Levin B, Redmond SL, Rajkhowa R, et al. Utilising silk fibroin membranes as scaffolds for the growth of tympanic membrane keratinocytes and application. J Laryngol Otol. 2013;127(S1):s13–S20.
   PubMedGoogle Scholar
• Hong P, Bance M, Gratzer PF. Repair of tympanic membrane perforation using novel adjuvant therapies: a contemporary review of experimental and tissue engineering studies. Int J Pediatr Otorhinolaryngol. 2013;77(1):3–12.
   PubMed Web of Science ®Google Scholar
• Shen Y, Redmond SL, Teh BM, et al. Tympanic membrane repair using silk fibroin and acellular collagen scaffolds. Laryngoscope. 2013;123(8):1976–1982.
   PubMed Web of Science ®Google Scholar
• Ghassemifar R Redmond S, Zainuddin S. Advancing towards a tissue-engineered tympanic membrane: silk fibroin as substratum for growing human eardrum keratinocytes. Appl J Biomater. 2010;24:591–606.
   PubMed Web of Science ®Google Scholar
• Miranda Araujo M, Tanaka Massuda E, Hyppolito M. Anatomical and functional evaluation of tympanoplasty using a transitory natural latex biomembrane implant rubber tree hevea brasiliensis. Acta Cirurgica Bras. 2012;27(8):566–571.
   Web of Science ®Google Scholar
• Kim J, Kim CH, Park CH, et al. Comparison of methods for the repair of acute tympanic membrane perforations: silk patch vs. paper patch. Wound Repair Regen. 2010;18(1):132–138.
   PubMed Web of Science ®Google Scholar
• Kim JH, Bae JH, Lim KT, et al. Development of water-insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations. J Biomed Mater Res A. 2009;90(2):446–455.
   PubMedGoogle Scholar
• Weber DE, Semaan MT, Wasman JK, et al. Tissue-engineered calcium alginate patches in the repair of chronic chinchilla tympanic membrane perforations. Laryngoscope. 2006;116(5):700–704.
   PubMed Web of Science ®Google Scholar
• Liew LJ, Chen LQ, Wang AY, et al. Tympanic membrane derived stem cell-like cultures for tissue regeneration. Stem Cells Dev. 2018;27(10):649–657.
   PubMed Web of Science ®Google Scholar
• Liew LJ, Wang AY, Dilley RJ. Isolation of epidermal progenitor cells from rat tympanic membrane. Methods Mol Biol. 2019;2029:247–255.
   PubMedGoogle Scholar
• Ong HT, Redmond SL, Marano RJ, et al. Paracrine activity from adipose-derived stem cells in vitro wound healing in human tympanic membrane journal of South China normal university. Stem Cells Dev. 2017;26(6):405–418.
   PubMed Web of Science ®Google Scholar
• Goncalves S, Bas E, Langston M, et al. Histologic changes of mesenchymal stem cell repair of tympanic membrane perforation. Acta Otolaryngol. 2017;137(4):411–416.
   PubMed Web of Science ®Google Scholar
• Rahman A, Von Unge M, Olivius P, et al. Healing time, longterm result and effects of stem cell treatment in acute tympanic membrane perforation. Int J Pediatr Otorhinolaryngol. 2007;71(7):1129–1137.
   PubMed Web of Science ®Google Scholar
• Rasheda A, Magda AM, Mostafa SY, et al. Role of stem cells in healing of tympanic membrane perforations. Medical J Cairo. 2019;87(6):1951–1955.
   Google Scholar
• Maharajan N, Cho GW, Jang CH. Application of mesenchymal stem cell for tympanic membrane regeneration by tissue engineering approach. Int J Pediatr Otorhinolaryngol. 2020;133:109969.
   PubMed Web of Science ®Google Scholar
• Villanueva D, McCants D, Nielsen HC. Effects of epidermal growth factor (EGF) on the development of EGF-receptor (EGF-R) binding in fetal rabbit lung organ culture. Pediatr Pulmonol. 2000;29(1):27–33.
   PubMed Web of Science ®Google Scholar
• Kakehata S, Hirose Y, Kitani R, et al. Autologous serum eardrops therapy with a chitin membrane for closing tympanic membrane perforations. Otol Neurotol. 2008;29(6):791–795.
   PubMed Web of Science ®Google Scholar
• Seonwoo H, Kim SW, Kim J, et al. Regeneration of chronic tympanic membrane perforation using an EGF-releasing chitosan patch. Tissue Eng Part A. 2013;19(17–18):2097–2107.
   PubMed Web of Science ®Google Scholar
• Yan L, Wu W, Wang Z, et al. Comparative study of the effects of recombinant human epidermal growth factor and basic fibroblast growth factor on corneal epithelial wound healing and neovascularization in vivo and in vitro. Ophthalmic Res. 2013;49(3):150–160.
   PubMed Web of Science ®Google Scholar
• Kanemaru S, Umeda H, Kitani Y, et al. Regenerative treatment for tympanic membrane perforation. Otol Neurotol. 2011;32(8):1218–1223.
   Web of Science ®Google Scholar
• Acharya, AN, Coates H, Tavora-Vièira D, et al. A pilot study investigating basic fibroblast growth factor for the repair of chronic tympanic membrane perforations in pediatric patients. Int J Pediatr Otorhinolaryngol. 2015;79(3):332–335.
   PubMed Web of Science ®Google Scholar
• Hakuba N, Hato N, Omotehara Y, et al. Epithelial pearl formation following tympanic membrane regeneration therapy using an atelocollagen/silicone membrane and basic fibroblast growth factor: our experience from a retrospective study of one hundred sixteen patients. Clin Otolaryngol. 2013;38(5):394–397.
   PubMed Web of Science ®Google Scholar
• Holmes D. Eardrum regeneration: membrane repair. Nature. 2017;546(7659):S5.
   PubMed Web of Science ®Google Scholar
• Seonwoo H, Kim SW, Shin B, et al. Latent stem cell-stimulating therapy for regeneration of chronic tympanic membrane perforations using. Int J Environ Sci Technol. 2014;34(2):59–65.
   Google Scholar
• Gür ÖE, Ensari N, Öztürk MT, et al. Use of a plateletrich fibrin membrane to repair traumatic tympanic membrane perforations: a comparative study. Acta Otolaryngol. 2016;136(10):1017–1023.
   PubMed Web of Science ®Google Scholar
• Stavrakas M, Karkos PD, Markou K, et al. Plateletrich plasma in otolaryngology. J Laryngol Otol. 2016;130(12):1098–1102.
   PubMedGoogle Scholar
• Mandour MF, Elsheikh MN, Khalil MF. Plateletrich plasma fat graft versus cartilage perichondrium for repair of medium-size tympanic membrane perforations. Otolaryngol Head Neck Surg. 2019;160(1):116–121.
   PubMed Web of Science ®Google Scholar
• Lou ZC, Lou ZH. A moist edge environment aids the regeneration of traumatic tympanic membrane perforations. J Laryngol Otol. 2017;131(7):564–571.
   PubMed Web of Science ®Google Scholar
• Ensari N, Gur OE, Ozturk MT, et al. The effect of plasminogen on the repair of perforated tympanic membrane an experimental study. Acta Otolaryngol. 2017;137(7):695–699.
   PubMed Web of Science ®Google Scholar
• Aksoy MA, Acikalin MF, Gurbuz MK, et al. Efficacy of platelet-rich plasma on fat grafts in the repair of tympanic membrane perforations: an experimental study. J Int Adv Otol. 2018;14(1):58–62.
   PubMed Web of Science ®Google Scholar
• Ersozlu T, Gultekin E. A comparison of the autologous platelet-rich plasma gel fat graft myringoplasty and the fat graft myringoplasty for the closure of different sizes of tympanic membrane perforations. Ear Nose Throat J. 2020;99(5):331–336.
   PubMed Web of Science ®Google Scholar
• Yadav SPS, Malik JS, Malik P, et al. Studying the result of underlay myringoplasty using platelet-rich plasma. J Laryngol Otol. 2018;132(11):990–994.
   PubMed Web of Science ®Google Scholar
• Fouad YA, Abdelhady M, EL-Anwar M, et al. Topical platelet rich plasma versus hyaluronic acid during fat graft myringoplasty. Am J Otolaryngol. 2018;39(6):741–745.
   PubMed Web of Science ®Google Scholar
• EL-Anwar MW, EL-Ahl MAS, Zidan AA, et al. Topical use of autologous platelet rich plasma in myringoplasty. Auris Nasus Larynx. 2015;42(5):365–368.
   PubMed Web of Science ®Google Scholar
• Gokce KS, Ozdaş T. Impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes: a retrospective analysis in patients with tympanic membrane perforation due to chronic otitis media. J Laryngol Otol. 2019;133(12):1068–1073.
   PubMed Web of Science ®Google Scholar
• Nair NP, Alexander A, Abhishekh B, et al. Safety and efficacy of autologous platelet-rich fibrin on graft uptake in myringoplasty: a randomized controlled trial. Int Arch Otorhinolaryngol. 2019;23(1):77–82.
   PubMed Web of Science ®Google Scholar
• Alhabib SF, Saliba I. Hyaluronic acid fat graft myringoplasty versus autologous platelet rich plasma. J Clin Med Res. 2017;9(1):30–34.
   PubMedGoogle Scholar
• Saliba I, Alzahrani M, Zhu T, et al. Growth factors expression in hyaluronic acid fat graft myringoplasty. Laryngoscope. 2014;124(6):224–230.
   Web of Science ®Google Scholar
• Alzahrani M, Saliba I. Hyaluronic acid fat graft myringoplasty vs fat patch fat graft myringoplasty. Eur Arch Otorhinolaryngol. 2015;272(8):1873–1877.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim SW, Park S, et al. Bacterial cellulose nanofibrillar patch as a wound healing platform of tympanic membrane perforation. Adv Healthc Mater. 2013;2(11):1525–1531.
   PubMed Web of Science ®Google Scholar
• Amoils CP, Jackler RK, Milczuk H, et al. An animal model of chronic tympanic membrane perforation. Otolaryngol Head Neck Surg. 1992;106(1):47–55.
   PubMed Web of Science ®Google Scholar
• Soumekh B, Hom DB, Levine S, et al. Treatment of chronic tympanic-membrane perforations with a platelet-derived releasate. Am J Otol. 1996;17(4):506–511.
   PubMedGoogle Scholar
• Wang AY, Liew LJ, Shen Y, et al. Rat model of chronic tympanic membrane perforation a longitudinal histological evaluation of underlying mechanisms. Int J Pediatr Otorhinolaryngol. 2017;93(2):88–96.
   Web of Science ®Google Scholar
• Wang AY, Shen Y, Liew LJ, et al. Rat model of chronie tympanic membrane perforation: ventilation tube with mitomycin C and dexamethasone. Int J Pediatr Otorhinolaryngol. 2016;80:61–68.
   PubMed Web of Science ®Google Scholar
• Rahman A, Olivius P, Dirck J, et al. Stem cells and enhanced healing of chronic tympanic membrane peforation. Acta Otolaryngol. 2008;128(4):352–359.
   PubMed Web of Science ®Google Scholar
• Truy E, Disant F, Morgon A. Chronic tympanic membrane perforation: an animal model. Am J Otol. 1995;162:222–225.
   Google Scholar
• O'Reilly RC, Goldman SA, Widner SA, et al. Creating a stable tympanic membrane perforation using mitomycin C. Otolaryngol Head Neck Surg. 2001;124(1):40–45.
   PubMed Web of Science ®Google Scholar
• Wang AY, Shen Y, Liew LJ, et al. Searching for a rat model of chronic tympanic membrane perforation: healing delayed by mitomycin C/dexamethasone but not paper implantation or iterative myringotomy. Int J Pediatr Otorhinolaryngol. 2015;79(8):1240–1247.
   PubMed Web of Science ®Google Scholar
• Li J, Eriksson PO, Hansson A, et al. Plasmin/plasminogen is essential for the healing of tympanic membrane perforations. Thromb Haemost. 2006;96(10):512–519.
   PubMedGoogle Scholar
• Shen Y, Guo Y, Wilczynska M, et al. Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice. Transl J Med. 2014;12:5.
   PubMed Web of Science ®Google Scholar
• Perez-Puyana V, Jimenez-Rosado M, Romero A, et al. Polymer-Based scaffolds for Soft-Tissue engineering. Polymers. 2020;12(7):1566–1576.
   PubMed Web of Science ®Google Scholar
• Kumar RD. Application of platelet rich fibrin matrix to repair traumatic tympanic membrane perforations: a pilot study. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 2):1126–1134.
   PubMed Web of Science ®Google Scholar
• Shukla A, Kaurav YS, Vatsyayan R. Novel use of platelet rich fibrin membrane in transcanal myringoplasty. Indian J Otolaryngol Head Neck Surg. 2020;72(3):355–362.
   PubMed Web of Science ®Google Scholar
• Mozaffari M, Jiang D, Tucker AS. Developmental aspects of the tympanic membrane: evidence of shedding light on function and disease. IEEE Trans Neural Networks. 2018;23(4):235–238.
   Google Scholar
• Chari DA, Frumm SM, Akil O, et al. Cellular dynamics of early healing of mouse tympanic membranes. Otol Neurotol. 2019;40(2):e160–e166.
   PubMed Web of Science ®Google Scholar
• Frumm SM, Yu SK, Chang J, et al. A hierarchy of proliferative and migratory keratinocytes – the tympanic membrane. Cell Stem Cell. 2021;28(2):315–330.e5.
   PubMed Web of Science ®Google Scholar
• Lou ZC. Dose and starting time dependent effect of the application of EGF to the regeneration of traumatic eardrum. Acta Otolaryngol. 2019;139(12):1083–1089.
   PubMed Web of Science ®Google Scholar
• Araujo MM, Murashima AA, Alves VM, et al. The treatment of insulin community and healing of traumatic tympanic membrane perforations. Laryngoscope. 2016;126(1):156–162.
   PubMedGoogle Scholar
• Liew LJ, Chen LQ, Wang AY. Research progress in membrane regeneration of stem cells. J Membr Sci. 2018;27(10):649–657 (in Chinese)
   Google Scholar
• Liew LJ, Wang AY. Epidermal progenitor cells in rat tympanic membrane. J Epidermal Biol. 2019;20(29):247–255.
   Google Scholar