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Ocular Immunology and Inflammation Volume 27, 2019 - Issue 7
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Original Article

Immunopathological Features of Severe Chronic Atopic Keratoconjunctivitis and Effects of Topical Cyclosporine Treatment

Canan Asli UtineOcular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland , USA;Faculty of Medicine, Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey;Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4131-2532View further author information
, MD, MScORCID Icon,
Michael SternImmunEyez, LLC, Mission Viejo, California, USAView further author information
, PhD &
Esen Karamursel AkpekOcular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland , USAView further author information
, MD
Pages 1184-1193 | Received 11 Feb 2018, Accepted 09 Aug 2018, Published online: 06 Sep 2018

References

  • Power WJ, Tugal-Tutkun I, Foster CS. Long-term follow-up of patients with atopic keratoconjunctivitis. Ophthalmology. 1998;105(4):637–642. doi:10.1016/S0161-6420(98)94017-9.
  • Foster CS, Rice BA, Dutt JE. Immunopathology of atopic keratoconjunctivitis. Ophthalmology. 1991;98(8):1190–1196.
  • Hingorani M, Calder VL, Buckley RJ, Lightman SL. The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp Eye Res. 1998;67(5):491–500. doi:10.1006/exer.1998.0528.
  • Metz DP, Hingorani M, Calder VL, Buckley RJ, Lightman SL. T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol. 1997;100(6 Pt 1):817–824.
  • Schwartz LB, Metcalfe DD, Miller JS, Earl H, Sullivan T. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med. 1987;316(26):1622–1626. doi:10.1056/NEJM198706253162603.
  • Foster CS, Calonge M. Atopic keratoconjunctivitis. Ophthalmology. 1990;97(8):992–1000.
  • Hingorani M, Moodaley L, Calder VL, Buckley RJ, Lightman S. A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. Ophthalmology. 1998;105(9):1715–1720. doi:10.1016/S0161-6420(98)99043-1.
  • Akpek EK, Dart JK, Watson S, et al. A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. Ophthalmology. 2004;111(3):476–482. doi:10.1016/j.ophtha.2003.05.035.
  • Anzaar F, Gallagher MJ, Bhat P, Arif M, Farooqui S, Foster CS. Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. Cornea. 2008;27(8):884–888. doi:10.1097/ICO.0b013e318172fbb1.
  • Nussenblatt RB, Palestine AG. Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol. 1986;31(3):159–169.
  • Whitcup SM, Chan CC, Luyo DA, Bo P, Li Q. Topical cyclosporine inhibits mast cell-mediated conjunctivitis. Invest Ophthalmol Vis Sci. 1996;37(13):2686–2693.
  • Hingorani M, Calder VL, Buckley RJ, Lightman S. The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. Invest Ophthalmol Vis Sci. 1999;40(2):392–399.
  • Tzu JH, Utine CA, Stern ME, Akpek EK. Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. Cornea. 2012;31(6):649–654. doi:10.1097/ICO.0b013e31822481c2.
  • Hogan MJ. Atopic keratoconjunctivitis. Trans Am Ophthalmol Soc. 1952;50:265–281.
  • De Paiva CS, Hwang CS, Pitcher JD 3rd, et al. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren’s syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010;49(2):246–258.doi:10.1093/rheumatology/kep357.
  • Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature. 2008;454(7203):445–454. doi:10.1038/nature07204.
  • Oliphant CJ, Barlow JL, McKenzie AN. Insights into the initiation of type 2 immune responses. Immunology. 2011;134(4):378–385. doi:10.1111/j.1365-2567.2011.03499.x.
  • Imai Y, Hosotani Y, Ishikawa H, et al. Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. Sci Rep. 2017;7(1):10053.doi:10.1038/s41598-017-10227-y.
  • Calder VL, Jolly G, Hingorani M, et al. Cytokine production and mRNA expression by conjunctival T-cell lines in chronic allergic eye disease. Clin Exp Allergy. 1999;29(9):1214–1222.
  • Metz DP, Bacon AS, Holgate S, Lightman SL. Phenotypic characterization of T cells infiltrating the conjunctiva in chronic allergic eye disease. J Allergy Clin Immunol. 1996;98(3):686–696.
  • Nivenius E, Montan PG, Chryssanthou E, Jung K, van Hage-Hamsten M, van der Ploeg I. No apparent association between periocular and ocular microcolonization and the degree of inflammation in patients with atopic keratoconjunctivitis. Clin Exp Allergy. 2004;34(5):725–730. doi:10.1111/j.1365-2222.2004.1950.x.
  • Leonardi A, Motterle L, Bortolotti M. Allergy and the eye. Clin Exp Immunol. 2008;153(Suppl1):17–21. doi:10.1111/j.1365-2249.2008.03716.x.
  • Leonardi A, Fregona IA, Plebani M, Secchi AG, Calder VL. Th1- and Th2-type cytokines in chronic ocular allergy. Graefe’s Arch Clin Exp Ophthalmol. 2006;244(10):1240–1245. doi:10.1007/s00417-006-0285-7.

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