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Research Article

Evaluating Truenat Assay for the Diagnosis of Ocular Tuberculosis and Detection of Drug Resistance

, MD, , MDORCID Icon, , MS, , MS, , DM, , MSORCID Icon, , MS & , MS show all
Received 02 Jun 2022, Accepted 16 Jan 2023, Published online: 01 Feb 2023

References

  • Krassas N, Wells J, Bell C, Woodhead M, Jones N. Presumed tuberculosis-associated uveitis: rising incidence and widening criteria for diagnosis in a non-endemic area. Eye. 2018;32(1):87–92. doi:10.1038/eye.2017.152.
  • Sharma K, Gupta V, Bansal R, Sharma A, Sharma M, Gupta A. Novel multi-targeted polymerase chain reaction for diagnosis of presumed tubercular uveitis. J Ophthalmic Inflamm Infect. 2013;3(1):25. doi:10.1186/1869-5760-3-25.
  • Sharma M, Singh R, Sharma A, Gupta V, Sharma K. IS1081-based multi-targeted LAMP: an opportunity to detect tubercular uveitis. Ocul Immunol Inflamm. 2020;1–6. doi:10.1080/09273948.2020.1787462.
  • Gunasekeran DV, Gupta B, Cardoso J, Pavesio CE, Agrawal R. Visual morbidity and ocular complications in presumed intraocular tuberculosis: an analysis of 354 cases from a non-endemic population. Ocul Immunol Inflamm. 2017;25:1–5. doi:10.1080/09273948.2017.1296580.
  • Sharma K, Gupta A, Sharma M, et al. The emerging challenge of diagnosing drug-resistant tubercular uveitis: experience of 110 eyes from North India. Ocul Immunol Inflamm. 2019;27:1–8. doi:10.1080/09273948.2019.1655581.
  • Sharma K, Sharma M, Ayyadurai N, et al. Comparative evaluation of GeneXpert MTB/RIF ultra and GeneXpert MTB/RIF for detecting tuberculosis and identifying rifampicin resistance in pars plana vitrectomy samples of patients with ocular tuberculosis. Ocul Immunol Inflamm. 2022:1–7. doi:10.1080/09273948.2022.2064880.
  • MoHFW. Ministry of health and family welfare government of India India TB report 2022. 2022. https://tbcindia.gov.in/index1.php?l.
  • Central TB Division Directorate General of Health Services. National Strategic Plan for Tuberculosis Elimination 2017-25. Nirman Bhavan, New Delhi, India.: Ministry of Health with Family Welfare; 2017.
  • Molbio Diagnostics Pvt. Ltd. Truenat MTB: chip-based real time PCR test for mycobacterium tuberculosis. 2016. https://www.molbiodiagnostics.com/uploads/product_.
  • World Health Organization (WHO). WHO Consolidated Guidelines on Tuberculosis Module 3: Diagnosis; Rapid Diagnostics for Tuberculosis Detection. Geneva: World Health Organization; 2020.
  • Molbio Diagnostics Pvt. Ltd. Truenat MTB plus: chip-based real time PCR test for mycobacterium tuberculosis. Package insert. 2019. https://www.molbiodiagnostics.com/uploads/product_download/20190927.152146~Truenat-MTB-Plus-packinsert.pdf.
  • Molbio Diagnostics Pvt. Ltd. Truenat MTB-RIF Dx: chip-based real time PCR test for rifampicin resistant mycobacterium tuberculosis. Package insert. 2020. https://www.molbiodiagnostics.com/uploads/product_.
  • Sharma K, Sharma M, Modi M, et al. Comparative analysis of truenat MTB plus and Xpert Ultra in diagnosing tuberculous meningitis. Int J Tuberc Lung Dis. 2021;25(8):626–631.doi:10.5588/ijtld.21.0156.
  • Sharma K, Sharma M, Sharma V, et al. Evaluating diagnostic performance of truenat MTB plus for gastrointestinal tuberculosis. J Gastroenterol Hepatol. 2022;37:1571–1578. doi:10.1111/jgh.15878.
  • Gupta A, Bansal R, Gupta V, Sharma A, Bambery P. Ocular signs predictive of tubercular uveitis. Am J Ophthalmol. 2010;149(4):562–570. doi:10.1016/j.ajo.2009.11.020.
  • Gupta A, Sharma A, Bansal R, Sharma K. Classification of intraocular tuberculosis. Ocul Immunol Inflamm. 2015;23(1):7–13. doi:10.3109/09273948.2014.967358.
  • Ghazy RM, El Saeh HM, Abdulaziz S, et al. A systematic review and meta-analysis of the catastrophic costs incurred by tuberculosis patients. Sci Rep. 2022;12(1):1–16.doi:10.1038/s41598-021-04345-x.
  • Jose RA, Gopal K, Johnson AKS, et al. Evaluation of truenat MTB/RIF test in comparison with microscopy and culture for diagnosis of extrapulmonary tuberculosis in a tertiary care centre. J Clin Diagn Res. 2021;15(1). doi:10.7860/JCDR/2021/46815.14432.
  • Kon OM, Beare N, Connell D, et al. British Thoracic Society Clinical Statement for the Diagnosis and Management of Ocular Tuberculosis. BMJ Open Resp Res. 2022;9:e001225. doi:10.1136/bmjresp-2022-001225.
  • Sharma K, Sharma M, Shree R, et al. Xpert MTB/RIF ultra for the diagnosis of tuberculous meningitis: a diagnostic accuracy study from India. Tuberculosis. 2020;125(September):101990.doi:10.1016/j.tube.2020.101990.
  • Chauhan D, Sharma V, Parashar D, et al. Molecular typing of mycobacterium tuberculosis isolates from different parts of India based on IS6110 element polymorphism using RFLP analysis. Indian J Med Res. 2007;125(4):577–581.
  • Opota O, Mazza-Stalder J, Greub G, Jaton K. The rapid molecular test Xpert MTB/RIF ultra: towards improved tuberculosis diagnosis and rifampicin resistance detection. Clin Microbiol Infect. 2019;25(11):1370–1376. doi:10.1016/j.cmi.2019.03.021.
  • Global Laboratories Initiative core group. Planning for Country Transition to Xpert® MTB/RIF Ultra Cartridges. Geneva, Switzerland: World Health Organization; 2017.
  • Sharma K, Sharma M, Chaudhary L, et al. Comparative evaluation of Xpert MTB/RIF assay with multiplex polymerase chain reaction for the diagnosis of tuberculous meningitis. Tuberculosis. 2018;113(September):38–42.doi:10.1016/j.tube.2018.09.002.
  • Kohli M, Schiller I, Dendukuri N, et al. Xpert MTB/RIF ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2021;1:CD012768. doi:10.1002/14651858.CD012768.pub3.
  • Sharma K, Sharma M, Modi M, et al. Heading toward resistance, head‑on: a case of XDR tuberculous meningitis. Neurol India. 2021;69(4):1101–1102. doi:10.4103/0028-3886.325329.
  • Sharma K, Gupta A, Sharma M, et al. Detection of viable mycobacterium tuberculosis in ocular fluids using mRNA-based multiplex polymerase chain reaction. Indian J Med Microbiol. 2022. doi:10.1016/j.ijmmb.2021.12.019.

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