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Original Articles

Nerve Growth Factor Protects Retinal Ganglion Cells Related to Inhibiting Endoplasmic Reticulum Stress by Inhibiting IRE1-JNK-CHOP Signaling Pathway

, &
Pages 1341-1346 | Received 26 Aug 2020, Accepted 30 Dec 2020, Published online: 01 Apr 2021

References

  • Soto I, Howell GR. The complex role of neuroinflammation in glaucoma. Cold Spring Harb Perspect Med. 2014;4(8):a017269. doi:10.1101/cshperspect.a017269.
  • Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262–267. doi:10.1136/bjo.2005.081224.
  • Almasieh M, Wilson AM, Morquette B, et al. The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res. 2012;31(2):152–181. doi:10.1016/j.preteyeres.2011.11.002.
  • Lambiase A, Mantelli F, Sacchetti M, et al. Clinical applications of NGF in ocular diseases. Arch Ital Biol. 2011;149(2):283–292. doi:10.4449/aib.v149i2.1363.
  • Lambiase A, Mantelli F, Bonini S. Nerve growth factor eye drops to treat glaucoma. Drug news & perspectives. 2010;23(6):361–367. doi:10.1358/dnp.2010.23.6.1472299.
  • Schwab ME, Kapfhammer JP, Bandtlow CE. Inhibitors of neurite growth. Annu Rev Neurosci. 1993;16(1):565–595. doi:10.1146/annurev.ne.16.030193.003025.
  • Pernet V, Schwab ME. Lost in the jungle: new hurdles for optic nerve axon regeneration. Trends Neurosci. 2014;37(7):381–387. doi:10.1016/j.tins.2014.05.002.
  • Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature. 2000;407(6807):963–970. doi:10.1038/35039559.
  • Berkelaar M, Clarke DB, Wang YC, et al. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci. 1994;14(7):4368–4374. doi:10.1523/JNEUROSCI.14-07-04368.1994.
  • Johnson EM, Deckwerth TL. Molecular mechanisms of developmental neuronal death. Annu Rev Neurosci. 1993;16(1):31–46. doi:10.1146/annurev.ne.16.030193.000335.
  • Mesentier-Louro LA, De Nicolo S, Rosso P, et al. Time-dependent nerve growth factor signaling changes in the rat retina during optic nerve crush-induced degeneration of retinal ganglion cells. Int J Mol Sci. 2017;18(1):1. doi:10.3390/ijms18010098.
  • Rosso P, De Nicolo S, Carito V, et al. Ocular nerve growth factor administration modulates brain-derived neurotrophic factor signaling in prefrontal cortex of healthy and diabetic rats. CNS Neurosci Ther. 2017;23(3):198–208. doi:10.1111/cns.12661.
  • Hu Y, Park KK, Yang L, et al. Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron. 2012;73(3):445–452. doi:10.1016/j.neuron.2011.11.026.
  • Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004;363(9422):1711–1720. doi:10.1016/S0140-6736(04)16257-0.
  • Liu H, Wang W, Xiang L, et al. High hydrostatic pressure induces apoptosis of retinal ganglion cells via regulation of the NGF signaling pathway. Mol Med Rep. 2019;19:5321–5334. doi:10.3892/mmr.2019.10206.
  • Sposato V, Parisi V, Manni L, et al. Glaucoma alters the expression of NGF and NGF receptors in visual cortex and geniculate nucleus of rats: effect of eye NGF application. Vision Res. 2009;49(1):54–63. doi:10.1016/j.visres.2008.09.024.
  • Rudzinski M, Wong TP, Saragovi HU. Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertension. J Neurobiol. 2004;58(3):341–354. doi:10.1002/neu.10293.
  • Wang XL, Yu T, Yan QC, et al. AGEs promote oxidative stress and induce apoptosis in retinal pigmented epithelium cells RAGE-dependently. J Mol Neurosci. 2015;56(2):449–460. doi:10.1007/s12031-015-0496-7.
  • Szegezdi E, Herbert KR, Kavanagh ET, et al. Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim. J Cell Mol Med. 2008;12(6a):2482–2496. doi:10.1111/j.1582-4934.2008.00268.x.
  • Viana RJ, Nunes AF, Rodrigues CM. Endoplasmic reticulum enrollment in Alzheimer’s disease. Mol Neurobiol. 2012;46(2):522–534. doi:10.1007/s12035-012-8301-x.
  • Lynch JM, Maillet M, Vanhoutte D, et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012;149(6):1257–1268. doi:10.1016/j.cell.2012.03.050.
  • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011;334(6059):1081–1086. doi:10.1126/science.1209038.
  • Hayashi T, Saito A, Okuno S, et al. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons. J Cereb Blood Flow Metab. 2005;25(1):41–53. doi:10.1038/sj.jcbfm.9600005.
  • Larner SF, Hayes RL, McKinsey DM, et al. Increased expression and processing of caspase-12 after traumatic brain injury in rats. J Neurochem. 2004;88(1):78–90. doi:10.1046/j.1471-4159.2003.02141.x.
  • Tobisawa S, Hozumi Y, Arawaka S, et al. Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice. Biochem Biophys Res Commun. 2003;303(2):496–503. doi:10.1016/S0006-291X(03)00353-X.
  • Wootz H, Hansson I, Korhonen L, et al. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem Biophys Res Commun. 2004;322(1):281–286. doi:10.1016/j.bbrc.2004.07.118.
  • Gardner BM, Pincus D, Gotthardt K, et al. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013;5(3):a013169. doi:10.1101/cshperspect.a013169.
  • Shen J, Chen X, Hendershot L, et al. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell. 2002;3(1):99–111. doi:10.1016/S1534-5807(02)00203-4.
  • Cubillos-Ruiz JR, Bettigole SE, Glimcher LH. Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell. 2017;168(4):692–706. doi:10.1016/j.cell.2016.12.004.
  • Khan I, Paul S, Jakhar R, et al. Novel quercetin derivative TEF induces ER stress and mitochondria-mediated apoptosis in human colon cancer HCT-116 cells. Biomed pharmacother. 2016;84:789–799. doi:10.1016/j.biopha.2016.09.094.
  • Kim TW, Lee SY, Kim M, et al. Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells. Cell Death Dis. 2018;9(9):875. doi:10.1038/s41419-018-0930-1.
  • Corazzari M, Rapino F, Ciccosanti F, et al. Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death Differ. 2015;22(6):946–958. doi:10.1038/cdd.2014.183.
  • Liang XH, Kleeman LK, Jiang HH, et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998;72(11):8586–8596. doi:10.1128/JVI.72.11.8586-8596.1998.
  • Wei Y, Pattingre S, Sinha S, et al. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008;30(6):678–688. doi:10.1016/j.molcel.2008.06.001.

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