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Review Articles

Tubulointerstitial Nephritis and Uveitis Syndrome in Pediatric Patients

, MD, MBA, , BSc & , MD
Pages 1955-1964 | Received 06 Sep 2023, Accepted 31 Oct 2023, Published online: 20 Nov 2023

References

  • Dobrin RS, Vernier RL, Fish AJ. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. Am J Med. 1975;59(3):325–333. doi:10.1016/0002-9343(75)90390-3.
  • Mackensen F, Smith JR, Rosenbaum JT. Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. Ophthalmology. 2007;114(5):995–999.e1. doi:10.1016/j.ophtha.2007.01.002.
  • Kanno H, Ishida K, Yamada W, et al. Clinical and genetic features of tubulointerstitial nephritis and uveitis syndrome with long-term follow-up. J Ophthalmol. 2018;2018:1–8. doi:10.1155/2018/4586532.
  • Mandeville JTH, Levinson RD, Holland GN. The tubulointerstitial nephritis and uveitis syndrome. Surv Ophthalmol. 2001;46(3):195–208. doi:10.1016/S0039-6257(01)00261-2.
  • Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for tubulointerstitial nephritis with uveitis syndrome. Am J Ophthalmol. 2021;228:255–261. doi:10.1016/j.ajo.2021.03.041.
  • Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T. Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study. Ophthalmology. 2013;120(7):1476–1481. doi:10.1016/j.ophtha.2012.12.039.
  • Koreishi AF, Zhou M, Goldstein DA. Tubulointerstitial nephritis and uveitis syndrome: characterization of clinical features. Ocul Immunol Inflamm. 2021;29(7–8):1312–1317. doi:10.1080/09273948.2020.1736311.
  • Hettinga YM, Scheerlinck LME, Lilien MR, Rothova A, De Boer JH. The value of measuring urinary β2-microglobulin and serum creatinine for detecting tubulointerstitial nephritis and uveitis syndrome in young patients with uveitis. JAMA Ophthalmol. 2015;133(2):140. doi:10.1001/jamaophthalmol.2014.4301.
  • Amaro D, Carreño E, Steeples LR, Oliveira-Ramos F, Marques-Neves C, Leal I. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review. Br J Ophthalmol. 2020;104(6):742–747. doi:10.1136/bjophthalmol-2019-314926.
  • Clive DM, Vanguri VK. The syndrome of Tubulointerstitial Nephritis with Uveitis (TINU). Am J Kidney Dis. 2018;72(1):118–128. doi:10.1053/j.ajkd.2017.11.013.
  • Bergner R, Löffler C. Renal sarcoidosis: approach to diagnosis and management. Curr Opin Pulm Med. 2018;24(5):513–520. doi:10.1097/MCP.0000000000000504.
  • Yao L, Foster CS. Tubulointerstitial nephritis and uveitis syndrome. Int Ophthalmol Clin. 2001;41(4):217–221. doi:10.1097/00004397-200110000-00019.
  • Okafor LO, Hewins P, Murray PI, Denniston AK. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors. Orphanet J Rare Dis. 2017;12(1):128. doi:10.1186/s13023-017-0677-2.
  • Jahnukainen T, Ala-Houhala M, Karikoski R, Kataja J, Saarela V, Nuutinen M. Clinical outcome and occurrence of uveitis in children with idiopathic tubulointerstitial nephritis. Pediatr Nephrol. 2011;26(2):291–299. doi:10.1007/s00467-010-1698-4.
  • Ohguro N, Sonoda KH, Takeuchi M, Matsumura M, Mochizuki M. The 2009 prospective multi-center epidemiologic survey of uveitis in Japan. Jpn J Ophthalmol. 2012;56(5):432–435. doi:10.1007/s10384-012-0158-z.
  • Jones NP. The Manchester Uveitis Clinic: the first 3000 patients—epidemiology and casemix. Ocul Immunol Inflamm. 2015;23(2):118–126. doi:10.3109/09273948.2013.855799.
  • Sakhinia F, Brice V, Ollerenshaw R, Gajendran S, Ashworth J, Shenoy M. Tubulointerstitial nephritis and uveitis in children during the COVID-19 pandemic: report of four cases. J Nephrol. 2023;36(5):1451–1455. doi:10.1007/s40620-022-01564-x.
  • Eser-Ozturk H, Izci Duran T, Aydog O, Sullu Y. Sarcoid-like uveitis with or without tubulointerstitial nephritis during COVID-19. Ocul Immunol Inflamm. 2023;31(3):483–490. doi:10.1080/09273948.2022.2032195.
  • Goda C, Kotake S, Ichiishi A, Namba K, Kitaichi N, Ohno S. Clinical features in Tubulointerstitial Nephritis and Uveitis (TINU) syndrome. Am J Ophthalmol. 2005;140(4):637–641. doi:10.1016/j.ajo.2005.04.019.
  • Yang M, Chi Y, Guo C, Huang J, Yang L, Yang L. Clinical profile, ultra-wide-field fluorescence angiography findings, and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis syndrome at one tertiary medical institute in China. Ocul Immunol Inflamm. 2019;27(3):371–379. doi:10.1080/09273948.2017.1394469.
  • Cao JL, Srivastava SK, Venkat A, Lowder CY, Sharma S. Ultra-widefield fluorescein angiography and OCT findings in tubulointerstitial nephritis and uveitis syndrome. Ophthalmol Retina. 2020;4(2):189–197. doi:10.1016/j.oret.2019.08.012.
  • Giralt L, Pérez-Fernández S, Adan A, Figueira L, Fonollosa A. The IBERTINU study group*. Clinical features and outcomes of tubulointerstitial nephritis and uveitis syndrome in Spain and Portugal: the IBERTINU project. Ocul Immunol Inflamm. 2023;31(2):286–291. doi:10.1080/09273948.2022.2026413.
  • Pichi F, Aljeneibi S, Neri P. Tubulointerstitial nephritis and uveitis syndrome in the United Arab Emirates. Ocul Immunol Inflamm. Published online February 15, 2023;1–5. doi:10.1080/09273948.2023.2178939.
  • Paroli MP, Cappiello D, Staccini D, Caccavale R, Paroli M. Tubulointerstitial Nephritis and Uveitis syndrome (TINU): a case series in a tertiary care uveitis setting. J Clin Med. 2022;11(17):4995. doi:10.3390/jcm11174995.
  • Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F. Tubulointerstitial nephritis and uveitis syndrome: a systematic review. Nephrol Dial Transplant. 2022;37(5):876–886. doi:10.1093/ndt/gfab030.
  • Tan Y, Yu F, Qu Z, et al. Modified C-Reactive protein might be a target autoantigen of TINU syndrome. Clin J Am Soc Nephrol. 2011;6(1):93–100. doi:10.2215/CJN.09051209.
  • Rodriguez A. Referral patterns of uveitis in a tertiary eye care center. Arch Ophthalmol. 1996;114(5):593. doi:10.1001/archopht.1996.01100130585016.
  • Rothova A, Buitenhuis HJ, Meenken C, et al. Uveitis and systemic disease. Br J Ophthalmol. 1992;76(3):137–141. doi:10.1136/bjo.76.3.137.
  • Mercanti A, Parolini B, Bonora A, Lequaglie Q, Tomazzoli L. Epidemiology of endogenous uveitis in north-eastern Italy. Analysis of 655 new cases. Acta Ophthalmol Scand. 2001;79(1):64–68. doi:10.1034/j.1600-0420.2001.079001064.x.
  • Levinson RD, Park MS, Rikkers SM, et al. Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Investig Opthalmol Vis Sci. 2003;44(2):653. doi:10.1167/iovs.02-0376.
  • Mackensen F, David F, Schwenger V, et al. HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone. Br J Ophthalmol. 2011;95(7):971–975. doi:10.1136/bjo.2010.187955.
  • Reddy AK, Hwang YS, Mandelcorn ED, Davis JL. HLA-DR, DQ class II DNA typing in pediatric panuveitis and tubulointerstitial nephritis and uveitis. Am J Ophthalmol. 2014;157(3):678–686.e2. doi:10.1016/j.ajo.2013.12.006.
  • Peräsaari J, Saarela V, Nikkilä J, et al. HLA associations with tubulointerstitial nephritis with or without uveitis in Finnish pediatric population: a nation-wide study: HLA association in TIN. Tissue Antigens. 2013;81(6):435–441. doi:10.1111/tan.12116.
  • Gorrono-Echebarria MB. The tubulointerstitial nephritis and uveitis (TINU) syndrome is associated with HLA-DR14 in Spanish patients. Br J Ophthalmol. 2001;85(8):1007c–11007. doi:10.1136/bjo.85.8.1007c.
  • Kanaya A. A report of an adult case of Tubulointerstitial Nephritis and Uveitis (TINU) syndrome, with a review of 102 Japanese cases. Am J Case Rep. 2015;16:119–123. doi:10.12659/AJCR.892788.
  • Sanchez-Burson J, Garcia-Porrua C, Montero-Granados R, Gonzalez-Escribano F, Gonzalez-Gay MA. Tubulointerstitial nephritis and uveitis syndrome in Southern Spain. Semin Arthritis Rheum. 2002;32(2):125–129. doi:10.1053/sarh.2002.33718.
  • Vohra S, Eddy A, Levin AV, Taylor G, Laxer RM. Tubulointerstitial nephritis and uveitis in children and adolescents: four new cases and a review of the literature. Pediatr Nephrol. 1999;13(5):426–432. doi:10.1007/s004670050634.
  • Rytkönen SH, Kulmala P, Autio-Harmainen H, et al. FOXP3+ T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome. Pediatr Nephrol. 2018;33(2):287–293. doi:10.1007/s00467-017-3796-z.
  • Rytkönen S, Ritari J, Peräsaari J, Saarela V, Nuutinen M, Jahnukainen T. IL-10 polymorphisms +434T/C, +504G/T, and -2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population. Ciccacci C, ed. PLOS ONE. 2019;14(2):e0211915. doi:10.1371/journal.pone.0211915.
  • Yanagihara T, Kitamura H, Aki K, Kuroda N, Fukunaga Y. Serial renal biopsies in three girls with tubulointerstitial nephritis and uveitis syndrome. Pediatr Nephrol. 2009;24(6):1159–1164. doi:10.1007/s00467-009-1142-9.
  • Shimazaki K, Jirawuthiworavong GV, Nguyen EV, Awazu M, Levinson RD, Gordon LK. Tubulointerstitial nephritis and uveitis syndrome: a case with an autoimmune reactivity against retinal and renal antigens. Ocul Immunol Inflamm. 2008;16(1–2):51–53. doi:10.1080/09273940801899772.
  • Abed L, Merouani A, Haddad E, Benoit G, Oligny LL, Sartelet H. Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. Nephrol Dial Transplant. 2007;23(4):1452–1455. doi:10.1093/ndt/gfm890.
  • Li C, Su T, Chu R, Li X, Yang L. Tubulointerstitial nephritis with uveitis in Chinese adults. Clin J Am Soc Nephrol. 2014;9(1):21–28. doi:10.2215/CJN.02540313.
  • Takemoto Y, Namba K, Mizuuchi K, Ohno S, Ishida S. Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. Eur J Ophthalmol. 2013;23(2):255–257. doi:10.5301/ejo.5000240.
  • Sobolewska B, Bayyoud T, Deuter C, Doycheva D, Zierhut M. Long-term follow-up of patients with Tubulointerstitial Nephritis and Uveitis (TINU) syndrome. Ocul Immunol Inflamm. 2016;1–7. doi:10.1080/09273948.2016.1247872.
  • Diala FGI, McCarthy K, Chen JL, Tsui E. Multimodal imaging in pediatric uveitis. Ther Adv Ophthalmol. 2021;13:251584142110592. doi:10.1177/25158414211059244.
  • Ali A, Rosenbaum JT. TINU (Tubulointerstitial Nephritis Uveitis) can be associated with chorioretinal scars. Ocul Immunol Inflamm. 2014;22(3):213–217. doi:10.3109/09273948.2013.841624.
  • Scifo L, Willermain F, Postelmans L, et al. Subclinical choroidal inflammation revealed by indocyanine green angiography in tubulointerstitial nephritis and uveitis syndrome. Ocul Immunol Inflamm. 2022;30(5):1190–1198. doi:10.1080/09273948.2020.1869267.
  • Gion N, Stavrou P, Foster CS. Immunomodulatory therapy for chronic tubulointerstitial nephritis–associated uveitis. Am J Ophthalmol. 2000;129(6):764–768. doi:10.1016/S0002-9394(00)00482-7.
  • Takemura T, Okada M, Hino S, et al. Course and outcome of tubulointerstitial nephritis and uveitis syndrome. Am J Kidney Dis. 1999;34(6):1016–1021. doi:10.1016/S0272-6386(99)70006-5.
  • Jahnukainen T, Saarela V, Arikoski P, et al. Prednisone in the treatment of tubulointerstitial nephritis in children. Pediatr Nephrol. 2013;28(8):1253–1260. doi:10.1007/s00467-013-2476-x.
  • Legendre M, Devilliers H, Perard L, et al. Clinicopathologic characteristics, treatment, and outcomes of tubulointerstitial nephritis and uveitis syndrome in adults: a national retrospective strobe-compliant study. Medicine. 2016;95(26):e3964. doi:10.1097/MD.0000000000003964.
  • Southgate G, Clarke P, Harmer MJ. Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis. J Nephrol. 2022;36(2):507–519. doi:10.1007/s40620-022-01478-8.