335
Views
6
CrossRef citations to date
0
Altmetric
Review

Drug-induced Uveitis in HIV Patients with Ocular Opportunistic Infections

, MD, , MDORCID Icon, , MDORCID Icon, , MD, , MD, , MD & , MD show all
Pages 1069-1075 | Received 30 Sep 2019, Accepted 06 Nov 2019, Published online: 18 Dec 2019

References

  • De Clercq E, Holy A, Rosenberg I, et al. A novel selective broad-spectrum anti-DNA virus agent. Nature. 1986;323:464–467. doi:10.1038/323464a0.
  • Snoeck R, Sakuma T, De Clercq E, et al. (S)-1-[3-hydroxy- 2-(phosphonylmethoxy)propyl]cytosine, a potent and selec- tive inhibitor of human cytomegalovirus replication. Anti- microb Agents Chemother. 1988;32:1839–1844. doi:10.1128/AAC.32.12.1839
  • Kaplan JE, Hanson D, Dworkin MS, et al. Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000;30(Suppl 1):S5–14. doi:10.1086/313843.
  • Hoover DR, Peng Y, Saah A, et al. Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. Arch Ophthalmol. 1996;114(7):821–827. doi:10.1001/archopht.1996.01100140035004.
  • Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc. 1995;93:623–683.
  • Gallant JE, Moore RD, Richman DD, Keruly J, Chaisson RE. Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group. J Infect Dis. 1992;166:1223–1227.
  • Kuppermann BD, Petty JG, Richman DD, et al. Correlation between CD4+ counts and prevalence of cytomegalovirus retinitis and human immunodeficiency virus-related noninfectious retinal vasculopathy in patients with acquired immunodeficiency syndrome. Am J Ophthalmol. 1993;115(5):575–582.
  • Ford N, Shubber Z, Saranchuk P, et al. Burden of HIV-related cytomegalovirus retinitis in resource-limited settings: a systematic review. Clin Infect Dis. Nov2013;57(9):1351–1361.
  • Stewart MW. Optimal management of cytomegalovirus retinitis in patients with AIDS. Clin Ophthalmol. 2010;4:285–299.
  • Jabs DA. Cytomegalovirus retinitis and the acquired immunodeficiency syndrome–bench to bedside: LXVII Edward Jackson Memorial Lecture. Am J Ophthalmol. 2011 Feb;151(2):198–216.e1. doi:10.1016/j.ajo.2010.10.018.
  • Masur H, Whitcup SM, Cartwright C, et al. Advances in the management of AIDS-related cytomegalovirus retinitis. Ann Intern Med. 1996;12(5):126–136. doi:10.7326/0003-4819-125-2-199607150-00009.
  • Kirsch LS, Arevalo JF, De Clercq E, et al. Phase I/II study of intravitreal cidofovir for the treatment of cytomegalovirus retinitis in patients with the acquired Immunodeficiency syndrome. Am J Ophthalmol. 1995;119:466–476.
  • Rahhal FM, Arevalo JF, Chavez de la Paz E, et al. Treatment of cytomegalovirus retinitis with intravitreous cidofovir in patients with AIDS. A preliminary report. Ann Intern Med. 1996;125:98–103. doi:10.7326/0003-4819-125-2-199607150-00003.
  • Lalezari JP, Stagg RJ, Kuppermann BD, et al. Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized controlled trial. Ann Intern Med. 1997;126:257–263. doi:10.7326/0003-4819-126-4-199702150-00001.
  • Bronson JJ, Ghazzouli I, Hitchcock MJM, et al. Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2- phosphonylmethoxy) propyl]cytosine. J Med Chem. 1989;32:1457–1463.
  • Hitchcock MJ, Woods KL, Bronson JJ, et al. Intracellular metabolism of the anti-herpes agent, (S)-1-[3-hydroxy-2-(phosphonyl- methoxy) propyl]cytosine (HPMPC). Mol Pharmacol. 1992;41:197–202.
  • Snoeck R, Sakuma R, De Clercq E, et al. (S)-1-[3-hydroxy-2- (phosphonylmethoxy)propyl]cytosine, a potent and selective in- hibitor of human cytomegalovirus replication. Antimicrob Agents Chemother. 1988;32:1839–1844. doi:10.1128/AAC.32.12.1839.
  • Soike K, Huang J-L, Zhang JY, et al. Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy) propyl]cytosine (HPMPC) on Simian Varicella infection in mon- keys. Antiviral Res. 1991;16:17–28. doi:10.1016/0166-3542(91)90055-V.
  • Li SB, Yang ZH, Feng JS, et al. Activity of (S)-1-[3-hydroxy-2- (phosphonylmethoxy) propyl]cytosine (HPMPC) against guinea pig cytomegalovirus infection in cultured cells and in guinea pigs. Antiviral Res. 1990;13:237–252. doi:10.1016/0166-3542(90)90069-J.
  • Chavez-de la Paz E, Arevalo JF, Kirsch LS, et al. Anterior nongranulomatous uveitis after intravitreal HPMPC (cidofovir) for the treatment of cytomegalovirus retinitis. Analysis and prevention. Ophthalmology. 1997 Mar; 104(3):539–544. Erratum in: Ophthalmology 1997 Jul;104(7):1063. doi:10.1016/S0161-6420(97)30278-4.
  • Kirsch LS, Arevalo JF, Chavez de la Paz E, Munguia D, de Clercq E, Freeman WR. Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Ophthalmology. 1995Apr;102(4):533–542. discussion 542-3. Erratum in: Ophthalmology 1995 May;102(5):702. doi:10.1016/S0161-6420(95)30985-2
  • Taskintuna I, Rahhal FM, Arevalo JF, et al. Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Ophthalmology. Jun 1997;104(6):1049–1057. doi:10.1016/S0161-6420(97)30188-2.
  • Banker AS, Arevalo JF, Munguia D, et al. Intraocular pressure and aqueous humor dynamics in patients with AIDS treated with intravitreal cidofovir (HPMPC) for cytomegalovirus retinitis. Am J Ophthalmol. Aug 1997;124(2):168–180. doi:10.1016/S0002-9394(14)70781-0.
  • Davis JL, Taskintuna I, Freeman WR, et al. Iritis and hypo- tony after treatment with intravenous cidofovir for cytome- galovirus retinitis. Arch Ophthalmol. 1997;115:733–737. doi:10.1001/archopht.1997.01100150735008.
  • Akler ME, Johnson DW, Burman WJ, et al. Anterior uveitis and hypopyon after intravenous cidofovir for the treatment of cytomegalovirus retinitis. Ophthalmology. 1998;105:651–657. doi:10.1016/S0161-6420(98)94019-2.
  • Ambati J, Wynne KB, Angerame MC, Robinson MR. Anterior uveitis associated with intravenous cidofovir use in patients with cytomegalovirus retinitis. Br J Ophthalmol. 1999;83(10):1153–1158. doi:10.1136/bjo.83.10.1153.
  • Cunningham ET Jr. Uveitis in HIV positive patients. Br J Ophthalmol. 2000;84(3):233–235. doi:10.1136/bjo.84.3.233.
  • Urban B, Bakunowicz-Łazarczyk A, Michalczuk M. Immune recovery uveitis: pathogenesis, clinical symptoms, and treatment. Mediators Inflamm. 2014;2014:971417. doi:10.1155/2014/971417.
  • Yeo TH, Yeo TK, Wong EP, Agrawal R, Teoh SC. Immune recovery uveitis in HIV patients with cytomegalovirus retinitis in the era of HAART therapy-a 5-year study from Singapore. J Ophthalmic Inflamm Infect. 2016 Dec;6(1):41. doi:10.1186/s12348-016-0110-3.
  • Lacy SA, Hitchcock MJ, Lee WA, Tellier P, Cundy KC. Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys. Toxicol Sci. 1998 Aug;44(2):97–106. doi:10.1093/toxsci/44.2.97.
  • Arevalo J, Munguia D, Faber D, et al. Correlation between intraocular pressure and CD4+ T-lymphocyte counts in patients with human immunodeficiency virus with and without cytomegalovirus retinitis. Am J Ophthalmol. 1996;122:91–96. doi:10.1016/S0002-9394(14)71968-3.
  • Accorinti M, Ciapparoni V, Pirraglia MP, Pivetti-Pezzi P. Treatment of severe ocular hypotony in AIDS patients with cytomegalovirus retinitis and cidofovir-associated uveitis. Ocul Immunol Inflamm 2001 9;Sep(3):211–217. doi:10.1076/ocii.9.3.211.3968.
  • Winchester LC, Podany AT, Baldwin JS, Robbins BL, Fletcher CV. Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS. J Pharm Biomed Anal. 2015;104:55–61. doi:10.1016/j.jpba.2014.11.011.
  • Havlir D, Torriani F, Dub E M. Uveitis associated with rifabutin prophylaxis. Ann Intern Med. 1194;121(7):510–512. doi:10.7326/0003-4819-121-7-199410010-00006.
  • Fuller JD, Stanfield LE, Craven DE. Rifabutin prophylaxis and uveitis. N Engl J Med. 1994;330:1315–1316. doi:10.1056/NEJM199405053301816.
  • Shafran SD, Descheˆnes J, Miller M, et al. Uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin, and ethambutol. MAC Study Group of the Canadian HIV Trials Network. N Engl J Med. 1994;330(6):438–439. doi:10.1056/NEJM199402103300616.
  • Siegal FP, Eilbott D, Burger H, et al. Dose-limiting toxicity of rifabutin in AIDS-related complex: syndrome of arthralgia/arthritis. AIDS. 1990;4(5):433–441. doi:10.1097/00002030-199005000-00009.
  • Nightingale SD, Cameron DW, Gordin FM, et al. Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. N Engl J Med. Sep 16 1993;329(12):828–833. doi:10.1056/NEJM199309163291202.
  • Saran BR, Maguire AM, Nichols C, et al. Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Myco- bacterium avium complex infection with rifabutin. Arch Ophthalmol. 1994;112:1159–1165. doi:10.1001/archopht.1994.01090210043015.
  • DATRI 001 Study Group. Coadministration of clarithromycin (CL) alters the concentration-time profile of rifabutin (RFB) [abstract]. In: Program and abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy (Orlando, FL). Washington, DC: American Society for Microbiology, 1994:3
  • Trapnell CB, Narang PK, Li R, Lewis R, Colborn D, Lavelle J. Fluconazole (FLU) increases rifabutin (RIF) absorption in HIV(/) patients on stable zidovudine (ZDV) therapy [abstract]. In: Program and abstracts: IX International Conference on AIDS/IV STD World Congress (Berlin). London: Wellcome Foundation, 1993:504
  • Narang PK, Trapnell CB, Schoenfelder JR, Lavelle JP, Bianchine JR. Fluconazole and enhanced effect of rifabutin prophylaxis [letter]. N Engl J Med. 1994;330:1316. doi:10.1056/NEJM199405053301817.
  • Shafran SD, Singer J, Zarowny DP, et al. Determinants of rifabutin-associated uveitis in patients treated with rifabutin, clarithromycin, and ethambutol for Mycobacterium avium complex bacteremia: a multivariate analysis. Canadian HIV Trials Network Protocol 010 Study Group. J Infect Dis. 1998;177(1):252–255. doi:10.1086/517366.
  • Skolik S, Willermain F, Caspers LE. Rifabutin-associated panuveitis with retinal vasculitis in pulmonary tuberculosis. Ocul Immunol Inflamm. 2005 Dec;13(6):483–485. PubMed PMID: 16321897. doi:10.1080/09273940590951115.
  • Smith WM, Reddy MG, Hutcheson KA, et al. Rifabutin-associated hypopyon uveitis and retinal vasculitis with a history of acute myeloid leukemia. J Ophthalmic Inflamm Infect. 2012;2(3):149–152. doi:10.1007/s12348-012-0059-9.
  • Chaknis MJ, Brooks SE, Mitchell KT, Marcus DM. Inflammatory opacities of the vitreous in rifabutin-associated uveitis. Am J Ophthalmol. 1996;122(4):580–582. doi:10.1016/S0002-9394(14)72124-5.
  • Trone MC, Manoli P, Mattei J, Thuret G, Gain P, Stephan JL. Rifabutin-associated uveitis in a 10-year-old child with HIV: case report and review of the literature. J Fr Ophtalmol. Oct 2018;41(8):e391–e393.
  • Dunn AM, Tizer K, Cervia JS. Rifabutin-associated uveitis in a pediatric patient. Pediatr Infect Dis J. 1995;14:246–247.
  • Le Saux N, MacDonald N, Dayneka N. Rifabutin ocular toxic- ity mimicking endophthalmitis. Pediatr Infect Dis J. 1997;16:716–718.
  • Smith JA, Mueller BU, Nussenblatt RB, Whitcup SM. Corneal endothelial deposits in children positive for human immunode- ficiency virus receiving rifabutin prophylaxis for Mycobacterium avium complex bacteremia. Am J Ophthalmol. 1999;127:164–169.
  • Worlledge S, Hong Kong Treatment Services-Royal Postgraduate Medical 33. School-British Medical Research Council Co-operative study of rifampicin plus ethambutol in daily and intermittent regimens. The detection of rifampicin- dependent antibodies. Scand J Respir Dis. 1973;84(S):60–63.
  • Nichols CW. Mycobacterium avium complex infection, rifabutin, and uveitis - is there a connection? Clin Infect Dis. 1996 Apr;22(Suppl 1):S43–7. discussion S47-9. Review.
  • Kemper CA, Havlir D, Bartok AE, et al. Transient bacteremia due to Mycobacterium avium complex in patients with AIDS. J Infect Dis. 1994;170:488–493.
  • Deeks SG, Smith M, Holodniy M, Kahn JO. HIV-1 protease inhibitors. A review for clinicians. JAMA. 1997;277:145–153.
  • Boyd M. Indinavir: the forgotten HIV-protease inhibitor. Does it still have a role? Expert Opin Pharmacother. 2007;8:957–964.
  • Tashima KT, Horowitz JD, Rosen S. Indinavir nephropathy. N Engl J Med. 1997;336:138–140.
  • Lacy MK, Abriola KP. Indinavir: a pharmacologic and clinical review of a new HIV protease inhibitor. Conn Med. 1996;60(12):723–727.
  • Gariano RF, Cooney EL. Uveitis following administration of the protease inhibitor indinavir to a patient with AIDS. Clin Infect Dis. 1997;24:529.
  • Sax PE, Wohl D, Yin MT, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials. Lancet. 2015;385:2606–2615.
  • Wohl D, Oka S, Clumeck N, et al. A randomized, double-blind comparison of tenofovir alafenamide versus tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine for initial HIV-1 treatment: week 96 results. J Acquir Immune Defi c Syndr. 2016;72:58–64.
  • Unger NR, Worley MV, Kisgen JJ, Sherman EM, Childs-Kean LM. Elvitegravir for the treatment of HIV. Expert Opin Pharmacother. 2016;17:2359–2370.
  • Gaur AH, Kizito H, Prasitsueubsai W, et al. Safety, efficacy, and pharmacokinetics of a single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in treatment-naive, HIV-infected adolescents: a single-arm, open-label trial. Lancet HIV. 2016;3(12):561–568.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.